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O75334

- LIPA2_HUMAN

UniProt

O75334 - LIPA2_HUMAN

Protein

Liprin-alpha-2

Gene

PPFIA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell-matrix adhesion Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Liprin-alpha-2
    Alternative name(s):
    Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
    Short name:
    PTPRF-interacting protein alpha-2
    Gene namesi
    Name:PPFIA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9246. PPFIA2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell surface 1 Publication
    Note: Colocalizes with PTPRF at the cell surface.

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. cytoplasm Source: ProtInc
    3. extracellular vesicular exosome Source: UniProt
    4. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12571257Liprin-alpha-2PRO_0000191027Add
    BLAST

    Proteomic databases

    MaxQBiO75334.
    PaxDbiO75334.
    PRIDEiO75334.

    PTM databases

    PhosphoSiteiO75334.

    Expressioni

    Tissue specificityi

    Expressed only in brain.1 Publication

    Gene expression databases

    ArrayExpressiO75334.
    BgeeiO75334.
    CleanExiHS_PPFIA2.
    GenevestigatoriO75334.

    Organism-specific databases

    HPAiHPA040724.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.1 Publication

    Protein-protein interaction databases

    BioGridi114071. 13 interactions.
    IntActiO75334. 3 interactions.
    STRINGi9606.ENSP00000388373.

    Structurei

    Secondary structure

    1
    1257
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi874 – 89017
    Helixi895 – 8973
    Helixi900 – 90910
    Helixi915 – 92410
    Helixi928 – 9325
    Helixi936 – 9416
    Helixi948 – 96417
    Helixi971 – 9733
    Helixi984 – 99411
    Helixi1021 – 10266
    Helixi1028 – 10314
    Helixi1035 – 10373
    Helixi1038 – 10436
    Helixi1048 – 10514
    Helixi1056 – 10616
    Helixi1068 – 108316
    Turni1084 – 10863
    Helixi1088 – 109710
    Beta strandi1099 – 11024
    Helixi1105 – 11073
    Helixi1110 – 111910
    Helixi1123 – 11264
    Helixi1127 – 11293
    Beta strandi1130 – 11323
    Helixi1136 – 11416
    Helixi1147 – 11537
    Helixi1161 – 117818

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TACX-ray2.20B866-1193[»]
    3TADX-ray2.90A/B866-1193[»]
    ProteinModelPortaliO75334.
    SMRiO75334. Positions 871-1182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini898 – 96467SAM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1020 – 108465SAM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1108 – 117770SAM 3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 154126Sequence AnalysisAdd
    BLAST
    Coiled coili185 – 541357Sequence AnalysisAdd
    BLAST
    Coiled coili643 – 69553Sequence AnalysisAdd
    BLAST
    Coiled coili1081 – 110727Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi115 – 528414Glu-richAdd
    BLAST
    Compositional biasi622 – 6276Poly-Asp

    Domaini

    The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

    Sequence similaritiesi

    Belongs to the liprin family. Liprin-alpha subfamily.Curated
    Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG322697.
    HOVERGENiHBG052330.
    InParanoidiO75334.
    OMAiWNRTQQI.
    OrthoDBiEOG7T7GS7.
    TreeFamiTF314207.

    Family and domain databases

    Gene3Di1.10.150.50. 2 hits.
    InterProiIPR029515. Liprin.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR021129. SAM_type1.
    [Graphical view]
    PANTHERiPTHR12587. PTHR12587. 1 hit.
    PfamiPF00536. SAM_1. 2 hits.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    SMARTiSM00454. SAM. 3 hits.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 3 hits.
    PROSITEiPS50105. SAM_DOMAIN. 3 hits.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75334-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR     50
    ETQESLSLAQ QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP 100
    PEFAALTKEL NACREQLLEK EEEISELKAE RNNTRLLLEH LECLVSRHER 150
    SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL FEHHKALDEK VRERLRVSLE 200
    RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE HLEGMEPGQK 250
    VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE 300
    VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA 350
    QRESTSIHDM NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM 400
    RKAETLPEVE AELAQRIAAL TKAEERHGNI EERMRHLEGQ LEEKNQELQR 450
    ARQREKMNEE HNKRLSDTVD RLLTESNERL QLHLKERMAA LEEKNVLIQE 500
    SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI EPTIPRTHLD 550
    TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW 600
    NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA 650
    MMLQEQLDAI NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP 700
    GTSITASVTA SSLASSSPPS GHSTPKLTPR SPAREMDRMG VMTLPSDLRK 750
    HRRKIAVVEE DGREDKATIK CETSPPPTPR ALRMTHTLPS SYHNDARSSL 800
    SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK KEKARLGQLR 850
    GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG 900
    PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH 950
    RLKLRLAIQE MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE 1000
    EGSWAQCPVF LQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM 1050
    LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LERRREASQH 1100
    EIKDVLVWSN DRVIRWIQAI GLREYANNIL ESGVHGSLIA LDENFDYSSL 1150
    ALLLQIPTQN TQARQILERE YNNLLALGTE RRLDESDDKN FRRGSTWRRQ 1200
    FPPREVHGIS MMPGSSETLP AGFRLTTTSG QSRKMTTDVA SSRLQRLDNS 1250
    TVRTYSC 1257
    Length:1,257
    Mass (Da):143,291
    Last modified:June 13, 2012 - v2
    Checksum:iBD77601F444EEE10
    GO
    Isoform 2 (identifier: O75334-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         84-101: Missing.
         881-881: K → NTSG
         1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

    Show »
    Length:1,232
    Mass (Da):140,673
    Checksum:i8A789850F4E1E605
    GO
    Isoform 3 (identifier: O75334-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1007-1012: Missing.

    Show »
    Length:1,251
    Mass (Da):142,603
    Checksum:i18169E6210D89CE5
    GO
    Isoform 4 (identifier: O75334-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         976-996: Missing.

    Show »
    Length:1,236
    Mass (Da):141,027
    Checksum:i27D95B02136893F6
    GO
    Isoform 5 (identifier: O75334-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-74: Missing.
         75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
         976-996: Missing.
         1007-1012: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,156
    Mass (Da):132,170
    Checksum:iF276981E4A68B4DF
    GO
    Isoform 6 (identifier: O75334-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-74: Missing.
         75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
         191-215: Missing.
         1007-1012: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,152
    Mass (Da):131,584
    Checksum:iEDBA76B39345FEE0
    GO
    Isoform 7 (identifier: O75334-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-433: Missing.
         976-1006: Missing.
         1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

    Note: No experimental confirmation available.

    Show »
    Length:783
    Mass (Da):89,059
    Checksum:iEB9A77B8B3279111
    GO
    Isoform 8 (identifier: O75334-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-783: Missing.
         976-1006: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:443
    Mass (Da):50,251
    Checksum:iA666F2024D2AA5C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti394 – 3941Q → E in AAC26100. (PubMed:9624153)Curated
    Sequence conflicti426 – 4261R → T in AAC26100. (PubMed:9624153)Curated
    Sequence conflicti517 – 5171R → S in AAC26100. (PubMed:9624153)Curated
    Sequence conflicti523 – 5231E → G in BAH11792. (PubMed:14702039)Curated
    Sequence conflicti697 – 6971R → M in AAC26100. (PubMed:9624153)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 783783Missing in isoform 8. 1 PublicationVSP_046718Add
    BLAST
    Alternative sequencei1 – 433433Missing in isoform 7. 1 PublicationVSP_046719Add
    BLAST
    Alternative sequencei1 – 7474Missing in isoform 5 and isoform 6. 1 PublicationVSP_046720Add
    BLAST
    Alternative sequencei75 – 10127RQLNS…GADPP → MIFSDMNTVSGSPKVHPPNG TRFYTFQ in isoform 5 and isoform 6. 1 PublicationVSP_046721Add
    BLAST
    Alternative sequencei84 – 10118Missing in isoform 2. 1 PublicationVSP_043819Add
    BLAST
    Alternative sequencei191 – 21525Missing in isoform 6. 1 PublicationVSP_046722Add
    BLAST
    Alternative sequencei881 – 8811K → NTSG in isoform 2. 1 PublicationVSP_043820
    Alternative sequencei976 – 100631Missing in isoform 7 and isoform 8. 1 PublicationVSP_046723Add
    BLAST
    Alternative sequencei976 – 99621Missing in isoform 4 and isoform 5. 2 PublicationsVSP_043821Add
    BLAST
    Alternative sequencei1007 – 10126Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsVSP_043822
    Alternative sequencei1239 – 125719VASSR…RTYSC → DGVFSVYST in isoform 2 and isoform 7. 1 PublicationVSP_043823Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034799 mRNA. Translation: AAC26100.1.
    AK123372 mRNA. Translation: BAG53897.1.
    AK126971 mRNA. Translation: BAG54412.1.
    AK294505 mRNA. Translation: BAH11792.1.
    AK296380 mRNA. Translation: BAH12335.1.
    AK299853 mRNA. Translation: BAH13149.1.
    AC011316 Genomic DNA. No translation available.
    AC069228 Genomic DNA. No translation available.
    AC078920 Genomic DNA. No translation available.
    AC079363 Genomic DNA. No translation available.
    AC079408 Genomic DNA. No translation available.
    BC104912 mRNA. Translation: AAI04913.1.
    BC143485 mRNA. Translation: AAI43486.1.
    CCDSiCCDS55850.1. [O75334-8]
    CCDS55851.1. [O75334-7]
    CCDS55852.1. [O75334-6]
    CCDS55853.1. [O75334-5]
    CCDS55854.1. [O75334-2]
    CCDS55855.1. [O75334-4]
    CCDS55856.1. [O75334-3]
    CCDS55857.1. [O75334-1]
    RefSeqiNP_001207403.1. NM_001220474.2. [O75334-2]
    NP_001207404.1. NM_001220475.2. [O75334-4]
    NP_001207405.1. NM_001220476.2. [O75334-3]
    NP_001207406.1. NM_001220477.2. [O75334-5]
    NP_001207407.1. NM_001220478.2. [O75334-6]
    NP_001207408.1. NM_001220479.2. [O75334-7]
    NP_001207409.1. NM_001220480.2. [O75334-8]
    NP_003616.2. NM_003625.4. [O75334-1]
    UniGeneiHs.506216.
    Hs.737103.

    Genome annotation databases

    EnsembliENST00000407050; ENSP00000385093; ENSG00000139220. [O75334-5]
    ENST00000443686; ENSP00000388373; ENSG00000139220. [O75334-6]
    ENST00000541017; ENSP00000445532; ENSG00000139220. [O75334-8]
    ENST00000541570; ENSP00000438337; ENSG00000139220. [O75334-7]
    ENST00000548586; ENSP00000449338; ENSG00000139220. [O75334-3]
    ENST00000549325; ENSP00000450298; ENSG00000139220. [O75334-2]
    ENST00000549396; ENSP00000450337; ENSG00000139220. [O75334-1]
    ENST00000552948; ENSP00000447868; ENSG00000139220. [O75334-4]
    GeneIDi8499.
    KEGGihsa:8499.
    UCSCiuc031qin.1. human. [O75334-2]
    uc031qio.1. human. [O75334-3]
    uc031qip.1. human. [O75334-4]
    uc031qis.1. human. [O75334-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034799 mRNA. Translation: AAC26100.1 .
    AK123372 mRNA. Translation: BAG53897.1 .
    AK126971 mRNA. Translation: BAG54412.1 .
    AK294505 mRNA. Translation: BAH11792.1 .
    AK296380 mRNA. Translation: BAH12335.1 .
    AK299853 mRNA. Translation: BAH13149.1 .
    AC011316 Genomic DNA. No translation available.
    AC069228 Genomic DNA. No translation available.
    AC078920 Genomic DNA. No translation available.
    AC079363 Genomic DNA. No translation available.
    AC079408 Genomic DNA. No translation available.
    BC104912 mRNA. Translation: AAI04913.1 .
    BC143485 mRNA. Translation: AAI43486.1 .
    CCDSi CCDS55850.1. [O75334-8 ]
    CCDS55851.1. [O75334-7 ]
    CCDS55852.1. [O75334-6 ]
    CCDS55853.1. [O75334-5 ]
    CCDS55854.1. [O75334-2 ]
    CCDS55855.1. [O75334-4 ]
    CCDS55856.1. [O75334-3 ]
    CCDS55857.1. [O75334-1 ]
    RefSeqi NP_001207403.1. NM_001220474.2. [O75334-2 ]
    NP_001207404.1. NM_001220475.2. [O75334-4 ]
    NP_001207405.1. NM_001220476.2. [O75334-3 ]
    NP_001207406.1. NM_001220477.2. [O75334-5 ]
    NP_001207407.1. NM_001220478.2. [O75334-6 ]
    NP_001207408.1. NM_001220479.2. [O75334-7 ]
    NP_001207409.1. NM_001220480.2. [O75334-8 ]
    NP_003616.2. NM_003625.4. [O75334-1 ]
    UniGenei Hs.506216.
    Hs.737103.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TAC X-ray 2.20 B 866-1193 [» ]
    3TAD X-ray 2.90 A/B 866-1193 [» ]
    ProteinModelPortali O75334.
    SMRi O75334. Positions 871-1182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114071. 13 interactions.
    IntActi O75334. 3 interactions.
    STRINGi 9606.ENSP00000388373.

    PTM databases

    PhosphoSitei O75334.

    Proteomic databases

    MaxQBi O75334.
    PaxDbi O75334.
    PRIDEi O75334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000407050 ; ENSP00000385093 ; ENSG00000139220 . [O75334-5 ]
    ENST00000443686 ; ENSP00000388373 ; ENSG00000139220 . [O75334-6 ]
    ENST00000541017 ; ENSP00000445532 ; ENSG00000139220 . [O75334-8 ]
    ENST00000541570 ; ENSP00000438337 ; ENSG00000139220 . [O75334-7 ]
    ENST00000548586 ; ENSP00000449338 ; ENSG00000139220 . [O75334-3 ]
    ENST00000549325 ; ENSP00000450298 ; ENSG00000139220 . [O75334-2 ]
    ENST00000549396 ; ENSP00000450337 ; ENSG00000139220 . [O75334-1 ]
    ENST00000552948 ; ENSP00000447868 ; ENSG00000139220 . [O75334-4 ]
    GeneIDi 8499.
    KEGGi hsa:8499.
    UCSCi uc031qin.1. human. [O75334-2 ]
    uc031qio.1. human. [O75334-3 ]
    uc031qip.1. human. [O75334-4 ]
    uc031qis.1. human. [O75334-1 ]

    Organism-specific databases

    CTDi 8499.
    GeneCardsi GC12M081584.
    H-InvDB HIX0010857.
    HGNCi HGNC:9246. PPFIA2.
    HPAi HPA040724.
    MIMi 603143. gene.
    neXtProti NX_O75334.
    PharmGKBi PA33567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322697.
    HOVERGENi HBG052330.
    InParanoidi O75334.
    OMAi WNRTQQI.
    OrthoDBi EOG7T7GS7.
    TreeFami TF314207.

    Miscellaneous databases

    ChiTaRSi PPFIA2. human.
    GenomeRNAii 8499.
    NextBioi 31801.
    PROi O75334.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75334.
    Bgeei O75334.
    CleanExi HS_PPFIA2.
    Genevestigatori O75334.

    Family and domain databases

    Gene3Di 1.10.150.50. 2 hits.
    InterProi IPR029515. Liprin.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR021129. SAM_type1.
    [Graphical view ]
    PANTHERi PTHR12587. PTHR12587. 1 hit.
    Pfami PF00536. SAM_1. 2 hits.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    SMARTi SM00454. SAM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 3 hits.
    PROSITEi PS50105. SAM_DOMAIN. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
      Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
      J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PTPRD; PTPRF AND PTPRS.
      Tissue: Brain, Fetal brain, Heart and Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6; 7 AND 8).
      Tissue: Amygdala, Brain, Caudate nucleus and Thalamus.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Brain.

    Entry informationi

    Entry nameiLIPA2_HUMAN
    AccessioniPrimary (citable) accession number: O75334
    Secondary accession number(s): B3KVT5
    , B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, Q2M3G8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3