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Protein

V-type proton ATPase subunit G 1

Gene

ATP6V1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).1 Publication

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to increased oxygen levels Source: UniProtKB
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • phagosome acidification Source: Reactome
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS06241-MONOMER.
ReactomeiR-HSA-1222556. ROS, RNS production in phagocytes.
R-HSA-77387. Insulin receptor recycling.
R-HSA-917977. Transferrin endocytosis and recycling.
R-HSA-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 1
Short name:
V-ATPase subunit G 1
Alternative name(s):
V-ATPase 13 kDa subunit 1
Vacuolar proton pump subunit G 1
Vacuolar proton pump subunit M16
Gene namesi
Name:ATP6V1G1
Synonyms:ATP6G, ATP6G1, ATP6J
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136888.6.
HGNCiHGNC:864. ATP6V1G1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9550.
OpenTargetsiENSG00000136888.
PharmGKBiPA25163.

Polymorphism and mutation databases

BioMutaiATP6V1G1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001928972 – 118V-type proton ATPase subunit G 1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75348.
PaxDbiO75348.
PeptideAtlasiO75348.
PRIDEiO75348.

PTM databases

iPTMnetiO75348.
PhosphoSitePlusiO75348.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000136888.
CleanExiHS_ATP6V1G1.
ExpressionAtlasiO75348. baseline and differential.
GenevisibleiO75348. HS.

Organism-specific databases

HPAiCAB004615.
HPA042898.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114922. 27 interactors.
IntActiO75348. 40 interactors.
MINTiMINT-5001706.
STRINGi9606.ENSP00000363162.

Structurei

3D structure databases

ProteinModelPortaliO75348.
SMRiO75348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiO75348.
KOiK02152.
OMAiEFHANYR.
OrthoDBiEOG091G0XIZ.
PhylomeDBiO75348.
TreeFamiTF313777.

Family and domain databases

InterProiView protein in InterPro
IPR005124. V-ATPase_G.
PANTHERiPTHR12713. PTHR12713. 1 hit.
PfamiView protein in Pfam
PF03179. V-ATPase_G. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ
60 70 80 90 100
REKEFKAKEA AALGSRGSCS TEVEKETQEK MTILQTYFRQ NRDEVLDNLL
110
AFVCDIRPEI HENYRING
Length:118
Mass (Da):13,758
Last modified:January 23, 2007 - v3
Checksum:iA289C1B96634E34C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038954 mRNA. Translation: AAC39868.1.
CR456971 mRNA. Translation: CAG33252.1.
CR542237 mRNA. Translation: CAG47033.1.
AL160275 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87424.1.
BC008452 mRNA. Translation: AAH08452.1.
CCDSiCCDS6807.1.
RefSeqiNP_004879.1. NM_004888.3.
UniGeneiHs.388654.

Genome annotation databases

EnsembliENST00000374050; ENSP00000363162; ENSG00000136888.
GeneIDi9550.
KEGGihsa:9550.
UCSCiuc004bjc.4. human.

Similar proteinsi

Entry informationi

Entry nameiVATG1_HUMAN
AccessioniPrimary (citable) accession number: O75348
Secondary accession number(s): Q6IB33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families