UniProtKB - O75362 (ZN217_HUMAN)
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Protein
Zinc finger protein 217
Gene
ZNF217
Organism
Homo sapiens (Human)
Status
Functioni
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 65 – 88 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 128 – 150 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 499 – 521 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: ProtInc
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcription regulatory region DNA binding Source: UniProtKB
GO - Biological processi
- multicellular organism development Source: GO_Central
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: UniProtKB
- signal transduction Source: GO_Central
- transcription, DNA-templated Source: ProtInc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SIGNORi | O75362. |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 217 |
Gene namesi | Name:ZNF217 Synonyms:ZABC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171940.13. |
HGNCi | HGNC:13009. ZNF217. |
MIMi | 602967. gene. |
neXtProti | NX_O75362. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7764. |
OpenTargetsi | ENSG00000171940. |
PharmGKBi | PA37588. |
Polymorphism and mutation databases
BioMutai | ZNF217. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047460 | 1 – 1048 | Zinc finger protein 217Add BLAST | 1048 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 106 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 648 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 662 | PhosphoserineCombined sources | 1 | |
Modified residuei | 795 | PhosphoserineCombined sources | 1 | |
Cross-linki | 819 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O75362. |
MaxQBi | O75362. |
PaxDbi | O75362. |
PeptideAtlasi | O75362. |
PRIDEi | O75362. |
PTM databases
iPTMneti | O75362. |
PhosphoSitePlusi | O75362. |
Expressioni
Gene expression databases
Bgeei | ENSG00000171940. |
CleanExi | HS_ZNF217. |
ExpressionAtlasi | O75362. baseline and differential. |
Genevisiblei | O75362. HS. |
Organism-specific databases
HPAi | HPA051857. |
Interactioni
Subunit structurei
Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications
Protein-protein interaction databases
BioGridi | 113547. 12 interactors. |
CORUMi | O75362. |
IntActi | O75362. 6 interactors. |
MINTi | O75362. |
STRINGi | 9606.ENSP00000304308. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Turni | 474 – 476 | Combined sources | 3 | |
Helixi | 483 – 494 | Combined sources | 12 | |
Beta strandi | 502 – 505 | Combined sources | 4 | |
Beta strandi | 507 – 510 | Combined sources | 4 | |
Helixi | 511 – 521 | Combined sources | 11 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HU2 | X-ray | 2.85 | B | 752-760 | [»] | |
3UK3 | X-ray | 2.10 | C/D | 469-523 | [»] | |
4F2J | X-ray | 2.64 | C | 469-523 | [»] | |
4IS1 | X-ray | 2.10 | C/D | 469-523 | [»] | |
ProteinModelPortali | O75362. | |||||
SMRi | O75362. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75362. |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 65 – 88 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 128 – 150 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 499 – 521 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721. Eukaryota. COG5048. LUCA. |
GeneTreei | ENSGT00530000063100. |
HOGENOMi | HOG000276541. |
HOVERGENi | HBG061769. |
InParanoidi | O75362. |
OMAi | PSITCPF. |
OrthoDBi | EOG091G010T. |
PhylomeDBi | O75362. |
TreeFami | TF332241. |
Family and domain databases
InterProi | View protein in InterPro IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type. |
SMARTi | View protein in SMART SM00355. ZnF_C2H2. 8 hits. |
SUPFAMi | SSF57667. SSF57667. 4 hits. |
PROSITEi | View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. |
i Sequence
Sequence statusi: Complete.
O75362-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA
60 70 80 90 100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV
110 120 130 140 150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH
160 170 180 190 200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN
210 220 230 240 250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ
260 270 280 290 300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ
310 320 330 340 350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK
360 370 380 390 400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD
410 420 430 440 450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP
460 470 480 490 500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK
510 520 530 540 550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD
560 570 580 590 600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ
610 620 630 640 650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP
660 670 680 690 700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI
710 720 730 740 750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR
760 770 780 790 800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG
810 820 830 840 850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA
860 870 880 890 900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF
910 920 930 940 950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG
960 970 980 990 1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV
1010 1020 1030 1040
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035572 | 323 | D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767530299Ensembl. | 1 | |
Natural variantiVAR_052795 | 739 | V → I. Corresponds to variant dbSNP:rs6063966Ensembl. | 1 | |
Natural variantiVAR_061939 | 889 | D → G. Corresponds to variant dbSNP:rs34323943Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041259 mRNA. Translation: AAC39895.1. AL157838 Genomic DNA. No translation available. CH471077 Genomic DNA. Translation: EAW75580.1. BC113427 mRNA. Translation: AAI13428.1. |
CCDSi | CCDS13443.1. |
RefSeqi | NP_006517.1. NM_006526.2. XP_016883548.1. XM_017028059.1. |
UniGenei | Hs.155040. Hs.711564. |
Genome annotation databases
Ensembli | ENST00000302342; ENSP00000304308; ENSG00000171940. ENST00000371471; ENSP00000360526; ENSG00000171940. |
GeneIDi | 7764. |
KEGGi | hsa:7764. |
UCSCi | uc002xwq.5. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZN217_HUMAN | |
Accessioni | O75362Primary (citable) accession number: O75362 Secondary accession number(s): E1P5Y6, Q14DB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |