O75334 (LIPA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Liprin-alpha-2

Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
Short name=PTPRF-interacting protein alpha-2

Gene names

Name:

PPFIA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1257 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Ref.1
Subunit structure	Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Ref.1
Subcellular location	Cytoplasm. Cell surface. Note: Colocalizes with PTPRF at the cell surface. Ref.1
Tissue specificity	Expressed only in brain. Ref.1
Domain	The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
Sequence similarities	Belongs to the liprin family. Liprin-alpha subfamily. Contains 3 SAM (sterile alpha motif) domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-matrix adhesion Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell surface Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Traceable author statement Ref.1. Source: ProtInc synapse Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75334-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75334-2)

The sequence of this isoform differs from the canonical sequence as follows:
     84-101: Missing.
     881-881: K → NTSG
     1238-1257: DVASSRLQRLDNSTVRTYSC → DDGVFSVYST

Isoform 3 (identifier: O75334-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1011: Missing.

Isoform 4 (identifier: O75334-4)

The sequence of this isoform differs from the canonical sequence as follows:
     975-995: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1257

1257

Liprin-alpha-2

PRO_0000191027

Regions

Domain

898 – 964

67

SAM 1

Domain

1020 – 1084

65

SAM 2

Domain

1108 – 1177

70

SAM 3

Coiled coil

29 – 154

126

Potential

Coiled coil

185 – 541

357

Potential

Coiled coil

643 – 695

53

Potential

Coiled coil

1081 – 1107

27

Potential

Compositional bias

115 – 528

414

Glu-rich

Compositional bias

622 – 627

6

Poly-Asp

Amino acid modifications

Modified residue

538

1

Phosphoserine By similarity

Modified residue

689

1

Phosphoserine By similarity

Modified residue

774

1

Phosphoserine By similarity

Natural variations

Alternative sequence

84 – 101

18

Missing in isoform 2.

VSP_043819

Alternative sequence

881

1

K → NTSG in isoform 2.

VSP_043820

Alternative sequence

975 – 995

21

Missing in isoform 4.

VSP_043821

Alternative sequence

1006 – 1011

6

Missing in isoform 3.

VSP_043822

Alternative sequence

1238 – 1257

20

DVASS…RTYSC → DDGVFSVYST in isoform 2.

VSP_043823

Experimental info

Sequence conflict

394

1

Q → E in AAC26100. Ref.1

Sequence conflict

426

1

R → T in AAC26100. Ref.1

Sequence conflict

517

1

R → S in AAC26100. Ref.1

Sequence conflict

697

1

R → M in AAC26100. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1257

Helix Strand Turn

Details...

Helix

874 – 890

17

Helix

895 – 897

3

Helix

900 – 909

10

Helix

915 – 924

10

Helix

928 – 932

5

Helix

936 – 941

6

Helix

948 – 964

17

Helix

971 – 973

3

Helix

984 – 994

11

Helix

1021 – 1026

6

Helix

1028 – 1031

4

Helix

1035 – 1037

3

Helix

1038 – 1043

6

Helix

1048 – 1051

4

Helix

1056 – 1061

6

Helix

1068 – 1083

16

Turn

1084 – 1086

3

Helix

1088 – 1097

10

Beta strand

1099 – 1102

4

Helix

1105 – 1107

3

Helix

1110 – 1119

10

Helix

1123 – 1126

4

Helix

1127 – 1129

3

Beta strand

1130 – 1132

3

Helix

1136 – 1141

6

Helix

1147 – 1153

7

Helix

1161 – 1178

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2012. Version 2. Checksum: BD77601F444EEE10	FASTA	1,257	143,291
	10 20 30 40 50 60 MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR ETQESLSLAQ 70 80 90 100 110 120 QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP PEFAALTKEL NACREQLLEK 130 140 150 160 170 180 EEEISELKAE RNNTRLLLEH LECLVSRHER SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL 190 200 210 220 230 240 FEHHKALDEK VRERLRVSLE RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE 250 260 270 280 290 300 HLEGMEPGQK VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE 310 320 330 340 350 360 VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA QRESTSIHDM 370 380 390 400 410 420 NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM RKAETLPEVE AELAQRIAAL 430 440 450 460 470 480 TKAEERHGNI EERMRHLEGQ LEEKNQELQR ARQREKMNEE HNKRLSDTVD RLLTESNERL 490 500 510 520 530 540 QLHLKERMAA LEEKNVLIQE SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI 550 560 570 580 590 600 EPTIPRTHLD TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW 610 620 630 640 650 660 NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA MMLQEQLDAI 670 680 690 700 710 720 NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP GTSITASVTA SSLASSSPPS 730 740 750 760 770 780 GHSTPKLTPR SPAREMDRMG VMTLPSDLRK HRRKIAVVEE DGREDKATIK CETSPPPTPR 790 800 810 820 830 840 ALRMTHTLPS SYHNDARSSL SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK 850 860 870 880 890 900 KEKARLGQLR GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG 910 920 930 940 950 960 PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE 970 980 990 1000 1010 1020 MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE EGSWAQCPVF LQTLAYGDMN 1030 1040 1050 1060 1070 1080 HEWIGNEWLP SLGLPQYRSY FMECLVDARM LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC 1090 1100 1110 1120 1130 1140 LKRLNYDRKE LERRREASQH EIKDVLVWSN DRVIRWIQAI GLREYANNIL ESGVHGSLIA 1150 1160 1170 1180 1190 1200 LDENFDYSSL ALLLQIPTQN TQARQILERE YNNLLALGTE RRLDESDDKN FRRGSTWRRQ 1210 1220 1230 1240 1250 FPPREVHGIS MMPGSSETLP AGFRLTTTSG QSRKMTTDVA SSRLQRLDNS TVRTYSC
	Isoform 2 [UniParc]. Checksum: 8A789850F4E1E605	FASTA	1,232	140,673
	10 20 30 40 50 60 MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR ETQESLSLAQ 70 80 90 100 110 120 QRLQDVIYDR DSLQRQLNSA LPQEFAALTK ELNACREQLL EKEEEISELK AERNNTRLLL 130 140 150 160 170 180 EHLECLVSRH ERSLRMTVVK RQAQSPSGVS SEVEVLKALK SLFEHHKALD EKVRERLRVS 190 200 210 220 230 240 LERVSALEEE LAAANQEIVA LREQNVHIQR KMASSEGSTE SEHLEGMEPG QKVHEKRLSN 250 260 270 280 290 300 GSIDSTDETS QIVELQELLE KQNYEMAQMK ERLAALSSRV GEVEQEAETA RKDLIKTEEM 310 320 330 340 350 360 NTKYQRDIRE AMAQKEDMEE RITTLEKRYL SAQRESTSIH DMNDKLENEL ANKEAILRQM 370 380 390 400 410 420 EEKNRQLQER LELAEQKLQQ TMRKAETLPE VEAELAQRIA ALTKAEERHG NIEERMRHLE 430 440 450 460 470 480 GQLEEKNQEL QRARQREKMN EEHNKRLSDT VDRLLTESNE RLQLHLKERM AALEEKNVLI 490 500 510 520 530 540 QESETFRKNL EESLHDKERL AEEIEKLRSE LDQLKMRTGS LIEPTIPRTH LDTSAELRYS 550 560 570 580 590 600 VGSLVDSQSD YRTTKVIRRP RRGRMGVRRD EPKVKSLGDH EWNRTQQIGV LSSHPFESDT 610 620 630 640 650 660 EMSDIDDDDR ETIFSSMDLL SPSGHSDAQT LAMMLQEQLD AINKEIRLIQ EEKESTELRA 670 680 690 700 710 720 EEIENRVASV SLEGLNLARV HPGTSITASV TASSLASSSP PSGHSTPKLT PRSPAREMDR 730 740 750 760 770 780 MGVMTLPSDL RKHRRKIAVV EEDGREDKAT IKCETSPPPT PRALRMTHTL PSSYHNDARS 790 800 810 820 830 840 SLSVSLEPES LGLGSANSSQ DSLHKAPKKK GIKSSIGRLF GKKEKARLGQ LRGFMETEAA 850 860 870 880 890 900 AQESLGLGKL GTQAEKDRRL KKNTSGHELL EEARRKGLPF AQWDGPTVVA WLELWLGMPA 910 920 930 940 950 960 WYVAACRANV KSGAIMSALS DTEIQREIGI SNPLHRLKLR LAIQEMVSLT SPSAPPTSRT 970 980 990 1000 1010 1020 PSGNVWVTHE EMENLAAPAK TKESEEGSWA QCPVFLQTLA YGDMNHEWIG NEWLPSLGLP 1030 1040 1050 1060 1070 1080 QYRSYFMECL VDARMLDHLT KKDLRVHLKM VDSFHRTSLQ YGIMCLKRLN YDRKELERRR 1090 1100 1110 1120 1130 1140 EASQHEIKDV LVWSNDRVIR WIQAIGLREY ANNILESGVH GSLIALDENF DYSSLALLLQ 1150 1160 1170 1180 1190 1200 IPTQNTQARQ ILEREYNNLL ALGTERRLDE SDDKNFRRGS TWRRQFPPRE VHGISMMPGS 1210 1220 1230 SETLPAGFRL TTTSGQSRKM TTDDGVFSVY ST
	Isoform 3 [UniParc]. Checksum: 18169E6210D89CE5	FASTA	1,251	142,603
	10 20 30 40 50 60 MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR ETQESLSLAQ 70 80 90 100 110 120 QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP PEFAALTKEL NACREQLLEK 130 140 150 160 170 180 EEEISELKAE RNNTRLLLEH LECLVSRHER SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL 190 200 210 220 230 240 FEHHKALDEK VRERLRVSLE RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE 250 260 270 280 290 300 HLEGMEPGQK VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE 310 320 330 340 350 360 VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA QRESTSIHDM 370 380 390 400 410 420 NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM RKAETLPEVE AELAQRIAAL 430 440 450 460 470 480 TKAEERHGNI EERMRHLEGQ LEEKNQELQR ARQREKMNEE HNKRLSDTVD RLLTESNERL 490 500 510 520 530 540 QLHLKERMAA LEEKNVLIQE SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI 550 560 570 580 590 600 EPTIPRTHLD TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW 610 620 630 640 650 660 NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA MMLQEQLDAI 670 680 690 700 710 720 NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP GTSITASVTA SSLASSSPPS 730 740 750 760 770 780 GHSTPKLTPR SPAREMDRMG VMTLPSDLRK HRRKIAVVEE DGREDKATIK CETSPPPTPR 790 800 810 820 830 840 ALRMTHTLPS SYHNDARSSL SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK 850 860 870 880 890 900 KEKARLGQLR GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG 910 920 930 940 950 960 PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE 970 980 990 1000 1010 1020 MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE EGSWAQTLAY GDMNHEWIGN 1030 1040 1050 1060 1070 1080 EWLPSLGLPQ YRSYFMECLV DARMLDHLTK KDLRVHLKMV DSFHRTSLQY GIMCLKRLNY 1090 1100 1110 1120 1130 1140 DRKELERRRE ASQHEIKDVL VWSNDRVIRW IQAIGLREYA NNILESGVHG SLIALDENFD 1150 1160 1170 1180 1190 1200 YSSLALLLQI PTQNTQARQI LEREYNNLLA LGTERRLDES DDKNFRRGST WRRQFPPREV 1210 1220 1230 1240 1250 HGISMMPGSS ETLPAGFRLT TTSGQSRKMT TDVASSRLQR LDNSTVRTYS C
	Isoform 4 [UniParc]. Checksum: 27D95B02136893F6	FASTA	1,236	141,027
	10 20 30 40 50 60 MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR ETQESLSLAQ 70 80 90 100 110 120 QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP PEFAALTKEL NACREQLLEK 130 140 150 160 170 180 EEEISELKAE RNNTRLLLEH LECLVSRHER SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL 190 200 210 220 230 240 FEHHKALDEK VRERLRVSLE RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE 250 260 270 280 290 300 HLEGMEPGQK VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE 310 320 330 340 350 360 VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA QRESTSIHDM 370 380 390 400 410 420 NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM RKAETLPEVE AELAQRIAAL 430 440 450 460 470 480 TKAEERHGNI EERMRHLEGQ LEEKNQELQR ARQREKMNEE HNKRLSDTVD RLLTESNERL 490 500 510 520 530 540 QLHLKERMAA LEEKNVLIQE SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI 550 560 570 580 590 600 EPTIPRTHLD TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW 610 620 630 640 650 660 NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA MMLQEQLDAI 670 680 690 700 710 720 NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP GTSITASVTA SSLASSSPPS 730 740 750 760 770 780 GHSTPKLTPR SPAREMDRMG VMTLPSDLRK HRRKIAVVEE DGREDKATIK CETSPPPTPR 790 800 810 820 830 840 ALRMTHTLPS SYHNDARSSL SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK 850 860 870 880 890 900 KEKARLGQLR GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG 910 920 930 940 950 960 PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE 970 980 990 1000 1010 1020 MVSLTSPSAP PTSRTKESEE GSWAQCPVFL QTLAYGDMNH EWIGNEWLPS LGLPQYRSYF 1030 1040 1050 1060 1070 1080 MECLVDARML DHLTKKDLRV HLKMVDSFHR TSLQYGIMCL KRLNYDRKEL ERRREASQHE 1090 1100 1110 1120 1130 1140 IKDVLVWSND RVIRWIQAIG LREYANNILE SGVHGSLIAL DENFDYSSLA LLLQIPTQNT 1150 1160 1170 1180 1190 1200 QARQILEREY NNLLALGTER RLDESDDKNF RRGSTWRRQF PPREVHGISM MPGSSETLPA 1210 1220 1230 GFRLTTTSGQ SRKMTTDVAS SRLQRLDNST VRTYSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins." Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M. J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PTPRD; PTPRF AND PTPRS. Tissue: Brain, Fetal brain, Heart and Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF034799 mRNA. Translation: AAC26100.1.
AK126971 mRNA. Translation: BAG54412.1.
AC011316 Genomic DNA. No translation available.
AC069228 Genomic DNA. No translation available.
AC078920 Genomic DNA. No translation available.
AC079363 Genomic DNA. No translation available.
AC079408 Genomic DNA. No translation available.
BC104912 mRNA. Translation: AAI04913.1.
BC143485 mRNA. Translation: AAI43486.1.

IPI

IPI00289271.

RefSeq

NP_001207403.1. NM_001220474.1.
NP_001207404.1. NM_001220475.1.
NP_001207405.1. NM_001220476.1.
NP_003616.2. NM_003625.3.

UniGene

Hs.506216.
Hs.737103.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TAC	X-ray	2.20	B	866-1193	[»]
3TAD	X-ray	2.90	A/B	866-1193	[»]

ProteinModelPortal

O75334.

SMR

O75334. Positions 871-1182.

ModBase

Search...

Protein-protein interaction databases

IntAct

O75334. 3 interactions.

STRING

9606.ENSP00000388373.

PTM databases

PhosphoSite

O75334.

Proteomic databases

PaxDb

O75334.

PRIDE

O75334.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000548586; ENSP00000449338; ENSG00000139220.
ENST00000549325; ENSP00000450298; ENSG00000139220.
ENST00000549396; ENSP00000450337; ENSG00000139220.
ENST00000552948; ENSP00000447868; ENSG00000139220.

GeneID

8499.

KEGG

hsa:8499.

Organism-specific databases

CTD

8499.

GeneCards

GC12M081584.

H-InvDB

HIX0010857.

HGNC

HGNC:9246. PPFIA2.

HPA

HPA040724.

MIM

603143. gene.

neXtProt

NX_O75334.

PharmGKB

PA33567.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG322697.

HOVERGEN

HBG052330.

InParanoid

O75334.

Gene expression databases

ArrayExpress

O75334.

Bgee

O75334.

CleanEx

HS_PPFIA2.

Genevestigator

O75334.

GermOnline

ENSG00000139220. Homo sapiens.

Family and domain databases

Gene3D

1.10.150.50. 2 hits.

InterPro

IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR021129. SAM_type1.
[Graphical view]

Pfam

PF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]

SMART

SM00454. SAM. 3 hits.
[Graphical view]

SUPFAM

SSF47769. SAM_homology. 3 hits.

PROSITE

PS50105. SAM_DOMAIN. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PPFIA2. human.

GenomeRNAi

8499.

NextBio

31801.

SOURCE

Search...

Entry information

Entry name

LIPA2_HUMAN

Accession

Primary (citable) accession number: O75334
Secondary accession number(s): B3KXA0 , B7ZKZ5, F8VP68, Q2M3G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	June 13, 2012
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.