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O75324

- SNN_HUMAN

UniProt

O75324 - SNN_HUMAN

Protein

Stannin

Gene

SNN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in the toxic effects of organotins.

    GO - Biological processi

    1. response to abiotic stimulus Source: ProtInc
    2. response to stress Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stannin
    Alternative name(s):
    AG8_1
    Gene namesi
    Name:SNN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11149. SNN.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35991.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8888StanninPRO_0000072014Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO75324.
    PRIDEiO75324.

    PTM databases

    PhosphoSiteiO75324.

    Expressioni

    Gene expression databases

    BgeeiO75324.
    CleanExiHS_SNN.
    GenevestigatoriO75324.

    Organism-specific databases

    HPAiHPA011055.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi113904. 1 interaction.
    STRINGi9606.ENSP00000329287.

    Structurei

    Secondary structure

    1
    88
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni5 – 84
    Helixi9 – 3325
    Turni34 – 363
    Turni48 – 547
    Beta strandi55 – 573
    Helixi60 – 7920
    Turni84 – 863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZZANMR-A1-88[»]
    DisProtiDP00162.
    ProteinModelPortaliO75324.
    SMRiO75324. Positions 1-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75324.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial intermembrane1 Publication
    Topological domaini32 – 8857Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the stannin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47301.
    HOGENOMiHOG000261688.
    HOVERGENiHBG017824.
    InParanoidiO75324.
    OrthoDBiEOG7N8ZZJ.
    PhylomeDBiO75324.
    TreeFamiTF336244.

    Family and domain databases

    Gene3Di4.10.280.20. 1 hit.
    InterProiIPR015137. SNN_cytoplasm.
    IPR015136. SNN_linker.
    IPR015135. SNN_transmemb.
    IPR027435. Stannin.
    [Graphical view]
    PfamiPF09051. SNN_cytoplasm. 1 hit.
    PF09050. SNN_linker. 1 hit.
    PF09049. SNN_transmemb. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI   50
    VGDGETKEPF LLVQYSAKGP CVERKAKLMT PNGPEVHG 88
    Length:88
    Mass (Da):9,497
    Last modified:November 1, 1998 - v1
    Checksum:i1E8DA73323C5D6DF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171V → I.1 Publication
    Corresponds to variant rs8191328 [ dbSNP | Ensembl ].
    VAR_018842
    Natural varianti88 – 881G → S.1 Publication
    Corresponds to variant rs8191329 [ dbSNP | Ensembl ].
    VAR_018843

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030196 mRNA. Translation: AAC28427.1.
    AF070673 mRNA. Translation: AAC83231.1.
    AL161976 mRNA. Translation: CAB82314.1.
    AY325800 Genomic DNA. Translation: AAP78484.1.
    CR542127 mRNA. Translation: CAG46924.1.
    CR542138 mRNA. Translation: CAG46935.1.
    CH471112 Genomic DNA. Translation: EAW85146.1.
    CH471112 Genomic DNA. Translation: EAW85147.1.
    BC036100 mRNA. Translation: AAH36100.1.
    BC036443 mRNA. Translation: AAH36443.1.
    CCDSiCCDS10549.1.
    PIRiT47139.
    RefSeqiNP_003489.1. NM_003498.5.
    UniGeneiHs.618526.

    Genome annotation databases

    EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
    GeneIDi8303.
    KEGGihsa:8303.
    UCSCiuc002dbf.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030196 mRNA. Translation: AAC28427.1 .
    AF070673 mRNA. Translation: AAC83231.1 .
    AL161976 mRNA. Translation: CAB82314.1 .
    AY325800 Genomic DNA. Translation: AAP78484.1 .
    CR542127 mRNA. Translation: CAG46924.1 .
    CR542138 mRNA. Translation: CAG46935.1 .
    CH471112 Genomic DNA. Translation: EAW85146.1 .
    CH471112 Genomic DNA. Translation: EAW85147.1 .
    BC036100 mRNA. Translation: AAH36100.1 .
    BC036443 mRNA. Translation: AAH36443.1 .
    CCDSi CCDS10549.1.
    PIRi T47139.
    RefSeqi NP_003489.1. NM_003498.5.
    UniGenei Hs.618526.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZZA NMR - A 1-88 [» ]
    DisProti DP00162.
    ProteinModelPortali O75324.
    SMRi O75324. Positions 1-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113904. 1 interaction.
    STRINGi 9606.ENSP00000329287.

    PTM databases

    PhosphoSitei O75324.

    Proteomic databases

    PaxDbi O75324.
    PRIDEi O75324.

    Protocols and materials databases

    DNASUi 8303.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329565 ; ENSP00000329287 ; ENSG00000184602 .
    GeneIDi 8303.
    KEGGi hsa:8303.
    UCSCi uc002dbf.3. human.

    Organism-specific databases

    CTDi 8303.
    GeneCardsi GC16P011669.
    HGNCi HGNC:11149. SNN.
    HPAi HPA011055.
    MIMi 603032. gene.
    neXtProti NX_O75324.
    PharmGKBi PA35991.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47301.
    HOGENOMi HOG000261688.
    HOVERGENi HBG017824.
    InParanoidi O75324.
    OrthoDBi EOG7N8ZZJ.
    PhylomeDBi O75324.
    TreeFami TF336244.

    Miscellaneous databases

    ChiTaRSi SNN. human.
    EvolutionaryTracei O75324.
    GeneWikii SNN_(gene).
    GenomeRNAii 8303.
    NextBioi 31111.
    PROi O75324.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75324.
    CleanExi HS_SNN.
    Genevestigatori O75324.

    Family and domain databases

    Gene3Di 4.10.280.20. 1 hit.
    InterProi IPR015137. SNN_cytoplasm.
    IPR015136. SNN_linker.
    IPR015135. SNN_transmemb.
    IPR027435. Stannin.
    [Graphical view ]
    Pfami PF09051. SNN_cytoplasm. 1 hit.
    PF09050. SNN_linker. 1 hit.
    PF09049. SNN_transmemb. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and characterization of the stannin (Snn) gene."
      Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
      Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
      Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
      Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Endothelial cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. NIEHS SNPs program
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-17 AND SER-88.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    8. "Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride."
      Buck-Koehntop B.A., Mascioni A., Buffy J.J., Veglia G.
      J. Mol. Biol. 354:652-665(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, SUBUNIT, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiSNN_HUMAN
    AccessioniPrimary (citable) accession number: O75324
    Secondary accession number(s): D3DUG4, Q6FGI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3