SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75310

- UDB11_HUMAN

UniProt

O75310 - UDB11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UDP-glucuronosyltransferase 2B11
Gene
UGT2B11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. estrogen metabolic process Source: ProtInc
  2. xenobiotic metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B11 (EC:2.4.1.17)
Short name:
UDPGT 2B11
Gene namesi
Name:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12545. UGT2B11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 529508UDP-glucuronosyltransferase 2B11
PRO_0000036035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75310.
PRIDEiO75310.

PTM databases

PhosphoSiteiO75310.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiO75310.
CleanExiHS_UGT2B11.
GenevestigatoriO75310.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304507.

Structurei

3D structure databases

ProteinModelPortaliO75310.
SMRiO75310. Positions 285-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75310.
KOiK00699.
OMAiIPIVMSK.
OrthoDBiEOG7GBFWS.
PhylomeDBiO75310.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75310-1 [UniParc]FASTAAdd to Basket

« Hide

MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG    50
HEVTVLASSA SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI 100
RKDSFWLYFS QEQEILWELY DIFRNFCKDV VSNKKVMKKL QESRFDIVFA 150
DAVFPCGELL AALLNIRFVY SLRFTPGYTI ERHSGGLIFP PSYIPIVMSK 200
LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL GRPTTLFETM 250
GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG 300
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN 350
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP 400
DNIAHMKAKG AAVRLDFNTM SSTDLLNALK TVINDPLYKE NIMKLSRIQH 450
DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC 500
VATVIFIITK FCLFCFWKFA RKGKKGKRD 529
Length:529
Mass (Da):61,038
Last modified:November 1, 1998 - v1
Checksum:iCE4AC3C71CFC2AB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016492 mRNA. Translation: AAC27891.1.
BC069441 mRNA. Translation: AAH69441.1.
BC107059 mRNA. Translation: AAI07060.1.
BC107060 mRNA. Translation: AAI07061.1.
CCDSiCCDS3527.1.
PIRiJE0200.
RefSeqiNP_001064.1. NM_001073.1.
UniGeneiHs.339811.

Genome annotation databases

EnsembliENST00000446444; ENSP00000387683; ENSG00000213759.
GeneIDi10720.
KEGGihsa:10720.
UCSCiuc003heh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016492 mRNA. Translation: AAC27891.1 .
BC069441 mRNA. Translation: AAH69441.1 .
BC107059 mRNA. Translation: AAI07060.1 .
BC107060 mRNA. Translation: AAI07061.1 .
CCDSi CCDS3527.1.
PIRi JE0200.
RefSeqi NP_001064.1. NM_001073.1.
UniGenei Hs.339811.

3D structure databases

ProteinModelPortali O75310.
SMRi O75310. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000304507.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei O75310.

Proteomic databases

PaxDbi O75310.
PRIDEi O75310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000446444 ; ENSP00000387683 ; ENSG00000213759 .
GeneIDi 10720.
KEGGi hsa:10720.
UCSCi uc003heh.3. human.

Organism-specific databases

CTDi 10720.
GeneCardsi GC04M070051.
HGNCi HGNC:12545. UGT2B11.
MIMi 603064. gene.
neXtProti NX_O75310.
PharmGKBi PA37187.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi O75310.
KOi K00699.
OMAi IPIVMSK.
OrthoDBi EOG7GBFWS.
PhylomeDBi O75310.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 2681.
Reactomei REACT_6784. Glucuronidation.

Miscellaneous databases

GenomeRNAii 10720.
NextBioi 40697.
PROi O75310.
SOURCEi Search...

Gene expression databases

Bgeei O75310.
CleanExi HS_UGT2B11.
Genevestigatori O75310.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11."
    Beaulieu M., Levesque E., Hum D.W., Belanger A.
    Biochem. Biophys. Res. Commun. 248:44-50(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUDB11_HUMAN
AccessioniPrimary (citable) accession number: O75310
Secondary accession number(s): Q3KNV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi