Zinc finger protein 217 - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
Zinc finger protein 217

Gene names

Name:	ZNF217
Synonyms:	ZABC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1048 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subunit structure	May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1048

1048

Zinc finger protein 217

PRO_0000047460

Regions

Zinc finger

65 – 88

24

C2H2-type 1

Zinc finger

128 – 150

23

C2H2-type 2

Zinc finger

156 – 178

23

C2H2-type 3

Zinc finger

216 – 238

23

C2H2-type 4

Zinc finger

375 – 397

23

C2H2-type 5

Zinc finger

471 – 493

23

C2H2-type 6

Zinc finger

499 – 521

23

C2H2-type 7

Amino acid modifications

Modified residue

321

1

Phosphoserine Ref.6

Modified residue

322

1

Phosphothreonine Ref.6

Modified residue

327

1

Phosphoserine Ref.6

Modified residue

407

1

Phosphoserine Ref.5

Modified residue

570

1

Phosphoserine Ref.5

Modified residue

648

1

Phosphothreonine Ref.6

Modified residue

662

1

Phosphoserine Ref.6

Modified residue

795

1

Phosphoserine Ref.5

Modified residue

848

1

Phosphoserine Ref.5

Natural variations

Natural variant

323

1

D → N in a colorectal cancer sample; somatic mutation. Ref.7

VAR_035572

Natural variant

739

1

V → I: dbSNP rs6063966.

VAR_052795

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Sequences

Sequence

Length

Mass (Da)

Tools

O75362-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 797FC620817D1E1F
Show »

FASTA

1,048

115,272

        10         20         30         40         50         60 
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA TQEKNVIQIE 

        70         80         90        100        110        120 
GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV EAEYLSPLDK SQVRTEPPKE 

       130        140        150        160        170        180 
KNCKENEFSC EVCGQTFRVA FDVEIHMRTH KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG 

       190        200        210        220        230        240 
KSGARSKLQQ GLESSPATIN EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK 

       250        260        270        280        290        300 
KTAFGTSSAQ TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 

       310        320        330        340        350        360 
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK CKHSHGEAPS 

       370        380        390        400        410        420 
VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD RRAGAESPTM SVDGRQPGTC 

       430        440        450        460        470        480 
SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP EGIHLDKNDD GGKIKHLTSS RECSYCGKFF 

       490        500        510        520        530        540 
RSNYYLNIHL RTHTGEKPYK CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ 

       550        560        570        580        590        600 
DTEDALLTAD SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 

       610        620        630        640        650        660 
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP PDGSTTHNLE 

       670        680        690        700        710        720 
VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI SLSKSLIPSI TCPFCTFKTF 

       730        740        750        760        770        780 
YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF 

       790        800        810        820        830        840 
PAQSKSLPSA KGKQSPPGPG KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE 

       850        860        870        880        890        900 
MFPKTSVSPA PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 

       910        920        930        940        950        960 
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG ITSLLPQDCV 

       970        980        990       1000       1010       1020 
YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV PAGSPASSST LEGKRPVSYQ 

      1030       1040 
HLSNSMAQKR NYENFIGNAH YRPNDKKT

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma." Collins C., Rommens J.M., Kowbel D., Godfrey T., Tanner M., Hwang S.-I., Polikoff D., Nonet G., Cochran J., Myambo K., Jay K.E., Froula J., Cloutier T., Kuo W.-L., Yaswen P., Dairkee S., Giovanola J., Hutchinson G.B. Gray J.W. Proc. Natl. Acad. Sci. U.S.A. 95:8703-8708(1998) [PubMed: 9671742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes." Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R. J. Biol. Chem. 278:7234-7239(2003) [PubMed: 12493763] [Abstract] Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; AOF2; RCOR1; PHF21A; ZMYM2; ZMYM3; KIAA0182 AND GTF2I.
[5]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; SER-570; SER-795 AND SER-848, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; SER-327; THR-648 AND SER-662, MASS SPECTROMETRY.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-323.
+	Additional computationally mapped references.

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Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Cross-references

Sequence databases

AF041259 mRNA. Translation: AAC39895.1.
AL157838 Genomic DNA. Translation: CAC08433.1.
BC113427 mRNA. Translation: AAI13428.1.

IPI

IPI00025310.

RefSeq

NP_006517.1.

UniGene

Hs.155040
Hs.711564

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HU2	X-ray	2.85	B	752-760	[»]

ModBase

Search...

PTM databases

PhosphoSite

O75362.

Proteomic databases

PRIDE

O75362.

Genome annotation databases

Ensembl

ENSG00000171940. Homo sapiens. [Contig view]

GeneID

7764.

KEGG

hsa:7764.

Organism-specific databases

GeneCards

GC20M051617.

HGNC

HGNC:13009. ZNF217.

MIM

602967. gene.

PharmGKB

PA37588.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

O75362.

HOVERGEN

O75362.

OMA

O75362. MPLDCMF.

Gene expression databases

ArrayExpress

O75362.

Bgee

O75362.

CleanEx

HS_ZNF217.

GermOnline

ENSG00000171940. Homo sapiens.

Family and domain databases

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.

Pfam

PF00096. zf-C2H2. 6 hits.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 8 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

30059.

SOURCE

Search...

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Entry information

Entry name

ZN217_HUMAN

Accession

Primary (citable) accession number: O75362
Secondary accession number(s): Q14DB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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