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Protein

RNA/RNP complex-1-interacting phosphatase

Gene

DUSP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1 Publication1
Active sitei158Proton donor/acceptorSequence analysis1

GO - Molecular functioni

  • nucleotide phosphatase activity, acting on free nucleotides Source: UniProtKB
  • phosphatase activity Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • polynucleotide 5'-phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • polynucleotide 5' dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • RNA metabolic process Source: UniProtKB
  • RNA processing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
Gene namesi
Name:DUSP11
Synonyms:PIR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3066. DUSP11.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleus speckle 1 Publication

GO - Cellular componenti

  • nuclear speck Source: UniProtKB
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119H → G: No effect on phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi152C → S: Loss of activity. No effect in RNA-binding. 3 Publications1
Mutagenesisi154H → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi157N → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi192R → K: Slightly decreases phosphatase activity with ATP. Strongly decreases phosphatase activity with ADP. 1 Publication1

Organism-specific databases

DisGeNETi8446.
PharmGKBiPA27521.

Polymorphism and mutation databases

BioMutaiDUSP11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948161 – 330RNA/RNP complex-1-interacting phosphataseAdd BLAST330

Proteomic databases

EPDiO75319.
MaxQBiO75319.
PaxDbiO75319.
PeptideAtlasiO75319.
PRIDEiO75319.

PTM databases

DEPODiO75319.
iPTMnetiO75319.
PhosphoSitePlusiO75319.

Expressioni

Gene expression databases

BgeeiENSG00000144048.
CleanExiHS_DUSP11.
ExpressionAtlasiO75319. baseline and differential.
GenevisibleiO75319. HS.

Organism-specific databases

HPAiHPA056973.

Interactioni

Subunit structurei

Monomer (PubMed:24531476). May interact with SFRS7 and SFRS9/SRP30C (PubMed:24447265).2 Publications

Protein-protein interaction databases

BioGridi114024. 23 interactors.
IntActiO75319. 5 interactors.
MINTiMINT-1401557.
STRINGi9606.ENSP00000272444.

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 37Combined sources3
Beta strandi48 – 53Combined sources6
Helixi59 – 64Combined sources6
Helixi67 – 69Combined sources3
Helixi73 – 82Combined sources10
Beta strandi87 – 92Combined sources6
Helixi102 – 104Combined sources3
Beta strandi111 – 113Combined sources3
Beta strandi118 – 120Combined sources3
Helixi124 – 139Combined sources16
Beta strandi147 – 151Combined sources5
Beta strandi153 – 156Combined sources4
Helixi157 – 171Combined sources15
Helixi175 – 186Combined sources12
Helixi193 – 201Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JMJX-ray2.38A28-208[»]
4MBBX-ray1.85A29-207[»]
4NYHX-ray1.20A/B/C29-205[»]
ProteinModelPortaliO75319.
SMRiO75319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 197Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 158Substrate binding1 Publication6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
HOGENOMiHOG000112295.
HOVERGENiHBG051420.
InParanoidiO75319.
KOiK14165.
OrthoDBiEOG091G0HD0.
PhylomeDBiO75319.
TreeFamiTF105124.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75319-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQWHHPRSG WGRRRDFSGR SSAKKKGGNH IPERWKDYLP VGQRMPGTRF
60 70 80 90 100
IAFKVPLQKS FEKKLAPEEC FSPLDLFNKI REQNEELGLI IDLTYTQRYY
110 120 130 140 150
KPEDLPETVP YLKIFTVGHQ VPDDETIFKF KHAVNGFLKE NKDNDKLIGV
160 170 180 190 200
HCTHGLNRTG YLICRYLIDV EGVRPDDAIE LFNRCRGHCL ERQNYIEDLQ
210 220 230 240 250
NGPIRKNWNS SVPRSSDFED SAHLMQPVHN KPVKQGPRYN LHQIQGHSAP
260 270 280 290 300
RHFHTQTQSL QQSVRKFSEN PHVYQRHHLP PPGPPGEDYS HRRYSWNVKP
310 320 330
NASRAAQDRR RWYPYNYSRL SYPACWEWTQ
Length:330
Mass (Da):38,939
Last modified:November 1, 1998 - v1
Checksum:i0C397F43043B450A
GO
Isoform 2 (identifier: O75319-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-226: YLIDVEGVRP...DFEDSAHLMQ → RSRALSPRLE...IFSRDVVSPC
     227-330: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):25,892
Checksum:i04748C59187B7CDF
GO

Sequence cautioni

The sequence CAH10467 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165R → I in AAH00346 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014136166 – 226YLIDV…AHLMQ → RSRALSPRLECSGTISTHSK FCFPSSRRSPASASQVAGTT GARHHARLIFCIFSRDVVSP C in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014137227 – 330Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023917 mRNA. Translation: AAC39925.1.
AK315271 mRNA. Translation: BAG37685.1.
CR627368 mRNA. Translation: CAH10467.1. Different initiation.
AC092653 Genomic DNA. No translation available.
BC000346 mRNA. Translation: AAH00346.1.
RefSeqiNP_003575.2. NM_003584.2.
UniGeneiHs.14611.

Genome annotation databases

EnsembliENST00000272444; ENSP00000272444; ENSG00000144048.
GeneIDi8446.
KEGGihsa:8446.
UCSCiuc002sjp.4. human. [O75319-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023917 mRNA. Translation: AAC39925.1.
AK315271 mRNA. Translation: BAG37685.1.
CR627368 mRNA. Translation: CAH10467.1. Different initiation.
AC092653 Genomic DNA. No translation available.
BC000346 mRNA. Translation: AAH00346.1.
RefSeqiNP_003575.2. NM_003584.2.
UniGeneiHs.14611.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JMJX-ray2.38A28-208[»]
4MBBX-ray1.85A29-207[»]
4NYHX-ray1.20A/B/C29-205[»]
ProteinModelPortaliO75319.
SMRiO75319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114024. 23 interactors.
IntActiO75319. 5 interactors.
MINTiMINT-1401557.
STRINGi9606.ENSP00000272444.

PTM databases

DEPODiO75319.
iPTMnetiO75319.
PhosphoSitePlusiO75319.

Polymorphism and mutation databases

BioMutaiDUSP11.

Proteomic databases

EPDiO75319.
MaxQBiO75319.
PaxDbiO75319.
PeptideAtlasiO75319.
PRIDEiO75319.

Protocols and materials databases

DNASUi8446.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272444; ENSP00000272444; ENSG00000144048.
GeneIDi8446.
KEGGihsa:8446.
UCSCiuc002sjp.4. human. [O75319-1]

Organism-specific databases

CTDi8446.
DisGeNETi8446.
GeneCardsiDUSP11.
H-InvDBHIX0017827.
HGNCiHGNC:3066. DUSP11.
HPAiHPA056973.
MIMi603092. gene.
neXtProtiNX_O75319.
PharmGKBiPA27521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
HOGENOMiHOG000112295.
HOVERGENiHBG051420.
InParanoidiO75319.
KOiK14165.
OrthoDBiEOG091G0HD0.
PhylomeDBiO75319.
TreeFamiTF105124.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144048-MONOMER.

Miscellaneous databases

ChiTaRSiDUSP11. human.
GenomeRNAii8446.
PROiO75319.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144048.
CleanExiHS_DUSP11.
ExpressionAtlasiO75319. baseline and differential.
GenevisibleiO75319. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS11_HUMAN
AccessioniPrimary (citable) accession number: O75319
Secondary accession number(s): B2RCT8, Q6AI47, Q9BWE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.