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O75362 - ZN217_HUMAN

UniProt

O75362 - ZN217_HUMAN

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Protein

Zinc finger protein 217

Gene

ZNF217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri65 – 8824C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 217
Gene namesi
Name:ZNF217
Synonyms:ZABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13009. ZNF217.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. histone deacetylase complex Source: UniProtKB
  2. nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10481048Zinc finger protein 217PRO_0000047460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211Phosphoserine1 Publication
Modified residuei322 – 3221Phosphothreonine1 Publication
Modified residuei407 – 4071Phosphoserine1 Publication
Modified residuei648 – 6481Phosphothreonine1 Publication
Modified residuei662 – 6621Phosphoserine1 Publication
Modified residuei795 – 7951Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75362.
PaxDbiO75362.
PRIDEiO75362.

PTM databases

PhosphoSiteiO75362.

Expressioni

Gene expression databases

BgeeiO75362.
CleanExiHS_ZNF217.
ExpressionAtlasiO75362. baseline and differential.
GenevestigatoriO75362.

Organism-specific databases

HPAiHPA051857.

Interactioni

Subunit structurei

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

BioGridi113547. 13 interactions.
IntActiO75362. 3 interactions.
MINTiMINT-7970236.
STRINGi9606.ENSP00000304308.

Structurei

Secondary structure

1
1048
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni474 – 4763Combined sources
Helixi483 – 49412Combined sources
Beta strandi502 – 5054Combined sources
Beta strandi507 – 5104Combined sources
Helixi511 – 52111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362.
SMRiO75362. Positions 58-93, 114-268, 368-403, 470-523.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75362.

Family & Domainsi

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri65 – 8824C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG319981.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000276541.
HOVERGENiHBG061769.
InParanoidiO75362.
OMAiNEVVQEH.
OrthoDBiEOG7CNZFG.
PhylomeDBiO75362.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA 
        60         70         80         90        100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV 
       110        120        130        140        150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH 
       160        170        180        190        200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN 
       210        220        230        240        250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ 
       260        270        280        290        300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 
       310        320        330        340        350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK 
       360        370        380        390        400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD 
       410        420        430        440        450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP 
       460        470        480        490        500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK 
       510        520        530        540        550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD 
       560        570        580        590        600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 
       610        620        630        640        650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP 
       660        670        680        690        700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI 
       710        720        730        740        750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR 
       760        770        780        790        800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG 
       810        820        830        840        850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA 
       860        870        880        890        900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 
       910        920        930        940        950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG 
       960        970        980        990       1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV 
      1010       1020       1030       1040 
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT
Length:1,048
Mass (Da):115,272
Last modified:November 1, 1998 - v1
Checksum:i797FC620817D1E1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti323 – 3231D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035572
Natural varianti739 – 7391V → I.
Corresponds to variant rs6063966 [ dbSNP | Ensembl ].		VAR_052795
Natural varianti889 – 8891D → G.
Corresponds to variant rs34323943 [ dbSNP | Ensembl ].		VAR_061939

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA. Translation: AAC39895.1.
AL157838 Genomic DNA. Translation: CAC08433.1.
CH471077 Genomic DNA. Translation: EAW75580.1.
BC113427 mRNA. Translation: AAI13428.1.
CCDSiCCDS13443.1.
RefSeqiNP_006517.1. NM_006526.2.
UniGeneiHs.155040.
Hs.711564.

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940.
ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDi7764.
KEGGihsa:7764.
UCSCiuc002xwq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA. Translation: AAC39895.1.
AL157838 Genomic DNA. Translation: CAC08433.1.
CH471077 Genomic DNA. Translation: EAW75580.1.
BC113427 mRNA. Translation: AAI13428.1.
CCDSiCCDS13443.1.
RefSeqiNP_006517.1. NM_006526.2.
UniGeneiHs.155040.
Hs.711564.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362.
SMRiO75362. Positions 58-93, 114-268, 368-403, 470-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113547. 13 interactions.
IntActiO75362. 3 interactions.
MINTiMINT-7970236.
STRINGi9606.ENSP00000304308.

PTM databases

PhosphoSiteiO75362.

Proteomic databases

MaxQBiO75362.
PaxDbiO75362.
PRIDEiO75362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940.
ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDi7764.
KEGGihsa:7764.
UCSCiuc002xwq.4. human.

Organism-specific databases

CTDi7764.
GeneCardsiGC20M052183.
HGNCiHGNC:13009. ZNF217.
HPAiHPA051857.
MIMi602967. gene.
neXtProtiNX_O75362.
PharmGKBiPA37588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319981.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000276541.
HOVERGENiHBG061769.
InParanoidiO75362.
OMAiNEVVQEH.
OrthoDBiEOG7CNZFG.
PhylomeDBiO75362.
TreeFamiTF332241.

Miscellaneous databases

ChiTaRSiZNF217. human.
EvolutionaryTraceiO75362.
GeneWikiiZNF217.
GenomeRNAii7764.
NextBioi30059.
PROiO75362.
SOURCEiSearch...

Gene expression databases

BgeeiO75362.
CleanExiHS_ZNF217.
ExpressionAtlasiO75362. baseline and differential.
GenevestigatoriO75362.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
    Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R.
    J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZMYM2; ZMYM3; KIAA0182 AND GTF2I.
  6. "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction."
    Huang G., Krig S., Kowbel D., Xu H., Hyun B., Volik S., Feuerstein B., Mills G.B., Stokoe D., Yaswen P., Collins C.
    Hum. Mol. Genet. 14:3219-3225(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays."
    Krig S.R., Jin V.X., Bieda M.C., O'Geen H., Yaswen P., Green R., Farnham P.J.
    J. Biol. Chem. 282:9703-9712(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex."
    Thillainadesan G., Isovic M., Loney E., Andrews J., Tini M., Torchia J.
    Mol. Cell. Biol. 28:6066-6077(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN A COMPLEX WITH HDAC2; KDM1A AND CTBP1, FUNCTION.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-795, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins."
    Quinlan K.G.R., Nardini M., Verger A., Francescato P., Yaswen P., Corda D., Bolognesi M., Crossley M.
    Mol. Cell. Biol. 26:8159-8172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 752-760 IN COMPLEX WITH CTBP1, INTERACTION WITH CTBP1 AND CTBP2, FUNCTION.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-323.
+Additional computationally mapped references.

Entry informationi

Entry nameiZN217_HUMAN
AccessioniPrimary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.