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Protein

Zinc finger protein ZPR1

Gene

ZPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O2-induced neuronal cell death.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: Ensembl
  • translation initiation factor binding Source: UniProtKB
  • zinc ion binding Source: Ensembl

GO - Biological processi

  • apoptotic process involved in development Source: UniProtKB
  • axon development Source: UniProtKB
  • Cajal body organization Source: UniProtKB
  • cell proliferation Source: ProtInc
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • DNA endoreduplication Source: UniProtKB
  • inner cell mass cell proliferation Source: Ensembl
  • microtubule cytoskeleton organization Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of motor neuron apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of growth Source: UniProtKB
  • positive regulation of protein import into nucleus Source: UniProtKB
  • positive regulation of RNA splicing Source: UniProtKB
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  • pre-mRNA catabolic process Source: UniProtKB
  • regulation of myelination Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW
  • signal transduction Source: ProtInc
  • spinal cord development Source: UniProtKB
  • trophectodermal cell proliferation Source: UniProtKB

Keywordsi

Biological processDifferentiation, mRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZPR1
Alternative name(s):
Zinc finger protein 259
Gene namesi
Name:ZPR1
Synonyms:ZNF259
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109917.10
HGNCiHGNC:13051 ZPR1
MIMi603901 gene
neXtProtiNX_O75312

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8882
OpenTargetsiENSG00000109917
PharmGKBiPA37629

Polymorphism and mutation databases

BioMutaiZNF259

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190361 – 459Zinc finger protein ZPR1Add BLAST459

Proteomic databases

EPDiO75312
MaxQBiO75312
PaxDbiO75312
PeptideAtlasiO75312
PRIDEiO75312

PTM databases

iPTMnetiO75312
PhosphoSitePlusiO75312

Expressioni

Tissue specificityi

Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.1 Publication

Gene expression databases

BgeeiENSG00000109917
CleanExiHS_ZNF259
ExpressionAtlasiO75312 baseline and differential
GenevisibleiO75312 HS

Organism-specific databases

HPAiCAB022596
HPA030979

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and the EGFR kinase activity. May also bind to the PDGFR receptor.4 Publications

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: Ensembl
  • translation initiation factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114401, 72 interactors
IntActiO75312, 2 interactors
STRINGi9606.ENSP00000227322

Structurei

3D structure databases

ProteinModelPortaliO75312
SMRiO75312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZPR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2703 Eukaryota
COG1779 LUCA
GeneTreeiENSGT00390000005306
HOGENOMiHOG000216492
HOVERGENiHBG002608
InParanoidiO75312
KOiK06874
OMAiECNAPAQ
OrthoDBiEOG091G07KC
PhylomeDBiO75312
TreeFamiTF313084

Family and domain databases

InterProiView protein in InterPro
IPR004457 Znf_ZPR1
PfamiView protein in Pfam
PF03367 zf-ZPR1, 2 hits
SMARTiView protein in SMART
SM00709 Zpr1, 2 hits
TIGRFAMsiTIGR00310 ZPR1_znf, 2 hits

Sequencei

Sequence statusi: Complete.

O75312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGAVEPG PPGAAVAPSP APAPPPAPDH LFRPISAEDE EQQPTEIESL
60 70 80 90 100
CMNCYCNGMT RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG
110 120 130 140 150
VRYTLSVRAL EDMNREVVKT DSAATRIPEL DFEIPAFSQK GALTTVEGLI
160 170 180 190 200
TRAISGLEQD QPARRANKDA TAERIDEFIV KLKELKQVAS PFTLIIDDPS
210 220 230 240 250
GNSFVENPHA PQKDDALVIT HYNRTRQQEE MLGLQEEAPA EKPEEEDLRN
260 270 280 290 300
EVLQFSTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS
310 320 330 340 350
GGAVEPLGTR ITLHITDASD MTRDLLKSET CSVEIPELEF ELGMAVLGGK
360 370 380 390 400
FTTLEGLLKD IRELVTKNPF TLGDSSNPGQ TERLQEFSQK MDQIIEGNMK
410 420 430 440 450
AHFIMDDPAG NSYLQNVYAP EDDPEMKVER YKRTFDQNEE LGLNDMKTEG

YEAGLAPQR
Length:459
Mass (Da):50,925
Last modified:November 1, 1998 - v1
Checksum:iE3DB820F490F2835
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052999264A → V. Corresponds to variant dbSNP:rs35120633Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019767 mRNA Translation: AAC33514.1
BT006642 mRNA Translation: AAP35288.1
BC004256 mRNA Translation: AAH04256.1
BC012162 mRNA Translation: AAH12162.1
BC017349 mRNA Translation: AAH17349.1
BC017380 mRNA Translation: AAH17380.1
BC111028 mRNA Translation: AAI11029.1
CCDSiCCDS8375.1
RefSeqiNP_001304015.1, NM_001317086.1
NP_003895.1, NM_003904.4
UniGeneiHs.7165

Genome annotation databases

EnsembliENST00000227322; ENSP00000227322; ENSG00000109917
GeneIDi8882
KEGGihsa:8882
UCSCiuc001ppp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZPR1_HUMAN
AccessioniPrimary (citable) accession number: O75312
Secondary accession number(s): Q2TAA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health