O75323 (NIPS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NipSnap homolog 2
Short name=NipSnap2

Alternative name(s):
Glioblastoma-amplified sequence

Gene names

Name:	GBAS
Synonyms:	NIPSNAP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed. Most abundant in heart and skeletal muscle.
Sequence similarities	Belongs to the NipSnap family.

Ontologies

Keywords
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	5	EBI-307133,EBI-712001
GABARAPL1	Q9H0R8	6	EBI-307133,EBI-746969
GABARAPL2	P60520	4	EBI-307133,EBI-720116
MAP1LC3B	Q9GZQ8	4	EBI-307133,EBI-373144
MAP1LC3C	Q9BXW4	2	EBI-307133,EBI-2603996

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Protein NipSnap homolog 2		PRO_0000221148
Amino acid modifications
	Modified residue	148	1	N6-acetyllysine Ref.7
Experimental info
	Sequence conflict	9 – 16	8	RGAAWAGG → AEALGRR in CAA04633. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O75323 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 7ED85297E4DC9D08	FASTA	286	33,743
	10 20 30 40 50 60 MAARVLRARG AAWAGGLLQR AAPCSLLPRL RTWTSSSNRS REDSWLKSLF VRKVDPRKDA 70 80 90 100 110 120 HSNLLAKKET SNLYKLQFHN VKPECLEAYN KICQEVLPKI HEDKHYPCTL VGTWNTWYGE 130 140 150 160 170 180 QDQAVHLWRY EGGYPALTEV MNKLRENKEF LEFRKARSDM LLSRKNQLLL EFSFWNEPVP 190 200 210 220 230 240 RSGPNIYELR SYQLRPGTMI EWGNYWARAI RFRQDGNEAV GGFFSQIGQL YMVHHLWAYR 250 260 270 280 DLQTREDIRN AAWHKHGWEE LVYYTVPLIQ EMESRIMIPL KTSPLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR." Wang X.-Y., Smith D.I., Liu W., James C.D. Genomics 49:448-451(1998) [PubMed: 9615231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family." Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P. Gene 212:13-20(1998) [PubMed: 9661659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Lung.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF029786 mRNA. Translation: AAC29002.1. AJ001259 mRNA. Translation: CAA04633.1. BT007112 mRNA. Translation: AAP35776.1. CR407612 mRNA. Translation: CAG28540.1. CH471140 Genomic DNA. Translation: EAX07967.1. BC000732 mRNA. Translation: AAH00732.1. BC001837 mRNA. Translation: AAH01837.1. BC030821 mRNA. Translation: AAH30821.1.
IPI	IPI00016077.
RefSeq	NP_001189398.1. NM_001202469.1. NP_001474.1. NM_001483.2.
UniGene	Hs.591069.
3D structure databases
ProteinModelPortal	O75323.
SMR	O75323. Positions 182-286.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75323. 36 interactions.
MINT	MINT-5003890.
STRING	O75323.
PTM databases
PhosphoSite	O75323.
2D gel databases
UCD-2DPAGE	O75323.
Proteomic databases
PeptideAtlas	O75323.
PRIDE	O75323.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322090; ENSP00000313050; ENSG00000146729.
GeneID	2631.
KEGG	hsa:2631.
UCSC	uc003tre.1. human.
Organism-specific databases
CTD	2631.
GeneCards	GC07P055999.
HGNC	HGNC:4179. GBAS.
MIM	603004. gene.
neXtProt	NX_O75323.
PharmGKB	PA28593.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05994.
GeneTree	ENSGT00530000063035.
HOGENOM	HBG444280.
HOVERGEN	HBG052627.
InParanoid	O75323.
OMA	FRQDGNE.
PhylomeDB	O75323.
Gene expression databases
ArrayExpress	O75323.
Bgee	O75323.
CleanEx	HS_GBAS.
Genevestigator	O75323.
GermOnline	ENSG00000146729. Homo sapiens.
Family and domain databases
InterPro	IPR011008. Dimeric_a/b-barrel. IPR012577. NIPSNAP. [Graphical view]
Pfam	PF07978. NIPSNAP. 1 hit. [Graphical view]
SUPFAM	SSF54909. Dimer_A_B_barrel. 2 hits.
ProtoNet	Search...
Other
NextBio	10372.
SOURCE	Search...

Entry information

Entry name

NIPS2_HUMAN

Accession

Primary (citable) accession number: O75323
Secondary accession number(s): O43801, Q53X96

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.