ZNF217

Functionⁱ

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	65 – 88	24	C2H2-type 1PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	128 – 150	23	C2H2-type 2PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	156 – 178	23	C2H2-type 3PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	216 – 238	23	C2H2-type 4PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	375 – 397	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	471 – 493	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	499 – 521	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 217
Gene namesⁱ	Name:ZNF217 Synonyms:ZABC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

HGNCⁱ	HGNC:13009. ZNF217.

HGNCⁱ

HGNC:13009. ZNF217.

Subcellular locationⁱ

Nucleus Curated

GO - Cellular componentⁱ

histone deacetylase complex
Source: UniProtKB
Inferred from direct assayⁱ
- 18625718
nucleoplasm
Source: UniProtKB
Inferred from direct assayⁱ
- 18625718

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA37588.

PharmGKBⁱ

PA37588.

Polymorphism and mutation databases

BioMutaⁱ	ZNF217.

BioMutaⁱ

ZNF217.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 1048	1048	Zinc finger protein 217		PRO_0000047460	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	106 – 106	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.11 "Toward a comprehensive characterization of a human cancer cell phosphoproteome." Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S. J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-407; SER-593 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	321 – 321	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.9 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	322 – 322	1	PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.9 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	407 – 407	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.10 "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-795, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.11 "Toward a comprehensive characterization of a human cancer cell phosphoproteome." Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S. J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-407; SER-593 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	593 – 593	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.11 "Toward a comprehensive characterization of a human cancer cell phosphoproteome." Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S. J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-407; SER-593 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	648 – 648	1	PhosphothreonineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.9 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	662 – 662	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.9 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; THR-648 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.11 "Toward a comprehensive characterization of a human cancer cell phosphoproteome." Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S. J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-407; SER-593 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	795 – 795	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.10 "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-795, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75362.
MaxQBⁱ	O75362.
PaxDbⁱ	O75362.
PeptideAtlasⁱ	O75362.
PRIDEⁱ	O75362.

PTM databases

iPTMnetⁱ	O75362.
PhosphoSiteⁱ	O75362.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171940.
CleanExⁱ	HS_ZNF217.
ExpressionAtlasⁱ	O75362. baseline and differential.
Genevisibleⁱ	O75362. HS.

Organism-specific databases

HPAⁱ	HPA051857.

Interactionⁱ

Subunit structureⁱ

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

BioGridⁱ	113547. 12 interactions.
IntActⁱ	O75362. 5 interactions.
MINTⁱ	MINT-7970236.
STRINGⁱ	9606.ENSP00000304308.

Structureⁱ

Secondary structure

1

1048

Legend: HelixTurnBeta strand

Show more details

Feature key	Position(s)	Length	Description
Turnⁱ	474 – 476	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:3UK3
Helixⁱ	483 – 494	12	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:3UK3
Beta strandⁱ	502 – 505	4	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:3UK3
Beta strandⁱ	507 – 510	4	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:3UK3
Helixⁱ	511 – 521	11	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:3UK3

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HU2	X-ray	2.85	B	752-760	[»]
3UK3	X-ray	2.10	C/D	469-523	[»]
4F2J	X-ray	2.64	C	469-523	[»]
4IS1	X-ray	2.10	C/D	469-523	[»]

ProteinModelPortalⁱ

O75362.

SMRⁱ

O75362. Positions 470-523.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O75362.

EvolutionaryTraceⁱ

O75362.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	65 – 88	24	C2H2-type 1PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	128 – 150	23	C2H2-type 2PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	156 – 178	23	C2H2-type 3PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	216 – 238	23	C2H2-type 4PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	375 – 397	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	471 – 493	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	499 – 521	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00530000063100.
HOGENOMⁱ	HOG000276541.
HOVERGENⁱ	HBG061769.
InParanoidⁱ	O75362.
OMAⁱ	EHSKVHT.
OrthoDBⁱ	EOG091G010T.
PhylomeDBⁱ	O75362.
TreeFamⁱ	TF332241.

Family and domain databases

Gene3Dⁱ	3.30.160.60. 4 hits.
InterProⁱ	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMARTⁱ	SM00355. ZnF_C2H2. 8 hits. [Graphical view]
PROSITEⁱ	PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

O75362-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA 
        60         70         80         90        100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV 
       110        120        130        140        150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH 
       160        170        180        190        200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN 
       210        220        230        240        250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ 
       260        270        280        290        300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 
       310        320        330        340        350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK 
       360        370        380        390        400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD 
       410        420        430        440        450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP 
       460        470        480        490        500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK 
       510        520        530        540        550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD 
       560        570        580        590        600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 
       610        620        630        640        650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP 
       660        670        680        690        700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI 
       710        720        730        740        750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR 
       760        770        780        790        800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG 
       810        820        830        840        850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA 
       860        870        880        890        900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 
       910        920        930        940        950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG 
       960        970        980        990       1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV 
      1010       1020       1030       1040 
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT

Length:1,048

Mass (Da):115,272

Last modified:November 1, 1998 - v1

Checksum:ⁱ797FC620817D1E1F

GO

Natural variant

Feature key	Position(s)	Length	Description	Feature identifier
Natural variantⁱ	323 – 323	1	D → N in a colorectal cancer sample; somatic mutation. 1 Publication Manual assertion based on experiment inⁱ Ref.13 "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-323. Corresponds to variant rs767530299 [ dbSNP \| Ensembl ].	VAR_035572
Natural variantⁱ	739 – 739	1	V → I. Corresponds to variant rs6063966 [ dbSNP \| Ensembl ].	VAR_052795
Natural variantⁱ	889 – 889	1	D → G. Corresponds to variant rs34323943 [ dbSNP \| Ensembl ].	VAR_061939

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF041259 mRNA. Translation: AAC39895.1. AL157838 Genomic DNA. Translation: CAC08433.1. CH471077 Genomic DNA. Translation: EAW75580.1. BC113427 mRNA. Translation: AAI13428.1.
CCDSⁱ	CCDS13443.1.
RefSeqⁱ	NP_006517.1. NM_006526.2.
UniGeneⁱ	Hs.155040. Hs.711564.

Genome annotation databases

Ensemblⁱ	ENST00000302342; ENSP00000304308; ENSG00000171940. ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDⁱ	7764.
KEGGⁱ	hsa:7764.
UCSCⁱ	uc002xwq.5. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF041259 mRNA. Translation: AAC39895.1. AL157838 Genomic DNA. Translation: CAC08433.1. CH471077 Genomic DNA. Translation: EAW75580.1. BC113427 mRNA. Translation: AAI13428.1.
CCDSⁱ	CCDS13443.1.
RefSeqⁱ	NP_006517.1. NM_006526.2.
UniGeneⁱ	Hs.155040. Hs.711564.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HU2	X-ray	2.85	B	752-760	[»]
3UK3	X-ray	2.10	C/D	469-523	[»]
4F2J	X-ray	2.64	C	469-523	[»]
4IS1	X-ray	2.10	C/D	469-523	[»]

ProteinModelPortalⁱ

O75362.

SMRⁱ

O75362. Positions 470-523.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protein-protein interaction databases

BioGridⁱ	113547. 12 interactions.
IntActⁱ	O75362. 5 interactions.
MINTⁱ	MINT-7970236.
STRINGⁱ	9606.ENSP00000304308.

PTM databases

iPTMnetⁱ	O75362.
PhosphoSiteⁱ	O75362.

Polymorphism and mutation databases

BioMutaⁱ	ZNF217.

BioMutaⁱ

ZNF217.

Proteomic databases

EPDⁱ	O75362.
MaxQBⁱ	O75362.
PaxDbⁱ	O75362.
PeptideAtlasⁱ	O75362.
PRIDEⁱ	O75362.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302342; ENSP00000304308; ENSG00000171940. ENST00000371471; ENSP00000360526; ENSG00000171940.
GeneIDⁱ	7764.
KEGGⁱ	hsa:7764.
UCSCⁱ	uc002xwq.5. human.

Organism-specific databases

CTDⁱ	7764.
GeneCardsⁱ	ZNF217.
HGNCⁱ	HGNC:13009. ZNF217.
HPAⁱ	HPA051857.
MIMⁱ	602967. gene.
neXtProtⁱ	NX_O75362.
PharmGKBⁱ	PA37588.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00530000063100.
HOGENOMⁱ	HOG000276541.
HOVERGENⁱ	HBG061769.
InParanoidⁱ	O75362.
OMAⁱ	EHSKVHT.
OrthoDBⁱ	EOG091G010T.
PhylomeDBⁱ	O75362.
TreeFamⁱ	TF332241.

Miscellaneous databases

ChiTaRSⁱ	ZNF217. human.
EvolutionaryTraceⁱ	O75362.
GeneWikiⁱ	ZNF217.
GenomeRNAiⁱ	7764.
PROⁱ	O75362.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171940.
CleanExⁱ	HS_ZNF217.
ExpressionAtlasⁱ	O75362. baseline and differential.
Genevisibleⁱ	O75362. HS.

Family and domain databases

Gene3Dⁱ	3.30.160.60. 4 hits.
InterProⁱ	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMARTⁱ	SM00355. ZnF_C2H2. 8 hits. [Graphical view]
PROSITEⁱ	PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

ZN217_HUMAN

Accessionⁱ

Primary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1998
Last modified:	September 7, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75362 (ZN217_HUMAN)

UniProt

O75362 - ZN217_HUMAN

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Zinc finger protein 217

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>Provides links to various web resources that are relevant for a specific protein.</p><p><a href='../manual/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ