Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA/RNP complex-1-interacting phosphatase

Gene

DUSP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.3 Publications

Caution

It is uncertain whether Met-1 or Met-48 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei199Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1 Publication1
Active sitei205Proton donor/acceptorSequence analysis1

GO - Molecular functioni

  • nucleotide phosphatase activity, acting on free nucleotides Source: UniProtKB
  • phosphatase activity Source: UniProtKB
  • polynucleotide 5'-phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • polynucleotide 5' dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • RNA metabolic process Source: UniProtKB
  • RNA processing Source: ProtInc

Keywordsi

Molecular functionHydrolase, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
Gene namesi
Name:DUSP11
Synonyms:PIR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144048.10
HGNCiHGNC:3066 DUSP11
MIMi603092 gene
neXtProtiNX_O75319

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi166H → G: No effect on phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi199C → S: Loss of activity. No effect in RNA-binding. 3 Publications1
Mutagenesisi201H → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi204N → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi239R → K: Slightly decreases phosphatase activity with ATP. Strongly decreases phosphatase activity with ADP. 1 Publication1

Organism-specific databases

DisGeNETi8446
OpenTargetsiENSG00000144048
PharmGKBiPA27521

Polymorphism and mutation databases

BioMutaiDUSP11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948161 – 377RNA/RNP complex-1-interacting phosphataseAdd BLAST377

Proteomic databases

EPDiO75319
MaxQBiO75319
PaxDbiO75319
PeptideAtlasiO75319
PRIDEiO75319
ProteomicsDBi49891
49892 [O75319-2]

PTM databases

DEPODiO75319
iPTMnetiO75319
PhosphoSitePlusiO75319

Expressioni

Gene expression databases

BgeeiENSG00000144048
CleanExiHS_DUSP11
ExpressionAtlasiO75319 baseline and differential
GenevisibleiO75319 HS

Organism-specific databases

HPAiHPA021052

Interactioni

Subunit structurei

Monomer (PubMed:24531476). May interact with SFRS7 and SFRS9/SRP30C (PubMed:24447265).2 Publications

Protein-protein interaction databases

BioGridi114024, 53 interactors
IntActiO75319, 5 interactors
STRINGi9606.ENSP00000272444

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi82 – 84Combined sources3
Beta strandi95 – 100Combined sources6
Helixi106 – 111Combined sources6
Helixi114 – 116Combined sources3
Helixi120 – 129Combined sources10
Beta strandi134 – 139Combined sources6
Helixi149 – 151Combined sources3
Beta strandi158 – 160Combined sources3
Beta strandi165 – 167Combined sources3
Helixi171 – 186Combined sources16
Beta strandi194 – 198Combined sources5
Beta strandi200 – 203Combined sources4
Helixi204 – 218Combined sources15
Helixi222 – 233Combined sources12
Helixi240 – 248Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JMJX-ray2.38A75-255[»]
4MBBX-ray1.85A76-254[»]
4NYHX-ray1.20A/B/C76-252[»]
ProteinModelPortaliO75319
SMRiO75319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 244Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 205Substrate binding1 Publication6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00530000063473
HOGENOMiHOG000112295
HOVERGENiHBG051420
InParanoidiO75319
KOiK14165
OrthoDBiEOG091G0HD0
PhylomeDBiO75319
TreeFamiTF105124

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75319-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRNSETLERG VGGCRVFSCL GSYPGIEGAG LALLADLALG GRLLGTHMSQ
60 70 80 90 100
WHHPRSGWGR RRDFSGRSSA KKKGGNHIPE RWKDYLPVGQ RMPGTRFIAF
110 120 130 140 150
KVPLQKSFEK KLAPEECFSP LDLFNKIREQ NEELGLIIDL TYTQRYYKPE
160 170 180 190 200
DLPETVPYLK IFTVGHQVPD DETIFKFKHA VNGFLKENKD NDKLIGVHCT
210 220 230 240 250
HGLNRTGYLI CRYLIDVEGV RPDDAIELFN RCRGHCLERQ NYIEDLQNGP
260 270 280 290 300
IRKNWNSSVP RSSDFEDSAH LMQPVHNKPV KQGPRYNLHQ IQGHSAPRHF
310 320 330 340 350
HTQTQSLQQS VRKFSENPHV YQRHHLPPPG PPGEDYSHRR YSWNVKPNAS
360 370
RAAQDRRRWY PYNYSRLSYP ACWEWTQ
Length:377
Mass (Da):43,710
Last modified:March 28, 2018 - v2
Checksum:i61002BD1E2B06A5D
GO
Isoform 2 (identifier: O75319-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-273: YLIDVEGVRP...DFEDSAHLMQ → RSLALSPRLE...IFSRDVVSPC
     274-377: Missing.

Show »
Length:273
Mass (Da):30,590
Checksum:i373A30BA85C828F2
GO

Sequence cautioni

The sequence AAC39925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH00346 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → W in AAC39925 (PubMed:9685386).Curated1
Sequence conflicti36D → G in CAH10467 (PubMed:17974005).Curated1
Sequence conflicti36D → G in AAC39925 (PubMed:9685386).Curated1
Sequence conflicti36D → G in BAG37685 (PubMed:14702039).Curated1
Sequence conflicti36D → G in AAH00346 (PubMed:15489334).Curated1
Sequence conflicti212R → I in AAH00346 (PubMed:15489334).Curated1
Isoform 2 (identifier: O75319-2)
Sequence conflicti215L → R in CAH10467 (PubMed:17974005).1
Sequence conflicti237G → S in CAH10467 (PubMed:17974005).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014136213 – 273YLIDV…AHLMQ → RSLALSPRLECSGTISTHSK FCFPGSRRSPASASQVAGTT GARHHARLIFCIFSRDVVSP C in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014137274 – 377Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR627368 mRNA Translation: CAH10467.1
AC092653 Genomic DNA No translation available.
AF023917 mRNA Translation: AAC39925.1 Different initiation.
AK315271 mRNA Translation: BAG37685.1 Different initiation.
BC000346 mRNA Translation: AAH00346.1 Different initiation.
CCDSiCCDS1928.2 [O75319-1]
RefSeqiNP_003575.2, NM_003584.2 [O75319-1]
UniGeneiHs.14611

Genome annotation databases

EnsembliENST00000272444; ENSP00000272444; ENSG00000144048 [O75319-1]
ENST00000443070; ENSP00000413444; ENSG00000144048 [O75319-2]
GeneIDi8446
KEGGihsa:8446
UCSCiuc002sjp.4 human [O75319-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDUS11_HUMAN
AccessioniPrimary (citable) accession number: O75319
Secondary accession number(s): B2RCT8
, C9JYA6, Q6AI47, Q9BWE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health