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Protein

UDP-glucuronosyltransferase 2B11

Gene

UGT2B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: GO_Central

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. estrogen metabolic process Source: ProtInc
  3. flavonoid biosynthetic process Source: GO_Central
  4. flavonoid glucuronidation Source: GO_Central
  5. xenobiotic metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B11 (EC:2.4.1.17)
Short name:
UDPGT 2B11
Gene namesi
Name:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12545. UGT2B11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 529508UDP-glucuronosyltransferase 2B11PRO_0000036035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75310.
PRIDEiO75310.

PTM databases

PhosphoSiteiO75310.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiO75310.
CleanExiHS_UGT2B11.
ExpressionAtlasiO75310. baseline.
GenevestigatoriO75310.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304507.

Structurei

3D structure databases

ProteinModelPortaliO75310.
SMRiO75310. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75310.
KOiK00699.
OMAiIPIVMSK.
OrthoDBiEOG7GBFWS.
PhylomeDBiO75310.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG
60 70 80 90 100
HEVTVLASSA SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI
110 120 130 140 150
RKDSFWLYFS QEQEILWELY DIFRNFCKDV VSNKKVMKKL QESRFDIVFA
160 170 180 190 200
DAVFPCGELL AALLNIRFVY SLRFTPGYTI ERHSGGLIFP PSYIPIVMSK
210 220 230 240 250
LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL GRPTTLFETM
260 270 280 290 300
GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP
410 420 430 440 450
DNIAHMKAKG AAVRLDFNTM SSTDLLNALK TVINDPLYKE NIMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIITK FCLFCFWKFA RKGKKGKRD
Length:529
Mass (Da):61,038
Last modified:October 31, 1998 - v1
Checksum:iCE4AC3C71CFC2AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016492 mRNA. Translation: AAC27891.1.
BC069441 mRNA. Translation: AAH69441.1.
BC107059 mRNA. Translation: AAI07060.1.
BC107060 mRNA. Translation: AAI07061.1.
CCDSiCCDS3527.1.
PIRiJE0200.
RefSeqiNP_001064.1. NM_001073.1.
UniGeneiHs.339811.

Genome annotation databases

EnsembliENST00000446444; ENSP00000387683; ENSG00000213759.
ENST00000615638; ENSP00000477842; ENSG00000213759.
GeneIDi10720.
KEGGihsa:10720.
UCSCiuc003heh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016492 mRNA. Translation: AAC27891.1.
BC069441 mRNA. Translation: AAH69441.1.
BC107059 mRNA. Translation: AAI07060.1.
BC107060 mRNA. Translation: AAI07061.1.
CCDSiCCDS3527.1.
PIRiJE0200.
RefSeqiNP_001064.1. NM_001073.1.
UniGeneiHs.339811.

3D structure databases

ProteinModelPortaliO75310.
SMRiO75310. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304507.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiO75310.

Proteomic databases

PaxDbiO75310.
PRIDEiO75310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446444; ENSP00000387683; ENSG00000213759.
ENST00000615638; ENSP00000477842; ENSG00000213759.
GeneIDi10720.
KEGGihsa:10720.
UCSCiuc003heh.3. human.

Organism-specific databases

CTDi10720.
GeneCardsiGC04M070051.
HGNCiHGNC:12545. UGT2B11.
HPAiHPA045108.
MIMi603064. gene.
neXtProtiNX_O75310.
PharmGKBiPA37187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75310.
KOiK00699.
OMAiIPIVMSK.
OrthoDBiEOG7GBFWS.
PhylomeDBiO75310.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Miscellaneous databases

GenomeRNAii10720.
NextBioi40697.
PROiO75310.
SOURCEiSearch...

Gene expression databases

BgeeiO75310.
CleanExiHS_UGT2B11.
ExpressionAtlasiO75310. baseline.
GenevestigatoriO75310.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11."
    Beaulieu M., Levesque E., Hum D.W., Belanger A.
    Biochem. Biophys. Res. Commun. 248:44-50(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUDB11_HUMAN
AccessioniPrimary (citable) accession number: O75310
Secondary accession number(s): Q3KNV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 31, 1998
Last modified: March 3, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.