Reviewed, UniProtKB/Swiss-Prot O75310 (UDB11_HUMAN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B11
      Short name=UDPGT 2B11
    EC=2.4.1.17

Gene names

Name:

UGT2B11

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	estrogen metabolic process Traceable author statement. Source: ProtInc xenobiotic metabolic process Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 529	508	UDP-glucuronosyltransferase 2B11		PRO_0000036035
Regions
	Transmembrane	493 – 513	21	Potential
Amino acid modifications
	Glycosylation	315	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O75310-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: CE4AC3C71CFC2AB4	FASTA	529	61,038
	10 20 30 40 50 60 MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA 70 80 90 100 110 120 SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY 130 140 150 160 170 180 DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI 190 200 210 220 230 240 ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL 250 260 270 280 290 300 GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM 430 440 450 460 470 480 SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11." Beaulieu M., Levesque E., Hum D.W., Belanger A. Biochem. Biophys. Res. Commun. 248:44-50(1998) [PubMed: 9675083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF016492 mRNA. Translation: AAC27891.1. BC069441 mRNA. Translation: AAH69441.1. BC107059 mRNA. Translation: AAI07060.1. BC107060 mRNA. Translation: AAI07061.1.
IPI	IPI00025242.
PIR	JE0200.
RefSeq	NP_001064.1.
UniGene	Hs.339811
3D structure databases
SMR	O75310. Positions 285-451.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	O75310.
Genome annotation databases
Ensembl	ENSG00000213759. Homo sapiens. [Contig view]
GeneID	10720.
KEGG	hsa:10720.
UCSC	uc003heh.1. human.
Organism-specific databases
GeneCards	GC04M069905.
H-InvDB	HIX0031356. HIX0031374. HIX0057472. HIX0057473.
HGNC	HGNC:12545. UGT2B11.
MIM	603064. gene.
PharmGKB	PA37187.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O75310.
HOVERGEN	O75310.
OMA	O75310. ELYDIFR.
Enzyme and pathway databases
BRENDA	2.4.1.17. 247.
Reactome	REACT_13433. Biological oxidations.
Gene expression databases
Bgee	O75310.
CleanEx	HS_UGT2B11.
GermOnline	ENSG00000198277. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40697.
SOURCE	Search...

Entry information

Entry name

UDB11_HUMAN

Accession

Primary (citable) accession number: O75310
Secondary accession number(s): Q3KNV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1998
Last modified:	July 7, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)