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O75344

- FKBP6_HUMAN

UniProt

O75344 - FKBP6_HUMAN

Protein

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

Gene

FKBP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes By similarity.By similarity

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. Hsp90 protein binding Source: UniProtKB
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. chaperone-mediated protein folding Source: RefGenome
    3. DNA methylation involved in gamete generation Source: UniProtKB
    4. gene silencing by RNA Source: UniProtKB
    5. meiotic nuclear division Source: UniProtKB
    6. piRNA metabolic process Source: UniProtKB
    7. protein folding Source: UniProtKB
    8. protein peptidyl-prolyl isomerization Source: RefGenome
    9. spermatogenesis Source: UniProtKB

    Keywords - Biological processi

    Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_75792. Meiotic synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive peptidyl-prolyl cis-trans isomerase FKBP6
    Short name:
    Inactive PPIase FKBP6
    Alternative name(s):
    36 kDa FK506-binding protein
    Short name:
    36 kDa FKBP
    Short name:
    FKBP-36
    FK506-binding protein 6
    Short name:
    FKBP-6
    Immunophilin FKBP36
    Gene namesi
    Name:FKBP6
    Synonyms:FKBP36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:3722. FKBP6.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity. Chromosome By similarity
    Note: Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. endoplasmic reticulum membrane Source: RefGenome
    4. synaptonemal complex Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).2 Publications
    Defects in FKBP6 may be a cause of azoospermia. A study based on 323 patients with azoospermia or severe oligozoospermia suggested an association between FKBP6 variants and azoospermia (PubMed:17307919). However, other studies suggest that defects in FKBP6 are not a common cause of non-obstructive azoospermia (PubMed:16227348).2 Publications

    Keywords - Diseasei

    Williams-Beuren syndrome

    Organism-specific databases

    Orphaneti904. Williams syndrome.
    PharmGKBiPA28163.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Inactive peptidyl-prolyl cis-trans isomerase FKBP6PRO_0000075329Add
    BLAST

    Proteomic databases

    PaxDbiO75344.
    PRIDEiO75344.

    PTM databases

    PhosphoSiteiO75344.

    Expressioni

    Tissue specificityi

    Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.

    Gene expression databases

    ArrayExpressiO75344.
    BgeeiO75344.
    CleanExiHS_FKBP6.
    GenevestigatoriO75344.

    Organism-specific databases

    HPAiHPA043046.

    Interactioni

    Subunit structurei

    Interacts (via TPR repeats) with HSP90 By similarity. Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    OSBPP220592EBI-744771,EBI-2681902
    Usp19Q3UJD6-22EBI-744771,EBI-9359023From a different organism.

    Protein-protein interaction databases

    BioGridi114046. 4 interactions.
    IntActiO75344. 19 interactions.
    MINTiMINT-1460144.
    STRINGi9606.ENSP00000252037.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 255
    Turni26 – 283
    Beta strandi30 – 4415
    Beta strandi47 – 504
    Beta strandi56 – 649
    Beta strandi72 – 743
    Helixi93 – 1008
    Beta strandi107 – 1126
    Helixi114 – 1163
    Turni117 – 1215
    Turni124 – 1263
    Beta strandi133 – 14311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3B7XX-ray2.10A12-144[»]
    ProteinModelPortaliO75344.
    SMRiO75344. Positions 19-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75344.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 14390PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST
    Repeati171 – 20434TPR 1Add
    BLAST
    Repeati219 – 25234TPR 2Add
    BLAST
    Repeati253 – 28634TPR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP6 family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation
    Contains 3 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000251594.
    HOVERGENiHBG051625.
    InParanoidiO75344.
    KOiK09572.
    OMAiEREMCHR.
    PhylomeDBiO75344.
    TreeFamiTF354214.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75344-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL    50
    VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL 100
    SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK 150
    FCALSAEQQD QFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL 200
    LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC YGEQALIIDQ 250
    KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY 300
    RDYVDKEKEM WHRMFAPCGD GSTAGES 327
    Length:327
    Mass (Da):37,214
    Last modified:November 1, 1998 - v1
    Checksum:iC137FA629B676623
    GO
    Isoform 2 (identifier: O75344-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MGGSALNQGVLEGDDAPGQ → MSASSWPQNGMPPS

    Note: No experimental confirmation available.

    Show »
    Length:322
    Mass (Da):36,874
    Checksum:iC3C697A7F1962706
    GO
    Isoform 3 (identifier: O75344-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         59-88: Missing.

    Show »
    Length:297
    Mass (Da):33,553
    Checksum:iBF5A6F2324830850
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031R → Q in AAP97324. 1 PublicationCurated
    Sequence conflicti123 – 1231C → S in AAP97324. 1 PublicationCurated
    Sequence conflicti136 – 1361E → K in AAP97324. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831R → C Probable polymorphism. 1 Publication
    VAR_070840

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919MGGSA…DAPGQ → MSASSWPQNGMPPS in isoform 2. 1 PublicationVSP_042038Add
    BLAST
    Alternative sequencei59 – 8830Missing in isoform 3. 1 PublicationVSP_054251Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038847 mRNA. Translation: AAC64249.1.
    AF447060 mRNA. Translation: AAP97324.1.
    AK302121 mRNA. Translation: BAG63499.1.
    BC036817 mRNA. Translation: AAH36817.1.
    AC005049 Genomic DNA. No translation available.
    AC073841 Genomic DNA. No translation available.
    CH471200 Genomic DNA. Translation: EAW69684.1.
    CH471200 Genomic DNA. Translation: EAW69686.1.
    CCDSiCCDS43595.1. [O75344-1]
    CCDS47604.1. [O75344-2]
    CCDS64670.1. [O75344-3]
    RefSeqiNP_001128683.1. NM_001135211.2. [O75344-2]
    NP_001268233.1. NM_001281304.1. [O75344-3]
    NP_003593.3. NM_003602.4. [O75344-1]
    UniGeneiHs.661266.

    Genome annotation databases

    EnsembliENST00000252037; ENSP00000252037; ENSG00000077800. [O75344-1]
    ENST00000413573; ENSP00000394952; ENSG00000077800. [O75344-3]
    ENST00000431982; ENSP00000416277; ENSG00000077800. [O75344-2]
    GeneIDi8468.
    KEGGihsa:8468.
    UCSCiuc003tya.2. human. [O75344-1]
    uc011kew.1. human. [O75344-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038847 mRNA. Translation: AAC64249.1 .
    AF447060 mRNA. Translation: AAP97324.1 .
    AK302121 mRNA. Translation: BAG63499.1 .
    BC036817 mRNA. Translation: AAH36817.1 .
    AC005049 Genomic DNA. No translation available.
    AC073841 Genomic DNA. No translation available.
    CH471200 Genomic DNA. Translation: EAW69684.1 .
    CH471200 Genomic DNA. Translation: EAW69686.1 .
    CCDSi CCDS43595.1. [O75344-1 ]
    CCDS47604.1. [O75344-2 ]
    CCDS64670.1. [O75344-3 ]
    RefSeqi NP_001128683.1. NM_001135211.2. [O75344-2 ]
    NP_001268233.1. NM_001281304.1. [O75344-3 ]
    NP_003593.3. NM_003602.4. [O75344-1 ]
    UniGenei Hs.661266.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3B7X X-ray 2.10 A 12-144 [» ]
    ProteinModelPortali O75344.
    SMRi O75344. Positions 19-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114046. 4 interactions.
    IntActi O75344. 19 interactions.
    MINTi MINT-1460144.
    STRINGi 9606.ENSP00000252037.

    PTM databases

    PhosphoSitei O75344.

    Proteomic databases

    PaxDbi O75344.
    PRIDEi O75344.

    Protocols and materials databases

    DNASUi 8468.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252037 ; ENSP00000252037 ; ENSG00000077800 . [O75344-1 ]
    ENST00000413573 ; ENSP00000394952 ; ENSG00000077800 . [O75344-3 ]
    ENST00000431982 ; ENSP00000416277 ; ENSG00000077800 . [O75344-2 ]
    GeneIDi 8468.
    KEGGi hsa:8468.
    UCSCi uc003tya.2. human. [O75344-1 ]
    uc011kew.1. human. [O75344-2 ]

    Organism-specific databases

    CTDi 8468.
    GeneCardsi GC07P072742.
    H-InvDB HIX0006777.
    HIX0078779.
    HIX0114828.
    HGNCi HGNC:3722. FKBP6.
    HPAi HPA043046.
    MIMi 604839. gene.
    neXtProti NX_O75344.
    Orphaneti 904. Williams syndrome.
    PharmGKBi PA28163.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000251594.
    HOVERGENi HBG051625.
    InParanoidi O75344.
    KOi K09572.
    OMAi EREMCHR.
    PhylomeDBi O75344.
    TreeFami TF354214.

    Enzyme and pathway databases

    Reactomei REACT_75792. Meiotic synapsis.

    Miscellaneous databases

    ChiTaRSi FKBP6. human.
    EvolutionaryTracei O75344.
    GenomeRNAii 8468.
    NextBioi 31692.
    PROi O75344.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75344.
    Bgeei O75344.
    CleanExi HS_FKBP6.
    Genevestigatori O75344.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human gene FKBP6 is deleted in Williams syndrome."
      Meng X., Lu X., Morris C.A., Keating M.T.
      Genomics 52:130-137(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Zan Q., Guo J.H., Yu L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6."
      Metcalfe K., Simeonov E., Beckett W., Donnai D., Tassabehji M.
      Clin. Dysmorphol. 14:61-65(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN WBS.
    8. "Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia."
      Westerveld G.H., Repping S., Lombardi M.P., van der Veen F.
      Mol. Hum. Reprod. 11:673-675(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-183, POSSIBLE INVOLVEMENT IN AZOOSPERMIA.
    9. "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men."
      Zhang W., Zhang S., Xiao C., Yang Y., Zhoucun A.
      Reproduction 133:511-516(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN AZOOSPERMIA.
    10. "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes."
      Jarczowski F., Fischer G., Edlich F.
      Biochemistry 47:6946-6952(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSPA2 AND CLTC.
    11. "FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor."
      Jarczowski F., Jahreis G., Erdmann F., Schierhorn A., Fischer G., Edlich F.
      J. Biol. Chem. 284:766-773(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GAPDH.

    Entry informationi

    Entry nameiFKBP6_HUMAN
    AccessioniPrimary (citable) accession number: O75344
    Secondary accession number(s): B4DXT7
    , G3V0I2, Q7Z4T4, Q9UDS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3