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Reviewed, UniProtKB/Swiss-Prot O75326 (SEM7A_HUMAN)

Last modified November 24, 2009. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Semaphorin-7A
Alternative name(s):
    Semaphorin-L
      Short name=Sema L
    Semaphorin-K1
      Short name=Sema K1
    John-Milton-Hargen human blood group Ag
    JMH blood group antigen
    CDw108
    CD_antigen=CD108
Gene names
Name: SEMA7A
Synonyms: CD108, SEMAL
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play an imortant role in the nervous system and in modulating immune function.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

Expressed in placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
GPI-anchor
Glycoprotein
Lipoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

immune response Ref.1

Traceable author statement. Source: ProtInc

nervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4444 Potential
Chain45 – 648604Semaphorin-7A
PRO_0000032347
Propeptide649 – 66618Removed in mature form Potential
PRO_0000032348

Regions

Domain53 – 490438Sema
Domain544 – 62986Ig-like C2-type
Motif267 – 2693Cell attachment site Potential

Amino acid modifications

Lipidation6481GPI-anchor amidated alanine Potential
Glycosylation1051N-linked (GlcNAc...) Probable
Glycosylation1571N-linked (GlcNAc...) Probable
Glycosylation2581N-linked (GlcNAc...) Probable
Glycosylation3301N-linked (GlcNAc...) Probable
Glycosylation6021N-linked (GlcNAc...) Probable
Disulfide bond120 ↔ 126 By similarity
Disulfide bond143 ↔ 152 By similarity
Disulfide bond266 ↔ 366 By similarity
Disulfide bond291 ↔ 335 By similarity
Disulfide bond566 ↔ 613 By similarity

Natural variations

Natural variant1151S → T: dbSNP rs16968733. Ref.5
VAR_029282
Natural variant2071R → Q: dbSNP rs55637216.
VAR_038836
Natural variant2071R → W: dbSNP rs56367230.
VAR_038837
Natural variant4601R → H: dbSNP rs56204206.
VAR_038838
Natural variant4611R → C: dbSNP rs56001514.
VAR_038839

Sequences

Sequence LengthMass (Da)Tools
O75326-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AD3ABE56B5EBE194

FASTA66674,824
        10         20         30         40         50         60 
MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG 

        70         80         90        100        110        120 
HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC 

       130        140        150        160        170        180 
LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV 

       190        200        210        220        230        240 
LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI 

       250        260        270        280        290        300 
YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 

       310        320        330        340        350        360 
NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN 

       370        380        390        400        410        420 
PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH 

       430        440        450        460        470        480 
GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS 

       490        500        510        520        530        540 
SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE 

       550        560        570        580        590        600 
CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 

       610        620        630        640        650        660 
ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT 


LGLLVH 

« Hide

References

« Hide 'large scale' references
[1]"New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.
Genomics 51:340-350(1998) [PubMed: 9721204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."
Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T., Sagawa K., Sugamura K., Itoh K.
J. Immunol. 162:4094-4100(1999) [PubMed: 10201933] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."
Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C., Ebens A., Luo Y.
J. Biol. Chem. 273:22428-22434(1998) [PubMed: 9712866] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]"The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."
Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M., Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C., DeLuca D.S., Blasczyk R.
Transfusion 47:133-146(2007) [PubMed: 17207242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLN-207; TRP-207; HIS-460 AND CYS-461.
Tissue: Peripheral blood.
[5]SeattleSNPs variation discovery resource
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-115.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.
[7]"Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."
Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V.
Immunobiology 200:234-245(1999) [PubMed: 10416131] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases

AF030698 mRNA. Translation: AAC34261.1.
AF030697 Genomic DNA. Translation: AAC34741.1.
AF069493 mRNA. Translation: AAC82642.1.
AF071542 mRNA. Translation: AAC80456.1.
AM180445 mRNA. Translation: CAJ55398.1.
AM180446 mRNA. Translation: CAJ55399.1.
AM180447 mRNA. Translation: CAJ55400.1.
AM180448 mRNA. Translation: CAJ55401.1.
AM180449 mRNA. Translation: CAJ55402.1.
AM180450 mRNA. Translation: CAJ55403.1.
AM180451 mRNA. Translation: CAJ55404.1.
AY885237 Genomic DNA. Translation: AAW62253.1.
BC101643 mRNA. Translation: AAI01644.1.
BC101647 mRNA. Translation: AAI01648.1.
IPIIPI00025257.
RefSeqNP_001139501.1.
NP_001139502.1.
NP_003603.1.
UniGeneHs.24640

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO75326. 4 interactions.
STRINGO75326.

PTM databases

PhosphoSiteO75326.

Proteomic databases

PeptideAtlasO75326.
PRIDEO75326.

Genome annotation databases

EnsemblENST00000261918; ENSP00000261918; ENSG00000138623; Homo sapiens. [Genome view]
GeneID8482.
KEGGhsa:8482.
UCSCuc002axv.1. human.

Organism-specific databases

CTD8482.
GeneCardsGC15M072489.
H-InvDBHIX0012429.
HGNCHGNC:10741. SEMA7A.
MIM607961. gene+phenotype.
PharmGKBPA35663.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO75326.
HOVERGENO75326.
OMACILFIEN
OrthoDBEOG9HX7KH

Enzyme and pathway databases

ReactomeREACT_18266. Axon guidance.

Gene expression databases

ArrayExpressO75326.
BgeeO75326.
CleanExHS_SEMA7A.
GenevestigatorO75326.
GermOnlineENSG00000138623. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR003599. Ig_sub.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio31739.
SOURCESearch...

Entry information

Entry nameSEM7A_HUMAN
AccessionPrimary (citable) accession number: O75326
Secondary accession number(s): Q1XE81 expand/collapse secondary AC list , Q1XE82, Q1XE83, Q1XE84, Q3MIY5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 24, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents