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O75366

- AVIL_HUMAN

UniProt

O75366 - AVIL_HUMAN

Protein

Advillin

Gene

AVIL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Ca2+-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProtKB

    GO - Biological processi

    1. actin filament capping Source: UniProtKB-KW
    2. cilium morphogenesis Source: UniProtKB
    3. cytoskeleton organization Source: InterPro
    4. nervous system development Source: ProtInc
    5. positive regulation of neuron projection development Source: UniProtKB

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding, Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Advillin
    Alternative name(s):
    p92
    Gene namesi
    Name:AVIL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14188. AVIL.

    Subcellular locationi

    Cytoplasmcytoskeleton. Cell projection By similarity. Cell projectionaxon By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: ProtInc
    2. axon Source: UniProtKB-SubCell
    3. cell projection Source: UniProtKB
    4. cytoplasm Source: UniProtKB-KW
    5. neuron projection Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi62 – 621W → A: Reduces interaction with F-actin. 1 Publication

    Organism-specific databases

    PharmGKBiPA38380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819AdvillinPRO_0000218736Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei85 – 851PhosphotyrosineBy similarity
    Modified residuei758 – 7581PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO75366.
    PRIDEiO75366.

    PTM databases

    PhosphoSiteiO75366.

    Expressioni

    Tissue specificityi

    Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus.1 Publication

    Gene expression databases

    ArrayExpressiO75366.
    BgeeiO75366.
    CleanExiHS_AVIL.
    GenevestigatoriO75366.

    Organism-specific databases

    HPAiHPA058864.

    Interactioni

    Subunit structurei

    Associates (via C-terminus) with actin. Interacts with SCARF1 By similarity. Interacts with F-actin.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi115918. 3 interactions.
    MINTiMINT-4990440.
    STRINGi9606.ENSP00000257861.

    Structurei

    Secondary structure

    1
    819
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi787 – 7948
    Helixi798 – 8036
    Helixi806 – 81712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UNDNMR-A784-819[»]
    ProteinModelPortaliO75366.
    SMRiO75366. Positions 7-722, 759-819.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75366.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 7350Gelsolin-like 1Add
    BLAST
    Repeati145 – 18541Gelsolin-like 2Add
    BLAST
    Repeati262 – 30645Gelsolin-like 3Add
    BLAST
    Repeati403 – 45452Gelsolin-like 4Add
    BLAST
    Repeati525 – 56541Gelsolin-like 5Add
    BLAST
    Repeati628 – 66942Gelsolin-like 6Add
    BLAST
    Domaini753 – 81967HPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 731731CoreBy similarityAdd
    BLAST
    Regioni109 – 1168Polyphosphoinositide bindingBy similarity
    Regioni135 – 1439Polyphosphoinositide bindingBy similarity
    Regioni731 – 81989HeadpieceBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the villin/gelsolin family.Curated
    Contains 6 gelsolin-like repeats.Curated
    Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG304849.
    HOGENOMiHOG000233630.
    HOVERGENiHBG004183.
    InParanoidiO75366.
    KOiK08017.
    OMAiCYVILST.
    OrthoDBiEOG7288RJ.
    PhylomeDBiO75366.
    TreeFamiTF313468.

    Family and domain databases

    Gene3Di1.10.950.10. 1 hit.
    3.40.20.10. 6 hits.
    InterProiIPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR007122. Villin/Gelsolin.
    IPR003128. Villin_headpiece.
    [Graphical view]
    PANTHERiPTHR11977. PTHR11977. 1 hit.
    PfamiPF00626. Gelsolin. 6 hits.
    PF02209. VHP. 1 hit.
    [Graphical view]
    PRINTSiPR00597. GELSOLIN.
    SMARTiSM00262. GEL. 6 hits.
    SM00153. VHP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47050. SSF47050. 1 hit.
    PROSITEiPS51089. HP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75366-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLTSAFRAV DNDPGIIVWR IEKMELALVP VSAHGNFYEG DCYVILSTRR    50
    VASLLSQDIH FWIGKDSSQD EQSCAAIYTT QLDDYLGGSP VQHREVQYHE 100
    SDTFRGYFKQ GIIYKQGGVA SGMKHVETNT YDVKRLLHVK GKRNIRATEV 150
    EMSWDSFNRG DVFLLDLGKV IIQWNGPESN SGERLKAMLL AKDIRDRERG 200
    GRAKIGVIEG DKEAASPELM KVLQDTLGRR SIIKPTVPDE IIDQKQKSTI 250
    MLYHISDSAG QLAVTEVATR PLVQDLLNHD DCYILDQSGT KIYVWKGKGA 300
    TKAEKQAAMS KALGFIKMKS YPSSTNVETV NDGAESAMFK QLFQKWSVKD 350
    QTMGLGKTFS IGKIAKVFQD KFDVTLLHTK PEVAAQERMV DDGNGKVEVW 400
    RIENLELVPV EYQWYGFFYG GDCYLVLYTY EVNGKPHHIL YIWQGRHASQ 450
    DELAASAYQA VEVDRQFDGA AVQVRVRMGT EPRHFMAIFK GKLVIFEGGT 500
    SRKGNAEPDP PVRLFQIHGN DKSNTKAVEV PAFASSLNSN DVFLLRTQAE 550
    HYLWYGKGSS GDERAMAKEL ASLLCDGSEN TVAEGQEPAE FWDLLGGKTP 600
    YANDKRLQQE ILDVQSRLFE CSNKTGQFVV TEITDFTQDD LNPTDVMLLD 650
    TWDQVFLWIG AEANATEKES ALATAQQYLH THPSGRDPDT PILIIKQGFE 700
    PPIFTGWFLA WDPNIWSAGK TYEQLKEELG DAAAIMRITA DMKNATLSLN 750
    SNDSEPKYYP IAVLLKNQNQ ELPEDVNPAK KENYLSEQDF VSVFGITRGQ 800
    FAALPGWKQL QMKKEKGLF 819
    Length:819
    Mass (Da):92,027
    Last modified:November 30, 2010 - v3
    Checksum:iF5EF3A94BA61E647
    GO
    Isoform 2 (identifier: O75366-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: MPLTSAFRAVDNDPGIIVWRI → MSSTGHPGSYKIWG

    Show »
    Length:812
    Mass (Da):91,163
    Checksum:iCAACCD7994F2D989
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti445 – 4451G → D in AAC25051. (PubMed:9664034)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti204 – 2041K → E.4 Publications
    Corresponds to variant rs2172521 [ dbSNP | Ensembl ].
    VAR_054974

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121MPLTS…IVWRI → MSSTGHPGSYKIWG in isoform 2. 1 PublicationVSP_036961Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041449 mRNA. Translation: AAC25051.1.
    AK314362 mRNA. Translation: BAG36994.1.
    AC025165 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97080.1.
    BC111730 mRNA. Translation: AAI11731.1.
    CCDSiCCDS8959.1. [O75366-1]
    RefSeqiNP_006567.3. NM_006576.3. [O75366-1]
    XP_006719261.1. XM_006719198.1. [O75366-1]
    UniGeneiHs.584854.

    Genome annotation databases

    EnsembliENST00000257861; ENSP00000257861; ENSG00000135407. [O75366-1]
    GeneIDi10677.
    KEGGihsa:10677.
    UCSCiuc001sqj.2. human. [O75366-1]
    uc009zqe.2. human. [O75366-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041449 mRNA. Translation: AAC25051.1 .
    AK314362 mRNA. Translation: BAG36994.1 .
    AC025165 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97080.1 .
    BC111730 mRNA. Translation: AAI11731.1 .
    CCDSi CCDS8959.1. [O75366-1 ]
    RefSeqi NP_006567.3. NM_006576.3. [O75366-1 ]
    XP_006719261.1. XM_006719198.1. [O75366-1 ]
    UniGenei Hs.584854.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UND NMR - A 784-819 [» ]
    ProteinModelPortali O75366.
    SMRi O75366. Positions 7-722, 759-819.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115918. 3 interactions.
    MINTi MINT-4990440.
    STRINGi 9606.ENSP00000257861.

    PTM databases

    PhosphoSitei O75366.

    Proteomic databases

    PaxDbi O75366.
    PRIDEi O75366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257861 ; ENSP00000257861 ; ENSG00000135407 . [O75366-1 ]
    GeneIDi 10677.
    KEGGi hsa:10677.
    UCSCi uc001sqj.2. human. [O75366-1 ]
    uc009zqe.2. human. [O75366-2 ]

    Organism-specific databases

    CTDi 10677.
    GeneCardsi GC12M058191.
    H-InvDB HIX0023233.
    HGNCi HGNC:14188. AVIL.
    HPAi HPA058864.
    MIMi 613397. gene.
    neXtProti NX_O75366.
    PharmGKBi PA38380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304849.
    HOGENOMi HOG000233630.
    HOVERGENi HBG004183.
    InParanoidi O75366.
    KOi K08017.
    OMAi CYVILST.
    OrthoDBi EOG7288RJ.
    PhylomeDBi O75366.
    TreeFami TF313468.

    Miscellaneous databases

    EvolutionaryTracei O75366.
    GenomeRNAii 10677.
    NextBioi 40597.
    PROi O75366.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75366.
    Bgeei O75366.
    CleanExi HS_AVIL.
    Genevestigatori O75366.

    Family and domain databases

    Gene3Di 1.10.950.10. 1 hit.
    3.40.20.10. 6 hits.
    InterProi IPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR007122. Villin/Gelsolin.
    IPR003128. Villin_headpiece.
    [Graphical view ]
    PANTHERi PTHR11977. PTHR11977. 1 hit.
    Pfami PF00626. Gelsolin. 6 hits.
    PF02209. VHP. 1 hit.
    [Graphical view ]
    PRINTSi PR00597. GELSOLIN.
    SMARTi SM00262. GEL. 6 hits.
    SM00153. VHP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47050. SSF47050. 1 hit.
    PROSITEi PS51089. HP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins."
      Marks P.W., Arai M., Bandura J.L., Kwiatkowski D.J.
      J. Cell Sci. 111:2129-2136(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-204.
      Tissue: Uterus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-204.
      Tissue: Brain.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-204.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-204.
    6. "Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2)."
      Tumer Z., Croucher P.J., Jensen L.R., Hampe J., Hansen C., Kalscheuer V., Ropers H.H., Tommerup N., Schreiber S.
      Gene 288:179-185(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Functional genomic screen for modulators of ciliogenesis and cilium length."
      Kim J., Lee J.E., Heynen-Genel S., Suyama E., Ono K., Lee K., Ideker T., Aza-Blanc P., Gleeson J.G.
      Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements."
      Vermeulen W., Vanhaesebrouck P., Van Troys M., Verschueren M., Fant F., Goethals M., Ampe C., Martins J.C., Borremans F.A.
      Protein Sci. 13:1276-1287(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 784-819, INTERACTION WITH F-ACTIN, MUTAGENESIS OF TRP-62.

    Entry informationi

    Entry nameiAVIL_HUMAN
    AccessioniPrimary (citable) accession number: O75366
    Secondary accession number(s): B2RAU7, Q2NKM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3