Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat neuronal protein 2

Gene

LRRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 2
Alternative name(s):
Glioma amplified on chromosome 1 protein
Leucine-rich repeat neuronal protein 5
Gene namesi
Name:LRRN2
Synonyms:GAC1, LRRN5
ORF Names:UNQ256/PRO293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16914. LRRN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 630612ExtracellularSequence analysisAdd
BLAST
Transmembranei631 – 65121HelicalSequence analysisAdd
BLAST
Topological domaini652 – 71362CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394661.

Polymorphism and mutation databases

BioMutaiLRRN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 713695Leucine-rich repeat neuronal protein 2PRO_0000014849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Disulfide bondi445 ↔ 497PROSITE-ProRule annotation
Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence analysis
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75325.
PRIDEiO75325.

PTM databases

iPTMnetiO75325.
PhosphoSiteiO75325.

Expressioni

Tissue specificityi

Overamplified in malignant gliomas.

Gene expression databases

BgeeiO75325.
CleanExiHS_LRRN2.
ExpressionAtlasiO75325. baseline and differential.
GenevisibleiO75325. HS.

Organism-specific databases

HPAiHPA029124.

Interactioni

Protein-protein interaction databases

BioGridi115711. 15 interactions.
IntActiO75325. 1 interaction.
STRINGi9606.ENSP00000356143.

Structurei

3D structure databases

ProteinModelPortaliO75325.
SMRiO75325. Positions 29-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 6950LRRNTAdd
BLAST
Repeati70 – 9122LRR 1Add
BLAST
Repeati94 – 11522LRR 2Add
BLAST
Repeati118 – 13922LRR 3Add
BLAST
Repeati142 – 16322LRR 4Add
BLAST
Repeati166 – 18722LRR 5Add
BLAST
Repeati190 – 21122LRR 6Add
BLAST
Repeati214 – 23522LRR 7Add
BLAST
Repeati238 – 25922LRR 8Add
BLAST
Repeati262 – 28322LRR 9Add
BLAST
Repeati286 – 30520LRR 10Add
BLAST
Repeati311 – 33323LRR 11Add
BLAST
Repeati336 – 35722LRR 12Add
BLAST
Domaini369 – 42254LRRCTAdd
BLAST
Domaini422 – 51190Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
InParanoidiO75325.
OMAiTEYWACL.
OrthoDBiEOG7WDN1W.
PhylomeDBiO75325.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA
60 70 80 90 100
TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL
110 120 130 140 150
SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH
160 170 180 190 200
NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK
210 220 230 240 250
VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA
260 270 280 290 300
RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS
310 320 330 340 350
IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL
360 370 380 390 400
HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP
410 420 430 440 450
PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE
460 470 480 490 500
PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ
510 520 530 540 550
NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN
560 570 580 590 600
TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA
610 620 630 640 650
FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL
660 670 680 690 700
GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS
710
EGETLLPPLS QNS
Length:713
Mass (Da):78,859
Last modified:March 15, 2005 - v2
Checksum:i8B97B131FF61254A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551V → A in AAH34047 (PubMed:15489334).Curated
Sequence conflicti355 – 3551V → A in AAH68541 (PubMed:15489334).Curated
Sequence conflicti474 – 4741Y → C in AAC39792 (PubMed:9662332).Curated
Sequence conflicti676 – 6761A → P in AAH34047 (PubMed:15489334).Curated
Sequence conflicti676 – 6761A → P in AAH68541 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71P → L.
Corresponds to variant rs3789044 [ dbSNP | Ensembl ].
VAR_021921
Natural varianti19 – 191A → T.1 Publication
Corresponds to variant rs36012907 [ dbSNP | Ensembl ].
VAR_049898
Natural varianti518 – 5181L → V.
Corresponds to variant rs3747631 [ dbSNP | Ensembl ].
VAR_021922
Natural varianti659 – 6591V → A.
Corresponds to variant rs34771052 [ dbSNP | Ensembl ].
VAR_049899
Natural varianti692 – 6921P → S.
Corresponds to variant rs11588857 [ dbSNP | Ensembl ].
VAR_049900

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030435 mRNA. Translation: AAC39792.1.
AY358290 mRNA. Translation: AAQ88657.1.
AK312408 mRNA. Translation: BAG35321.1.
AL512306 Genomic DNA. Translation: CAI14096.1.
CH471067 Genomic DNA. Translation: EAW91520.1.
BC034047 mRNA. Translation: AAH34047.1.
BC068541 mRNA. Translation: AAH68541.1.
CCDSiCCDS1448.1.
RefSeqiNP_006329.2. NM_006338.2.
NP_963924.1. NM_201630.1.
XP_005244884.1. XM_005244827.2.
XP_011507368.1. XM_011509066.1.
UniGeneiHs.26312.

Genome annotation databases

EnsembliENST00000367175; ENSP00000356143; ENSG00000170382.
ENST00000367176; ENSP00000356144; ENSG00000170382.
ENST00000367177; ENSP00000356145; ENSG00000170382.
GeneIDi10446.
KEGGihsa:10446.
UCSCiuc001hbe.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030435 mRNA. Translation: AAC39792.1.
AY358290 mRNA. Translation: AAQ88657.1.
AK312408 mRNA. Translation: BAG35321.1.
AL512306 Genomic DNA. Translation: CAI14096.1.
CH471067 Genomic DNA. Translation: EAW91520.1.
BC034047 mRNA. Translation: AAH34047.1.
BC068541 mRNA. Translation: AAH68541.1.
CCDSiCCDS1448.1.
RefSeqiNP_006329.2. NM_006338.2.
NP_963924.1. NM_201630.1.
XP_005244884.1. XM_005244827.2.
XP_011507368.1. XM_011509066.1.
UniGeneiHs.26312.

3D structure databases

ProteinModelPortaliO75325.
SMRiO75325. Positions 29-514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115711. 15 interactions.
IntActiO75325. 1 interaction.
STRINGi9606.ENSP00000356143.

PTM databases

iPTMnetiO75325.
PhosphoSiteiO75325.

Polymorphism and mutation databases

BioMutaiLRRN2.

Proteomic databases

PaxDbiO75325.
PRIDEiO75325.

Protocols and materials databases

DNASUi10446.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367175; ENSP00000356143; ENSG00000170382.
ENST00000367176; ENSP00000356144; ENSG00000170382.
ENST00000367177; ENSP00000356145; ENSG00000170382.
GeneIDi10446.
KEGGihsa:10446.
UCSCiuc001hbe.3. human.

Organism-specific databases

CTDi10446.
GeneCardsiLRRN2.
H-InvDBHIX0001502.
HGNCiHGNC:16914. LRRN2.
HPAiHPA029124.
MIMi605492. gene.
neXtProtiNX_O75325.
PharmGKBiPA162394661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
InParanoidiO75325.
OMAiTEYWACL.
OrthoDBiEOG7WDN1W.
PhylomeDBiO75325.
TreeFamiTF334360.

Miscellaneous databases

GeneWikiiLRRN2.
GenomeRNAii10446.
PROiO75325.
SOURCEiSearch...

Gene expression databases

BgeeiO75325.
CleanExiHS_LRRN2.
ExpressionAtlasiO75325. baseline and differential.
GenevisibleiO75325. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas."
    Malfoy B., Almeida A., Zhu X.X., Vogt N., Tyagi R., Muleris M., Dutrillaux A.-M., Dutrillaux B., Ross D., Hanash S.
    Oncogene 16:2997-3002(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Glial tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-19.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLRRN2_HUMAN
AccessioniPrimary (citable) accession number: O75325
Secondary accession number(s): B2R624
, Q5T0Y0, Q6UXM0, Q8N182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.