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O75309

- CAD16_HUMAN

UniProt

O75309 - CAD16_HUMAN

Protein

Cadherin-16

Gene

CDH16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-16
    Alternative name(s):
    Kidney-specific cadherin
    Short name:
    Ksp-cadherin
    Gene namesi
    Name:CDH16
    ORF Names:UNQ695/PRO1340
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1755. CDH16.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26289.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 829811Cadherin-16PRO_0000003809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi722 – 7221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO75309.
    PRIDEiO75309.

    PTM databases

    PhosphoSiteiO75309.

    Expressioni

    Tissue specificityi

    Kidney specific.

    Gene expression databases

    ArrayExpressiO75309.
    BgeeiO75309.
    CleanExiHS_CDH16.
    GenevestigatoriO75309.

    Organism-specific databases

    HPAiCAB013526.
    HPA036260.

    Interactioni

    Protein-protein interaction databases

    BioGridi107449. 3 interactions.
    IntActiO75309. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO75309.
    SMRiO75309. Positions 27-747.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 786768ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini808 – 82922CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei787 – 80721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 126102Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini131 – 235105Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini242 – 33695Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini341 – 449109Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 564110Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini569 – 66597Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni666 – 786121Ectodomain GAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259000.
    HOGENOMiHOG000231613.
    HOVERGENiHBG050766.
    InParanoidiO75309.
    KOiK06810.
    OMAiRLMDFAI.
    OrthoDBiEOG7Z3F4D.
    PhylomeDBiO75309.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75309-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG    50
    AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM 100
    QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA 150
    SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD 200
    HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL 250
    KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA 300
    EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP 350
    PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV 400
    TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI 450
    TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG 500
    LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT 550
    VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL 600
    VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA 650
    PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG 700
    PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA 750
    QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF 800
    LILIFTHWTM SRKKDPDQPA DSVPLKATV 829
    Length:829
    Mass (Da):89,923
    Last modified:November 1, 1998 - v1
    Checksum:i41966915E4BFC891
    GO
    Isoform 2 (identifier: O75309-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         642-663: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:807
    Mass (Da):87,614
    Checksum:iB41914FE7B643744
    GO
    Isoform 3 (identifier: O75309-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-217: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:732
    Mass (Da):79,196
    Checksum:i7A91F3743DD857BF
    GO
    Isoform 4 (identifier: O75309-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         642-680: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:790
    Mass (Da):85,774
    Checksum:iF4F26806CF6FE2EA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911L → F.
    Corresponds to variant rs2271024 [ dbSNP | Ensembl ].
    VAR_021870
    Natural varianti257 – 2571H → Y.
    Corresponds to variant rs2271023 [ dbSNP | Ensembl ].
    VAR_021871
    Natural varianti717 – 7171R → H.
    Corresponds to variant rs34621310 [ dbSNP | Ensembl ].
    VAR_061058

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei121 – 21797Missing in isoform 3. 1 PublicationVSP_046027Add
    BLAST
    Alternative sequencei642 – 68039Missing in isoform 4. 1 PublicationVSP_046467Add
    BLAST
    Alternative sequencei642 – 66322Missing in isoform 2. 1 PublicationVSP_013354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016272 mRNA. Translation: AAC34255.1.
    AY358911 mRNA. Translation: AAQ89270.1.
    AK225544 mRNA. No translation available.
    AK298255 mRNA. Translation: BAG60520.1.
    AC009084 Genomic DNA. No translation available.
    BC027912 mRNA. Translation: AAH27912.1.
    CCDSiCCDS10823.1. [O75309-1]
    CCDS56002.1. [O75309-2]
    CCDS58471.1. [O75309-4]
    CCDS58472.1. [O75309-3]
    RefSeqiNP_001191673.1. NM_001204744.1. [O75309-2]
    NP_001191674.1. NM_001204745.1. [O75309-4]
    NP_001191675.1. NM_001204746.1. [O75309-3]
    NP_004053.1. NM_004062.3. [O75309-1]
    XP_005255825.1. XM_005255768.2. [O75309-1]
    UniGeneiHs.513660.

    Genome annotation databases

    EnsembliENST00000299752; ENSP00000299752; ENSG00000166589. [O75309-1]
    ENST00000394055; ENSP00000377619; ENSG00000166589. [O75309-2]
    ENST00000565796; ENSP00000454784; ENSG00000166589. [O75309-4]
    ENST00000568632; ENSP00000455263; ENSG00000166589. [O75309-3]
    GeneIDi1014.
    KEGGihsa:1014.
    UCSCiuc002eql.3. human. [O75309-1]
    uc010cdy.3. human. [O75309-2]
    uc021tjx.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016272 mRNA. Translation: AAC34255.1 .
    AY358911 mRNA. Translation: AAQ89270.1 .
    AK225544 mRNA. No translation available.
    AK298255 mRNA. Translation: BAG60520.1 .
    AC009084 Genomic DNA. No translation available.
    BC027912 mRNA. Translation: AAH27912.1 .
    CCDSi CCDS10823.1. [O75309-1 ]
    CCDS56002.1. [O75309-2 ]
    CCDS58471.1. [O75309-4 ]
    CCDS58472.1. [O75309-3 ]
    RefSeqi NP_001191673.1. NM_001204744.1. [O75309-2 ]
    NP_001191674.1. NM_001204745.1. [O75309-4 ]
    NP_001191675.1. NM_001204746.1. [O75309-3 ]
    NP_004053.1. NM_004062.3. [O75309-1 ]
    XP_005255825.1. XM_005255768.2. [O75309-1 ]
    UniGenei Hs.513660.

    3D structure databases

    ProteinModelPortali O75309.
    SMRi O75309. Positions 27-747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107449. 3 interactions.
    IntActi O75309. 2 interactions.

    PTM databases

    PhosphoSitei O75309.

    Proteomic databases

    PaxDbi O75309.
    PRIDEi O75309.

    Protocols and materials databases

    DNASUi 1014.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299752 ; ENSP00000299752 ; ENSG00000166589 . [O75309-1 ]
    ENST00000394055 ; ENSP00000377619 ; ENSG00000166589 . [O75309-2 ]
    ENST00000565796 ; ENSP00000454784 ; ENSG00000166589 . [O75309-4 ]
    ENST00000568632 ; ENSP00000455263 ; ENSG00000166589 . [O75309-3 ]
    GeneIDi 1014.
    KEGGi hsa:1014.
    UCSCi uc002eql.3. human. [O75309-1 ]
    uc010cdy.3. human. [O75309-2 ]
    uc021tjx.1. human.

    Organism-specific databases

    CTDi 1014.
    GeneCardsi GC16M066942.
    HGNCi HGNC:1755. CDH16.
    HPAi CAB013526.
    HPA036260.
    MIMi 603118. gene.
    neXtProti NX_O75309.
    PharmGKBi PA26289.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259000.
    HOGENOMi HOG000231613.
    HOVERGENi HBG050766.
    InParanoidi O75309.
    KOi K06810.
    OMAi RLMDFAI.
    OrthoDBi EOG7Z3F4D.
    PhylomeDBi O75309.
    TreeFami TF316817.

    Miscellaneous databases

    GeneWikii CDH16.
    GenomeRNAii 1014.
    NextBioi 4261.
    PROi O75309.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75309.
    Bgeei O75309.
    CleanExi HS_CDH16.
    Genevestigatori O75309.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
      Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
      Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Kidney.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Kidney.
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Spleen.

    Entry informationi

    Entry nameiCAD16_HUMAN
    AccessioniPrimary (citable) accession number: O75309
    Secondary accession number(s): B4DPA8, H3BPD3, Q6UW93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3