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UniProtKB - O75362 (ZN217_HUMAN)

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Protein

Zinc finger protein 217

Gene

ZNF217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • multicellular organism development Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • signal transduction Source: GO_Central
  • transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO75362.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 217
Gene namesi
Name:ZNF217
Synonyms:ZABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13009. ZNF217.

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7764.
OpenTargetsiENSG00000171940.
PharmGKBiPA37588.

Polymorphism and mutation databases

BioMutaiZNF217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474601 – 1048Zinc finger protein 217Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75362.
MaxQBiO75362.
PaxDbiO75362.
PeptideAtlasiO75362.
PRIDEiO75362.

PTM databases

iPTMnetiO75362.
PhosphoSitePlusiO75362.

Expressioni

Gene expression databases

BgeeiENSG00000171940.
CleanExiHS_ZNF217.
ExpressionAtlasiO75362. baseline and differential.
GenevisibleiO75362. HS.

Organism-specific databases

HPAiHPA051857.

Interactioni

Subunit structurei

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

BioGridi113547. 12 interactors.
IntActiO75362. 6 interactors.
MINTiMINT-7970236.
STRINGi9606.ENSP00000304308.

Structurei

Secondary structure

11048
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni474 – 476Combined sources3
Helixi483 – 494Combined sources12
Beta strandi502 – 505Combined sources4
Beta strandi507 – 510Combined sources4
Helixi511 – 521Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362.
SMRiO75362.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75362.

Family & Domainsi

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000276541.
HOVERGENiHBG061769.
InParanoidiO75362.
OMAiPSITCPF.
OrthoDBiEOG091G010T.
PhylomeDBiO75362.
TreeFamiTF332241.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

O75362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA 
        60         70         80         90        100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV 
       110        120        130        140        150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH 
       160        170        180        190        200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN 
       210        220        230        240        250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ 
       260        270        280        290        300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 
       310        320        330        340        350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK 
       360        370        380        390        400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD 
       410        420        430        440        450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP 
       460        470        480        490        500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK 
       510        520        530        540        550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD 
       560        570        580        590        600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 
       610        620        630        640        650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP 
       660        670        680        690        700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI 
       710        720        730        740        750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR 
       760        770        780        790        800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG 
       810        820        830        840        850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA 
       860        870        880        890        900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 
       910        920        930        940        950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG 
       960        970        980        990       1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV 
      1010       1020       1030       1040 
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT
Length:1,048
Mass (Da):115,272
Last modified:November 1, 1998 - v1
Checksum:i797FC620817D1E1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035572323D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767530299Ensembl.1
Natural variantiVAR_052795739V → I. Corresponds to variant dbSNP:rs6063966Ensembl.1
Natural variantiVAR_061939889D → G. Corresponds to variant dbSNP:rs34323943Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA. Translation: AAC39895.1.
AL157838 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75580.1.
BC113427 mRNA. Translation: AAI13428.1.
CCDSiCCDS13443.1.
RefSeqiNP_006517.1. NM_006526.2.
XP_016883548.1. XM_017028059.1.
UniGeneiHs.155040.
Hs.711564.

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940.
ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDi7764.
KEGGihsa:7764.
UCSCiuc002xwq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN217_HUMAN
AccessioniPrimary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families