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Protein

Guanylate cyclase soluble subunit beta-2

Gene

GUCY1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Caution

Could be the product of a pseudogene.Curated

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Cofactori

hemeBy similarityNote: Binds 1 or 2 heme groups per heterodimer.By similarity

Enzyme regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Iron (heme proximal ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.2 2681
ReactomeiR-HSA-392154 Nitric oxide stimulates guanylate cyclase
SIGNORiO75343

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit beta-2 (EC:4.6.1.2)
Short name:
GCS-beta-2
Gene namesi
Name:GUCY1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4686 GUCY1B2
MIMi603695 gene
neXtProtiNX_O75343

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741191 – 617Guanylate cyclase soluble subunit beta-2Add BLAST617

Proteomic databases

EPDiO75343
MaxQBiO75343
PeptideAtlasiO75343
PRIDEiO75343

PTM databases

iPTMnetiO75343
PhosphoSitePlusiO75343

Expressioni

Tissue specificityi

Expressed in gastric signet ring cell carcinoma, but not in the normal stomach.1 Publication

Gene expression databases

CleanExiHS_GUCY1B2

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliO75343
SMRiO75343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 519Guanylate cyclasePROSITE-ProRule annotationAdd BLAST129

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG051715
InParanoidiO75343
PhylomeDBiO75343

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O75343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYDRMLRT LGGNLMEFIE NLDALHSYLA LSYQEMNAPS FRVERGADGK
60 70 80 90 100
MFLHYYSDRS GLCHIVPGII EAVAKDFFDI DVIMDILDMN EEVERTGKKE
110 120 130 140 150
HVVFLIVQKA HRKMRKTKPK RLQDSQGMER DQEALQAAFL KMKEKYLNVS
160 170 180 190 200
ACPVKKSHWD VVRSIVMFGK GHLMNTFEPI YPERLWIEEK TFCNAFPFHI
210 220 230 240 250
VFDESLQVKQ ARVNIQKYVP GLQTQNIQLD EYFSIIHPQV TFNIFSIRRF
260 270 280 290 300
INSQFVLKTR REMMPVAWQS RTTLKLQGQM IWMESMWCMV YLCSPKLRSL
310 320 330 340 350
QELEELNMHL SDIAPNDTTR DLILLNQQRL AEIELSNQLE RKKEELQVLS
360 370 380 390 400
KHLAIEKKKT ETLLYAMLPK HVANQLREGK KVAAGEFKSC TILFSDVVTF
410 420 430 440 450
TNICTACEPI QIVNVLNSMY SKFDRLTSVH AVYKVETIGD AYMVVGGVPV
460 470 480 490 500
PIGNHAQRVA NFALGMRISA KEVTNPVTGE PIQLRVGIHT GPVLADVVGD
510 520 530 540 550
KMPRYCLFGD TVNTASRMES HGLPNKVHLS PTAYRALKNQ GFKIIERGEI
560 570 580 590 600
EVKGKGRMTT YFLIQNLNAT EDEIMGRSKT PVDHKGSTQK ASLPTTKLQG
610
SVQPSCPEHS SLASWLL
Length:617
Mass (Da):70,368
Last modified:July 11, 2001 - v2
Checksum:i1B6C965CAB9A5E3E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02446955Y → C. Corresponds to variant dbSNP:rs9568497Ensembl.1
Natural variantiVAR_024470128M → I. Corresponds to variant dbSNP:rs11841997Ensembl.1
Natural variantiVAR_022131316N → H. Corresponds to variant dbSNP:rs1328361Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038499 mRNA Translation: AAD09440.2
AF218383 Genomic DNA Translation: AAF66105.1
UniGeneiHs.411573

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGCYB2_HUMAN
AccessioniPrimary (citable) accession number: O75343
Secondary accession number(s): Q9NZ64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 11, 2001
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health