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Protein

Breast carcinoma-amplified sequence 1

Gene

BCAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Breast carcinoma-amplified sequence 1
Alternative name(s):
Amplified and overexpressed in breast cancer
Novel amplified in breast cancer 1
Gene namesi
Name:BCAS1
Synonyms:AIBC1, NABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:974. BCAS1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25284.

Polymorphism and mutation databases

BioMutaiBCAS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Breast carcinoma-amplified sequence 1PRO_0000064859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei192 – 1921PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei399 – 3991PhosphoserineBy similarity
Modified residuei480 – 4801PhosphothreonineBy similarity
Modified residuei552 – 5521PhosphoserineBy similarity
Isoform 2 (identifier: O75363-2)
Modified residuei340 – 3401PhosphoserineCurated

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75363.
PaxDbiO75363.
PeptideAtlasiO75363.
PRIDEiO75363.

PTM databases

iPTMnetiO75363.
PhosphoSiteiO75363.

Expressioni

Tissue specificityi

Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.2 Publications

Gene expression databases

BgeeiO75363.
CleanExiHS_BCAS1.
ExpressionAtlasiO75363. baseline and differential.
GenevisibleiO75363. HS.

Organism-specific databases

HPAiCAB033558.
HPA051816.
HPA054745.

Interactioni

Subunit structurei

Homodimer. May interact with DYNLL1 and DYNLL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi114107. 3 interactions.
STRINGi9606.ENSP00000379290.

Structurei

3D structure databases

ProteinModelPortaliO75363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IJ5W. Eukaryota.
ENOG41119UT. LUCA.
GeneTreeiENSGT00390000003167.
HOGENOMiHOG000232037.
HOVERGENiHBG082347.
InParanoidiO75363.
OMAiTQGAAKN.
OrthoDBiEOG72VH5X.
PhylomeDBiO75363.
TreeFamiTF335555.

Family and domain databases

InterProiIPR026115. NABC1.
[Graphical view]
PANTHERiPTHR15016. PTHR15016. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75363-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNQMSVPQR VEDQENEPEA ETYQDNASAL NGVPVVVSTH TVQHLEEVDL
60 70 80 90 100
GISVKTDNVA TSSPETTEIS AVADANGKNL GKEAKPEAPA AKSRFFLMLS
110 120 130 140 150
RPVPGRTGDQ AADSSLGSVK LDVSSNKAPA NKDPSESWTL PVAAGPGQDT
160 170 180 190 200
DKTPGHAPAQ DKVLSAARDP TLLPPETGGA GGEAPSKPKD SSFFDKFFKL
210 220 230 240 250
DKGQEKVPGD SQQEAKRAEH QDKVDEVPGL SGQSDDVPAG KDIVDGKEKE
260 270 280 290 300
GQELGTADCS VPGDPEGLET AKDDSQAAAI AENNNSIMSF FKTLVSPNKA
310 320 330 340 350
ETKKDPEDTG AEKSPTTSAD LKSDKANFTS QETQGAGKNS KGCNPSGHTQ
360 370 380 390 400
SVTTPEPAKE GTKEKSGPTS LPLGKLFWKK SVKEDSVPTG AEENVVCESP
410 420 430 440 450
VEIIKSKEVE SALQTVDLNE GDAAPEPTEA KLKREESKPR TSLMAFLRQM
460 470 480 490 500
SVKGDGGITH SEEINGKDSS CQTSDSTEKT ITPPEPEPTG APQKGKEGSS
510 520 530 540 550
KDKKSAAEMN KQKSNKQEAK EPAQCTEQAT VDTNSLQNGD KLQKRPEKRQ
560 570 580
QSLGGFFKGL GPKRMLDAQV QTDPVSIGPV GKSK
Length:584
Mass (Da):61,709
Last modified:June 13, 2006 - v2
Checksum:i22921C0B37129944
GO
Isoform 2 (identifier: O75363-2) [UniParc]FASTAAdd to basket

Also known as: 5B

The sequence of this isoform differs from the canonical sequence as follows:
     309-309: T → TASKAESVCDGQAGQKTSEIQARGTKKKHLDSPRLGLAFRKFFRHK
     381-394: Missing.
     451-472: Missing.
     584-584: K → KYTGKCVFSHVKKKWPFQEWSY

Show »
Length:614
Mass (Da):65,663
Checksum:iDA05CD7CEB86C170
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611G → D in CAH18437 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241Q → K.
Corresponds to variant rs394732 [ dbSNP | Ensembl ].
VAR_026674
Natural varianti163 – 1631V → A.
Corresponds to variant rs158551 [ dbSNP | Ensembl ].
VAR_026675
Natural varianti255 – 2551G → E.
Corresponds to variant rs6022903 [ dbSNP | Ensembl ].
VAR_024251
Natural varianti472 – 4721Q → H.
Corresponds to variant rs35575210 [ dbSNP | Ensembl ].
VAR_050691
Natural varianti583 – 5831S → P.1 Publication
Corresponds to variant rs1055246 [ dbSNP | Ensembl ].
VAR_026676

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei309 – 3091T → TASKAESVCDGQAGQKTSEI QARGTKKKHLDSPRLGLAFR KFFRHK in isoform 2. 2 PublicationsVSP_018520
Alternative sequencei381 – 39414Missing in isoform 2. 2 PublicationsVSP_018521Add
BLAST
Alternative sequencei451 – 47222Missing in isoform 2. 2 PublicationsVSP_018522Add
BLAST
Alternative sequencei584 – 5841K → KYTGKCVFSHVKKKWPFQEW SY in isoform 2. 2 PublicationsVSP_018523

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041260 mRNA. Translation: AAC39896.1.
AC004501 Genomic DNA. No translation available.
AC005220 Genomic DNA. No translation available.
BC126346 mRNA. Translation: AAI26347.1.
AI904532 mRNA. No translation available.
CR749643 mRNA. Translation: CAH18437.1.
CCDSiCCDS13444.1. [O75363-1]
RefSeqiNP_003648.2. NM_003657.3. [O75363-1]
UniGeneiHs.400556.

Genome annotation databases

EnsembliENST00000395961; ENSP00000379290; ENSG00000064787. [O75363-1]
GeneIDi8537.
KEGGihsa:8537.
UCSCiuc002xws.3. human. [O75363-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041260 mRNA. Translation: AAC39896.1.
AC004501 Genomic DNA. No translation available.
AC005220 Genomic DNA. No translation available.
BC126346 mRNA. Translation: AAI26347.1.
AI904532 mRNA. No translation available.
CR749643 mRNA. Translation: CAH18437.1.
CCDSiCCDS13444.1. [O75363-1]
RefSeqiNP_003648.2. NM_003657.3. [O75363-1]
UniGeneiHs.400556.

3D structure databases

ProteinModelPortaliO75363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114107. 3 interactions.
STRINGi9606.ENSP00000379290.

PTM databases

iPTMnetiO75363.
PhosphoSiteiO75363.

Polymorphism and mutation databases

BioMutaiBCAS1.

Proteomic databases

MaxQBiO75363.
PaxDbiO75363.
PeptideAtlasiO75363.
PRIDEiO75363.

Protocols and materials databases

DNASUi8537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395961; ENSP00000379290; ENSG00000064787. [O75363-1]
GeneIDi8537.
KEGGihsa:8537.
UCSCiuc002xws.3. human. [O75363-1]

Organism-specific databases

CTDi8537.
GeneCardsiBCAS1.
H-InvDBHIX0015925.
HGNCiHGNC:974. BCAS1.
HPAiCAB033558.
HPA051816.
HPA054745.
MIMi602968. gene.
neXtProtiNX_O75363.
PharmGKBiPA25284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ5W. Eukaryota.
ENOG41119UT. LUCA.
GeneTreeiENSGT00390000003167.
HOGENOMiHOG000232037.
HOVERGENiHBG082347.
InParanoidiO75363.
OMAiTQGAAKN.
OrthoDBiEOG72VH5X.
PhylomeDBiO75363.
TreeFamiTF335555.

Miscellaneous databases

ChiTaRSiBCAS1. human.
GeneWikiiBCAS1.
GenomeRNAii8537.
PROiO75363.
SOURCEiSearch...

Gene expression databases

BgeeiO75363.
CleanExiHS_BCAS1.
ExpressionAtlasiO75363. baseline and differential.
GenevisibleiO75363. HS.

Family and domain databases

InterProiIPR026115. NABC1.
[Graphical view]
PANTHERiPTHR15016. PTHR15016. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-583.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors."
    Correa R.G., de Carvalho A.F., Pinheiro N.A., Simpson A.J.G., de Souza S.J.
    Genomics 65:299-302(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-330 (ISOFORM 2), TISSUE SPECIFICITY.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 275-584 (ISOFORM 2).
    Tissue: Amygdala.
  6. "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product."
    Beardsley D.I., Kowbel D., Lataxes T.A., Mannino J.M., Xin H., Kim W.-J., Collins C., Brown K.D.
    Exp. Cell Res. 290:402-413(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBCAS1_HUMAN
AccessioniPrimary (citable) accession number: O75363
Secondary accession number(s): A0AVG5, Q68CZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.