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O75362

- ZN217_HUMAN

UniProt

O75362 - ZN217_HUMAN

Protein

Zinc finger protein 217

Gene

ZNF217

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri65 – 8824C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri471 – 49323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 52123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 217
    Gene namesi
    Name:ZNF217
    Synonyms:ZABC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13009. ZNF217.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. histone deacetylase complex Source: UniProtKB
    2. nucleoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10481048Zinc finger protein 217PRO_0000047460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei321 – 3211Phosphoserine1 Publication
    Modified residuei322 – 3221Phosphothreonine1 Publication
    Modified residuei407 – 4071Phosphoserine1 Publication
    Modified residuei648 – 6481Phosphothreonine1 Publication
    Modified residuei662 – 6621Phosphoserine1 Publication
    Modified residuei795 – 7951Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75362.
    PaxDbiO75362.
    PRIDEiO75362.

    PTM databases

    PhosphoSiteiO75362.

    Expressioni

    Gene expression databases

    ArrayExpressiO75362.
    BgeeiO75362.
    CleanExiHS_ZNF217.
    GenevestigatoriO75362.

    Organism-specific databases

    HPAiHPA051857.

    Interactioni

    Subunit structurei

    Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

    Protein-protein interaction databases

    BioGridi113547. 12 interactions.
    IntActiO75362. 3 interactions.
    MINTiMINT-7970236.
    STRINGi9606.ENSP00000304308.

    Structurei

    Secondary structure

    1
    1048
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni474 – 4763
    Helixi483 – 49412
    Beta strandi502 – 5054
    Beta strandi507 – 5104
    Helixi511 – 52111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HU2X-ray2.85B752-760[»]
    3UK3X-ray2.10C/D469-523[»]
    4F2JX-ray2.64C469-523[»]
    4IS1X-ray2.10C/D469-523[»]
    ProteinModelPortaliO75362.
    SMRiO75362. Positions 58-93, 114-268, 368-403, 469-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75362.

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri65 – 8824C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri471 – 49323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 52123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG319981.
    HOGENOMiHOG000276541.
    HOVERGENiHBG061769.
    InParanoidiO75362.
    OMAiTGNMPTQ.
    OrthoDBiEOG7CNZFG.
    PhylomeDBiO75362.
    TreeFamiTF332241.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA     50
    TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV 100
    EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH 150
    KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN 200
    EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ 250
    TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 300
    LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK 350
    CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD 400
    RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP 450
    EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK 500
    CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD 550
    SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 600
    DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP 650
    PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI 700
    SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR 750
    SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG 800
    KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA 850
    PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 900
    CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG 950
    ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV 1000
    PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT 1048
    Length:1,048
    Mass (Da):115,272
    Last modified:November 1, 1998 - v1
    Checksum:i797FC620817D1E1F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti323 – 3231D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035572
    Natural varianti739 – 7391V → I.
    Corresponds to variant rs6063966 [ dbSNP | Ensembl ].
    VAR_052795
    Natural varianti889 – 8891D → G.
    Corresponds to variant rs34323943 [ dbSNP | Ensembl ].
    VAR_061939

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041259 mRNA. Translation: AAC39895.1.
    AL157838 Genomic DNA. Translation: CAC08433.1.
    CH471077 Genomic DNA. Translation: EAW75580.1.
    BC113427 mRNA. Translation: AAI13428.1.
    CCDSiCCDS13443.1.
    RefSeqiNP_006517.1. NM_006526.2.
    UniGeneiHs.155040.
    Hs.711564.

    Genome annotation databases

    EnsembliENST00000302342; ENSP00000304308; ENSG00000171940.
    ENST00000371471; ENSP00000360526; ENSG00000171940.
    GeneIDi7764.
    KEGGihsa:7764.
    UCSCiuc002xwq.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041259 mRNA. Translation: AAC39895.1 .
    AL157838 Genomic DNA. Translation: CAC08433.1 .
    CH471077 Genomic DNA. Translation: EAW75580.1 .
    BC113427 mRNA. Translation: AAI13428.1 .
    CCDSi CCDS13443.1.
    RefSeqi NP_006517.1. NM_006526.2.
    UniGenei Hs.155040.
    Hs.711564.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HU2 X-ray 2.85 B 752-760 [» ]
    3UK3 X-ray 2.10 C/D 469-523 [» ]
    4F2J X-ray 2.64 C 469-523 [» ]
    4IS1 X-ray 2.10 C/D 469-523 [» ]
    ProteinModelPortali O75362.
    SMRi O75362. Positions 58-93, 114-268, 368-403, 469-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113547. 12 interactions.
    IntActi O75362. 3 interactions.
    MINTi MINT-7970236.
    STRINGi 9606.ENSP00000304308.

    PTM databases

    PhosphoSitei O75362.

    Proteomic databases

    MaxQBi O75362.
    PaxDbi O75362.
    PRIDEi O75362.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302342 ; ENSP00000304308 ; ENSG00000171940 .
    ENST00000371471 ; ENSP00000360526 ; ENSG00000171940 .
    GeneIDi 7764.
    KEGGi hsa:7764.
    UCSCi uc002xwq.4. human.

    Organism-specific databases

    CTDi 7764.
    GeneCardsi GC20M052183.
    HGNCi HGNC:13009. ZNF217.
    HPAi HPA051857.
    MIMi 602967. gene.
    neXtProti NX_O75362.
    PharmGKBi PA37588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319981.
    HOGENOMi HOG000276541.
    HOVERGENi HBG061769.
    InParanoidi O75362.
    OMAi TGNMPTQ.
    OrthoDBi EOG7CNZFG.
    PhylomeDBi O75362.
    TreeFami TF332241.

    Miscellaneous databases

    ChiTaRSi ZNF217. human.
    EvolutionaryTracei O75362.
    GeneWikii ZNF217.
    GenomeRNAii 7764.
    NextBioi 30059.
    PROi O75362.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75362.
    Bgeei O75362.
    CleanExi HS_ZNF217.
    Genevestigatori O75362.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
      Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R.
      J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZMYM2; ZMYM3; KIAA0182 AND GTF2I.
    6. "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction."
      Huang G., Krig S., Kowbel D., Xu H., Hyun B., Volik S., Feuerstein B., Mills G.B., Stokoe D., Yaswen P., Collins C.
      Hum. Mol. Genet. 14:3219-3225(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays."
      Krig S.R., Jin V.X., Bieda M.C., O'Geen H., Yaswen P., Green R., Farnham P.J.
      J. Biol. Chem. 282:9703-9712(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex."
      Thillainadesan G., Isovic M., Loney E., Andrews J., Tini M., Torchia J.
      Mol. Cell. Biol. 28:6066-6077(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, IDENTIFICATION IN A COMPLEX WITH HDAC2; KDM1A AND CTBP1, FUNCTION.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-795, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins."
      Quinlan K.G.R., Nardini M., Verger A., Francescato P., Yaswen P., Corda D., Bolognesi M., Crossley M.
      Mol. Cell. Biol. 26:8159-8172(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 752-760 IN COMPLEX WITH CTBP1, INTERACTION WITH CTBP1 AND CTBP2, FUNCTION.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-323.

    Entry informationi

    Entry nameiZN217_HUMAN
    AccessioniPrimary (citable) accession number: O75362
    Secondary accession number(s): E1P5Y6, Q14DB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3