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O75330

- HMMR_HUMAN

UniProt

O75330 - HMMR_HUMAN

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Protein
Hyaluronan mediated motility receptor
Gene
HMMR, IHABP, RHAMM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. glycosaminoglycan metabolic process Source: Reactome
  3. hyaluronan catabolic process Source: Reactome
  4. hyaluronan metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

ReactomeiREACT_120996. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:HMMR
Synonyms:IHABP, RHAMM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5012. HMMR.

Subcellular locationi

Cell surface. Cytoplasm By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Hyaluronan mediated motility receptor
PRO_0000084007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine1 Publication
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi477 – 4771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi588 – 5881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO75330.
PaxDbiO75330.
PRIDEiO75330.

2D gel databases

REPRODUCTION-2DPAGEO75330.

PTM databases

PhosphoSiteiO75330.

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and in normal breast tissue.

Gene expression databases

ArrayExpressiO75330.
BgeeiO75330.
CleanExiHS_HMMR.
GenevestigatoriO75330.

Organism-specific databases

HPAiCAB002433.
HPA043926.

Interactioni

Subunit structurei

Subunit of the HARC complex.

Protein-protein interaction databases

BioGridi109404. 20 interactions.
DIPiDIP-56496N.
IntActiO75330. 8 interactions.
MINTiMINT-4989385.
STRINGi9606.ENSP00000377492.

Structurei

3D structure databases

ProteinModelPortaliO75330.
SMRiO75330. Positions 645-678.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni635 – 64511Hyaluronic acid-binding Reviewed prediction
Add
BLAST
Regioni657 – 66610Hyaluronic acid-binding Reviewed prediction

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG146600.
HOVERGENiHBG044411.
KOiK06267.
OMAiKPFQLQL.
PhylomeDBiO75330.
TreeFamiTF333963.

Family and domain databases

InterProiIPR026203. IHABP.
[Graphical view]
PANTHERiPTHR18956. PTHR18956. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES    50
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA 100
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL 150
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR 200
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY 250
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 300
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK 350
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK 400
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ 450
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA 500
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED 550
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 600
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ 650
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA 700
LKTPLKEGNT NCYRAPMECQ ESWK 724
Length:724
Mass (Da):84,100
Last modified:April 17, 2007 - v2
Checksum:iF2C3C0DBA863955F
GO
Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     76-90: Missing.

Show »
Length:709
Mass (Da):82,301
Checksum:i29E7F070B99FD30C
GO
Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: K → KK

Show »
Length:725
Mass (Da):84,229
Checksum:i2515512EEDFB1DA1
GO
Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

Show »
Length:638
Mass (Da):74,495
Checksum:iBFD153D3EC20FE5D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921R → C.1 Publication
Corresponds to variant rs299284 [ dbSNP | Ensembl ].
VAR_024155
Natural varianti305 – 3051N → K.
Corresponds to variant rs2303077 [ dbSNP | Ensembl ].
VAR_031661
Natural varianti320 – 3201N → K.
Corresponds to variant rs2303077 [ dbSNP | Ensembl ].
VAR_056917
Natural varianti332 – 3321R → H.
Corresponds to variant rs2303078 [ dbSNP | Ensembl ].
VAR_024156
Natural varianti368 – 3681V → A.2 Publications
Corresponds to variant rs299290 [ dbSNP | Ensembl ].
VAR_020044
Natural varianti484 – 4841A → V.2 Publications
Corresponds to variant rs299295 [ dbSNP | Ensembl ].
VAR_024157
Natural varianti557 – 5571D → H.
Corresponds to variant rs2230362 [ dbSNP | Ensembl ].
VAR_056918
Natural varianti595 – 5951L → I.
Corresponds to variant rs2230363 [ dbSNP | Ensembl ].
VAR_056919

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090MSFPK…ILEKE → MTLL in isoform 4.
VSP_041266Add
BLAST
Alternative sequencei75 – 751K → KK in isoform 3.
VSP_038378
Alternative sequencei76 – 9015Missing in isoform 2.
VSP_004286Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031R → S in AAC32548. 1 Publication
Sequence conflicti277 – 2771E → D in AAC52049. 1 Publication
Sequence conflicti298 – 2981K → T in AAC52049. 1 Publication
Sequence conflicti322 – 3221K → E in AAC52049. 1 Publication
Sequence conflicti330 – 3323QER → REH in AAC52049. 1 Publication
Sequence conflicti547 – 5471Q → R in BAF83266. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29343 mRNA. Translation: AAC52049.1.
AF032862 mRNA. Translation: AAC32548.1.
AK290577 mRNA. Translation: BAF83266.1.
AK303616 mRNA. Translation: BAG64626.1.
AC112205 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61522.1.
CH471062 Genomic DNA. Translation: EAW61523.1.
CH471062 Genomic DNA. Translation: EAW61524.1.
CH471062 Genomic DNA. Translation: EAW61525.1.
BC108904 mRNA. Translation: AAI08905.1.
CCDSiCCDS4362.1. [O75330-1]
CCDS4363.1. [O75330-2]
CCDS47334.1. [O75330-3]
CCDS47335.1. [O75330-4]
PIRiJC5016.
RefSeqiNP_001136028.1. NM_001142556.1. [O75330-3]
NP_001136029.1. NM_001142557.1. [O75330-4]
NP_036616.2. NM_012484.2. [O75330-1]
NP_036617.2. NM_012485.2. [O75330-2]
UniGeneiHs.740467.

Genome annotation databases

EnsembliENST00000353866; ENSP00000185942; ENSG00000072571. [O75330-2]
ENST00000358715; ENSP00000351554; ENSG00000072571. [O75330-1]
ENST00000393915; ENSP00000377492; ENSG00000072571. [O75330-3]
ENST00000432118; ENSP00000402673; ENSG00000072571. [O75330-4]
GeneIDi3161.
KEGGihsa:3161.
UCSCiuc003lzf.3. human. [O75330-1]
uc003lzg.3. human. [O75330-2]
uc003lzh.3. human. [O75330-3]
uc011dem.2. human. [O75330-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29343 mRNA. Translation: AAC52049.1 .
AF032862 mRNA. Translation: AAC32548.1 .
AK290577 mRNA. Translation: BAF83266.1 .
AK303616 mRNA. Translation: BAG64626.1 .
AC112205 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61522.1 .
CH471062 Genomic DNA. Translation: EAW61523.1 .
CH471062 Genomic DNA. Translation: EAW61524.1 .
CH471062 Genomic DNA. Translation: EAW61525.1 .
BC108904 mRNA. Translation: AAI08905.1 .
CCDSi CCDS4362.1. [O75330-1 ]
CCDS4363.1. [O75330-2 ]
CCDS47334.1. [O75330-3 ]
CCDS47335.1. [O75330-4 ]
PIRi JC5016.
RefSeqi NP_001136028.1. NM_001142556.1. [O75330-3 ]
NP_001136029.1. NM_001142557.1. [O75330-4 ]
NP_036616.2. NM_012484.2. [O75330-1 ]
NP_036617.2. NM_012485.2. [O75330-2 ]
UniGenei Hs.740467.

3D structure databases

ProteinModelPortali O75330.
SMRi O75330. Positions 645-678.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109404. 20 interactions.
DIPi DIP-56496N.
IntActi O75330. 8 interactions.
MINTi MINT-4989385.
STRINGi 9606.ENSP00000377492.

PTM databases

PhosphoSitei O75330.

2D gel databases

REPRODUCTION-2DPAGE O75330.

Proteomic databases

MaxQBi O75330.
PaxDbi O75330.
PRIDEi O75330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000353866 ; ENSP00000185942 ; ENSG00000072571 . [O75330-2 ]
ENST00000358715 ; ENSP00000351554 ; ENSG00000072571 . [O75330-1 ]
ENST00000393915 ; ENSP00000377492 ; ENSG00000072571 . [O75330-3 ]
ENST00000432118 ; ENSP00000402673 ; ENSG00000072571 . [O75330-4 ]
GeneIDi 3161.
KEGGi hsa:3161.
UCSCi uc003lzf.3. human. [O75330-1 ]
uc003lzg.3. human. [O75330-2 ]
uc003lzh.3. human. [O75330-3 ]
uc011dem.2. human. [O75330-4 ]

Organism-specific databases

CTDi 3161.
GeneCardsi GC05P162887.
H-InvDB HIX0032412.
HGNCi HGNC:5012. HMMR.
HPAi CAB002433.
HPA043926.
MIMi 600936. gene.
neXtProti NX_O75330.
PharmGKBi PA29340.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146600.
HOVERGENi HBG044411.
KOi K06267.
OMAi KPFQLQL.
PhylomeDBi O75330.
TreeFami TF333963.

Enzyme and pathway databases

Reactomei REACT_120996. Hyaluronan uptake and degradation.

Miscellaneous databases

GeneWikii Hyaluronan-mediated_motility_receptor.
GenomeRNAii 3161.
NextBioi 12532.
PROi O75330.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75330.
Bgeei O75330.
CleanExi HS_HMMR.
Genevestigatori O75330.

Family and domain databases

InterProi IPR026203. IHABP.
[Graphical view ]
PANTHERi PTHR18956. PTHR18956. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains."
    Wang C., Entwistle J., Hou G., Li Q., Turley E.A.
    Gene 174:299-306(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Mammary gland.
  2. "The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells."
    Assmann V., Marshall J.F., Fieber C., Hofmann M., Hart I.R.
    J. Cell Sci. 111:1685-1694(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 2), CHARACTERIZATION.
    Tissue: Mammary carcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANTS ALA-368 AND VAL-484.
    Tissue: Thymus.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS CYS-92; ALA-368 AND VAL-484.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMMR_HUMAN
AccessioniPrimary (citable) accession number: O75330
Secondary accession number(s): A8K3G2
, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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