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O75326 (SEM7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Semaphorin-7A
Alternative name(s):
CDw108
JMH blood group antigen
John-Milton-Hargen human blood group Ag
Semaphorin-K1
Short name=Sema K1
Semaphorin-L
Short name=Sema L
CD_antigen=CD108
Gene names
Name:SEMA7A
Synonyms:CD108, SEMAL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Ref.10 Ref.11 Ref.12

Subunit structure

Interacts with ITGA1 and ITGB1 Probable. Interacts with PLXNC1. Ref.10 Ref.11 Ref.12 Ref.13

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side. Note: Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. Ref.2 Ref.3 Ref.12

Tissue specificity

Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. Ref.2 Ref.3 Ref.12

Induction

Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes. Ref.12

Polymorphism

Genetic variations in SEMA7A define the John Milton Hagen blood group system (JMH) [MIM:614745]. Three different JMH phenotypes have been identified based on the presence or absence of the high-frequency JMH antigen: JMH-weak, JMH-negative, and JMH-variant. The JMH-weak and -negative phenotypes can be either acquired or inherited and are characterized by a reduction or complete loss of JMH expression on red blood cells. Individuals with the JMH-variant phenotype are usually JMH-positive and have alloantibodies compatible with JMH-negative red blood cells. The JMH-variant phenotype results from rare SEMA7A missense variants.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Inflammatory response
Neurogenesis
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Traceable author statement. Source: Reactome

immune response

Traceable author statement Ref.1. Source: ProtInc

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

integrin-mediated signaling pathway

Inferred from direct assay Ref.10. Source: UniProtKB

osteoblast differentiation

Inferred from direct assay PubMed 16210410. Source: UniProt

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay Ref.10. Source: UniProtKB

positive regulation of axon extension

Inferred from direct assay Ref.10. Source: UniProtKB

positive regulation of macrophage cytokine production

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

external side of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

membrane

Inferred from direct assay PubMed 16210410. Source: UniProt

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17474147Ref.13. Source: IntAct

receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75326-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75326-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-124: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4444 Potential
Chain45 – 648604Semaphorin-7A
PRO_0000032347
Propeptide649 – 66618Removed in mature form Potential
PRO_0000032348

Regions

Domain53 – 490438Sema
Domain544 – 62986Ig-like C2-type
Region267 – 2693Interaction with integrins
Motif267 – 2693Cell attachment site Potential

Amino acid modifications

Lipidation6481GPI-anchor amidated alanine Potential
Glycosylation1051N-linked (GlcNAc...) Ref.13
Glycosylation1571N-linked (GlcNAc...) Ref.13
Glycosylation2581N-linked (GlcNAc...) Ref.13
Glycosylation3301N-linked (GlcNAc...) Ref.13
Glycosylation6021N-linked (GlcNAc...) Probable
Disulfide bond120 ↔ 126 Ref.13
Disulfide bond143 ↔ 152 Ref.13
Disulfide bond266 ↔ 366 Ref.13
Disulfide bond291 ↔ 335 Ref.13
Disulfide bond493 ↔ 511 Ref.13
Disulfide bond500 ↔ 541 Ref.13
Disulfide bond503 ↔ 518 Ref.13
Disulfide bond566 ↔ 613 Ref.13
Disulfide bond587 ↔ 596 Ref.13

Natural variations

Alternative sequence111 – 12414Missing in isoform 2.
VSP_045349
Natural variant1151S → T. Ref.6
Corresponds to variant rs16968733 [ dbSNP | Ensembl ].
VAR_029282
Natural variant2071R → Q Rare polymorphism that results in JMH-variant phenotype. Ref.4
Corresponds to variant rs55637216 [ dbSNP | Ensembl ].
VAR_038836
Natural variant2071R → W Rare polymorphism that results in JMH-variant phenotype. Ref.4
Corresponds to variant rs56367230 [ dbSNP | Ensembl ].
VAR_038837
Natural variant3471R → L Rare polymorphism that results in JMH-variant phenotype. Ref.14
VAR_068679
Natural variant4601R → H Rare polymorphism that results in JMH-variant phenotype. Ref.4
Corresponds to variant rs56204206 [ dbSNP | Ensembl ].
VAR_038838
Natural variant4611R → C Rare polymorphism that results in JMH-variant phenotype. Ref.4
Corresponds to variant rs56001514 [ dbSNP | Ensembl ].
VAR_038839

Experimental info

Mutagenesis2671R → K: Abolishes ITGB1-dependent enhancement of axon growth; when associated with E-269. Ref.10
Mutagenesis2691D → E: Abolishes ITGB1-dependent enhancement of axon growth; when associated with K-267. Ref.10
Sequence conflict5451K → E in BAG56808. Ref.5

Secondary structure

....................................................................................................... 666
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AD3ABE56B5EBE194

FASTA66674,824
        10         20         30         40         50         60 
MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG 

        70         80         90        100        110        120 
HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC 

       130        140        150        160        170        180 
LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV 

       190        200        210        220        230        240 
LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI 

       250        260        270        280        290        300 
YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 

       310        320        330        340        350        360 
NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN 

       370        380        390        400        410        420 
PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH 

       430        440        450        460        470        480 
GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS 

       490        500        510        520        530        540 
SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE 

       550        560        570        580        590        600 
CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 

       610        620        630        640        650        660 
ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT 


LGLLVH 

« Hide

Isoform 2 [UniParc].

Checksum: 0EB0B9085C9DCCA0
Show »

FASTA65273,364

References

« Hide 'large scale' references
[1]"New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.
Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."
Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T., Sagawa K., Sugamura K., Itoh K.
J. Immunol. 162:4094-4100(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
[3]"Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."
Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C., Ebens A., Luo Y.
J. Biol. Chem. 273:22428-22434(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Placenta.
[4]"The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."
Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M., Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C., DeLuca D.S., Blasczyk R.
Transfusion 47:133-146(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN JOHN MILTON HAGEN BLOOD GROUP SYSTEM, VARIANTS GLN-207; TRP-207; HIS-460 AND CYS-461.
Tissue: Peripheral blood.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]SeattleSNPs variation discovery resource
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-115.
[7]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain cortex.
[9]"Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."
Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V.
Immunobiology 200:234-245(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[10]"Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."
Pasterkamp R.J., Peschon J.J., Spriggs M.K., Kolodkin A.L.
Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ITGB1, MUTAGENESIS OF ARG-267 AND ASP-269.
[11]"Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."
Suzuki K., Okuno T., Yamamoto M., Pasterkamp R.J., Takegahara N., Takamatsu H., Kitao T., Takagi J., Rennert P.D., Kolodkin A.L., Kumanogoh A., Kikutani H.
Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ITGA1 AND ITGB1.
[12]"Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins."
Scott G.A., McClelland L.A., Fricke A.F.
J. Invest. Dermatol. 128:151-161(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ITGB1, INDUCTION, TISSUE SPECIFICITY.
[13]"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 45-634 IN COMPLEX WITH PLXNC1, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-105; ASN-157; ASN-258 AND ASN-330.
[14]"A new SEMA7A variant found in Native Americans with alloantibody."
Richard M., St-Laurent J., Perreault J., Long A., St-Louis M.
Vox Sang. 100:322-326(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-347.
+Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030698 mRNA. Translation: AAC34261.1.
AF030697 Genomic DNA. Translation: AAC34741.1.
AF069493 mRNA. Translation: AAC82642.1.
AF071542 mRNA. Translation: AAC80456.1.
AM180445 mRNA. Translation: CAJ55398.1.
AM180446 mRNA. Translation: CAJ55399.1.
AM180447 mRNA. Translation: CAJ55400.1.
AM180448 mRNA. Translation: CAJ55401.1.
AM180449 mRNA. Translation: CAJ55402.1.
AM180450 mRNA. Translation: CAJ55403.1.
AM180451 mRNA. Translation: CAJ55404.1.
AK293280 mRNA. Translation: BAG56808.1.
AY885237 Genomic DNA. Translation: AAW62253.1.
AC012435 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC101643 mRNA. Translation: AAI01644.1.
BC101647 mRNA. Translation: AAI01648.1.
CCDSCCDS10262.1. [O75326-1]
CCDS53959.1. [O75326-2]
RefSeqNP_001139501.1. NM_001146029.1. [O75326-2]
NP_001139502.1. NM_001146030.1.
NP_003603.1. NM_003612.3. [O75326-1]
UniGeneHs.24640.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3NVQX-ray2.40A/E45-634[»]
ProteinModelPortalO75326.
SMRO75326. Positions 46-633.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO75326. 6 interactions.
MINTMINT-1958248.
STRING9606.ENSP00000261918.

PTM databases

PhosphoSiteO75326.

Proteomic databases

MaxQBO75326.
PaxDbO75326.
PeptideAtlasO75326.
PRIDEO75326.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261918; ENSP00000261918; ENSG00000138623. [O75326-1]
ENST00000543145; ENSP00000438966; ENSG00000138623. [O75326-2]
GeneID8482.
KEGGhsa:8482.
UCSCuc002axv.3. human. [O75326-1]

Organism-specific databases

CTD8482.
GeneCardsGC15M074701.
HGNCHGNC:10741. SEMA7A.
HPAHPA042273.
MIM607961. gene+phenotype.
614745. phenotype.
neXtProtNX_O75326.
PharmGKBPA35663.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277924.
HOGENOMHOG000154284.
HOVERGENHBG079171.
InParanoidO75326.
KOK06529.
OMAEPMGPLK.
OrthoDBEOG754HNX.
PhylomeDBO75326.
TreeFamTF333698.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressO75326.
BgeeO75326.
CleanExHS_SEMA7A.
GenevestigatorO75326.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PfamPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSEMA7A. human.
EvolutionaryTraceO75326.
GeneWikiSEMA7A.
GenomeRNAi8482.
NextBio31739.
PROO75326.
SOURCESearch...

Entry information

Entry nameSEM7A_HUMAN
AccessionPrimary (citable) accession number: O75326
Secondary accession number(s): B4DDP7 expand/collapse secondary AC list , F5H1S0, Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries