ID   O75339      PRELIMINARY;      PRT;  1184 AA.
AC   O75339;
DT   01-NOV-1998 (TrEMBLrel. 08, Created)
DT   01-NOV-1998 (TrEMBLrel. 08, Last sequence update)
DT   25-JAN-2005 (TrEMBLrel. 29, Last annotation update)
DE   Cartilage intermediate layer protein.
GN   Name=CILP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Articular cartilage;
RX   MEDLINE=98389785; PubMed=9722584; DOI=10.1074/jbc.273.36.23469;
RA   Lorenzo P., Neame P., Sommarin Y., Heinegard D.;
RT   "Cloning and deduced amino acid sequence of a novel cartilage protein
RT   (CILP) identifies a proform including a nucleotide
RT   pyrophosphohydrolase.";
RL   J. Biol. Chem. 273:23469-23475(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20068039; PubMed=10601732; DOI=10.1016/S0945-053X(99)00035-9;
RA   Lorenzo P., Aman P., Sommarin Y., Heinegard D.;
RT   "The human CILP gene: exon/intron organization and chromosomal
RT   mapping.";
RL   Matrix Biol. 18:445-454(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Nakamura I., Okawa A., Ikegawa S., Takaoka K., Nakamura Y.;
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF035408; AAC33838.1; -.
DR   EMBL; AF035455; AAF14689.1; -.
DR   EMBL; AF035448; AAF14689.1; JOINED.
DR   EMBL; AF035451; AAF14689.1; JOINED.
DR   EMBL; AB022430; BAA76692.1; -.
DR   EMBL; AF035453; AAF14689.1; JOINED.
DR   EMBL; AF035449; AAF14689.1; JOINED.
DR   PIR; T09484; T09484.
DR   HSSP; P07996; 1LSL.
DR   Ensembl; ENSG00000138615; Homo sapiens.
DR   Genew; HGNC:1980; CILP.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; TAS.
DR   GO; GO:0006139; P:nucleobase, nucleoside, nucleotide and nucl...; TAS.
DR   InterPro; IPR002086; Aldehyd_dehydrog.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR003598; Ig_c2.
DR   InterPro; IPR000884; TSP1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; UNKNOWN_1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; UNKNOWN_1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
SQ   SEQUENCE   1184 AA;  132538 MW;  4449F05537CC99C3 CRC64;
     MVGTKAWVFS FLVLEVTSVL GRQTMLTQSV RRVQPGKKNP SIFAKPADTL ESPGEWTTLF
     NIDYPGGKGD YERLDAIRFY YGDRVCARPL RLEARTTDWT PAGSTGQVVH GSPREGFWCL
     NREQRPGQNC SNYTVRFLCP PGSLRRDTER IWSPWSPWSK CSAACGQTGV QTRTRICLAE
     MVSLCSEASE EGQHCMGQDC TACDLTCPMG QVNADCDACM CQDFMLHGAV SLPGGAPASG
     AAIYLLTKTP KLLTQTDSDG RFRIPGLCPD GKSILKITKV KFAPIVLTMP KTSLKAATIK
     AEFVRAETPY MVMNPETKAR RAGQSVSLCC KATGKPRPDK YFWYHNDTLL DPSLYKHESK
     LVLRKLQQHQ AGEYFCKAQS DAGAVKSKVA QLIVTASDET PCNPVPESYL IRLPHDCFQN
     ATNSFYYDVG RCPVKTCAGQ QDNGIRCRDA VQNCCGISKT EEREIQCSGY TLPTKVAKEC
     SCQRCTETRS IVRGRVSAAD NGEPMRFGHV YMGNSRVSMT GYKGTFTLHV PQDTERLVLT
     FVDRLQKFVN TTKVLPFNKK GSAVFHEIKM LRRKEPITLE AMETNIIPLG EVVGEDPMAE
     LEIPSRSFYR QNGEPYIGKV KASVTFLDPR NISTATAAQT DLNFINDEGD TFPLRTYGMF
     SVDFRDEVTS EPLNAGKVKV HLDSTQVKMP EHISTVKLWS LNPDTGLWEE EGDFKFENQR
     RNKREDRTFL VGNLEIRERR LFNLDVPESR RCFVKVRAYR SERFLPSEQI QGVVISVINL
     EPRTGFLSNP RAWGRFDSVI TGPNGACVPA FCDDQSPDAY SAYVLASLAG EELQAVESSP
     KFNPNAIGVP QPYLNKLNYR RTDHEDPRVK KTAFQISMAK PRPNSAEESN GPIYAFENLR
     ACEEAPPSAA HFRFYQIEGD RYDYNTVPFN EDDPMSWTED YLAWWPKPME FRACYIKVKI
     VGPLEVNVRS RNMGGTHRRT VGKLYGIRDV RSTRDRDQPN VSAACLEFKC SGMLYDQDRV
     DRTLVKVIPQ GSCRRASVNP MLHEYLVNHL PLAVNNDTSE YTMLAPLDPL GHNYGIYTVT
     DQDPRTAKEI ALGRCFDGTS DGSSRIMKSN VGVALTFNCV ERQVGRQSAF QYLQSTPAQS
     PAAGTVQGRV PSRRQQRASR GGQRQSGVVA SLRFPRVAQQ PLIN
//