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O75323 (NIPS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NipSnap homolog 2

Short name=NipSnap2
Alternative name(s):
Glioblastoma-amplified sequence
Gene names
Name:GBAS
Synonyms:NIPSNAP2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed. Most abundant in heart and skeletal muscle.

Sequence similarities

Belongs to the NipSnap family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Protein NipSnap homolog 2
PRO_0000221148

Amino acid modifications

Modified residue1481N6-acetyllysine Ref.7

Experimental info

Sequence conflict9 – 168RGAAWAGG → AEALGRR in CAA04633. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O75323 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7ED85297E4DC9D08

FASTA28633,743
        10         20         30         40         50         60 
MAARVLRARG AAWAGGLLQR AAPCSLLPRL RTWTSSSNRS REDSWLKSLF VRKVDPRKDA 

        70         80         90        100        110        120 
HSNLLAKKET SNLYKLQFHN VKPECLEAYN KICQEVLPKI HEDKHYPCTL VGTWNTWYGE 

       130        140        150        160        170        180 
QDQAVHLWRY EGGYPALTEV MNKLRENKEF LEFRKARSDM LLSRKNQLLL EFSFWNEPVP 

       190        200        210        220        230        240 
RSGPNIYELR SYQLRPGTMI EWGNYWARAI RFRQDGNEAV GGFFSQIGQL YMVHHLWAYR 

       250        260        270        280 
DLQTREDIRN AAWHKHGWEE LVYYTVPLIQ EMESRIMIPL KTSPLQ 

« Hide

References

« Hide 'large scale' references
[1]"GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR."
Wang X.-Y., Smith D.I., Liu W., James C.D.
Genomics 49:448-451(1998) [PubMed: 9615231] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family."
Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.
Gene 212:13-20(1998) [PubMed: 9661659] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Lung.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148, MASS SPECTROMETRY.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF029786 mRNA. Translation: AAC29002.1.
AJ001259 mRNA. Translation: CAA04633.1.
BT007112 mRNA. Translation: AAP35776.1.
CR407612 mRNA. Translation: CAG28540.1.
CH471140 Genomic DNA. Translation: EAX07967.1.
BC000732 mRNA. Translation: AAH00732.1.
BC001837 mRNA. Translation: AAH01837.1.
BC030821 mRNA. Translation: AAH30821.1.
IPIIPI00016077.
RefSeqNP_001189398.1. NM_001202469.1.
NP_001474.1. NM_001483.2.
UniGeneHs.591069.

3D structure databases

ProteinModelPortalO75323.
SMRO75323. Positions 182-286.
ModBaseSearch...

Protein-protein interaction databases

IntActO75323. 36 interactions.
MINTMINT-5003890.
STRINGO75323.

PTM databases

PhosphoSiteO75323.

2D gel databases

UCD-2DPAGEO75323.

Proteomic databases

PeptideAtlasO75323.
PRIDEO75323.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322090; ENSP00000313050; ENSG00000146729.
GeneID2631.
KEGGhsa:2631.
UCSCuc003tre.1. human.

Organism-specific databases

CTD2631.
GeneCardsGC07P055999.
HGNCHGNC:4179. GBAS.
MIM603004. gene.
neXtProtNX_O75323.
PharmGKBPA28593.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG05994.
GeneTreeENSGT00530000063035.
HOGENOMHBG444280.
HOVERGENHBG052627.
InParanoidO75323.
OMAFRQDGNE.
PhylomeDBO75323.

Gene expression databases

ArrayExpressO75323.
BgeeO75323.
CleanExHS_GBAS.
GenevestigatorO75323.
GermOnlineENSG00000146729. Homo sapiens.

Family and domain databases

InterProIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamPF07978. NIPSNAP. 1 hit.
[Graphical view]
SUPFAMSSF54909. Dimer_A_B_barrel. 2 hits.
ProtoNetSearch...

Other

NextBio10372.
SOURCESearch...

Entry information

Entry nameNIPS2_HUMAN
AccessionPrimary (citable) accession number: O75323
Secondary accession number(s): O43801, Q53X96
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families