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Protein

Hyaluronan mediated motility receptor

Gene

HMMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-HSA-2160916. Hyaluronan uptake and degradation.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:HMMR
Synonyms:IHABP, RHAMM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5012. HMMR.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3161.
MalaCardsiHMMR.
OpenTargetsiENSG00000072571.
PharmGKBiPA29340.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiHMMR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840071 – 724Hyaluronan mediated motility receptorAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei703PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75330.
MaxQBiO75330.
PaxDbiO75330.
PeptideAtlasiO75330.
PRIDEiO75330.

2D gel databases

REPRODUCTION-2DPAGEiO75330.

PTM databases

iPTMnetiO75330.
PhosphoSitePlusiO75330.

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and in normal breast tissue.

Gene expression databases

BgeeiENSG00000072571.
CleanExiHS_HMMR.
ExpressionAtlasiO75330. baseline and differential.
GenevisibleiO75330. HS.

Organism-specific databases

HPAiCAB002433.
HPA040025.
HPA043926.
HPA061524.

Interactioni

Subunit structurei

Subunit of the HARC complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
MORN4Q8NDC43EBI-2556203,EBI-10269566

Protein-protein interaction databases

BioGridi109404. 51 interactors.
DIPiDIP-56496N.
IntActiO75330. 27 interactors.
MINTiMINT-4989385.
STRINGi9606.ENSP00000377492.

Structurei

3D structure databases

ProteinModelPortaliO75330.
SMRiO75330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni635 – 645Hyaluronic acid-bindingSequence analysisAdd BLAST11
Regioni657 – 666Hyaluronic acid-bindingSequence analysis10

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ28. Eukaryota.
ENOG4111G1K. LUCA.
GeneTreeiENSGT00390000007135.
HOVERGENiHBG044411.
InParanoidiO75330.
KOiK06267.
OMAiISCASDQ.
OrthoDBiEOG091G03MO.
PhylomeDBiO75330.
TreeFamiTF333963.

Family and domain databases

InterProiView protein in InterPro
IPR031794. HMMR_C.
IPR031787. HMMR_N.
IPR026203. IHABP.
PANTHERiPTHR18956. PTHR18956. 1 hit.
PfamiView protein in Pfam
PF15908. HMMR_C. 1 hit.
PF15905. HMMR_N. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES
60 70 80 90 100
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA
110 120 130 140 150
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL
160 170 180 190 200
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR
210 220 230 240 250
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY
260 270 280 290 300
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
310 320 330 340 350
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK
360 370 380 390 400
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK
410 420 430 440 450
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ
460 470 480 490 500
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA
510 520 530 540 550
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED
560 570 580 590 600
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
610 620 630 640 650
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ
660 670 680 690 700
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA
710 720
LKTPLKEGNT NCYRAPMECQ ESWK
Length:724
Mass (Da):84,100
Last modified:April 17, 2007 - v2
Checksum:iF2C3C0DBA863955F
GO
Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     76-90: Missing.

Show »
Length:709
Mass (Da):82,301
Checksum:i29E7F070B99FD30C
GO
Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: K → KK

Show »
Length:725
Mass (Da):84,229
Checksum:i2515512EEDFB1DA1
GO
Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

Show »
Length:638
Mass (Da):74,495
Checksum:iBFD153D3EC20FE5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103R → S in AAC32548 (PubMed:9601098).Curated1
Sequence conflicti277E → D in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti298K → T in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti322K → E in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti330 – 332QER → REH in AAC52049 (PubMed:8890751).Curated3
Sequence conflicti547Q → R in BAF83266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02415592R → C1 PublicationCorresponds to variant dbSNP:rs299284Ensembl.1
Natural variantiVAR_031661305N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_056917320N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_024156332R → H. Corresponds to variant dbSNP:rs2303078Ensembl.1
Natural variantiVAR_020044368V → A2 PublicationsCorresponds to variant dbSNP:rs299290Ensembl.1
Natural variantiVAR_024157484A → V2 PublicationsCorresponds to variant dbSNP:rs299295Ensembl.1
Natural variantiVAR_056918557D → H. Corresponds to variant dbSNP:rs2230362Ensembl.1
Natural variantiVAR_056919595L → I. Corresponds to variant dbSNP:rs2230363Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0412661 – 90MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03837875K → KK in isoform 3. 2 Publications1
Alternative sequenceiVSP_00428676 – 90Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29343 mRNA. Translation: AAC52049.1.
AF032862 mRNA. Translation: AAC32548.1.
AK290577 mRNA. Translation: BAF83266.1.
AK303616 mRNA. Translation: BAG64626.1.
AC112205 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61522.1.
CH471062 Genomic DNA. Translation: EAW61523.1.
CH471062 Genomic DNA. Translation: EAW61524.1.
CH471062 Genomic DNA. Translation: EAW61525.1.
BC108904 mRNA. Translation: AAI08905.1.
CCDSiCCDS4362.1. [O75330-1]
CCDS4363.1. [O75330-2]
CCDS47334.1. [O75330-3]
CCDS47335.1. [O75330-4]
PIRiJC5016.
RefSeqiNP_001136028.1. NM_001142556.1. [O75330-3]
NP_001136029.1. NM_001142557.1. [O75330-4]
NP_036616.2. NM_012484.2. [O75330-1]
NP_036617.2. NM_012485.2. [O75330-2]
UniGeneiHs.740467.

Genome annotation databases

EnsembliENST00000353866; ENSP00000185942; ENSG00000072571. [O75330-2]
ENST00000358715; ENSP00000351554; ENSG00000072571. [O75330-1]
ENST00000393915; ENSP00000377492; ENSG00000072571. [O75330-3]
ENST00000432118; ENSP00000402673; ENSG00000072571. [O75330-4]
GeneIDi3161.
KEGGihsa:3161.
UCSCiuc003lzf.5. human. [O75330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHMMR_HUMAN
AccessioniPrimary (citable) accession number: O75330
Secondary accession number(s): A8K3G2
, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: August 30, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot