Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75330

- HMMR_HUMAN

UniProt

O75330 - HMMR_HUMAN

Protein

Hyaluronan mediated motility receptor

Gene

HMMR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glycosaminoglycan metabolic process Source: Reactome
    3. hyaluronan catabolic process Source: Reactome
    4. hyaluronan metabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome

    Keywords - Ligandi

    Hyaluronic acid

    Enzyme and pathway databases

    ReactomeiREACT_120996. Hyaluronan uptake and degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan mediated motility receptor
    Alternative name(s):
    Intracellular hyaluronic acid-binding protein
    Receptor for hyaluronan-mediated motility
    CD_antigen: CD168
    Gene namesi
    Name:HMMR
    Synonyms:IHABP, RHAMM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5012. HMMR.

    Subcellular locationi

    Cell surface. Cytoplasm By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29340.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 724724Hyaluronan mediated motility receptorPRO_0000084007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Phosphoserine1 Publication
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi588 – 5881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO75330.
    PaxDbiO75330.
    PRIDEiO75330.

    2D gel databases

    REPRODUCTION-2DPAGEO75330.

    PTM databases

    PhosphoSiteiO75330.

    Expressioni

    Tissue specificityi

    Expressed in breast cancer cell lines and in normal breast tissue.

    Gene expression databases

    ArrayExpressiO75330.
    BgeeiO75330.
    CleanExiHS_HMMR.
    GenevestigatoriO75330.

    Organism-specific databases

    HPAiCAB002433.
    HPA043926.

    Interactioni

    Subunit structurei

    Subunit of the HARC complex.

    Protein-protein interaction databases

    BioGridi109404. 20 interactions.
    DIPiDIP-56496N.
    IntActiO75330. 8 interactions.
    MINTiMINT-4989385.
    STRINGi9606.ENSP00000377492.

    Structurei

    3D structure databases

    ProteinModelPortaliO75330.
    SMRiO75330. Positions 645-678.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni635 – 64511Hyaluronic acid-bindingSequence AnalysisAdd
    BLAST
    Regioni657 – 66610Hyaluronic acid-bindingSequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG146600.
    HOVERGENiHBG044411.
    KOiK06267.
    OMAiKPFQLQL.
    PhylomeDBiO75330.
    TreeFamiTF333963.

    Family and domain databases

    InterProiIPR026203. IHABP.
    [Graphical view]
    PANTHERiPTHR18956. PTHR18956. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES    50
    KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA 100
    QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL 150
    KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR 200
    SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY 250
    KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 300
    EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK 350
    ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK 400
    QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ 450
    SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA 500
    TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED 550
    FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 600
    EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ 650
    LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA 700
    LKTPLKEGNT NCYRAPMECQ ESWK 724
    Length:724
    Mass (Da):84,100
    Last modified:April 17, 2007 - v2
    Checksum:iF2C3C0DBA863955F
    GO
    Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         76-90: Missing.

    Show »
    Length:709
    Mass (Da):82,301
    Checksum:i29E7F070B99FD30C
    GO
    Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-75: K → KK

    Show »
    Length:725
    Mass (Da):84,229
    Checksum:i2515512EEDFB1DA1
    GO
    Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

    Show »
    Length:638
    Mass (Da):74,495
    Checksum:iBFD153D3EC20FE5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031R → S in AAC32548. (PubMed:9601098)Curated
    Sequence conflicti277 – 2771E → D in AAC52049. (PubMed:8890751)Curated
    Sequence conflicti298 – 2981K → T in AAC52049. (PubMed:8890751)Curated
    Sequence conflicti322 – 3221K → E in AAC52049. (PubMed:8890751)Curated
    Sequence conflicti330 – 3323QER → REH in AAC52049. (PubMed:8890751)Curated
    Sequence conflicti547 – 5471Q → R in BAF83266. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921R → C.1 Publication
    Corresponds to variant rs299284 [ dbSNP | Ensembl ].
    VAR_024155
    Natural varianti305 – 3051N → K.
    Corresponds to variant rs2303077 [ dbSNP | Ensembl ].
    VAR_031661
    Natural varianti320 – 3201N → K.
    Corresponds to variant rs2303077 [ dbSNP | Ensembl ].
    VAR_056917
    Natural varianti332 – 3321R → H.
    Corresponds to variant rs2303078 [ dbSNP | Ensembl ].
    VAR_024156
    Natural varianti368 – 3681V → A.2 Publications
    Corresponds to variant rs299290 [ dbSNP | Ensembl ].
    VAR_020044
    Natural varianti484 – 4841A → V.2 Publications
    Corresponds to variant rs299295 [ dbSNP | Ensembl ].
    VAR_024157
    Natural varianti557 – 5571D → H.
    Corresponds to variant rs2230362 [ dbSNP | Ensembl ].
    VAR_056918
    Natural varianti595 – 5951L → I.
    Corresponds to variant rs2230363 [ dbSNP | Ensembl ].
    VAR_056919

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationVSP_041266Add
    BLAST
    Alternative sequencei75 – 751K → KK in isoform 3. 2 PublicationsVSP_038378
    Alternative sequencei76 – 9015Missing in isoform 2. 1 PublicationVSP_004286Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29343 mRNA. Translation: AAC52049.1.
    AF032862 mRNA. Translation: AAC32548.1.
    AK290577 mRNA. Translation: BAF83266.1.
    AK303616 mRNA. Translation: BAG64626.1.
    AC112205 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61522.1.
    CH471062 Genomic DNA. Translation: EAW61523.1.
    CH471062 Genomic DNA. Translation: EAW61524.1.
    CH471062 Genomic DNA. Translation: EAW61525.1.
    BC108904 mRNA. Translation: AAI08905.1.
    CCDSiCCDS4362.1. [O75330-1]
    CCDS4363.1. [O75330-2]
    CCDS47334.1. [O75330-3]
    CCDS47335.1. [O75330-4]
    PIRiJC5016.
    RefSeqiNP_001136028.1. NM_001142556.1. [O75330-3]
    NP_001136029.1. NM_001142557.1. [O75330-4]
    NP_036616.2. NM_012484.2. [O75330-1]
    NP_036617.2. NM_012485.2. [O75330-2]
    UniGeneiHs.740467.

    Genome annotation databases

    EnsembliENST00000353866; ENSP00000185942; ENSG00000072571. [O75330-2]
    ENST00000358715; ENSP00000351554; ENSG00000072571. [O75330-1]
    ENST00000393915; ENSP00000377492; ENSG00000072571. [O75330-3]
    ENST00000432118; ENSP00000402673; ENSG00000072571. [O75330-4]
    GeneIDi3161.
    KEGGihsa:3161.
    UCSCiuc003lzf.3. human. [O75330-1]
    uc003lzg.3. human. [O75330-2]
    uc003lzh.3. human. [O75330-3]
    uc011dem.2. human. [O75330-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29343 mRNA. Translation: AAC52049.1 .
    AF032862 mRNA. Translation: AAC32548.1 .
    AK290577 mRNA. Translation: BAF83266.1 .
    AK303616 mRNA. Translation: BAG64626.1 .
    AC112205 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61522.1 .
    CH471062 Genomic DNA. Translation: EAW61523.1 .
    CH471062 Genomic DNA. Translation: EAW61524.1 .
    CH471062 Genomic DNA. Translation: EAW61525.1 .
    BC108904 mRNA. Translation: AAI08905.1 .
    CCDSi CCDS4362.1. [O75330-1 ]
    CCDS4363.1. [O75330-2 ]
    CCDS47334.1. [O75330-3 ]
    CCDS47335.1. [O75330-4 ]
    PIRi JC5016.
    RefSeqi NP_001136028.1. NM_001142556.1. [O75330-3 ]
    NP_001136029.1. NM_001142557.1. [O75330-4 ]
    NP_036616.2. NM_012484.2. [O75330-1 ]
    NP_036617.2. NM_012485.2. [O75330-2 ]
    UniGenei Hs.740467.

    3D structure databases

    ProteinModelPortali O75330.
    SMRi O75330. Positions 645-678.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109404. 20 interactions.
    DIPi DIP-56496N.
    IntActi O75330. 8 interactions.
    MINTi MINT-4989385.
    STRINGi 9606.ENSP00000377492.

    PTM databases

    PhosphoSitei O75330.

    2D gel databases

    REPRODUCTION-2DPAGE O75330.

    Proteomic databases

    MaxQBi O75330.
    PaxDbi O75330.
    PRIDEi O75330.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353866 ; ENSP00000185942 ; ENSG00000072571 . [O75330-2 ]
    ENST00000358715 ; ENSP00000351554 ; ENSG00000072571 . [O75330-1 ]
    ENST00000393915 ; ENSP00000377492 ; ENSG00000072571 . [O75330-3 ]
    ENST00000432118 ; ENSP00000402673 ; ENSG00000072571 . [O75330-4 ]
    GeneIDi 3161.
    KEGGi hsa:3161.
    UCSCi uc003lzf.3. human. [O75330-1 ]
    uc003lzg.3. human. [O75330-2 ]
    uc003lzh.3. human. [O75330-3 ]
    uc011dem.2. human. [O75330-4 ]

    Organism-specific databases

    CTDi 3161.
    GeneCardsi GC05P162887.
    H-InvDB HIX0032412.
    HGNCi HGNC:5012. HMMR.
    HPAi CAB002433.
    HPA043926.
    MIMi 600936. gene.
    neXtProti NX_O75330.
    PharmGKBi PA29340.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146600.
    HOVERGENi HBG044411.
    KOi K06267.
    OMAi KPFQLQL.
    PhylomeDBi O75330.
    TreeFami TF333963.

    Enzyme and pathway databases

    Reactomei REACT_120996. Hyaluronan uptake and degradation.

    Miscellaneous databases

    GeneWikii Hyaluronan-mediated_motility_receptor.
    GenomeRNAii 3161.
    NextBioi 12532.
    PROi O75330.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75330.
    Bgeei O75330.
    CleanExi HS_HMMR.
    Genevestigatori O75330.

    Family and domain databases

    InterProi IPR026203. IHABP.
    [Graphical view ]
    PANTHERi PTHR18956. PTHR18956. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains."
      Wang C., Entwistle J., Hou G., Li Q., Turley E.A.
      Gene 174:299-306(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Mammary gland.
    2. "The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells."
      Assmann V., Marshall J.F., Fieber C., Hofmann M., Hart I.R.
      J. Cell Sci. 111:1685-1694(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 2), CHARACTERIZATION.
      Tissue: Mammary carcinoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANTS ALA-368 AND VAL-484.
      Tissue: Thymus.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS CYS-92; ALA-368 AND VAL-484.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMMR_HUMAN
    AccessioniPrimary (citable) accession number: O75330
    Secondary accession number(s): A8K3G2
    , B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3