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O75326

- SEM7A_HUMAN

UniProt

O75326 - SEM7A_HUMAN

Protein

Semaphorin-7A

Gene

SEMA7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. immune response Source: ProtInc
    3. inflammatory response Source: UniProtKB-KW
    4. integrin-mediated signaling pathway Source: UniProtKB
    5. osteoblast differentiation Source: UniProt
    6. positive regulation of axon extension Source: UniProtKB
    7. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    8. positive regulation of macrophage cytokine production Source: UniProtKB
    9. regulation of inflammatory response Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Inflammatory response, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_19200. Other semaphorin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-7A
    Alternative name(s):
    CDw108
    JMH blood group antigen
    John-Milton-Hargen human blood group Ag
    Semaphorin-K1
    Short name:
    Sema K1
    Semaphorin-L
    Short name:
    Sema L
    CD_antigen: CD108
    Gene namesi
    Name:SEMA7A
    Synonyms:CD108, SEMAL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10741. SEMA7A.

    Subcellular locationi

    Cell membrane 3 Publications; Lipid-anchorGPI-anchor 3 Publications; Extracellular side 3 Publications
    Note: Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: UniProtKB
    3. membrane Source: UniProt
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi267 – 2671R → K: Abolishes ITGB1-dependent enhancement of axon growth; when associated with E-269. 1 Publication
    Mutagenesisi269 – 2691D → E: Abolishes ITGB1-dependent enhancement of axon growth; when associated with K-267. 1 Publication

    Organism-specific databases

    MIMi607961. gene+phenotype.
    614745. phenotype.
    PharmGKBiPA35663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4444Sequence AnalysisAdd
    BLAST
    Chaini45 – 648604Semaphorin-7APRO_0000032347Add
    BLAST
    Propeptidei649 – 66618Removed in mature formSequence AnalysisPRO_0000032348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)2 Publications
    Disulfide bondi120 ↔ 1261 Publication
    Disulfide bondi143 ↔ 1521 Publication
    Glycosylationi157 – 1571N-linked (GlcNAc...)2 Publications
    Glycosylationi258 – 2581N-linked (GlcNAc...)2 Publications
    Disulfide bondi266 ↔ 3661 Publication
    Disulfide bondi291 ↔ 3351 Publication
    Glycosylationi330 – 3301N-linked (GlcNAc...)2 Publications
    Disulfide bondi493 ↔ 5111 Publication
    Disulfide bondi500 ↔ 5411 Publication
    Disulfide bondi503 ↔ 5181 Publication
    Disulfide bondi566 ↔ 6131 Publication
    Disulfide bondi587 ↔ 5961 Publication
    Glycosylationi602 – 6021N-linked (GlcNAc...)1 Publication
    Lipidationi648 – 6481GPI-anchor amidated alanineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiO75326.
    PaxDbiO75326.
    PeptideAtlasiO75326.
    PRIDEiO75326.

    PTM databases

    PhosphoSiteiO75326.

    Expressioni

    Tissue specificityi

    Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.3 Publications

    Inductioni

    Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes.1 Publication

    Gene expression databases

    ArrayExpressiO75326.
    BgeeiO75326.
    CleanExiHS_SEMA7A.
    GenevestigatoriO75326.

    Organism-specific databases

    HPAiHPA042273.

    Interactioni

    Subunit structurei

    Interacts with ITGA1 and ITGB1 Probable. Interacts with PLXNC1.4 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163332EBI-1753538,EBI-389883
    PLXNC1O604864EBI-1753538,EBI-2927384

    Protein-protein interaction databases

    IntActiO75326. 6 interactions.
    MINTiMINT-1958248.
    STRINGi9606.ENSP00000261918.

    Structurei

    Secondary structure

    1
    666
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni62 – 643
    Beta strandi65 – 684
    Beta strandi77 – 793
    Beta strandi85 – 906
    Beta strandi92 – 998
    Beta strandi110 – 1123
    Beta strandi129 – 1368
    Beta strandi139 – 1446
    Turni146 – 1483
    Beta strandi151 – 1588
    Beta strandi160 – 1656
    Beta strandi180 – 1834
    Beta strandi186 – 1894
    Beta strandi204 – 2107
    Beta strandi223 – 2308
    Helixi235 – 2373
    Beta strandi239 – 2479
    Beta strandi257 – 26610
    Beta strandi272 – 2743
    Turni275 – 2795
    Beta strandi285 – 2895
    Turni294 – 2963
    Beta strandi302 – 3098
    Helixi316 – 3183
    Beta strandi320 – 3267
    Beta strandi332 – 3387
    Helixi339 – 34810
    Beta strandi368 – 3703
    Helixi375 – 3839
    Beta strandi386 – 3894
    Beta strandi394 – 3974
    Beta strandi401 – 4066
    Beta strandi408 – 41710
    Beta strandi423 – 4319
    Beta strandi436 – 4405
    Beta strandi451 – 4566
    Beta strandi467 – 4715
    Turni472 – 4754
    Beta strandi476 – 4805
    Beta strandi482 – 4898
    Helixi499 – 5057
    Beta strandi511 – 5144
    Beta strandi517 – 5204
    Beta strandi523 – 5264
    Beta strandi533 – 5353
    Turni537 – 5404
    Beta strandi541 – 5455
    Beta strandi551 – 5566
    Beta strandi562 – 5676
    Beta strandi573 – 5797
    Beta strandi582 – 5876
    Beta strandi592 – 60211
    Beta strandi609 – 61911
    Beta strandi621 – 63111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NVQX-ray2.40A/E45-634[»]
    ProteinModelPortaliO75326.
    SMRiO75326. Positions 46-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75326.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 490438SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini544 – 62986Ig-like C2-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni267 – 2693Interaction with integrins

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi267 – 2693Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG277924.
    HOGENOMiHOG000154284.
    HOVERGENiHBG079171.
    InParanoidiO75326.
    KOiK06529.
    OMAiEPMGPLK.
    OrthoDBiEOG754HNX.
    PhylomeDBiO75326.
    TreeFamiTF333698.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75326-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS    50
    GPRIFAVWKG HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF 100
    PEGKNASVRT VNIGSTKGSC LDKRDCENYI TLLERRSEGL LACGTNARHP 150
    SCWNLVNGTV VPLGEMRGYA PFSPDENSLV LFEGDEVYST IRKQEYNGKI 200
    PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI YYFFREDNPD 250
    KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 300
    NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS 350
    LKGYHSSLPN PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP 400
    LFHSKYHYQK VAVHRMQASH GETFHVLYLT TDRGTIHKVV EPGEQEHSFA 450
    FNIMEIQPFR RAAAIQTMSL DAERRKLYVS SQWEVSQVPL DLCEVYGGGC 500
    HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE CPNPKPDKAP 550
    LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 600
    ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS 650
    LWLGVLPTLT LGLLVH 666
    Length:666
    Mass (Da):74,824
    Last modified:November 1, 1998 - v1
    Checksum:iAD3ABE56B5EBE194
    GO
    Isoform 2 (identifier: O75326-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         111-124: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:652
    Mass (Da):73,364
    Checksum:i0EB0B9085C9DCCA0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti545 – 5451K → E in BAG56808. (PubMed:14702039)Curated

    Polymorphismi

    Genetic variations in SEMA7A define the John Milton Hagen blood group system (JMH) [MIMi:614745]. Three different JMH phenotypes have been identified based on the presence or absence of the high-frequency JMH antigen: JMH-weak, JMH-negative, and JMH-variant. The JMH-weak and -negative phenotypes can be either acquired or inherited and are characterized by a reduction or complete loss of JMH expression on red blood cells. Individuals with the JMH-variant phenotype are usually JMH-positive and have alloantibodies compatible with JMH-negative red blood cells. The JMH-variant phenotype results from rare SEMA7A missense variants.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151S → T.1 Publication
    Corresponds to variant rs16968733 [ dbSNP | Ensembl ].
    VAR_029282
    Natural varianti207 – 2071R → Q Rare polymorphism that results in JMH-variant phenotype. 1 Publication
    Corresponds to variant rs55637216 [ dbSNP | Ensembl ].
    VAR_038836
    Natural varianti207 – 2071R → W Rare polymorphism that results in JMH-variant phenotype. 1 Publication
    Corresponds to variant rs56367230 [ dbSNP | Ensembl ].
    VAR_038837
    Natural varianti347 – 3471R → L Rare polymorphism that results in JMH-variant phenotype. 1 Publication
    VAR_068679
    Natural varianti460 – 4601R → H Rare polymorphism that results in JMH-variant phenotype. 1 Publication
    Corresponds to variant rs56204206 [ dbSNP | Ensembl ].
    VAR_038838
    Natural varianti461 – 4611R → C Rare polymorphism that results in JMH-variant phenotype. 1 Publication
    Corresponds to variant rs56001514 [ dbSNP | Ensembl ].
    VAR_038839

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei111 – 12414Missing in isoform 2. 1 PublicationVSP_045349Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030698 mRNA. Translation: AAC34261.1.
    AF030697 Genomic DNA. Translation: AAC34741.1.
    AF069493 mRNA. Translation: AAC82642.1.
    AF071542 mRNA. Translation: AAC80456.1.
    AM180445 mRNA. Translation: CAJ55398.1.
    AM180446 mRNA. Translation: CAJ55399.1.
    AM180447 mRNA. Translation: CAJ55400.1.
    AM180448 mRNA. Translation: CAJ55401.1.
    AM180449 mRNA. Translation: CAJ55402.1.
    AM180450 mRNA. Translation: CAJ55403.1.
    AM180451 mRNA. Translation: CAJ55404.1.
    AK293280 mRNA. Translation: BAG56808.1.
    AY885237 Genomic DNA. Translation: AAW62253.1.
    AC012435 Genomic DNA. No translation available.
    AC090826 Genomic DNA. No translation available.
    BC101643 mRNA. Translation: AAI01644.1.
    BC101647 mRNA. Translation: AAI01648.1.
    CCDSiCCDS10262.1. [O75326-1]
    CCDS53959.1. [O75326-2]
    RefSeqiNP_001139501.1. NM_001146029.1. [O75326-2]
    NP_001139502.1. NM_001146030.1.
    NP_003603.1. NM_003612.3. [O75326-1]
    UniGeneiHs.24640.

    Genome annotation databases

    EnsembliENST00000261918; ENSP00000261918; ENSG00000138623. [O75326-1]
    ENST00000543145; ENSP00000438966; ENSG00000138623. [O75326-2]
    GeneIDi8482.
    KEGGihsa:8482.
    UCSCiuc002axv.3. human. [O75326-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030698 mRNA. Translation: AAC34261.1 .
    AF030697 Genomic DNA. Translation: AAC34741.1 .
    AF069493 mRNA. Translation: AAC82642.1 .
    AF071542 mRNA. Translation: AAC80456.1 .
    AM180445 mRNA. Translation: CAJ55398.1 .
    AM180446 mRNA. Translation: CAJ55399.1 .
    AM180447 mRNA. Translation: CAJ55400.1 .
    AM180448 mRNA. Translation: CAJ55401.1 .
    AM180449 mRNA. Translation: CAJ55402.1 .
    AM180450 mRNA. Translation: CAJ55403.1 .
    AM180451 mRNA. Translation: CAJ55404.1 .
    AK293280 mRNA. Translation: BAG56808.1 .
    AY885237 Genomic DNA. Translation: AAW62253.1 .
    AC012435 Genomic DNA. No translation available.
    AC090826 Genomic DNA. No translation available.
    BC101643 mRNA. Translation: AAI01644.1 .
    BC101647 mRNA. Translation: AAI01648.1 .
    CCDSi CCDS10262.1. [O75326-1 ]
    CCDS53959.1. [O75326-2 ]
    RefSeqi NP_001139501.1. NM_001146029.1. [O75326-2 ]
    NP_001139502.1. NM_001146030.1.
    NP_003603.1. NM_003612.3. [O75326-1 ]
    UniGenei Hs.24640.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NVQ X-ray 2.40 A/E 45-634 [» ]
    ProteinModelPortali O75326.
    SMRi O75326. Positions 46-633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O75326. 6 interactions.
    MINTi MINT-1958248.
    STRINGi 9606.ENSP00000261918.

    PTM databases

    PhosphoSitei O75326.

    Proteomic databases

    MaxQBi O75326.
    PaxDbi O75326.
    PeptideAtlasi O75326.
    PRIDEi O75326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261918 ; ENSP00000261918 ; ENSG00000138623 . [O75326-1 ]
    ENST00000543145 ; ENSP00000438966 ; ENSG00000138623 . [O75326-2 ]
    GeneIDi 8482.
    KEGGi hsa:8482.
    UCSCi uc002axv.3. human. [O75326-1 ]

    Organism-specific databases

    CTDi 8482.
    GeneCardsi GC15M074701.
    HGNCi HGNC:10741. SEMA7A.
    HPAi HPA042273.
    MIMi 607961. gene+phenotype.
    614745. phenotype.
    neXtProti NX_O75326.
    PharmGKBi PA35663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277924.
    HOGENOMi HOG000154284.
    HOVERGENi HBG079171.
    InParanoidi O75326.
    KOi K06529.
    OMAi EPMGPLK.
    OrthoDBi EOG754HNX.
    PhylomeDBi O75326.
    TreeFami TF333698.

    Enzyme and pathway databases

    Reactomei REACT_19200. Other semaphorin interactions.

    Miscellaneous databases

    ChiTaRSi SEMA7A. human.
    EvolutionaryTracei O75326.
    GeneWikii SEMA7A.
    GenomeRNAii 8482.
    NextBioi 31739.
    PROi O75326.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75326.
    Bgeei O75326.
    CleanExi HS_SEMA7A.
    Genevestigatori O75326.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
      Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.
      Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."
      Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T., Sagawa K., Sugamura K., Itoh K.
      J. Immunol. 162:4094-4100(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
    3. "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."
      Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C., Ebens A., Luo Y.
      J. Biol. Chem. 273:22428-22434(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    4. "The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."
      Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M., Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C., DeLuca D.S., Blasczyk R.
      Transfusion 47:133-146(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN JOHN MILTON HAGEN BLOOD GROUP SYSTEM, VARIANTS GLN-207; TRP-207; HIS-460 AND CYS-461.
      Tissue: Peripheral blood.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. SeattleSNPs variation discovery resource
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-115.
    7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain cortex.
    9. "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."
      Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V.
      Immunobiology 200:234-245(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    10. "Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."
      Pasterkamp R.J., Peschon J.J., Spriggs M.K., Kolodkin A.L.
      Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ITGB1, MUTAGENESIS OF ARG-267 AND ASP-269.
    11. "Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."
      Suzuki K., Okuno T., Yamamoto M., Pasterkamp R.J., Takegahara N., Takamatsu H., Kitao T., Takagi J., Rennert P.D., Kolodkin A.L., Kumanogoh A., Kikutani H.
      Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ITGA1 AND ITGB1.
    12. "Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins."
      Scott G.A., McClelland L.A., Fricke A.F.
      J. Invest. Dermatol. 128:151-161(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ITGB1, INDUCTION, TISSUE SPECIFICITY.
    13. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
      Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
      Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 45-634 IN COMPLEX WITH PLXNC1, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-105; ASN-157; ASN-258 AND ASN-330.
    14. "A new SEMA7A variant found in Native Americans with alloantibody."
      Richard M., St-Laurent J., Perreault J., Long A., St-Louis M.
      Vox Sang. 100:322-326(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-347.

    Entry informationi

    Entry nameiSEM7A_HUMAN
    AccessioniPrimary (citable) accession number: O75326
    Secondary accession number(s): B4DDP7
    , F5H1S0, Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3