##gff-version 3
O75342	UniProtKB	Chain	1	701	.	.	.	ID=PRO_0000220689;Note=Arachidonate 12-lipoxygenase%2C 12R-type	
O75342	UniProtKB	Domain	2	119	.	.	.	Note=PLAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00152	
O75342	UniProtKB	Domain	120	701	.	.	.	Note=Lipoxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Binding site	398	398	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Binding site	403	403	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Binding site	578	578	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Binding site	582	582	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Binding site	701	701	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00726	
O75342	UniProtKB	Natural variant	24	24	.	.	.	ID=VAR_069545;Note=In ARCI2. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs201575829,PMID:16116617	
O75342	UniProtKB	Natural variant	67	67	.	.	.	ID=VAR_069546;Note=In ARCI2. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19890349;Dbxref=dbSNP:rs397514533,PMID:19890349	
O75342	UniProtKB	Natural variant	94	94	.	.	.	ID=VAR_050000;Note=G->S;Dbxref=dbSNP:rs8077661	
O75342	UniProtKB	Natural variant	114	114	.	.	.	ID=VAR_069547;Note=In ARCI2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs397514526,PMID:16116617	
O75342	UniProtKB	Natural variant	127	127	.	.	.	ID=VAR_069548;Note=In ARCI2%3B benign. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs72842957,PMID:16116617	
O75342	UniProtKB	Natural variant	195	195	.	.	.	ID=VAR_069549;Note=In ARCI2%3B complete loss of the enzyme activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19131948;Dbxref=dbSNP:rs200516538,PMID:19131948	
O75342	UniProtKB	Natural variant	318	318	.	.	.	ID=VAR_069550;Note=In ARCI2. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=PMID:16116617	
O75342	UniProtKB	Natural variant	382	382	.	.	.	ID=VAR_069551;Note=In ARCI2%3B complete loss of the enzyme activity. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19131948;Dbxref=dbSNP:rs1567981916,PMID:19131948	
O75342	UniProtKB	Natural variant	383	383	.	.	.	ID=VAR_069552;Note=In ARCI2. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs760428119,PMID:16116617	
O75342	UniProtKB	Natural variant	416	416	.	.	.	ID=VAR_069553;Note=In ARCI2. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs1039399607,PMID:16116617	
O75342	UniProtKB	Natural variant	426	426	.	.	.	ID=VAR_015173;Note=In ARCI2%3B complete loss of the enzyme activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11773004,ECO:0000269|PubMed:15629692;Dbxref=dbSNP:rs137853023,PMID:11773004,PMID:15629692	
O75342	UniProtKB	Natural variant	462	462	.	.	.	ID=VAR_069554;Note=In ARCI2. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19890349;Dbxref=dbSNP:rs774958790,PMID:19890349	
O75342	UniProtKB	Natural variant	488	488	.	.	.	ID=VAR_069555;Note=In ARCI2%3B complete loss of the enzyme activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs763468558,PMID:16116617	
O75342	UniProtKB	Natural variant	521	521	.	.	.	ID=VAR_069556;Note=In ARCI2. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16116617,ECO:0000269|PubMed:19890349;Dbxref=dbSNP:rs199766569,PMID:16116617,PMID:19890349	
O75342	UniProtKB	Natural variant	527	527	.	.	.	ID=VAR_069557;Note=In ARCI2. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19890349;Dbxref=dbSNP:rs199545653,PMID:19890349	
O75342	UniProtKB	Natural variant	578	578	.	.	.	ID=VAR_015174;Note=In ARCI2%3B complete loss of the enzyme activity. H->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11773004,ECO:0000269|PubMed:15629692;Dbxref=dbSNP:rs137853024,PMID:11773004,PMID:15629692	
O75342	UniProtKB	Natural variant	597	597	.	.	.	ID=VAR_069558;Note=In ARCI2. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19890349;Dbxref=dbSNP:rs752509098,PMID:19890349	
O75342	UniProtKB	Natural variant	664	664	.	.	.	ID=VAR_069559;Note=In ARCI2%3B complete loss of the enzyme activity. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=PMID:16116617	
O75342	UniProtKB	Natural variant	679	679	.	.	.	ID=VAR_069560;Note=In ARCI2. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16116617;Dbxref=dbSNP:rs397514528,PMID:16116617