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Protein

Stannin

Gene

SNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins.

GO - Biological processi

  1. response to abiotic stimulus Source: ProtInc
  2. response to stress Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Alternative name(s):
AG8_1
Gene namesi
Name:SNN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11149. SNN.

Subcellular locationi

  1. Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembrane1 Publication
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 8857Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35991.

Polymorphism and mutation databases

BioMutaiSNN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888StanninPRO_0000072014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75324.
PaxDbiO75324.
PRIDEiO75324.

PTM databases

PhosphoSiteiO75324.

Expressioni

Gene expression databases

BgeeiO75324.
CleanExiHS_SNN.
GenevestigatoriO75324.

Organism-specific databases

HPAiHPA011055.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi113904. 1 interaction.
STRINGi9606.ENSP00000329287.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 84Combined sources
Helixi9 – 3325Combined sources
Turni34 – 363Combined sources
Turni48 – 547Combined sources
Beta strandi55 – 573Combined sources
Helixi60 – 7920Combined sources
Turni84 – 863Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162.
ProteinModelPortaliO75324.
SMRiO75324. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75324.

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47301.
GeneTreeiENSGT00390000009447.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiO75324.
OMAiYSARGPC.
OrthoDBiEOG7N8ZZJ.
PhylomeDBiO75324.
TreeFamiTF336244.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI
60 70 80
VGDGETKEPF LLVQYSAKGP CVERKAKLMT PNGPEVHG
Length:88
Mass (Da):9,497
Last modified:November 1, 1998 - v1
Checksum:i1E8DA73323C5D6DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171V → I.1 Publication
Corresponds to variant rs8191328 [ dbSNP | Ensembl ].
VAR_018842
Natural varianti88 – 881G → S.1 Publication
Corresponds to variant rs8191329 [ dbSNP | Ensembl ].
VAR_018843

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSiCCDS10549.1.
PIRiT47139.
RefSeqiNP_003489.1. NM_003498.5.
UniGeneiHs.618526.

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
GeneIDi8303.
KEGGihsa:8303.
UCSCiuc002dbf.3. human.

Polymorphism and mutation databases

BioMutaiSNN.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSiCCDS10549.1.
PIRiT47139.
RefSeqiNP_003489.1. NM_003498.5.
UniGeneiHs.618526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162.
ProteinModelPortaliO75324.
SMRiO75324. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113904. 1 interaction.
STRINGi9606.ENSP00000329287.

PTM databases

PhosphoSiteiO75324.

Polymorphism and mutation databases

BioMutaiSNN.

Proteomic databases

MaxQBiO75324.
PaxDbiO75324.
PRIDEiO75324.

Protocols and materials databases

DNASUi8303.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602.
GeneIDi8303.
KEGGihsa:8303.
UCSCiuc002dbf.3. human.

Organism-specific databases

CTDi8303.
GeneCardsiGC16P011669.
HGNCiHGNC:11149. SNN.
HPAiHPA011055.
MIMi603032. gene.
neXtProtiNX_O75324.
PharmGKBiPA35991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47301.
GeneTreeiENSGT00390000009447.
HOGENOMiHOG000261688.
HOVERGENiHBG017824.
InParanoidiO75324.
OMAiYSARGPC.
OrthoDBiEOG7N8ZZJ.
PhylomeDBiO75324.
TreeFamiTF336244.

Miscellaneous databases

ChiTaRSiSNN. human.
EvolutionaryTraceiO75324.
GeneWikiiSNN_(gene).
GenomeRNAii8303.
NextBioi31111.
PROiO75324.
SOURCEiSearch...

Gene expression databases

BgeeiO75324.
CleanExiHS_SNN.
GenevestigatoriO75324.

Family and domain databases

Gene3Di4.10.280.20. 1 hit.
InterProiIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamiPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and characterization of the stannin (Snn) gene."
    Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
    Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
    Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
    Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endothelial cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. NIEHS SNPs program
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-17 AND SER-88.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  8. "Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride."
    Buck-Koehntop B.A., Mascioni A., Buffy J.J., Veglia G.
    J. Mol. Biol. 354:652-665(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SUBUNIT, SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiSNN_HUMAN
AccessioniPrimary (citable) accession number: O75324
Secondary accession number(s): D3DUG4, Q6FGI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 29, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.