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Protein

Hyaluronan mediated motility receptor

Gene

HMMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:HMMR
Synonyms:IHABP, RHAMM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000072571.19
HGNCiHGNC:5012 HMMR
MIMi600936 gene
neXtProtiNX_O75330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3161
MalaCardsiHMMR
OpenTargetsiENSG00000072571
PharmGKBiPA29340

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiHMMR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840071 – 724Hyaluronan mediated motility receptorAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei703PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75330
MaxQBiO75330
PaxDbiO75330
PeptideAtlasiO75330
PRIDEiO75330

2D gel databases

REPRODUCTION-2DPAGEiO75330

PTM databases

iPTMnetiO75330
PhosphoSitePlusiO75330

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and in normal breast tissue.

Gene expression databases

BgeeiENSG00000072571
CleanExiHS_HMMR
ExpressionAtlasiO75330 baseline and differential
GenevisibleiO75330 HS

Organism-specific databases

HPAiCAB002433
HPA040025
HPA043926
HPA061524

Interactioni

Subunit structurei

Subunit of the HARC complex. Interacts with ANKRD26 (PubMed:22666460).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109404, 52 interactors
CORUMiO75330
DIPiDIP-56496N
IntActiO75330, 30 interactors
MINTiO75330
STRINGi9606.ENSP00000377492

Structurei

3D structure databases

ProteinModelPortaliO75330
SMRiO75330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni635 – 645Hyaluronic acid-bindingSequence analysisAdd BLAST11
Regioni657 – 666Hyaluronic acid-bindingSequence analysis10

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ28 Eukaryota
ENOG4111G1K LUCA
GeneTreeiENSGT00390000007135
HOVERGENiHBG044411
InParanoidiO75330
KOiK06267
OMAiISCASDQ
OrthoDBiEOG091G03MO
PhylomeDBiO75330
TreeFamiTF333963

Family and domain databases

InterProiView protein in InterPro
IPR031794 HMMR_C
IPR031787 HMMR_N
IPR026203 IHABP
PANTHERiPTHR18956 PTHR18956, 2 hits
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF15905 HMMR_N, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES
60 70 80 90 100
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA
110 120 130 140 150
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL
160 170 180 190 200
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR
210 220 230 240 250
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY
260 270 280 290 300
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
310 320 330 340 350
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK
360 370 380 390 400
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK
410 420 430 440 450
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ
460 470 480 490 500
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA
510 520 530 540 550
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED
560 570 580 590 600
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
610 620 630 640 650
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ
660 670 680 690 700
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA
710 720
LKTPLKEGNT NCYRAPMECQ ESWK
Length:724
Mass (Da):84,100
Last modified:April 17, 2007 - v2
Checksum:iF2C3C0DBA863955F
GO
Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     76-90: Missing.

Show »
Length:709
Mass (Da):82,301
Checksum:i29E7F070B99FD30C
GO
Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: K → KK

Show »
Length:725
Mass (Da):84,229
Checksum:i2515512EEDFB1DA1
GO
Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

Show »
Length:638
Mass (Da):74,495
Checksum:iBFD153D3EC20FE5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103R → S in AAC32548 (PubMed:9601098).Curated1
Sequence conflicti277E → D in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti298K → T in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti322K → E in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti330 – 332QER → REH in AAC52049 (PubMed:8890751).Curated3
Sequence conflicti547Q → R in BAF83266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02415592R → C1 PublicationCorresponds to variant dbSNP:rs299284Ensembl.1
Natural variantiVAR_031661305N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_056917320N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_024156332R → H. Corresponds to variant dbSNP:rs2303078Ensembl.1
Natural variantiVAR_020044368V → A2 PublicationsCorresponds to variant dbSNP:rs299290Ensembl.1
Natural variantiVAR_024157484A → V2 PublicationsCorresponds to variant dbSNP:rs299295Ensembl.1
Natural variantiVAR_056918557D → H. Corresponds to variant dbSNP:rs2230362Ensembl.1
Natural variantiVAR_056919595L → I. Corresponds to variant dbSNP:rs2230363Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0412661 – 90MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03837875K → KK in isoform 3. 2 Publications1
Alternative sequenceiVSP_00428676 – 90Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29343 mRNA Translation: AAC52049.1
AF032862 mRNA Translation: AAC32548.1
AK290577 mRNA Translation: BAF83266.1
AK303616 mRNA Translation: BAG64626.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61522.1
CH471062 Genomic DNA Translation: EAW61523.1
CH471062 Genomic DNA Translation: EAW61524.1
CH471062 Genomic DNA Translation: EAW61525.1
BC108904 mRNA Translation: AAI08905.1
CCDSiCCDS4362.1 [O75330-1]
CCDS4363.1 [O75330-2]
CCDS47334.1 [O75330-3]
CCDS47335.1 [O75330-4]
PIRiJC5016
RefSeqiNP_001136028.1, NM_001142556.1 [O75330-3]
NP_001136029.1, NM_001142557.1 [O75330-4]
NP_036616.2, NM_012484.2 [O75330-1]
NP_036617.2, NM_012485.2 [O75330-2]
UniGeneiHs.740467

Genome annotation databases

EnsembliENST00000353866; ENSP00000185942; ENSG00000072571 [O75330-2]
ENST00000358715; ENSP00000351554; ENSG00000072571 [O75330-1]
ENST00000393915; ENSP00000377492; ENSG00000072571 [O75330-3]
ENST00000432118; ENSP00000402673; ENSG00000072571 [O75330-4]
GeneIDi3161
KEGGihsa:3161
UCSCiuc003lzf.5 human [O75330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHMMR_HUMAN
AccessioniPrimary (citable) accession number: O75330
Secondary accession number(s): A8K3G2
, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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