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O75312

- ZPR1_HUMAN

UniProt

O75312 - ZPR1_HUMAN

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Protein
Zinc finger protein ZPR1
Gene
ZPR1, ZNF259
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O(2)-induced neuronal cell death.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri51 – 8333C4-type 1
Add
BLAST
Zinc fingeri259 – 29133C4-type 2
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. translation initiation factor binding Source: UniProtKB
  3. zinc ion binding Source: Ensembl

GO - Biological processi

  1. Cajal body organization Source: UniProtKB
  2. DNA endoreduplication Source: UniProtKB
  3. RNA splicing Source: UniProtKB-KW
  4. apoptotic process involved in development Source: UniProtKB
  5. axon development Source: UniProtKB
  6. cell proliferation Source: ProtInc
  7. cellular response to epidermal growth factor stimulus Source: UniProtKB
  8. mRNA processing Source: UniProtKB-KW
  9. microtubule cytoskeleton organization Source: UniProtKB
  10. negative regulation of motor neuron apoptotic process Source: UniProtKB
  11. positive regulation of RNA splicing Source: UniProtKB
  12. positive regulation of gene expression Source: UniProtKB
  13. positive regulation of growth Source: UniProtKB
  14. positive regulation of protein import into nucleus Source: UniProtKB
  15. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  16. pre-mRNA catabolic process Source: UniProtKB
  17. regulation of myelination Source: UniProtKB
  18. signal transduction Source: ProtInc
  19. spinal cord development Source: UniProtKB
  20. trophectodermal cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZPR1
Alternative name(s):
Zinc finger protein 259
Gene namesi
Name:ZPR1
Synonyms:ZNF259
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13051. ZPR1.

Subcellular locationi

Nucleus. Nucleusnucleolus. Nucleusgem. NucleusCajal body. Cytoplasmperinuclear region. Cytoplasm. Cell projectionaxon By similarity. Cell projectiongrowth cone By similarity
Note: Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons By similarity. Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner.5 Publications

GO - Cellular componenti

  1. Cajal body Source: UniProtKB
  2. Gemini of coiled bodies Source: UniProtKB
  3. SMN complex Source: UniProtKB
  4. axon Source: UniProtKB
  5. cytoplasm Source: UniProtKB
  6. growth cone Source: UniProtKB
  7. neuronal cell body Source: UniProtKB
  8. nucleolus Source: UniProtKB
  9. nucleoplasm Source: UniProtKB
  10. nucleus Source: UniProtKB
  11. perikaryon Source: UniProtKB
  12. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Zinc finger protein ZPR1
PRO_0000119036Add
BLAST

Proteomic databases

MaxQBiO75312.
PaxDbiO75312.
PRIDEiO75312.

PTM databases

PhosphoSiteiO75312.

Expressioni

Tissue specificityi

Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.1 Publication

Gene expression databases

ArrayExpressiO75312.
BgeeiO75312.
CleanExiHS_ZNF259.
GenevestigatoriO75312.

Organism-specific databases

HPAiCAB022596.

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and the EGFR kinase activity. May also bind to the PDGFR receptor.4 Publications

Protein-protein interaction databases

BioGridi114401. 64 interactions.
IntActiO75312. 2 interactions.
MINTiMINT-1371628.
STRINGi9606.ENSP00000227322.

Structurei

3D structure databases

ProteinModelPortaliO75312.
SMRiO75312. Positions 47-440.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZPR1 family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1779.
HOGENOMiHOG000216492.
HOVERGENiHBG002608.
InParanoidiO75312.
KOiK06874.
OMAiFIMNDPA.
PhylomeDBiO75312.
TreeFamiTF313084.

Family and domain databases

InterProiIPR004457. Znf_ZPR1.
[Graphical view]
PfamiPF03367. zf-ZPR1. 2 hits.
[Graphical view]
SMARTiSM00709. Zpr1. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00310. ZPR1_znf. 2 hits.

Sequencei

Sequence statusi: Complete.

O75312-1 [UniParc]FASTAAdd to Basket

« Hide

MAASGAVEPG PPGAAVAPSP APAPPPAPDH LFRPISAEDE EQQPTEIESL    50
CMNCYCNGMT RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG 100
VRYTLSVRAL EDMNREVVKT DSAATRIPEL DFEIPAFSQK GALTTVEGLI 150
TRAISGLEQD QPARRANKDA TAERIDEFIV KLKELKQVAS PFTLIIDDPS 200
GNSFVENPHA PQKDDALVIT HYNRTRQQEE MLGLQEEAPA EKPEEEDLRN 250
EVLQFSTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS 300
GGAVEPLGTR ITLHITDASD MTRDLLKSET CSVEIPELEF ELGMAVLGGK 350
FTTLEGLLKD IRELVTKNPF TLGDSSNPGQ TERLQEFSQK MDQIIEGNMK 400
AHFIMDDPAG NSYLQNVYAP EDDPEMKVER YKRTFDQNEE LGLNDMKTEG 450
YEAGLAPQR 459
Length:459
Mass (Da):50,925
Last modified:November 1, 1998 - v1
Checksum:iE3DB820F490F2835
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti264 – 2641A → V.
Corresponds to variant rs35120633 [ dbSNP | Ensembl ].
VAR_052999

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019767 mRNA. Translation: AAC33514.1.
BT006642 mRNA. Translation: AAP35288.1.
BC004256 mRNA. Translation: AAH04256.1.
BC012162 mRNA. Translation: AAH12162.1.
BC017349 mRNA. Translation: AAH17349.1.
BC017380 mRNA. Translation: AAH17380.1.
BC111028 mRNA. Translation: AAI11029.1.
CCDSiCCDS8375.1.
RefSeqiNP_003895.1. NM_003904.3.
UniGeneiHs.7165.

Genome annotation databases

EnsembliENST00000227322; ENSP00000227322; ENSG00000109917.
GeneIDi8882.
KEGGihsa:8882.
UCSCiuc001ppp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019767 mRNA. Translation: AAC33514.1 .
BT006642 mRNA. Translation: AAP35288.1 .
BC004256 mRNA. Translation: AAH04256.1 .
BC012162 mRNA. Translation: AAH12162.1 .
BC017349 mRNA. Translation: AAH17349.1 .
BC017380 mRNA. Translation: AAH17380.1 .
BC111028 mRNA. Translation: AAI11029.1 .
CCDSi CCDS8375.1.
RefSeqi NP_003895.1. NM_003904.3.
UniGenei Hs.7165.

3D structure databases

ProteinModelPortali O75312.
SMRi O75312. Positions 47-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114401. 64 interactions.
IntActi O75312. 2 interactions.
MINTi MINT-1371628.
STRINGi 9606.ENSP00000227322.

PTM databases

PhosphoSitei O75312.

Proteomic databases

MaxQBi O75312.
PaxDbi O75312.
PRIDEi O75312.

Protocols and materials databases

DNASUi 8882.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227322 ; ENSP00000227322 ; ENSG00000109917 .
GeneIDi 8882.
KEGGi hsa:8882.
UCSCi uc001ppp.3. human.

Organism-specific databases

CTDi 8882.
GeneCardsi GC11M116648.
HGNCi HGNC:13051. ZPR1.
HPAi CAB022596.
MIMi 603901. gene.
neXtProti NX_O75312.
PharmGKBi PA37629.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1779.
HOGENOMi HOG000216492.
HOVERGENi HBG002608.
InParanoidi O75312.
KOi K06874.
OMAi FIMNDPA.
PhylomeDBi O75312.
TreeFami TF313084.

Miscellaneous databases

GeneWikii ZNF259.
GenomeRNAii 8882.
NextBioi 33353.
PROi O75312.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75312.
Bgeei O75312.
CleanExi HS_ZNF259.
Genevestigatori O75312.

Family and domain databases

InterProi IPR004457. Znf_ZPR1.
[Graphical view ]
Pfami PF03367. zf-ZPR1. 2 hits.
[Graphical view ]
SMARTi SM00709. Zpr1. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00310. ZPR1_znf. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells."
    Gangwani L., Mikrut M., Galcheva-Gargova Z., Davis R.J.
    J. Cell Biol. 143:1471-1484(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EEF1A1.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Pancreas and Skin.
  4. "Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor."
    Galcheva-Gargova Z., Konstantinov K.N., Wu I.-H., Klier F.G., Barrett T., Davis R.J.
    Science 272:1797-1802(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EGFR, SUBCELLULAR LOCATION.
  5. "The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells."
    Galcheva-Gargova Z., Gangwani L., Konstantinov K.N., Mikrut M., Theroux S.J., Enoch T., Davis R.J.
    Mol. Biol. Cell 9:2963-2971(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein."
    Gangwani L., Mikrut M., Theroux S., Sharma M., Davis R.J.
    Nat. Cell Biol. 3:376-383(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMN1, SUBCELLULAR LOCATION.
  7. "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta."
    Narayanan U., Ospina J.K., Frey M.R., Hebert M.D., Matera A.G.
    Hum. Mol. Genet. 11:1785-1795(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN AN IMPORT SNRNP COMPLEX.
  8. "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression."
    Gangwani L.
    J. Biol. Chem. 281:40330-40340(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy."
    Ahmad S., Wang Y., Shaik G.M., Burghes A.H., Gangwani L.
    Hum. Mol. Genet. 21:2745-2758(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiZPR1_HUMAN
AccessioniPrimary (citable) accession number: O75312
Secondary accession number(s): Q2TAA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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