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O75344

- FKBP6_HUMAN

UniProt

O75344 - FKBP6_HUMAN

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Protein
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Gene
FKBP6, FKBP36
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes By similarity.

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. Hsp90 protein binding Source: UniProtKB
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. DNA methylation involved in gamete generation Source: UniProtKB
  2. cell differentiation Source: UniProtKB-KW
  3. chaperone-mediated protein folding Source: RefGenome
  4. gene silencing by RNA Source: UniProtKB
  5. meiotic nuclear division Source: UniProtKB
  6. piRNA metabolic process Source: UniProtKB
  7. protein folding Source: UniProtKB
  8. protein peptidyl-prolyl isomerization Source: RefGenome
  9. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_75792. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Short name:
Inactive PPIase FKBP6
Alternative name(s):
36 kDa FK506-binding protein
Short name:
36 kDa FKBP
Short name:
FKBP-36
FK506-binding protein 6
Short name:
FKBP-6
Immunophilin FKBP36
Gene namesi
Name:FKBP6
Synonyms:FKBP36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3722. FKBP6.

Subcellular locationi

Cytoplasmcytosol By similarity. Nucleus By similarity. Chromosome By similarity
Note: Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. endoplasmic reticulum membrane Source: RefGenome
  4. synaptonemal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (1 Publication). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (1 Publication).1 Publication
Defects in FKBP6 may be a cause of azoospermia. A study based on 323 patients with azoospermia or severe oligozoospermia suggested an association between FKBP6 variants and azoospermia (1 Publication). However, other studies suggest that defects in FKBP6 are not a common cause of non-obstructive azoospermia (1 Publication).

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

Orphaneti904. Williams syndrome.
PharmGKBiPA28163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Inactive peptidyl-prolyl cis-trans isomerase FKBP6
PRO_0000075329Add
BLAST

Proteomic databases

PaxDbiO75344.
PRIDEiO75344.

PTM databases

PhosphoSiteiO75344.

Expressioni

Tissue specificityi

Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.

Gene expression databases

ArrayExpressiO75344.
BgeeiO75344.
CleanExiHS_FKBP6.
GenevestigatoriO75344.

Organism-specific databases

HPAiHPA043046.

Interactioni

Subunit structurei

Interacts (via TPR repeats) with HSP90 By similarity. Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity.2 Publications

Protein-protein interaction databases

BioGridi114046. 4 interactions.
IntActiO75344. 2 interactions.
MINTiMINT-1460144.
STRINGi9606.ENSP00000252037.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 255
Turni26 – 283
Beta strandi30 – 4415
Beta strandi47 – 504
Beta strandi56 – 649
Beta strandi72 – 743
Helixi93 – 1008
Beta strandi107 – 1126
Helixi114 – 1163
Turni117 – 1215
Turni124 – 1263
Beta strandi133 – 14311

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B7XX-ray2.10A12-144[»]
ProteinModelPortaliO75344.
SMRiO75344. Positions 19-315.

Miscellaneous databases

EvolutionaryTraceiO75344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 14390PPIase FKBP-type
Add
BLAST
Repeati171 – 20434TPR 1
Add
BLAST
Repeati219 – 25234TPR 2
Add
BLAST
Repeati253 – 28634TPR 3
Add
BLAST

Sequence similaritiesi

Belongs to the FKBP6 family.
Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000251594.
HOVERGENiHBG051625.
InParanoidiO75344.
KOiK09572.
OMAiEREMCHR.
PhylomeDBiO75344.
TreeFamiTF354214.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75344-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL    50
VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL 100
SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK 150
FCALSAEQQD QFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL 200
LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC YGEQALIIDQ 250
KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY 300
RDYVDKEKEM WHRMFAPCGD GSTAGES 327
Length:327
Mass (Da):37,214
Last modified:November 1, 1998 - v1
Checksum:iC137FA629B676623
GO
Isoform 2 (identifier: O75344-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MGGSALNQGVLEGDDAPGQ → MSASSWPQNGMPPS

Note: No experimental confirmation available.

Show »
Length:322
Mass (Da):36,874
Checksum:iC3C697A7F1962706
GO
Isoform 3 (identifier: O75344-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-88: Missing.

Show »
Length:297
Mass (Da):33,553
Checksum:iBF5A6F2324830850
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831R → C Probable polymorphism. 1 Publication
VAR_070840

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MGGSA…DAPGQ → MSASSWPQNGMPPS in isoform 2.
VSP_042038Add
BLAST
Alternative sequencei59 – 8830Missing in isoform 3.
VSP_054251Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031R → Q in AAP97324. 1 Publication
Sequence conflicti123 – 1231C → S in AAP97324. 1 Publication
Sequence conflicti136 – 1361E → K in AAP97324. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038847 mRNA. Translation: AAC64249.1.
AF447060 mRNA. Translation: AAP97324.1.
AK302121 mRNA. Translation: BAG63499.1.
BC036817 mRNA. Translation: AAH36817.1.
AC005049 Genomic DNA. No translation available.
AC073841 Genomic DNA. No translation available.
CH471200 Genomic DNA. Translation: EAW69684.1.
CH471200 Genomic DNA. Translation: EAW69686.1.
CCDSiCCDS43595.1. [O75344-1]
CCDS47604.1. [O75344-2]
CCDS64670.1. [O75344-3]
RefSeqiNP_001128683.1. NM_001135211.2. [O75344-2]
NP_001268233.1. NM_001281304.1. [O75344-3]
NP_003593.3. NM_003602.4. [O75344-1]
UniGeneiHs.661266.

Genome annotation databases

EnsembliENST00000252037; ENSP00000252037; ENSG00000077800. [O75344-1]
ENST00000413573; ENSP00000394952; ENSG00000077800.
ENST00000431982; ENSP00000416277; ENSG00000077800. [O75344-2]
ENST00000572911; ENSP00000458784; ENSG00000262532. [O75344-1]
ENST00000574089; ENSP00000459768; ENSG00000262532. [O75344-2]
GeneIDi8468.
KEGGihsa:8468.
UCSCiuc003tya.2. human. [O75344-1]
uc011kew.1. human. [O75344-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038847 mRNA. Translation: AAC64249.1 .
AF447060 mRNA. Translation: AAP97324.1 .
AK302121 mRNA. Translation: BAG63499.1 .
BC036817 mRNA. Translation: AAH36817.1 .
AC005049 Genomic DNA. No translation available.
AC073841 Genomic DNA. No translation available.
CH471200 Genomic DNA. Translation: EAW69684.1 .
CH471200 Genomic DNA. Translation: EAW69686.1 .
CCDSi CCDS43595.1. [O75344-1 ]
CCDS47604.1. [O75344-2 ]
CCDS64670.1. [O75344-3 ]
RefSeqi NP_001128683.1. NM_001135211.2. [O75344-2 ]
NP_001268233.1. NM_001281304.1. [O75344-3 ]
NP_003593.3. NM_003602.4. [O75344-1 ]
UniGenei Hs.661266.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3B7X X-ray 2.10 A 12-144 [» ]
ProteinModelPortali O75344.
SMRi O75344. Positions 19-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114046. 4 interactions.
IntActi O75344. 2 interactions.
MINTi MINT-1460144.
STRINGi 9606.ENSP00000252037.

PTM databases

PhosphoSitei O75344.

Proteomic databases

PaxDbi O75344.
PRIDEi O75344.

Protocols and materials databases

DNASUi 8468.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252037 ; ENSP00000252037 ; ENSG00000077800 . [O75344-1 ]
ENST00000413573 ; ENSP00000394952 ; ENSG00000077800 .
ENST00000431982 ; ENSP00000416277 ; ENSG00000077800 . [O75344-2 ]
ENST00000572911 ; ENSP00000458784 ; ENSG00000262532 . [O75344-1 ]
ENST00000574089 ; ENSP00000459768 ; ENSG00000262532 . [O75344-2 ]
GeneIDi 8468.
KEGGi hsa:8468.
UCSCi uc003tya.2. human. [O75344-1 ]
uc011kew.1. human. [O75344-2 ]

Organism-specific databases

CTDi 8468.
GeneCardsi GC07P072742.
H-InvDB HIX0006777.
HIX0078779.
HIX0114828.
HGNCi HGNC:3722. FKBP6.
HPAi HPA043046.
MIMi 604839. gene.
neXtProti NX_O75344.
Orphaneti 904. Williams syndrome.
PharmGKBi PA28163.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000251594.
HOVERGENi HBG051625.
InParanoidi O75344.
KOi K09572.
OMAi EREMCHR.
PhylomeDBi O75344.
TreeFami TF354214.

Enzyme and pathway databases

Reactomei REACT_75792. Meiotic synapsis.

Miscellaneous databases

ChiTaRSi FKBP6. human.
EvolutionaryTracei O75344.
GenomeRNAii 8468.
NextBioi 31692.
PROi O75344.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75344.
Bgeei O75344.
CleanExi HS_FKBP6.
Genevestigatori O75344.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene FKBP6 is deleted in Williams syndrome."
    Meng X., Lu X., Morris C.A., Keating M.T.
    Genomics 52:130-137(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Zan Q., Guo J.H., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6."
    Metcalfe K., Simeonov E., Beckett W., Donnai D., Tassabehji M.
    Clin. Dysmorphol. 14:61-65(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN WBS.
  8. "Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia."
    Westerveld G.H., Repping S., Lombardi M.P., van der Veen F.
    Mol. Hum. Reprod. 11:673-675(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYS-183, POSSIBLE INVOLVEMENT IN AZOOSPERMIA.
  9. "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men."
    Zhang W., Zhang S., Xiao C., Yang Y., Zhoucun A.
    Reproduction 133:511-516(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN AZOOSPERMIA.
  10. "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes."
    Jarczowski F., Fischer G., Edlich F.
    Biochemistry 47:6946-6952(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSPA2 AND CLTC.
  11. "FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor."
    Jarczowski F., Jahreis G., Erdmann F., Schierhorn A., Fischer G., Edlich F.
    J. Biol. Chem. 284:766-773(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GAPDH.

Entry informationi

Entry nameiFKBP6_HUMAN
AccessioniPrimary (citable) accession number: O75344
Secondary accession number(s): B4DXT7
, G3V0I2, Q7Z4T4, Q9UDS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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