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Protein

Liprin-alpha-2

Gene

PPFIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

GO - Biological processi

  • cell-matrix adhesion Source: ProtInc
  • glutamate secretion Source: Reactome
  • neurotransmitter secretion Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-181429. Serotonin Neurotransmitter Release Cycle.
R-HSA-181430. Norepinephrine Neurotransmitter Release Cycle.
R-HSA-210500. Glutamate Neurotransmitter Release Cycle.
R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
R-HSA-264642. Acetylcholine Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha-2
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
Short name:
PTPRF-interacting protein alpha-2
Gene namesi
Name:PPFIA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9246. PPFIA2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell surface 1 Publication

  • Note: Colocalizes with PTPRF at the cell surface.

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • presynaptic active zone Source: ParkinsonsUK-UCL

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8499.
OpenTargetsiENSG00000139220.
PharmGKBiPA33567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910271 – 1257Liprin-alpha-2Add BLAST1257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineBy similarity1
Modified residuei237PhosphothreonineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei817PhosphoserineBy similarity1
Modified residuei820PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75334.
PaxDbiO75334.
PeptideAtlasiO75334.
PRIDEiO75334.

PTM databases

iPTMnetiO75334.
PhosphoSitePlusiO75334.

Expressioni

Tissue specificityi

Expressed only in brain.1 Publication

Gene expression databases

BgeeiENSG00000139220.
CleanExiHS_PPFIA2.
ExpressionAtlasiO75334. baseline and differential.
GenevisibleiO75334. HS.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.1 Publication

Protein-protein interaction databases

BioGridi114071. 14 interactors.
IntActiO75334. 3 interactors.
STRINGi9606.ENSP00000450337.

Structurei

Secondary structure

11257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi874 – 890Combined sources17
Helixi895 – 897Combined sources3
Helixi900 – 909Combined sources10
Helixi915 – 924Combined sources10
Helixi928 – 932Combined sources5
Helixi936 – 941Combined sources6
Helixi948 – 964Combined sources17
Helixi971 – 973Combined sources3
Helixi984 – 994Combined sources11
Helixi1021 – 1026Combined sources6
Helixi1028 – 1031Combined sources4
Helixi1035 – 1037Combined sources3
Helixi1038 – 1043Combined sources6
Helixi1048 – 1051Combined sources4
Helixi1056 – 1061Combined sources6
Helixi1068 – 1083Combined sources16
Turni1084 – 1086Combined sources3
Helixi1088 – 1097Combined sources10
Beta strandi1099 – 1102Combined sources4
Helixi1105 – 1107Combined sources3
Helixi1110 – 1119Combined sources10
Helixi1123 – 1126Combined sources4
Helixi1127 – 1129Combined sources3
Beta strandi1130 – 1132Combined sources3
Helixi1136 – 1141Combined sources6
Helixi1147 – 1153Combined sources7
Helixi1161 – 1178Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TACX-ray2.20B866-1193[»]
3TADX-ray2.90A/B866-1193[»]
ProteinModelPortaliO75334.
SMRiO75334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini898 – 964SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini1020 – 1084SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1108 – 1177SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 154Sequence analysisAdd BLAST126
Coiled coili185 – 541Sequence analysisAdd BLAST357
Coiled coili643 – 695Sequence analysisAdd BLAST53
Coiled coili1081 – 1107Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 528Glu-richAdd BLAST414
Compositional biasi622 – 627Poly-Asp6

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000017513.
HOVERGENiHBG052330.
InParanoidiO75334.
OMAiSWAQCPV.
OrthoDBiEOG091G14UK.
TreeFamiTF314207.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiView protein in InterPro
IPR029515. Liprin.
IPR030441. PPFIA2.
IPR001660. SAM.
IPR013761. SAM/pointed.
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF32. PTHR12587:SF32. 1 hit.
PfamiView protein in Pfam
PF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
SMARTiView protein in SMART
SM00454. SAM. 3 hits.
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiView protein in PROSITE
PS50105. SAM_DOMAIN. 3 hits.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75334-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR
60 70 80 90 100
ETQESLSLAQ QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP
110 120 130 140 150
PEFAALTKEL NACREQLLEK EEEISELKAE RNNTRLLLEH LECLVSRHER
160 170 180 190 200
SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL FEHHKALDEK VRERLRVSLE
210 220 230 240 250
RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE HLEGMEPGQK
260 270 280 290 300
VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE
310 320 330 340 350
VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA
360 370 380 390 400
QRESTSIHDM NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM
410 420 430 440 450
RKAETLPEVE AELAQRIAAL TKAEERHGNI EERMRHLEGQ LEEKNQELQR
460 470 480 490 500
ARQREKMNEE HNKRLSDTVD RLLTESNERL QLHLKERMAA LEEKNVLIQE
510 520 530 540 550
SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI EPTIPRTHLD
560 570 580 590 600
TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW
610 620 630 640 650
NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA
660 670 680 690 700
MMLQEQLDAI NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP
710 720 730 740 750
GTSITASVTA SSLASSSPPS GHSTPKLTPR SPAREMDRMG VMTLPSDLRK
760 770 780 790 800
HRRKIAVVEE DGREDKATIK CETSPPPTPR ALRMTHTLPS SYHNDARSSL
810 820 830 840 850
SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK KEKARLGQLR
860 870 880 890 900
GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG
910 920 930 940 950
PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH
960 970 980 990 1000
RLKLRLAIQE MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE
1010 1020 1030 1040 1050
EGSWAQCPVF LQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM
1060 1070 1080 1090 1100
LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LERRREASQH
1110 1120 1130 1140 1150
EIKDVLVWSN DRVIRWIQAI GLREYANNIL ESGVHGSLIA LDENFDYSSL
1160 1170 1180 1190 1200
ALLLQIPTQN TQARQILERE YNNLLALGTE RRLDESDDKN FRRGSTWRRQ
1210 1220 1230 1240 1250
FPPREVHGIS MMPGSSETLP AGFRLTTTSG QSRKMTTDVA SSRLQRLDNS

TVRTYSC
Length:1,257
Mass (Da):143,291
Last modified:June 13, 2012 - v2
Checksum:iBD77601F444EEE10
GO
Isoform 2 (identifier: O75334-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-101: Missing.
     881-881: K → NTSG
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Show »
Length:1,232
Mass (Da):140,673
Checksum:i8A789850F4E1E605
GO
Isoform 3 (identifier: O75334-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1007-1012: Missing.

Show »
Length:1,251
Mass (Da):142,603
Checksum:i18169E6210D89CE5
GO
Isoform 4 (identifier: O75334-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     976-996: Missing.

Show »
Length:1,236
Mass (Da):141,027
Checksum:i27D95B02136893F6
GO
Isoform 5 (identifier: O75334-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     976-996: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.
Show »
Length:1,156
Mass (Da):132,170
Checksum:iF276981E4A68B4DF
GO
Isoform 6 (identifier: O75334-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     191-215: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.
Show »
Length:1,152
Mass (Da):131,584
Checksum:iEDBA76B39345FEE0
GO
Isoform 7 (identifier: O75334-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     976-1006: Missing.
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Note: No experimental confirmation available.
Show »
Length:783
Mass (Da):89,059
Checksum:iEB9A77B8B3279111
GO
Isoform 8 (identifier: O75334-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.
     976-1006: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):50,251
Checksum:iA666F2024D2AA5C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394Q → E in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti426R → T in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti517R → S in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti523E → G in BAH11792 (PubMed:14702039).Curated1
Sequence conflicti697R → M in AAC26100 (PubMed:9624153).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467181 – 783Missing in isoform 8. 1 PublicationAdd BLAST783
Alternative sequenceiVSP_0467191 – 433Missing in isoform 7. 1 PublicationAdd BLAST433
Alternative sequenceiVSP_0467201 – 74Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_04672175 – 101RQLNS…GADPP → MIFSDMNTVSGSPKVHPPNG TRFYTFQ in isoform 5 and isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_04381984 – 101Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_046722191 – 215Missing in isoform 6. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_043820881K → NTSG in isoform 2. 1 Publication1
Alternative sequenceiVSP_046723976 – 1006Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_043821976 – 996Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0438221007 – 1012Missing in isoform 3, isoform 5 and isoform 6. 2 Publications6
Alternative sequenceiVSP_0438231239 – 1257VASSR…RTYSC → DGVFSVYST in isoform 2 and isoform 7. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034799 mRNA. Translation: AAC26100.1.
AK123372 mRNA. Translation: BAG53897.1.
AK126971 mRNA. Translation: BAG54412.1.
AK294505 mRNA. Translation: BAH11792.1.
AK296380 mRNA. Translation: BAH12335.1.
AK299853 mRNA. Translation: BAH13149.1.
AC011316 Genomic DNA. No translation available.
AC069228 Genomic DNA. No translation available.
AC078920 Genomic DNA. No translation available.
AC079363 Genomic DNA. No translation available.
AC079408 Genomic DNA. No translation available.
BC104912 mRNA. Translation: AAI04913.1.
BC143485 mRNA. Translation: AAI43486.1.
CCDSiCCDS55850.1. [O75334-8]
CCDS55851.1. [O75334-7]
CCDS55852.1. [O75334-6]
CCDS55853.1. [O75334-5]
CCDS55854.1. [O75334-2]
CCDS55855.1. [O75334-4]
CCDS55856.1. [O75334-3]
CCDS55857.1. [O75334-1]
RefSeqiNP_001207403.1. NM_001220474.2. [O75334-2]
NP_001207404.1. NM_001220475.2. [O75334-4]
NP_001207405.1. NM_001220476.2. [O75334-3]
NP_001207406.1. NM_001220477.2. [O75334-5]
NP_001207407.1. NM_001220478.2. [O75334-6]
NP_001207408.1. NM_001220479.2. [O75334-7]
NP_001207409.1. NM_001220480.2. [O75334-8]
NP_003616.2. NM_003625.4. [O75334-1]
XP_016875569.1. XM_017020080.1. [O75334-1]
XP_016875571.1. XM_017020082.1. [O75334-3]
UniGeneiHs.506216.
Hs.737103.

Genome annotation databases

EnsembliENST00000333447; ENSP00000327416; ENSG00000139220. [O75334-6]
ENST00000407050; ENSP00000385093; ENSG00000139220. [O75334-5]
ENST00000443686; ENSP00000388373; ENSG00000139220. [O75334-6]
ENST00000541017; ENSP00000445532; ENSG00000139220. [O75334-8]
ENST00000541570; ENSP00000438337; ENSG00000139220. [O75334-7]
ENST00000548586; ENSP00000449338; ENSG00000139220. [O75334-3]
ENST00000549325; ENSP00000450298; ENSG00000139220. [O75334-2]
ENST00000549396; ENSP00000450337; ENSG00000139220. [O75334-1]
ENST00000552948; ENSP00000447868; ENSG00000139220. [O75334-4]
GeneIDi8499.
KEGGihsa:8499.
UCSCiuc058rjg.1. human. [O75334-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034799 mRNA. Translation: AAC26100.1.
AK123372 mRNA. Translation: BAG53897.1.
AK126971 mRNA. Translation: BAG54412.1.
AK294505 mRNA. Translation: BAH11792.1.
AK296380 mRNA. Translation: BAH12335.1.
AK299853 mRNA. Translation: BAH13149.1.
AC011316 Genomic DNA. No translation available.
AC069228 Genomic DNA. No translation available.
AC078920 Genomic DNA. No translation available.
AC079363 Genomic DNA. No translation available.
AC079408 Genomic DNA. No translation available.
BC104912 mRNA. Translation: AAI04913.1.
BC143485 mRNA. Translation: AAI43486.1.
CCDSiCCDS55850.1. [O75334-8]
CCDS55851.1. [O75334-7]
CCDS55852.1. [O75334-6]
CCDS55853.1. [O75334-5]
CCDS55854.1. [O75334-2]
CCDS55855.1. [O75334-4]
CCDS55856.1. [O75334-3]
CCDS55857.1. [O75334-1]
RefSeqiNP_001207403.1. NM_001220474.2. [O75334-2]
NP_001207404.1. NM_001220475.2. [O75334-4]
NP_001207405.1. NM_001220476.2. [O75334-3]
NP_001207406.1. NM_001220477.2. [O75334-5]
NP_001207407.1. NM_001220478.2. [O75334-6]
NP_001207408.1. NM_001220479.2. [O75334-7]
NP_001207409.1. NM_001220480.2. [O75334-8]
NP_003616.2. NM_003625.4. [O75334-1]
XP_016875569.1. XM_017020080.1. [O75334-1]
XP_016875571.1. XM_017020082.1. [O75334-3]
UniGeneiHs.506216.
Hs.737103.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TACX-ray2.20B866-1193[»]
3TADX-ray2.90A/B866-1193[»]
ProteinModelPortaliO75334.
SMRiO75334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114071. 14 interactors.
IntActiO75334. 3 interactors.
STRINGi9606.ENSP00000450337.

PTM databases

iPTMnetiO75334.
PhosphoSitePlusiO75334.

Proteomic databases

MaxQBiO75334.
PaxDbiO75334.
PeptideAtlasiO75334.
PRIDEiO75334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333447; ENSP00000327416; ENSG00000139220. [O75334-6]
ENST00000407050; ENSP00000385093; ENSG00000139220. [O75334-5]
ENST00000443686; ENSP00000388373; ENSG00000139220. [O75334-6]
ENST00000541017; ENSP00000445532; ENSG00000139220. [O75334-8]
ENST00000541570; ENSP00000438337; ENSG00000139220. [O75334-7]
ENST00000548586; ENSP00000449338; ENSG00000139220. [O75334-3]
ENST00000549325; ENSP00000450298; ENSG00000139220. [O75334-2]
ENST00000549396; ENSP00000450337; ENSG00000139220. [O75334-1]
ENST00000552948; ENSP00000447868; ENSG00000139220. [O75334-4]
GeneIDi8499.
KEGGihsa:8499.
UCSCiuc058rjg.1. human. [O75334-1]

Organism-specific databases

CTDi8499.
DisGeNETi8499.
GeneCardsiPPFIA2.
H-InvDBiHIX0010857.
HGNCiHGNC:9246. PPFIA2.
MIMi603143. gene.
neXtProtiNX_O75334.
OpenTargetsiENSG00000139220.
PharmGKBiPA33567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000017513.
HOVERGENiHBG052330.
InParanoidiO75334.
OMAiSWAQCPV.
OrthoDBiEOG091G14UK.
TreeFamiTF314207.

Enzyme and pathway databases

ReactomeiR-HSA-181429. Serotonin Neurotransmitter Release Cycle.
R-HSA-181430. Norepinephrine Neurotransmitter Release Cycle.
R-HSA-210500. Glutamate Neurotransmitter Release Cycle.
R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
R-HSA-264642. Acetylcholine Neurotransmitter Release Cycle.

Miscellaneous databases

ChiTaRSiPPFIA2. human.
GenomeRNAii8499.
PROiPR:O75334.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139220.
CleanExiHS_PPFIA2.
ExpressionAtlasiO75334. baseline and differential.
GenevisibleiO75334. HS.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiView protein in InterPro
IPR029515. Liprin.
IPR030441. PPFIA2.
IPR001660. SAM.
IPR013761. SAM/pointed.
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF32. PTHR12587:SF32. 1 hit.
PfamiView protein in Pfam
PF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
SMARTiView protein in SMART
SM00454. SAM. 3 hits.
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiView protein in PROSITE
PS50105. SAM_DOMAIN. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiLIPA2_HUMAN
AccessioniPrimary (citable) accession number: O75334
Secondary accession number(s): B3KVT5
, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, Q2M3G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 13, 2012
Last modified: April 12, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.