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O75334

- LIPA2_HUMAN

UniProt

O75334 - LIPA2_HUMAN

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Protein

Liprin-alpha-2

Gene

PPFIA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

GO - Biological processi

  1. cell-matrix adhesion Source: ProtInc
  2. signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha-2
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
Short name:
PTPRF-interacting protein alpha-2
Gene namesi
Name:PPFIA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9246. PPFIA2.

Subcellular locationi

Cytoplasm 1 Publication. Cell surface 1 Publication
Note: Colocalizes with PTPRF at the cell surface.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. presynaptic active zone Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12571257Liprin-alpha-2PRO_0000191027Add
BLAST

Proteomic databases

MaxQBiO75334.
PaxDbiO75334.
PRIDEiO75334.

PTM databases

PhosphoSiteiO75334.

Expressioni

Tissue specificityi

Expressed only in brain.1 Publication

Gene expression databases

BgeeiO75334.
CleanExiHS_PPFIA2.
ExpressionAtlasiO75334. baseline.
GenevestigatoriO75334.

Organism-specific databases

HPAiHPA040724.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.1 Publication

Protein-protein interaction databases

BioGridi114071. 13 interactions.
IntActiO75334. 3 interactions.
STRINGi9606.ENSP00000388373.

Structurei

Secondary structure

1
1257
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi874 – 89017
Helixi895 – 8973
Helixi900 – 90910
Helixi915 – 92410
Helixi928 – 9325
Helixi936 – 9416
Helixi948 – 96417
Helixi971 – 9733
Helixi984 – 99411
Helixi1021 – 10266
Helixi1028 – 10314
Helixi1035 – 10373
Helixi1038 – 10436
Helixi1048 – 10514
Helixi1056 – 10616
Helixi1068 – 108316
Turni1084 – 10863
Helixi1088 – 109710
Beta strandi1099 – 11024
Helixi1105 – 11073
Helixi1110 – 111910
Helixi1123 – 11264
Helixi1127 – 11293
Beta strandi1130 – 11323
Helixi1136 – 11416
Helixi1147 – 11537
Helixi1161 – 117818

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TACX-ray2.20B866-1193[»]
3TADX-ray2.90A/B866-1193[»]
ProteinModelPortaliO75334.
SMRiO75334. Positions 871-1182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini898 – 96467SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini1020 – 108465SAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini1108 – 117770SAM 3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 154126Sequence AnalysisAdd
BLAST
Coiled coili185 – 541357Sequence AnalysisAdd
BLAST
Coiled coili643 – 69553Sequence AnalysisAdd
BLAST
Coiled coili1081 – 110727Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi115 – 528414Glu-richAdd
BLAST
Compositional biasi622 – 6276Poly-Asp

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated
Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG322697.
GeneTreeiENSGT00760000119138.
HOVERGENiHBG052330.
InParanoidiO75334.
OMAiWNRTQQI.
OrthoDBiEOG7T7GS7.
TreeFamiTF314207.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
InterProiIPR029515. Liprin.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR021129. SAM_type1.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 3 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75334-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR
60 70 80 90 100
ETQESLSLAQ QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP
110 120 130 140 150
PEFAALTKEL NACREQLLEK EEEISELKAE RNNTRLLLEH LECLVSRHER
160 170 180 190 200
SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL FEHHKALDEK VRERLRVSLE
210 220 230 240 250
RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE HLEGMEPGQK
260 270 280 290 300
VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE
310 320 330 340 350
VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA
360 370 380 390 400
QRESTSIHDM NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM
410 420 430 440 450
RKAETLPEVE AELAQRIAAL TKAEERHGNI EERMRHLEGQ LEEKNQELQR
460 470 480 490 500
ARQREKMNEE HNKRLSDTVD RLLTESNERL QLHLKERMAA LEEKNVLIQE
510 520 530 540 550
SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI EPTIPRTHLD
560 570 580 590 600
TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW
610 620 630 640 650
NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA
660 670 680 690 700
MMLQEQLDAI NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP
710 720 730 740 750
GTSITASVTA SSLASSSPPS GHSTPKLTPR SPAREMDRMG VMTLPSDLRK
760 770 780 790 800
HRRKIAVVEE DGREDKATIK CETSPPPTPR ALRMTHTLPS SYHNDARSSL
810 820 830 840 850
SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK KEKARLGQLR
860 870 880 890 900
GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG
910 920 930 940 950
PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH
960 970 980 990 1000
RLKLRLAIQE MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE
1010 1020 1030 1040 1050
EGSWAQCPVF LQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM
1060 1070 1080 1090 1100
LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LERRREASQH
1110 1120 1130 1140 1150
EIKDVLVWSN DRVIRWIQAI GLREYANNIL ESGVHGSLIA LDENFDYSSL
1160 1170 1180 1190 1200
ALLLQIPTQN TQARQILERE YNNLLALGTE RRLDESDDKN FRRGSTWRRQ
1210 1220 1230 1240 1250
FPPREVHGIS MMPGSSETLP AGFRLTTTSG QSRKMTTDVA SSRLQRLDNS

TVRTYSC
Length:1,257
Mass (Da):143,291
Last modified:June 13, 2012 - v2
Checksum:iBD77601F444EEE10
GO
Isoform 2 (identifier: O75334-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-101: Missing.
     881-881: K → NTSG
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Show »
Length:1,232
Mass (Da):140,673
Checksum:i8A789850F4E1E605
GO
Isoform 3 (identifier: O75334-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1007-1012: Missing.

Show »
Length:1,251
Mass (Da):142,603
Checksum:i18169E6210D89CE5
GO
Isoform 4 (identifier: O75334-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     976-996: Missing.

Show »
Length:1,236
Mass (Da):141,027
Checksum:i27D95B02136893F6
GO
Isoform 5 (identifier: O75334-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     976-996: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.

Show »
Length:1,156
Mass (Da):132,170
Checksum:iF276981E4A68B4DF
GO
Isoform 6 (identifier: O75334-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     191-215: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.

Show »
Length:1,152
Mass (Da):131,584
Checksum:iEDBA76B39345FEE0
GO
Isoform 7 (identifier: O75334-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     976-1006: Missing.
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Note: No experimental confirmation available.

Show »
Length:783
Mass (Da):89,059
Checksum:iEB9A77B8B3279111
GO
Isoform 8 (identifier: O75334-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.
     976-1006: Missing.

Note: No experimental confirmation available.

Show »
Length:443
Mass (Da):50,251
Checksum:iA666F2024D2AA5C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti394 – 3941Q → E in AAC26100. (PubMed:9624153)Curated
Sequence conflicti426 – 4261R → T in AAC26100. (PubMed:9624153)Curated
Sequence conflicti517 – 5171R → S in AAC26100. (PubMed:9624153)Curated
Sequence conflicti523 – 5231E → G in BAH11792. (PubMed:14702039)Curated
Sequence conflicti697 – 6971R → M in AAC26100. (PubMed:9624153)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 783783Missing in isoform 8. 1 PublicationVSP_046718Add
BLAST
Alternative sequencei1 – 433433Missing in isoform 7. 1 PublicationVSP_046719Add
BLAST
Alternative sequencei1 – 7474Missing in isoform 5 and isoform 6. 1 PublicationVSP_046720Add
BLAST
Alternative sequencei75 – 10127RQLNS…GADPP → MIFSDMNTVSGSPKVHPPNG TRFYTFQ in isoform 5 and isoform 6. 1 PublicationVSP_046721Add
BLAST
Alternative sequencei84 – 10118Missing in isoform 2. 1 PublicationVSP_043819Add
BLAST
Alternative sequencei191 – 21525Missing in isoform 6. 1 PublicationVSP_046722Add
BLAST
Alternative sequencei881 – 8811K → NTSG in isoform 2. 1 PublicationVSP_043820
Alternative sequencei976 – 100631Missing in isoform 7 and isoform 8. 1 PublicationVSP_046723Add
BLAST
Alternative sequencei976 – 99621Missing in isoform 4 and isoform 5. 2 PublicationsVSP_043821Add
BLAST
Alternative sequencei1007 – 10126Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsVSP_043822
Alternative sequencei1239 – 125719VASSR…RTYSC → DGVFSVYST in isoform 2 and isoform 7. 1 PublicationVSP_043823Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034799 mRNA. Translation: AAC26100.1.
AK123372 mRNA. Translation: BAG53897.1.
AK126971 mRNA. Translation: BAG54412.1.
AK294505 mRNA. Translation: BAH11792.1.
AK296380 mRNA. Translation: BAH12335.1.
AK299853 mRNA. Translation: BAH13149.1.
AC011316 Genomic DNA. No translation available.
AC069228 Genomic DNA. No translation available.
AC078920 Genomic DNA. No translation available.
AC079363 Genomic DNA. No translation available.
AC079408 Genomic DNA. No translation available.
BC104912 mRNA. Translation: AAI04913.1.
BC143485 mRNA. Translation: AAI43486.1.
CCDSiCCDS55850.1. [O75334-8]
CCDS55851.1. [O75334-7]
CCDS55852.1. [O75334-6]
CCDS55853.1. [O75334-5]
CCDS55854.1. [O75334-2]
CCDS55855.1. [O75334-4]
CCDS55856.1. [O75334-3]
CCDS55857.1. [O75334-1]
RefSeqiNP_001207403.1. NM_001220474.2. [O75334-2]
NP_001207404.1. NM_001220475.2. [O75334-4]
NP_001207405.1. NM_001220476.2. [O75334-3]
NP_001207406.1. NM_001220477.2. [O75334-5]
NP_001207407.1. NM_001220478.2. [O75334-6]
NP_001207408.1. NM_001220479.2. [O75334-7]
NP_001207409.1. NM_001220480.2. [O75334-8]
NP_003616.2. NM_003625.4. [O75334-1]
UniGeneiHs.506216.
Hs.737103.

Genome annotation databases

EnsembliENST00000333447; ENSP00000327416; ENSG00000139220. [O75334-6]
ENST00000407050; ENSP00000385093; ENSG00000139220. [O75334-5]
ENST00000443686; ENSP00000388373; ENSG00000139220. [O75334-6]
ENST00000541017; ENSP00000445532; ENSG00000139220. [O75334-8]
ENST00000541570; ENSP00000438337; ENSG00000139220. [O75334-7]
ENST00000548586; ENSP00000449338; ENSG00000139220. [O75334-3]
ENST00000549325; ENSP00000450298; ENSG00000139220. [O75334-2]
ENST00000549396; ENSP00000450337; ENSG00000139220. [O75334-1]
ENST00000552948; ENSP00000447868; ENSG00000139220. [O75334-4]
GeneIDi8499.
KEGGihsa:8499.
UCSCiuc031qih.1. human.
uc031qij.1. human.
uc031qik.1. human.
uc031qin.1. human. [O75334-2]
uc031qio.1. human. [O75334-3]
uc031qip.1. human. [O75334-4]
uc031qis.1. human. [O75334-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034799 mRNA. Translation: AAC26100.1 .
AK123372 mRNA. Translation: BAG53897.1 .
AK126971 mRNA. Translation: BAG54412.1 .
AK294505 mRNA. Translation: BAH11792.1 .
AK296380 mRNA. Translation: BAH12335.1 .
AK299853 mRNA. Translation: BAH13149.1 .
AC011316 Genomic DNA. No translation available.
AC069228 Genomic DNA. No translation available.
AC078920 Genomic DNA. No translation available.
AC079363 Genomic DNA. No translation available.
AC079408 Genomic DNA. No translation available.
BC104912 mRNA. Translation: AAI04913.1 .
BC143485 mRNA. Translation: AAI43486.1 .
CCDSi CCDS55850.1. [O75334-8 ]
CCDS55851.1. [O75334-7 ]
CCDS55852.1. [O75334-6 ]
CCDS55853.1. [O75334-5 ]
CCDS55854.1. [O75334-2 ]
CCDS55855.1. [O75334-4 ]
CCDS55856.1. [O75334-3 ]
CCDS55857.1. [O75334-1 ]
RefSeqi NP_001207403.1. NM_001220474.2. [O75334-2 ]
NP_001207404.1. NM_001220475.2. [O75334-4 ]
NP_001207405.1. NM_001220476.2. [O75334-3 ]
NP_001207406.1. NM_001220477.2. [O75334-5 ]
NP_001207407.1. NM_001220478.2. [O75334-6 ]
NP_001207408.1. NM_001220479.2. [O75334-7 ]
NP_001207409.1. NM_001220480.2. [O75334-8 ]
NP_003616.2. NM_003625.4. [O75334-1 ]
UniGenei Hs.506216.
Hs.737103.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TAC X-ray 2.20 B 866-1193 [» ]
3TAD X-ray 2.90 A/B 866-1193 [» ]
ProteinModelPortali O75334.
SMRi O75334. Positions 871-1182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114071. 13 interactions.
IntActi O75334. 3 interactions.
STRINGi 9606.ENSP00000388373.

PTM databases

PhosphoSitei O75334.

Proteomic databases

MaxQBi O75334.
PaxDbi O75334.
PRIDEi O75334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333447 ; ENSP00000327416 ; ENSG00000139220 . [O75334-6 ]
ENST00000407050 ; ENSP00000385093 ; ENSG00000139220 . [O75334-5 ]
ENST00000443686 ; ENSP00000388373 ; ENSG00000139220 . [O75334-6 ]
ENST00000541017 ; ENSP00000445532 ; ENSG00000139220 . [O75334-8 ]
ENST00000541570 ; ENSP00000438337 ; ENSG00000139220 . [O75334-7 ]
ENST00000548586 ; ENSP00000449338 ; ENSG00000139220 . [O75334-3 ]
ENST00000549325 ; ENSP00000450298 ; ENSG00000139220 . [O75334-2 ]
ENST00000549396 ; ENSP00000450337 ; ENSG00000139220 . [O75334-1 ]
ENST00000552948 ; ENSP00000447868 ; ENSG00000139220 . [O75334-4 ]
GeneIDi 8499.
KEGGi hsa:8499.
UCSCi uc031qih.1. human.
uc031qij.1. human.
uc031qik.1. human.
uc031qin.1. human. [O75334-2 ]
uc031qio.1. human. [O75334-3 ]
uc031qip.1. human. [O75334-4 ]
uc031qis.1. human. [O75334-1 ]

Organism-specific databases

CTDi 8499.
GeneCardsi GC12M081584.
H-InvDB HIX0010857.
HGNCi HGNC:9246. PPFIA2.
HPAi HPA040724.
MIMi 603143. gene.
neXtProti NX_O75334.
PharmGKBi PA33567.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322697.
GeneTreei ENSGT00760000119138.
HOVERGENi HBG052330.
InParanoidi O75334.
OMAi WNRTQQI.
OrthoDBi EOG7T7GS7.
TreeFami TF314207.

Miscellaneous databases

ChiTaRSi PPFIA2. human.
GenomeRNAii 8499.
NextBioi 31801.
PROi O75334.
SOURCEi Search...

Gene expression databases

Bgeei O75334.
CleanExi HS_PPFIA2.
ExpressionAtlasi O75334. baseline.
Genevestigatori O75334.

Family and domain databases

Gene3Di 1.10.150.50. 2 hits.
InterProi IPR029515. Liprin.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR021129. SAM_type1.
[Graphical view ]
PANTHERi PTHR12587. PTHR12587. 1 hit.
Pfami PF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view ]
SMARTi SM00454. SAM. 3 hits.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 3 hits.
PROSITEi PS50105. SAM_DOMAIN. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
    Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
    J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PTPRD; PTPRF AND PTPRS.
    Tissue: Brain, Fetal brain, Heart and Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6; 7 AND 8).
    Tissue: Amygdala, Brain, Caudate nucleus and Thalamus.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Brain.

Entry informationi

Entry nameiLIPA2_HUMAN
AccessioniPrimary (citable) accession number: O75334
Secondary accession number(s): B3KVT5
, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, Q2M3G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 13, 2012
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3