Reviewed,
UniProtKB/Swiss-Prot O75310 (UDB11_HUMAN)
Last modified
July 7, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 2B11 Short name=UDPGT 2B11 EC=2.4.1.17 | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 529 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. |
| Tissue specificity | Widely expressed. |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Domain | Signal Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | estrogen metabolic process Traceable author statement. Source: ProtInc xenobiotic metabolic processTraceable author statement. Source: ProtInc |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW microsomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11." Beaulieu M., Levesque E., Hum D.W., Belanger A. Biochem. Biophys. Res. Commun. 248:44-50(1998) [PubMed: 9675083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| AF016492 mRNA. Translation: AAC27891.1. BC069441 mRNA. Translation: AAH69441.1. BC107059 mRNA. Translation: AAI07060.1. BC107060 mRNA. Translation: AAI07061.1. | |
| IPI | IPI00025242. |
| PIR | JE0200. |
| RefSeq | NP_001064.1. |
| UniGene | Hs.339811 |
3D structure databases | |
| SMR | O75310. Positions 285-451. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
Proteomic databases | |
| PRIDE | O75310. |
Genome annotation databases | |
| Ensembl | ENSG00000213759. Homo sapiens. [Contig view] |
| GeneID | 10720. |
| KEGG | hsa:10720. |
| UCSC | uc003heh.1. human. |
Organism-specific databases | |
| GeneCards | GC04M069905. |
| H-InvDB | HIX0031356. HIX0031374. HIX0057472. HIX0057473. |
| HGNC | HGNC:12545. UGT2B11. |
| MIM | 603064. gene. |
| PharmGKB | PA37187. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O75310. |
| HOVERGEN | O75310. |
| OMA | O75310. ELYDIFR. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.17. 247. |
| Reactome | REACT_13433. Biological oxidations. |
Gene expression databases | |
| Bgee | O75310. |
| CleanEx | HS_UGT2B11. |
| GermOnline | ENSG00000198277. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 40697. |
| SOURCE | Search... |
Entry information
| Entry name | UDB11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O75310 Secondary accession number(s): Q3KNV9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


