Reviewed, UniProtKB/Swiss-Prot O75326 (SEM7A_HUMAN)

Names and origin

Protein names

Recommended name:
    Semaphorin-7A
Alternative name(s):
    Semaphorin-L
      Short name=Sema L
    Semaphorin-K1
      Short name=Sema K1
    John-Milton-Hargen human blood group Ag
    JMH blood group antigen
    CDw108
    CD_antigen=CD108

Gene names

Name:	SEMA7A
Synonyms:	CD108, SEMAL

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play an imortant role in the nervous system and in modulating immune function.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Expressed in placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 PSI domain. Contains 1 Sema domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
Molecular function	Developmental protein
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW immune response Ref.1 Traceable author statement. Source: ProtInc nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1753538,EBI-375543
FYN	P06241	1	EBI-1753538,EBI-515315
GRB2	P62993	1	EBI-1753538,EBI-401755
NCK1	P16333	1	EBI-1753538,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 44	44	Potential
	Chain	45 – 648	604	Semaphorin-7A		PRO_0000032347
	Propeptide	649 – 666	18	Removed in mature form Potential		PRO_0000032348
Regions
	Domain	53 – 490	438	Sema
	Domain	544 – 629	86	Ig-like C2-type
	Motif	267 – 269	3	Cell attachment site Potential
Amino acid modifications
	Lipidation	648	1	GPI-anchor amidated alanine Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Probable
	Glycosylation	157	1	N-linked (GlcNAc...) Probable
	Glycosylation	258	1	N-linked (GlcNAc...) Probable
	Glycosylation	330	1	N-linked (GlcNAc...) Probable
	Glycosylation	602	1	N-linked (GlcNAc...) Probable
	Disulfide bond	120 ↔ 126		By similarity
	Disulfide bond	143 ↔ 152		By similarity
	Disulfide bond	266 ↔ 366		By similarity
	Disulfide bond	291 ↔ 335		By similarity
	Disulfide bond	566 ↔ 613		By similarity
Natural variations
	Natural variant	115	1	S → T: dbSNP rs16968733. Ref.5		VAR_029282
	Natural variant	207	1	R → Q: dbSNP rs55637216.		VAR_038836
	Natural variant	207	1	R → W: dbSNP rs56367230.		VAR_038837
	Natural variant	460	1	R → H: dbSNP rs56204206.		VAR_038838
	Natural variant	461	1	R → C: dbSNP rs56001514.		VAR_038839

Sequences

	Sequence		Length	Mass (Da)
	O75326-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: AD3ABE56B5EBE194	FASTA	666	74,824
	10 20 30 40 50 60 MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG 70 80 90 100 110 120 HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC 130 140 150 160 170 180 LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV 190 200 210 220 230 240 LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI 250 260 270 280 290 300 YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 310 320 330 340 350 360 NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN 370 380 390 400 410 420 PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH 430 440 450 460 470 480 GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS 490 500 510 520 530 540 SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE 550 560 570 580 590 600 CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 610 620 630 640 650 660 ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT LGLLVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New eukaryotic semaphorins with close homology to semaphorins of DNA viruses." Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A. Genomics 51:340-350(1998) [PubMed: 9721204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108." Yamada A., Kubo K., Takeshita T., Harashima N., Kawano K., Mine T., Sagawa K., Sugamura K., Itoh K. J. Immunol. 162:4094-4100(1999) [PubMed: 10201933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins." Xu X., Ng S., Wu Z.-L., Nguyen D., Homburger S., Seidel-Dugan C., Ebens A., Luo Y. J. Biol. Chem. 273:22428-22434(1998) [PubMed: 9712866] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	"The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens." Seltsam A., Strigens S., Levene C., Yahalom V., Moulds M., Moulds J.J., Hustinx H., Weisbach V., Figueroa D., Bade-Doeding C., DeLuca D.S., Blasczyk R. Transfusion 47:133-146(2007) [PubMed: 17207242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLN-207; TRP-207; HIS-460 AND CYS-461. Tissue: Peripheral blood.
[5]	SeattleSNPs variation discovery resource Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-115.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.
[7]	"Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules." Angelisova P., Drbal K., Cerny J., Hilgert I., Horejsi V. Immunobiology 200:234-245(1999) [PubMed: 10416131] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF030698 mRNA. Translation: AAC34261.1. AF030697 Genomic DNA. Translation: AAC34741.1. AF069493 mRNA. Translation: AAC82642.1. AF071542 mRNA. Translation: AAC80456.1. AM180445 mRNA. Translation: CAJ55398.1. AM180446 mRNA. Translation: CAJ55399.1. AM180447 mRNA. Translation: CAJ55400.1. AM180448 mRNA. Translation: CAJ55401.1. AM180449 mRNA. Translation: CAJ55402.1. AM180450 mRNA. Translation: CAJ55403.1. AM180451 mRNA. Translation: CAJ55404.1. AY885237 Genomic DNA. Translation: AAW62253.1. BC101643 mRNA. Translation: AAI01644.1. BC101647 mRNA. Translation: AAI01648.1.
IPI	IPI00025257.
RefSeq	NP_001139501.1. NP_001139502.1. NP_003603.1.
UniGene	Hs.24640
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75326. 4 interactions.
STRING	O75326.
PTM databases
PhosphoSite	O75326.
Proteomic databases
PeptideAtlas	O75326.
PRIDE	O75326.
Genome annotation databases
Ensembl	ENST00000261918; ENSP00000261918; ENSG00000138623; Homo sapiens. [Genome view]
GeneID	8482.
KEGG	hsa:8482.
UCSC	uc002axv.1. human.
Organism-specific databases
CTD	8482.
GeneCards	GC15M072489.
H-InvDB	HIX0012429.
HGNC	HGNC:10741. SEMA7A.
MIM	607961. gene+phenotype.
PharmGKB	PA35663.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O75326.
HOVERGEN	O75326.
OMA	CILFIEN
OrthoDB	EOG9HX7KH
Enzyme and pathway databases
Reactome	REACT_18266. Axon guidance.
Gene expression databases
ArrayExpress	O75326.
Bgee	O75326.
CleanEx	HS_SEMA7A.
Genevestigator	O75326.
GermOnline	ENSG00000138623. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002165. Plexin_repeat. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31739.
SOURCE	Search...

Entry information

Entry name

SEM7A_HUMAN

Accession

Primary (citable) accession number: O75326
Secondary accession number(s): Q1XE81 , Q1XE82, Q1XE83, Q1XE84, Q3MIY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1998
Last modified:	November 24, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.