##gff-version 3
O75366	UniProtKB	Chain	1	819	.	.	.	ID=PRO_0000218736;Note=Advillin	
O75366	UniProtKB	Repeat	24	73	.	.	.	Note=Gelsolin-like 1	
O75366	UniProtKB	Repeat	145	185	.	.	.	Note=Gelsolin-like 2	
O75366	UniProtKB	Repeat	262	306	.	.	.	Note=Gelsolin-like 3	
O75366	UniProtKB	Repeat	403	454	.	.	.	Note=Gelsolin-like 4	
O75366	UniProtKB	Repeat	525	565	.	.	.	Note=Gelsolin-like 5	
O75366	UniProtKB	Repeat	628	669	.	.	.	Note=Gelsolin-like 6	
O75366	UniProtKB	Domain	753	819	.	.	.	Note=HP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00595	
O75366	UniProtKB	Region	1	731	.	.	.	Note=Core;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O75366	UniProtKB	Region	628	819	.	.	.	Note=Required for interaction with F-actin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29058690;Dbxref=PMID:29058690	
O75366	UniProtKB	Region	731	819	.	.	.	Note=Headpiece;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O75366	UniProtKB	Binding site	109	116	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O75366	UniProtKB	Binding site	135	143	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O75366	UniProtKB	Modified residue	85	85	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88398	
O75366	UniProtKB	Modified residue	758	758	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88398	
O75366	UniProtKB	Alternative sequence	1	21	.	.	.	ID=VSP_036961;Note=In isoform 2. MPLTSAFRAVDNDPGIIVWRI->MSSTGHPGSYKIWG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
O75366	UniProtKB	Natural variant	135	135	.	.	.	ID=VAR_083229;Note=In NPHS21%3B inhibited actin bundling capacity%3B slightly decreased interaction with PLCE1%3B disrupted EGF-induced diacylglycerol generation by PLCE1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29058690;Dbxref=dbSNP:rs138047529,PMID:29058690	
O75366	UniProtKB	Natural variant	204	204	.	.	.	ID=VAR_054974;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16541075,ECO:0000269|PubMed:9664034;Dbxref=dbSNP:rs2172521,PMID:14702039,PMID:15489334,PMID:16541075,PMID:9664034	
O75366	UniProtKB	Natural variant	425	425	.	.	.	ID=VAR_083230;Note=In NPHS21%3B inhibited actin bundling capacity%3B decreases interaction with PLCE1%3B disrupted EGF-induced diacylglycerol generation by PLCE1. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29058690;Dbxref=dbSNP:rs763782471,PMID:29058690	
O75366	UniProtKB	Natural variant	446	446	.	.	.	ID=VAR_083231;Note=In NPHS21%3B uncertain significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29058690;Dbxref=dbSNP:rs1334894971,PMID:29058690	
O75366	UniProtKB	Mutagenesis	62	62	.	.	.	Note=Reduces interaction with F-actin. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15096633;Dbxref=PMID:15096633	
O75366	UniProtKB	Sequence conflict	445	445	.	.	.	Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75366	UniProtKB	Helix	787	794	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UND	
O75366	UniProtKB	Helix	798	803	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UND	
O75366	UniProtKB	Helix	806	817	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UND