Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O75324 (SNN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stannin
Alternative name(s):
AG8_1
Gene names
Name:SNN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the toxic effects of organotins.

Subunit structure

Monomer. Ref.8

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein Ref.8.

Sequence similarities

Belongs to the stannin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8888Stannin
PRO_0000072014

Regions

Topological domain1 – 1010Mitochondrial intermembrane Ref.8
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 8857Cytoplasmic Ref.8

Amino acid modifications

Modified residue491Phosphoserine By similarity

Natural variations

Natural variant171V → I. Ref.4
Corresponds to variant rs8191328 [ dbSNP | Ensembl ].
VAR_018842
Natural variant881G → S. Ref.4
Corresponds to variant rs8191329 [ dbSNP | Ensembl ].
VAR_018843

Secondary structure

............ 88
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O75324 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 1E8DA73323C5D6DF

FASTA889,497
        10         20         30         40         50         60 
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF 

        70         80 
LLVQYSAKGP CVERKAKLMT PNGPEVHG 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal localization and characterization of the stannin (Snn) gene."
Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.
Mamm. Genome 9:556-564(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[4]NIEHS SNPs program
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-17 AND SER-88.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[8]"Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride."
Buck-Koehntop B.A., Mascioni A., Buffy J.J., Veglia G.
J. Mol. Biol. 354:652-665(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, SUBUNIT, SUBCELLULAR LOCATION, TOPOLOGY.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030196 mRNA. Translation: AAC28427.1.
AF070673 mRNA. Translation: AAC83231.1.
AL161976 mRNA. Translation: CAB82314.1.
AY325800 Genomic DNA. Translation: AAP78484.1.
CR542127 mRNA. Translation: CAG46924.1.
CR542138 mRNA. Translation: CAG46935.1.
CH471112 Genomic DNA. Translation: EAW85146.1.
CH471112 Genomic DNA. Translation: EAW85147.1.
BC036100 mRNA. Translation: AAH36100.1.
BC036443 mRNA. Translation: AAH36443.1.
CCDSCCDS10549.1.
PIRT47139.
RefSeqNP_003489.1. NM_003498.5.
UniGeneHs.618526.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtDP00162.
ProteinModelPortalO75324.
SMRO75324. Positions 1-88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113904. 1 interaction.
STRING9606.ENSP00000329287.

PTM databases

PhosphoSiteO75324.

Proteomic databases

PaxDbO75324.
PRIDEO75324.

Protocols and materials databases

DNASU8303.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329565; ENSP00000329287; ENSG00000184602.
GeneID8303.
KEGGhsa:8303.
UCSCuc002dbf.3. human.

Organism-specific databases

CTD8303.
GeneCardsGC16P011669.
HGNCHGNC:11149. SNN.
HPAHPA011055.
MIM603032. gene.
neXtProtNX_O75324.
PharmGKBPA35991.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47301.
HOGENOMHOG000261688.
HOVERGENHBG017824.
InParanoidO75324.
OrthoDBEOG7N8ZZJ.
PhylomeDBO75324.
TreeFamTF336244.

Gene expression databases

BgeeO75324.
CleanExHS_SNN.
GenevestigatorO75324.

Family and domain databases

Gene3D4.10.280.20. 1 hit.
InterProIPR015137. SNN_cytoplasm.
IPR015136. SNN_linker.
IPR015135. SNN_transmemb.
IPR027435. Stannin.
[Graphical view]
PfamPF09051. SNN_cytoplasm. 1 hit.
PF09050. SNN_linker. 1 hit.
PF09049. SNN_transmemb. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNN. human.
EvolutionaryTraceO75324.
GeneWikiSNN_(gene).
GenomeRNAi8303.
NextBio31111.
PROO75324.
SOURCESearch...

Entry information

Entry nameSNN_HUMAN
AccessionPrimary (citable) accession number: O75324
Secondary accession number(s): D3DUG4, Q6FGI0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM