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Protein

Stannin

Gene

SNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).2 Publications

Enzyme and pathway databases

BioCyciZFISH:G66-32470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Alternative name(s):
AG8_1
Gene namesi
Name:SNN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11149. SNN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembrane1 Publication10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 88Cytoplasmic1 PublicationAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184602.
PharmGKBiPA35991.

Polymorphism and mutation databases

BioMutaiSNN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720141 – 88StanninAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75324.
PeptideAtlasiO75324.
PRIDEiO75324.

PTM databases

iPTMnetiO75324.
PhosphoSitePlusiO75324.

Expressioni

Gene expression databases

BgeeiENSG00000184602.
CleanExiHS_SNN.
GenevisibleiO75324. HS.

Organism-specific databases

HPAiHPA011055.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi113904. 5 interactors.
STRINGi9606.ENSP00000329287.

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 8Combined sources4
Helixi9 – 33Combined sources25
Turni34 – 36Combined sources3
Turni48 – 54Combined sources7
Beta strandi55 – 57Combined sources3
Helixi60 – 79Combined sources20
Turni84 – 86Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162.
ProteinModelPortaliO75324.
SMRiO75324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75324.

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYFC. Eukaryota.
ENOG4111TD3. LUCA.
GeneTreeiENSGT00390000009447.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiO75324.
OMAiYSARGPC.
OrthoDBiEOG091G16Q5.
PhylomeDBiO75324.
TreeFamiTF336244.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI
60 70 80
VGDGETKEPF LLVQYSAKGP CVERKAKLMT PNGPEVHG
Length:88
Mass (Da):9,497
Last modified:November 1, 1998 - v1
Checksum:i1E8DA73323C5D6DF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01884217V → I.1 PublicationCorresponds to variant rs8191328dbSNPEnsembl.1
Natural variantiVAR_01884388G → S.1 PublicationCorresponds to variant rs8191329dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSiCCDS10549.1.
PIRiT47139.
RefSeqiNP_003489.1. NM_003498.5.
XP_016879231.1. XM_017023742.1.
UniGeneiHs.618526.

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
GeneIDi8303.
KEGGihsa:8303.
UCSCiuc002dbf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSiCCDS10549.1.
PIRiT47139.
RefSeqiNP_003489.1. NM_003498.5.
XP_016879231.1. XM_017023742.1.
UniGeneiHs.618526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162.
ProteinModelPortaliO75324.
SMRiO75324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113904. 5 interactors.
STRINGi9606.ENSP00000329287.

PTM databases

iPTMnetiO75324.
PhosphoSitePlusiO75324.

Polymorphism and mutation databases

BioMutaiSNN.

Proteomic databases

PaxDbiO75324.
PeptideAtlasiO75324.
PRIDEiO75324.

Protocols and materials databases

DNASUi8303.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
GeneIDi8303.
KEGGihsa:8303.
UCSCiuc002dbf.5. human.

Organism-specific databases

CTDi8303.
GeneCardsiSNN.
HGNCiHGNC:11149. SNN.
HPAiHPA011055.
MIMi603032. gene.
neXtProtiNX_O75324.
OpenTargetsiENSG00000184602.
PharmGKBiPA35991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYFC. Eukaryota.
ENOG4111TD3. LUCA.
GeneTreeiENSGT00390000009447.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiO75324.
OMAiYSARGPC.
OrthoDBiEOG091G16Q5.
PhylomeDBiO75324.
TreeFamiTF336244.

Enzyme and pathway databases

BioCyciZFISH:G66-32470-MONOMER.

Miscellaneous databases

ChiTaRSiSNN. human.
EvolutionaryTraceiO75324.
GeneWikiiSNN_(gene).
GenomeRNAii8303.
PROiO75324.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184602.
CleanExiHS_SNN.
GenevisibleiO75324. HS.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNN_HUMAN
AccessioniPrimary (citable) accession number: O75324
Secondary accession number(s): D3DUG4, Q6FGI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.