O75348 (VATG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit G 1
Short name=V-ATPase subunit G 1

Alternative name(s):
V-ATPase 13 kDa subunit 1
Vacuolar proton pump subunit G 1
Vacuolar proton pump subunit M16

Gene names

Name:	ATP6V1G1
Synonyms:	ATP6G, ATP6G1, ATP6J

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Tissue specificity	Ubiquitous. Ref.4
Sequence similarities	Belongs to the V-ATPase G subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome transferrin transport Traceable author statement. Source: Reactome
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from direct assay. Source: UniProtKB
Molecular function	ATPase binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 118	117	V-type proton ATPase subunit G 1		PRO_0000192897
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O75348 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A289C1B96634E34C	FASTA	118	13,758
	10 20 30 40 50 60 MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ REKEFKAKEA 70 80 90 100 110 AALGSRGSCS TEVEKETQEK MTILQTYFRQ NRDEVLDNLL AFVCDIRPEI HENYRING

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	Kanor S., Bienvenut W.V., Quadroni M. Submitted (DEC-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-16; 38-48 AND 81-89, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Melanoma.
[4]	"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed: 12384298] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF038954 mRNA. Translation: AAC39868.1. BC008452 mRNA. Translation: AAH08452.1.
IPI	IPI00025285.
RefSeq	NP_004879.1. NM_004888.3.
UniGene	Hs.388654.
3D structure databases
ProteinModelPortal	O75348.
SMR	O75348. Positions 1-59.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75348. 4 interactions.
MINT	MINT-1377978.
STRING	O75348.
Protein family/group databases
TCDB	3.A.2.2.4. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily.
Proteomic databases
PeptideAtlas	O75348.
PRIDE	O75348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374050; ENSP00000363162; ENSG00000136888.
GeneID	9550.
KEGG	hsa:9550.
UCSC	uc004bjc.1. human.
Organism-specific databases
CTD	9550.
GeneCards	GC09P117350.
H-InvDB	HIX0008322.
HGNC	HGNC:864. ATP6V1G1.
HPA	CAB004615.
MIM	607296. gene.
neXtProt	NX_O75348.
PharmGKB	PA25163.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21247.
HOGENOM	HBG621942.
HOVERGEN	HBG057827.
InParanoid	O75348.
OMA	HGNSAVE.
OrthoDB	EOG483D67.
PhylomeDB	O75348.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O75348.
Bgee	O75348.
CleanEx	HS_ATP6V1G1.
Genevestigator	O75348.
GermOnline	ENSG00000136888. Homo sapiens.
Family and domain databases
InterPro	IPR005124. V-ATPase_G. [Graphical view]
KO	K02152.
PANTHER	PTHR12713. V-ATPase_G. 1 hit.
Pfam	PF03179. V-ATPase_G. 1 hit. [Graphical view]
TIGRFAMs	TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNet	Search...
Other
NextBio	35807.
SOURCE	Search...

Entry information

Entry name

VATG1_HUMAN

Accession

Primary (citable) accession number: O75348

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.