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O75326

- SEM7A_HUMAN

UniProt

O75326 - SEM7A_HUMAN

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Protein
Semaphorin-7A
Gene
SEMA7A, CD108, SEMAL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.3 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: Reactome
  2. immune response Source: ProtInc
  3. inflammatory response Source: UniProtKB-KW
  4. integrin-mediated signaling pathway Source: UniProtKB
  5. osteoblast differentiation Source: UniProt
  6. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  7. positive regulation of axon extension Source: UniProtKB
  8. positive regulation of macrophage cytokine production Source: UniProtKB
  9. regulation of inflammatory response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Inflammatory response, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_19200. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-7A
Alternative name(s):
CDw108
JMH blood group antigen
John-Milton-Hargen human blood group Ag
Semaphorin-K1
Short name:
Sema K1
Semaphorin-L
Short name:
Sema L
CD_antigen: CD108
Gene namesi
Name:SEMA7A
Synonyms:CD108, SEMAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10741. SEMA7A.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side
Note: Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.3 Publications

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. external side of plasma membrane Source: UniProtKB
  3. membrane Source: UniProt
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi267 – 2671R → K: Abolishes ITGB1-dependent enhancement of axon growth; when associated with E-269. 1 Publication
Mutagenesisi269 – 2691D → E: Abolishes ITGB1-dependent enhancement of axon growth; when associated with K-267. 1 Publication

Organism-specific databases

MIMi607961. gene+phenotype.
614745. phenotype.
PharmGKBiPA35663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444 Reviewed prediction
Add
BLAST
Chaini45 – 648604Semaphorin-7A
PRO_0000032347Add
BLAST
Propeptidei649 – 66618Removed in mature form Reviewed prediction
PRO_0000032348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)1 Publication
Disulfide bondi120 ↔ 1261 Publication
Disulfide bondi143 ↔ 1521 Publication
Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
Glycosylationi258 – 2581N-linked (GlcNAc...)1 Publication
Disulfide bondi266 ↔ 3661 Publication
Disulfide bondi291 ↔ 3351 Publication
Glycosylationi330 – 3301N-linked (GlcNAc...)1 Publication
Disulfide bondi493 ↔ 5111 Publication
Disulfide bondi500 ↔ 5411 Publication
Disulfide bondi503 ↔ 5181 Publication
Disulfide bondi566 ↔ 6131 Publication
Disulfide bondi587 ↔ 5961 Publication
Glycosylationi602 – 6021N-linked (GlcNAc...) Inferred
Lipidationi648 – 6481GPI-anchor amidated alanine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO75326.
PaxDbiO75326.
PeptideAtlasiO75326.
PRIDEiO75326.

PTM databases

PhosphoSiteiO75326.

Expressioni

Tissue specificityi

Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.3 Publications

Inductioni

Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes.1 Publication

Gene expression databases

ArrayExpressiO75326.
BgeeiO75326.
CleanExiHS_SEMA7A.
GenevestigatoriO75326.

Organism-specific databases

HPAiHPA042273.

Interactioni

Subunit structurei

Interacts with ITGA1 and ITGB1 Inferred. Interacts with PLXNC1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1753538,EBI-389883
PLXNC1O604864EBI-1753538,EBI-2927384

Protein-protein interaction databases

IntActiO75326. 6 interactions.
MINTiMINT-1958248.
STRINGi9606.ENSP00000261918.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni62 – 643
Beta strandi65 – 684
Beta strandi77 – 793
Beta strandi85 – 906
Beta strandi92 – 998
Beta strandi110 – 1123
Beta strandi129 – 1368
Beta strandi139 – 1446
Turni146 – 1483
Beta strandi151 – 1588
Beta strandi160 – 1656
Beta strandi180 – 1834
Beta strandi186 – 1894
Beta strandi204 – 2107
Beta strandi223 – 2308
Helixi235 – 2373
Beta strandi239 – 2479
Beta strandi257 – 26610
Beta strandi272 – 2743
Turni275 – 2795
Beta strandi285 – 2895
Turni294 – 2963
Beta strandi302 – 3098
Helixi316 – 3183
Beta strandi320 – 3267
Beta strandi332 – 3387
Helixi339 – 34810
Beta strandi368 – 3703
Helixi375 – 3839
Beta strandi386 – 3894
Beta strandi394 – 3974
Beta strandi401 – 4066
Beta strandi408 – 41710
Beta strandi423 – 4319
Beta strandi436 – 4405
Beta strandi451 – 4566
Beta strandi467 – 4715
Turni472 – 4754
Beta strandi476 – 4805
Beta strandi482 – 4898
Helixi499 – 5057
Beta strandi511 – 5144
Beta strandi517 – 5204
Beta strandi523 – 5264
Beta strandi533 – 5353
Turni537 – 5404
Beta strandi541 – 5455
Beta strandi551 – 5566
Beta strandi562 – 5676
Beta strandi573 – 5797
Beta strandi582 – 5876
Beta strandi592 – 60211
Beta strandi609 – 61911
Beta strandi621 – 63111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NVQX-ray2.40A/E45-634[»]
ProteinModelPortaliO75326.
SMRiO75326. Positions 46-633.

Miscellaneous databases

EvolutionaryTraceiO75326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 490438Sema
Add
BLAST
Domaini544 – 62986Ig-like C2-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni267 – 2693Interaction with integrins

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi267 – 2693Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG277924.
HOGENOMiHOG000154284.
HOVERGENiHBG079171.
InParanoidiO75326.
KOiK06529.
OMAiEPMGPLK.
OrthoDBiEOG754HNX.
PhylomeDBiO75326.
TreeFamiTF333698.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75326-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS    50
GPRIFAVWKG HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF 100
PEGKNASVRT VNIGSTKGSC LDKRDCENYI TLLERRSEGL LACGTNARHP 150
SCWNLVNGTV VPLGEMRGYA PFSPDENSLV LFEGDEVYST IRKQEYNGKI 200
PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI YYFFREDNPD 250
KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 300
NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS 350
LKGYHSSLPN PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP 400
LFHSKYHYQK VAVHRMQASH GETFHVLYLT TDRGTIHKVV EPGEQEHSFA 450
FNIMEIQPFR RAAAIQTMSL DAERRKLYVS SQWEVSQVPL DLCEVYGGGC 500
HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE CPNPKPDKAP 550
LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 600
ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS 650
LWLGVLPTLT LGLLVH 666
Length:666
Mass (Da):74,824
Last modified:November 1, 1998 - v1
Checksum:iAD3ABE56B5EBE194
GO
Isoform 2 (identifier: O75326-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-124: Missing.

Note: No experimental confirmation available.

Show »
Length:652
Mass (Da):73,364
Checksum:i0EB0B9085C9DCCA0
GO

Polymorphismi

Genetic variations in SEMA7A define the John Milton Hagen blood group system (JMH) [MIMi:614745]. Three different JMH phenotypes have been identified based on the presence or absence of the high-frequency JMH antigen: JMH-weak, JMH-negative, and JMH-variant. The JMH-weak and -negative phenotypes can be either acquired or inherited and are characterized by a reduction or complete loss of JMH expression on red blood cells. Individuals with the JMH-variant phenotype are usually JMH-positive and have alloantibodies compatible with JMH-negative red blood cells. The JMH-variant phenotype results from rare SEMA7A missense variants.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151S → T.1 Publication
Corresponds to variant rs16968733 [ dbSNP | Ensembl ].
VAR_029282
Natural varianti207 – 2071R → Q Rare polymorphism that results in JMH-variant phenotype. 1 Publication
Corresponds to variant rs55637216 [ dbSNP | Ensembl ].
VAR_038836
Natural varianti207 – 2071R → W Rare polymorphism that results in JMH-variant phenotype. 1 Publication
Corresponds to variant rs56367230 [ dbSNP | Ensembl ].
VAR_038837
Natural varianti347 – 3471R → L Rare polymorphism that results in JMH-variant phenotype. 1 Publication
VAR_068679
Natural varianti460 – 4601R → H Rare polymorphism that results in JMH-variant phenotype. 1 Publication
Corresponds to variant rs56204206 [ dbSNP | Ensembl ].
VAR_038838
Natural varianti461 – 4611R → C Rare polymorphism that results in JMH-variant phenotype. 1 Publication
Corresponds to variant rs56001514 [ dbSNP | Ensembl ].
VAR_038839

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei111 – 12414Missing in isoform 2.
VSP_045349Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti545 – 5451K → E in BAG56808. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030698 mRNA. Translation: AAC34261.1.
AF030697 Genomic DNA. Translation: AAC34741.1.
AF069493 mRNA. Translation: AAC82642.1.
AF071542 mRNA. Translation: AAC80456.1.
AM180445 mRNA. Translation: CAJ55398.1.
AM180446 mRNA. Translation: CAJ55399.1.
AM180447 mRNA. Translation: CAJ55400.1.
AM180448 mRNA. Translation: CAJ55401.1.
AM180449 mRNA. Translation: CAJ55402.1.
AM180450 mRNA. Translation: CAJ55403.1.
AM180451 mRNA. Translation: CAJ55404.1.
AK293280 mRNA. Translation: BAG56808.1.
AY885237 Genomic DNA. Translation: AAW62253.1.
AC012435 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC101643 mRNA. Translation: AAI01644.1.
BC101647 mRNA. Translation: AAI01648.1.
CCDSiCCDS10262.1. [O75326-1]
CCDS53959.1. [O75326-2]
RefSeqiNP_001139501.1. NM_001146029.1. [O75326-2]
NP_001139502.1. NM_001146030.1.
NP_003603.1. NM_003612.3. [O75326-1]
UniGeneiHs.24640.

Genome annotation databases

EnsembliENST00000261918; ENSP00000261918; ENSG00000138623. [O75326-1]
ENST00000543145; ENSP00000438966; ENSG00000138623. [O75326-2]
GeneIDi8482.
KEGGihsa:8482.
UCSCiuc002axv.3. human. [O75326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030698 mRNA. Translation: AAC34261.1 .
AF030697 Genomic DNA. Translation: AAC34741.1 .
AF069493 mRNA. Translation: AAC82642.1 .
AF071542 mRNA. Translation: AAC80456.1 .
AM180445 mRNA. Translation: CAJ55398.1 .
AM180446 mRNA. Translation: CAJ55399.1 .
AM180447 mRNA. Translation: CAJ55400.1 .
AM180448 mRNA. Translation: CAJ55401.1 .
AM180449 mRNA. Translation: CAJ55402.1 .
AM180450 mRNA. Translation: CAJ55403.1 .
AM180451 mRNA. Translation: CAJ55404.1 .
AK293280 mRNA. Translation: BAG56808.1 .
AY885237 Genomic DNA. Translation: AAW62253.1 .
AC012435 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC101643 mRNA. Translation: AAI01644.1 .
BC101647 mRNA. Translation: AAI01648.1 .
CCDSi CCDS10262.1. [O75326-1 ]
CCDS53959.1. [O75326-2 ]
RefSeqi NP_001139501.1. NM_001146029.1. [O75326-2 ]
NP_001139502.1. NM_001146030.1.
NP_003603.1. NM_003612.3. [O75326-1 ]
UniGenei Hs.24640.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NVQ X-ray 2.40 A/E 45-634 [» ]
ProteinModelPortali O75326.
SMRi O75326. Positions 46-633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O75326. 6 interactions.
MINTi MINT-1958248.
STRINGi 9606.ENSP00000261918.

PTM databases

PhosphoSitei O75326.

Proteomic databases

MaxQBi O75326.
PaxDbi O75326.
PeptideAtlasi O75326.
PRIDEi O75326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261918 ; ENSP00000261918 ; ENSG00000138623 . [O75326-1 ]
ENST00000543145 ; ENSP00000438966 ; ENSG00000138623 . [O75326-2 ]
GeneIDi 8482.
KEGGi hsa:8482.
UCSCi uc002axv.3. human. [O75326-1 ]

Organism-specific databases

CTDi 8482.
GeneCardsi GC15M074701.
HGNCi HGNC:10741. SEMA7A.
HPAi HPA042273.
MIMi 607961. gene+phenotype.
614745. phenotype.
neXtProti NX_O75326.
PharmGKBi PA35663.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277924.
HOGENOMi HOG000154284.
HOVERGENi HBG079171.
InParanoidi O75326.
KOi K06529.
OMAi EPMGPLK.
OrthoDBi EOG754HNX.
PhylomeDBi O75326.
TreeFami TF333698.

Enzyme and pathway databases

Reactomei REACT_19200. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSi SEMA7A. human.
EvolutionaryTracei O75326.
GeneWikii SEMA7A.
GenomeRNAii 8482.
NextBioi 31739.
PROi O75326.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75326.
Bgeei O75326.
CleanExi HS_SEMA7A.
Genevestigatori O75326.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
    Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.
    Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."
    Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T., Sagawa K., Sugamura K., Itoh K.
    J. Immunol. 162:4094-4100(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  3. "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."
    Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C., Ebens A., Luo Y.
    J. Biol. Chem. 273:22428-22434(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  4. "The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."
    Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M., Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C., DeLuca D.S., Blasczyk R.
    Transfusion 47:133-146(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN JOHN MILTON HAGEN BLOOD GROUP SYSTEM, VARIANTS GLN-207; TRP-207; HIS-460 AND CYS-461.
    Tissue: Peripheral blood.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. SeattleSNPs variation discovery resource
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-115.
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain cortex.
  9. "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."
    Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V.
    Immunobiology 200:234-245(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  10. "Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."
    Pasterkamp R.J., Peschon J.J., Spriggs M.K., Kolodkin A.L.
    Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ITGB1, MUTAGENESIS OF ARG-267 AND ASP-269.
  11. "Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."
    Suzuki K., Okuno T., Yamamoto M., Pasterkamp R.J., Takegahara N., Takamatsu H., Kitao T., Takagi J., Rennert P.D., Kolodkin A.L., Kumanogoh A., Kikutani H.
    Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ITGA1 AND ITGB1.
  12. "Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins."
    Scott G.A., McClelland L.A., Fricke A.F.
    J. Invest. Dermatol. 128:151-161(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ITGB1, INDUCTION, TISSUE SPECIFICITY.
  13. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
    Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
    Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 45-634 IN COMPLEX WITH PLXNC1, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-105; ASN-157; ASN-258 AND ASN-330.
  14. "A new SEMA7A variant found in Native Americans with alloantibody."
    Richard M., St-Laurent J., Perreault J., Long A., St-Louis M.
    Vox Sang. 100:322-326(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-347.

Entry informationi

Entry nameiSEM7A_HUMAN
AccessioniPrimary (citable) accession number: O75326
Secondary accession number(s): B4DDP7
, F5H1S0, Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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