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O75324

- SNN_HUMAN

UniProt

O75324 - SNN_HUMAN

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Protein

Stannin

Gene
SNN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins.

GO - Biological processi

  1. response to abiotic stimulus Source: ProtInc
  2. response to stress Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Alternative name(s):
AG8_1
Gene namesi
Name:SNN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11149. SNN.

Subcellular locationi

Mitochondrion outer membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembrane1 Publication
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Topological domaini32 – 8857Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888StanninPRO_0000072014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75324.
PRIDEiO75324.

PTM databases

PhosphoSiteiO75324.

Expressioni

Gene expression databases

BgeeiO75324.
CleanExiHS_SNN.
GenevestigatoriO75324.

Organism-specific databases

HPAiHPA011055.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi113904. 1 interaction.
STRINGi9606.ENSP00000329287.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 84
Helixi9 – 3325
Turni34 – 363
Turni48 – 547
Beta strandi55 – 573
Helixi60 – 7920
Turni84 – 863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162.
ProteinModelPortaliO75324.
SMRiO75324. Positions 1-88.

Miscellaneous databases

EvolutionaryTraceiO75324.

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47301.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiO75324.
OrthoDBiEOG7N8ZZJ.
PhylomeDBiO75324.
TreeFamiTF336244.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75324-1 [UniParc]FASTAAdd to Basket

« Hide

MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI   50
VGDGETKEPF LLVQYSAKGP CVERKAKLMT PNGPEVHG 88
Length:88
Mass (Da):9,497
Last modified:November 1, 1998 - v1
Checksum:i1E8DA73323C5D6DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171V → I.1 Publication
Corresponds to variant rs8191328 [ dbSNP | Ensembl ].
VAR_018842
Natural varianti88 – 881G → S.1 Publication
Corresponds to variant rs8191329 [ dbSNP | Ensembl ].
VAR_018843

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSiCCDS10549.1.
PIRiT47139.
RefSeqiNP_003489.1. NM_003498.5.
UniGeneiHs.618526.

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
GeneIDi8303.
KEGGihsa:8303.
UCSCiuc002dbf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030196 mRNA. Translation: AAC28427.1 .
AF070673 mRNA. Translation: AAC83231.1 .
AL161976 mRNA. Translation: CAB82314.1 .
AY325800 Genomic DNA. Translation: AAP78484.1 .
CR542127 mRNA. Translation: CAG46924.1 .
CR542138 mRNA. Translation: CAG46935.1 .
CH471112 Genomic DNA. Translation: EAW85146.1 .
CH471112 Genomic DNA. Translation: EAW85147.1 .
BC036100 mRNA. Translation: AAH36100.1 .
BC036443 mRNA. Translation: AAH36443.1 .
CCDSi CCDS10549.1.
PIRi T47139.
RefSeqi NP_003489.1. NM_003498.5.
UniGenei Hs.618526.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZZA NMR - A 1-88 [» ]
DisProti DP00162.
ProteinModelPortali O75324.
SMRi O75324. Positions 1-88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113904. 1 interaction.
STRINGi 9606.ENSP00000329287.

PTM databases

PhosphoSitei O75324.

Proteomic databases

PaxDbi O75324.
PRIDEi O75324.

Protocols and materials databases

DNASUi 8303.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329565 ; ENSP00000329287 ; ENSG00000184602 .
GeneIDi 8303.
KEGGi hsa:8303.
UCSCi uc002dbf.3. human.

Organism-specific databases

CTDi 8303.
GeneCardsi GC16P011669.
HGNCi HGNC:11149. SNN.
HPAi HPA011055.
MIMi 603032. gene.
neXtProti NX_O75324.
PharmGKBi PA35991.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47301.
HOGENOMi HOG000261688.
HOVERGENi HBG017824.
InParanoidi O75324.
OrthoDBi EOG7N8ZZJ.
PhylomeDBi O75324.
TreeFami TF336244.

Miscellaneous databases

ChiTaRSi SNN. human.
EvolutionaryTracei O75324.
GeneWikii SNN_(gene).
GenomeRNAii 8303.
NextBioi 31111.
PROi O75324.
SOURCEi Search...

Gene expression databases

Bgeei O75324.
CleanExi HS_SNN.
Genevestigatori O75324.

Family and domain databases

Gene3Di 4.10.280.20. 1 hit.
InterProi IPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view ]
Pfami PF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and characterization of the stannin (Snn) gene."
    Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
    Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
    Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
    Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endothelial cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. NIEHS SNPs program
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-17 AND SER-88.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  8. "Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride."
    Buck-Koehntop B.A., Mascioni A., Buffy J.J., Veglia G.
    J. Mol. Biol. 354:652-665(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SUBUNIT, SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiSNN_HUMAN
AccessioniPrimary (citable) accession number: O75324
Secondary accession number(s): D3DUG4, Q6FGI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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