##gff-version 3
O75355	UniProtKB	Chain	1	529	.	.	.	ID=PRO_0000209910;Note=Ectonucleoside triphosphate diphosphohydrolase 3	
O75355	UniProtKB	Topological domain	1	22	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Transmembrane	23	43	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Topological domain	44	485	.	.	.	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Transmembrane	486	506	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Topological domain	507	529	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Active site	182	182	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35795	
O75355	UniProtKB	Binding site	222	226	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35795	
O75355	UniProtKB	Glycosylation	81	81	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	149	149	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	238	238	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	381	381	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	392	392	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	402	402	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Glycosylation	454	454	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O75355	UniProtKB	Disulfide bond	92	116	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724	
O75355	UniProtKB	Disulfide bond	261	308	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724	
O75355	UniProtKB	Disulfide bond	289	334	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724	
O75355	UniProtKB	Disulfide bond	347	353	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724	
O75355	UniProtKB	Disulfide bond	399	422	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15966724;Dbxref=PMID:15966724	
O75355	UniProtKB	Alternative sequence	452	529	.	.	.	ID=VSP_054237;Note=In isoform 2. VGNSSIAWSLGYMLSLTNQIPAESPLIRLPIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD->E;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
O75355	UniProtKB	Natural variant	24	24	.	.	.	ID=VAR_070813;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852714,PMID:15489334	
O75355	UniProtKB	Natural variant	264	264	.	.	.	ID=VAR_061384;Note=R->Q;Dbxref=dbSNP:rs34266806	
O75355	UniProtKB	Natural variant	440	440	.	.	.	ID=VAR_027541;Note=E->D;Dbxref=dbSNP:rs4470483	
O75355	UniProtKB	Natural variant	496	496	.	.	.	ID=VAR_027542;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9676430;Dbxref=dbSNP:rs1047855,PMID:9676430	
O75355	UniProtKB	Natural variant	505	505	.	.	.	ID=VAR_027543;Note=L->F;Dbxref=dbSNP:rs3733167	
O75355	UniProtKB	Mutagenesis	67	67	.	.	.	Note=Increase of activity. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	143	143	.	.	.	Note=Loss of activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	143	143	.	.	.	Note=Increase of activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	146	146	.	.	.	Note=No effect. R->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	146	146	.	.	.	Note=Increase of ATPase activity%2C decrease of ADPase activity. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	146	146	.	.	.	Note=Increase of activity. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	182	182	.	.	.	Note=Complete loss of activity. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	182	182	.	.	.	Note=Complete loss of activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	187	187	.	.	.	Note=Complete loss of activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10231536;Dbxref=PMID:10231536	
O75355	UniProtKB	Mutagenesis	191	191	.	.	.	Note=Loss of ATPase activity%2C increase of ADPase activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	219	219	.	.	.	Note=Increase of activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10231536;Dbxref=PMID:10231536	
O75355	UniProtKB	Mutagenesis	224	224	.	.	.	Note=Complete loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	226	226	.	.	.	Note=Loss of activity. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11300774;Dbxref=PMID:11300774	
O75355	UniProtKB	Mutagenesis	459	459	.	.	.	Note=Increase of activity%2C especially the ATP hydrolysis. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10231536;Dbxref=PMID:10231536