O75348 (VATG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 104.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: V-type proton ATPase subunit G 1 Short name=V-ATPase subunit G 1 Alternative name(s): V-ATPase 13 kDa subunit 1 Vacuolar proton pump subunit G 1 Vacuolar proton pump subunit M16 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 118 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. |
| Subunit structure | V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). |
| Tissue specificity | Ubiquitous. Ref.4 |
| Sequence similarities | Belongs to the V-ATPase G subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen ion transport Ion transport Transport |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathwayTraceable author statement. Source: Reactome transferrin transportTraceable author statement. Source: Reactome |
| Cellular component | cytosol Inferred from sequence or structural similarity. Source: UniProtKB plasma membraneInferred from direct assay. Source: UniProtKB |
| Molecular function | ATPase binding Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle. |
| [3] | Kanor S., Bienvenut W.V., Quadroni M. Submitted (DEC-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-16; 38-48 AND 81-89, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Melanoma. |
| [4] | "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed: 12384298] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [5] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [6] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF038954 mRNA. Translation: AAC39868.1. BC008452 mRNA. Translation: AAH08452.1. |
| IPI | IPI00025285. |
| RefSeq | NP_004879.1. NM_004888.3. |
| UniGene | Hs.388654. |
3D structure databases | |
| ProteinModelPortal | O75348. |
| SMR | O75348. Positions 1-59. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O75348. 4 interactions. |
| MINT | MINT-1377978. |
| STRING | O75348. |
Protein family/group databases | |
| TCDB | 3.A.2.2.4. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily. |
Proteomic databases | |
| PeptideAtlas | O75348. |
| PRIDE | O75348. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000374050; ENSP00000363162; ENSG00000136888. |
| GeneID | 9550. |
| KEGG | hsa:9550. |
| UCSC | uc004bjc.1. human. |
Organism-specific databases | |
| CTD | 9550. |
| GeneCards | GC09P117350. |
| H-InvDB | HIX0008322. |
| HGNC | HGNC:864. ATP6V1G1. |
| HPA | CAB004615. |
| MIM | 607296. gene. |
| neXtProt | NX_O75348. |
| PharmGKB | PA25163. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG21247. |
| HOGENOM | HBG621942. |
| HOVERGEN | HBG057827. |
| InParanoid | O75348. |
| OMA | HGNSAVE. |
| OrthoDB | EOG483D67. |
| PhylomeDB | O75348. |
Enzyme and pathway databases | |
| Reactome | REACT_111102. Signal Transduction. REACT_15518. Transmembrane transport of small molecules. |
Gene expression databases | |
| ArrayExpress | O75348. |
| Bgee | O75348. |
| CleanEx | HS_ATP6V1G1. |
| Genevestigator | O75348. |
| GermOnline | ENSG00000136888. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005124. V-ATPase_G. [Graphical view] |
| KO | K02152. |
| PANTHER | PTHR12713. V-ATPase_G. 1 hit. |
| Pfam | PF03179. V-ATPase_G. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01147. V_ATP_synt_G. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 35807. |
| SOURCE | Search... |
Entry information
| Entry name | VATG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O75348 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with