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O75310 (UDB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B11

Short name=UDPGT 2B11
EC=2.4.1.17
Gene names
Name:UGT2B11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 529508UDP-glucuronosyltransferase 2B11
PRO_0000036035

Regions

Transmembrane493 – 51321Helical; Potential

Amino acid modifications

Glycosylation3151N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O75310 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CE4AC3C71CFC2AB4

FASTA52961,038
        10         20         30         40         50         60 
MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA 

        70         80         90        100        110        120 
SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY 

       130        140        150        160        170        180 
DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI 

       190        200        210        220        230        240 
ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL 

       250        260        270        280        290        300 
GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM 

       430        440        450        460        470        480 
SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA 

       490        500        510        520 
HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11."
Beaulieu M., Levesque E., Hum D.W., Belanger A.
Biochem. Biophys. Res. Commun. 248:44-50(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016492 mRNA. Translation: AAC27891.1.
BC069441 mRNA. Translation: AAH69441.1.
BC107059 mRNA. Translation: AAI07060.1.
BC107060 mRNA. Translation: AAI07061.1.
CCDSCCDS3527.1.
PIRJE0200.
RefSeqNP_001064.1. NM_001073.1.
UniGeneHs.339811.

3D structure databases

ProteinModelPortalO75310.
SMRO75310. Positions 285-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000304507.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteO75310.

Proteomic databases

PaxDbO75310.
PRIDEO75310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000446444; ENSP00000387683; ENSG00000213759.
GeneID10720.
KEGGhsa:10720.
UCSCuc003heh.3. human.

Organism-specific databases

CTD10720.
GeneCardsGC04M070051.
HGNCHGNC:12545. UGT2B11.
MIM603064. gene.
neXtProtNX_O75310.
PharmGKBPA37187.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidO75310.
KOK00699.
OMAIPIVMSK.
OrthoDBEOG7GBFWS.
PhylomeDBO75310.
TreeFamTF315472.

Enzyme and pathway databases

BRENDA2.4.1.17. 2681.
ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeO75310.
CleanExHS_UGT2B11.
GenevestigatorO75310.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10720.
NextBio40697.
PROO75310.
SOURCESearch...

Entry information

Entry nameUDB11_HUMAN
AccessionPrimary (citable) accession number: O75310
Secondary accession number(s): Q3KNV9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM