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O75362

- ZN217_HUMAN

UniProt

O75362 - ZN217_HUMAN

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Protein
Zinc finger protein 217
Gene
ZNF217, ZABC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri65 – 8824C2H2-type 1
Add
BLAST
Zinc fingeri128 – 15023C2H2-type 2
Add
BLAST
Zinc fingeri156 – 17823C2H2-type 3
Add
BLAST
Zinc fingeri216 – 23823C2H2-type 4
Add
BLAST
Zinc fingeri375 – 39723C2H2-type 5
Add
BLAST
Zinc fingeri471 – 49323C2H2-type 6
Add
BLAST
Zinc fingeri499 – 52123C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 217
Gene namesi
Name:ZNF217
Synonyms:ZABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13009. ZNF217.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. histone deacetylase complex Source: UniProtKB
  2. nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10481048Zinc finger protein 217
PRO_0000047460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211Phosphoserine1 Publication
Modified residuei322 – 3221Phosphothreonine1 Publication
Modified residuei407 – 4071Phosphoserine1 Publication
Modified residuei648 – 6481Phosphothreonine1 Publication
Modified residuei662 – 6621Phosphoserine1 Publication
Modified residuei795 – 7951Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75362.
PaxDbiO75362.
PRIDEiO75362.

PTM databases

PhosphoSiteiO75362.

Expressioni

Gene expression databases

ArrayExpressiO75362.
BgeeiO75362.
CleanExiHS_ZNF217.
GenevestigatoriO75362.

Organism-specific databases

HPAiHPA051857.

Interactioni

Subunit structurei

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

BioGridi113547. 12 interactions.
IntActiO75362. 3 interactions.
MINTiMINT-7970236.
STRINGi9606.ENSP00000304308.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni474 – 4763
Helixi483 – 49412
Beta strandi502 – 5054
Beta strandi507 – 5104
Helixi511 – 52111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362.
SMRiO75362. Positions 58-93, 114-268, 368-403, 469-551.

Miscellaneous databases

EvolutionaryTraceiO75362.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG319981.
HOGENOMiHOG000276541.
HOVERGENiHBG061769.
InParanoidiO75362.
OMAiTGNMPTQ.
OrthoDBiEOG7CNZFG.
PhylomeDBiO75362.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75362-1 [UniParc]FASTAAdd to Basket

« Hide

MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA     50
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV 100
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH 150
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN 200
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ 250
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 300
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK 350
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD 400
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP 450
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK 500
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD 550
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 600
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP 650
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI 700
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR 750
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG 800
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA 850
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 900
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG 950
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV 1000
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT 1048
Length:1,048
Mass (Da):115,272
Last modified:November 1, 1998 - v1
Checksum:i797FC620817D1E1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti323 – 3231D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035572
Natural varianti739 – 7391V → I.
Corresponds to variant rs6063966 [ dbSNP | Ensembl ].
VAR_052795
Natural varianti889 – 8891D → G.
Corresponds to variant rs34323943 [ dbSNP | Ensembl ].
VAR_061939

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041259 mRNA. Translation: AAC39895.1.
AL157838 Genomic DNA. Translation: CAC08433.1.
CH471077 Genomic DNA. Translation: EAW75580.1.
BC113427 mRNA. Translation: AAI13428.1.
CCDSiCCDS13443.1.
RefSeqiNP_006517.1. NM_006526.2.
UniGeneiHs.155040.
Hs.711564.

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940.
ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDi7764.
KEGGihsa:7764.
UCSCiuc002xwq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041259 mRNA. Translation: AAC39895.1 .
AL157838 Genomic DNA. Translation: CAC08433.1 .
CH471077 Genomic DNA. Translation: EAW75580.1 .
BC113427 mRNA. Translation: AAI13428.1 .
CCDSi CCDS13443.1.
RefSeqi NP_006517.1. NM_006526.2.
UniGenei Hs.155040.
Hs.711564.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HU2 X-ray 2.85 B 752-760 [» ]
3UK3 X-ray 2.10 C/D 469-523 [» ]
4F2J X-ray 2.64 C 469-523 [» ]
4IS1 X-ray 2.10 C/D 469-523 [» ]
ProteinModelPortali O75362.
SMRi O75362. Positions 58-93, 114-268, 368-403, 469-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113547. 12 interactions.
IntActi O75362. 3 interactions.
MINTi MINT-7970236.
STRINGi 9606.ENSP00000304308.

PTM databases

PhosphoSitei O75362.

Proteomic databases

MaxQBi O75362.
PaxDbi O75362.
PRIDEi O75362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302342 ; ENSP00000304308 ; ENSG00000171940 .
ENST00000371471 ; ENSP00000360526 ; ENSG00000171940 .
GeneIDi 7764.
KEGGi hsa:7764.
UCSCi uc002xwq.4. human.

Organism-specific databases

CTDi 7764.
GeneCardsi GC20M052183.
HGNCi HGNC:13009. ZNF217.
HPAi HPA051857.
MIMi 602967. gene.
neXtProti NX_O75362.
PharmGKBi PA37588.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319981.
HOGENOMi HOG000276541.
HOVERGENi HBG061769.
InParanoidi O75362.
OMAi TGNMPTQ.
OrthoDBi EOG7CNZFG.
PhylomeDBi O75362.
TreeFami TF332241.

Miscellaneous databases

ChiTaRSi ZNF217. human.
EvolutionaryTracei O75362.
GeneWikii ZNF217.
GenomeRNAii 7764.
NextBioi 30059.
PROi O75362.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75362.
Bgeei O75362.
CleanExi HS_ZNF217.
Genevestigatori O75362.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
    Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R.
    J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZMYM2; ZMYM3; KIAA0182 AND GTF2I.
  6. "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction."
    Huang G., Krig S., Kowbel D., Xu H., Hyun B., Volik S., Feuerstein B., Mills G.B., Stokoe D., Yaswen P., Collins C.
    Hum. Mol. Genet. 14:3219-3225(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays."
    Krig S.R., Jin V.X., Bieda M.C., O'Geen H., Yaswen P., Green R., Farnham P.J.
    J. Biol. Chem. 282:9703-9712(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex."
    Thillainadesan G., Isovic M., Loney E., Andrews J., Tini M., Torchia J.
    Mol. Cell. Biol. 28:6066-6077(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN A COMPLEX WITH HDAC2; KDM1A AND CTBP1, FUNCTION.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-795, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins."
    Quinlan K.G.R., Nardini M., Verger A., Francescato P., Yaswen P., Corda D., Bolognesi M., Crossley M.
    Mol. Cell. Biol. 26:8159-8172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 752-760 IN COMPLEX WITH CTBP1, INTERACTION WITH CTBP1 AND CTBP2, FUNCTION.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-323.

Entry informationi

Entry nameiZN217_HUMAN
AccessioniPrimary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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