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O75309

- CAD16_HUMAN

UniProt

O75309 - CAD16_HUMAN

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Protein

Cadherin-16

Gene

CDH16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: Ensembl
  2. cell adhesion Source: ProtInc
  3. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:CDH16
ORF Names:UNQ695/PRO1340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1755. CDH16.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 829811Cadherin-16PRO_0000003809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi722 – 7221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75309.
PRIDEiO75309.

PTM databases

PhosphoSiteiO75309.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiO75309.
CleanExiHS_CDH16.
ExpressionAtlasiO75309. baseline and differential.
GenevestigatoriO75309.

Organism-specific databases

HPAiCAB013526.
HPA036260.

Interactioni

Protein-protein interaction databases

BioGridi107449. 3 interactions.
IntActiO75309. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO75309.
SMRiO75309. Positions 27-747.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 786768ExtracellularSequence AnalysisAdd
BLAST
Topological domaini808 – 82922CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei787 – 80721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 126102Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 235105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini242 – 33695Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini341 – 449109Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 564110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 66597Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni666 – 786121Ectodomain GAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259000.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO75309.
KOiK06810.
OMAiRLMDFAI.
OrthoDBiEOG7Z3F4D.
PhylomeDBiO75309.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75309-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG
60 70 80 90 100
AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM
110 120 130 140 150
QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA
160 170 180 190 200
SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD
210 220 230 240 250
HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL
260 270 280 290 300
KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
310 320 330 340 350
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP
360 370 380 390 400
PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV
410 420 430 440 450
TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI
460 470 480 490 500
TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG
510 520 530 540 550
LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT
560 570 580 590 600
VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
610 620 630 640 650
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA
660 670 680 690 700
PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG
710 720 730 740 750
PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA
760 770 780 790 800
QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF
810 820
LILIFTHWTM SRKKDPDQPA DSVPLKATV
Length:829
Mass (Da):89,923
Last modified:November 1, 1998 - v1
Checksum:i41966915E4BFC891
GO
Isoform 2 (identifier: O75309-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-663: Missing.

Note: No experimental confirmation available.

Show »
Length:807
Mass (Da):87,614
Checksum:iB41914FE7B643744
GO
Isoform 3 (identifier: O75309-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-217: Missing.

Note: No experimental confirmation available.

Show »
Length:732
Mass (Da):79,196
Checksum:i7A91F3743DD857BF
GO
Isoform 4 (identifier: O75309-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-680: Missing.

Note: No experimental confirmation available.

Show »
Length:790
Mass (Da):85,774
Checksum:iF4F26806CF6FE2EA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911L → F.
Corresponds to variant rs2271024 [ dbSNP | Ensembl ].
VAR_021870
Natural varianti257 – 2571H → Y.
Corresponds to variant rs2271023 [ dbSNP | Ensembl ].
VAR_021871
Natural varianti717 – 7171R → H.
Corresponds to variant rs34621310 [ dbSNP | Ensembl ].
VAR_061058

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 21797Missing in isoform 3. 1 PublicationVSP_046027Add
BLAST
Alternative sequencei642 – 68039Missing in isoform 4. 1 PublicationVSP_046467Add
BLAST
Alternative sequencei642 – 66322Missing in isoform 2. 1 PublicationVSP_013354Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016272 mRNA. Translation: AAC34255.1.
AY358911 mRNA. Translation: AAQ89270.1.
AK225544 mRNA. No translation available.
AK298255 mRNA. Translation: BAG60520.1.
AC009084 Genomic DNA. No translation available.
BC027912 mRNA. Translation: AAH27912.1.
CCDSiCCDS10823.1. [O75309-1]
CCDS56002.1. [O75309-2]
CCDS58471.1. [O75309-4]
CCDS58472.1. [O75309-3]
RefSeqiNP_001191673.1. NM_001204744.1. [O75309-2]
NP_001191674.1. NM_001204745.1. [O75309-4]
NP_001191675.1. NM_001204746.1. [O75309-3]
NP_004053.1. NM_004062.3. [O75309-1]
XP_005255825.1. XM_005255768.2. [O75309-1]
UniGeneiHs.513660.

Genome annotation databases

EnsembliENST00000299752; ENSP00000299752; ENSG00000166589. [O75309-1]
ENST00000394055; ENSP00000377619; ENSG00000166589. [O75309-2]
ENST00000565796; ENSP00000454784; ENSG00000166589. [O75309-4]
ENST00000568632; ENSP00000455263; ENSG00000166589. [O75309-3]
GeneIDi1014.
KEGGihsa:1014.
UCSCiuc002eql.3. human. [O75309-1]
uc010cdy.3. human. [O75309-2]
uc021tjx.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016272 mRNA. Translation: AAC34255.1 .
AY358911 mRNA. Translation: AAQ89270.1 .
AK225544 mRNA. No translation available.
AK298255 mRNA. Translation: BAG60520.1 .
AC009084 Genomic DNA. No translation available.
BC027912 mRNA. Translation: AAH27912.1 .
CCDSi CCDS10823.1. [O75309-1 ]
CCDS56002.1. [O75309-2 ]
CCDS58471.1. [O75309-4 ]
CCDS58472.1. [O75309-3 ]
RefSeqi NP_001191673.1. NM_001204744.1. [O75309-2 ]
NP_001191674.1. NM_001204745.1. [O75309-4 ]
NP_001191675.1. NM_001204746.1. [O75309-3 ]
NP_004053.1. NM_004062.3. [O75309-1 ]
XP_005255825.1. XM_005255768.2. [O75309-1 ]
UniGenei Hs.513660.

3D structure databases

ProteinModelPortali O75309.
SMRi O75309. Positions 27-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107449. 3 interactions.
IntActi O75309. 2 interactions.

PTM databases

PhosphoSitei O75309.

Proteomic databases

PaxDbi O75309.
PRIDEi O75309.

Protocols and materials databases

DNASUi 1014.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299752 ; ENSP00000299752 ; ENSG00000166589 . [O75309-1 ]
ENST00000394055 ; ENSP00000377619 ; ENSG00000166589 . [O75309-2 ]
ENST00000565796 ; ENSP00000454784 ; ENSG00000166589 . [O75309-4 ]
ENST00000568632 ; ENSP00000455263 ; ENSG00000166589 . [O75309-3 ]
GeneIDi 1014.
KEGGi hsa:1014.
UCSCi uc002eql.3. human. [O75309-1 ]
uc010cdy.3. human. [O75309-2 ]
uc021tjx.1. human.

Organism-specific databases

CTDi 1014.
GeneCardsi GC16M066942.
HGNCi HGNC:1755. CDH16.
HPAi CAB013526.
HPA036260.
MIMi 603118. gene.
neXtProti NX_O75309.
PharmGKBi PA26289.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259000.
GeneTreei ENSGT00740000115559.
HOGENOMi HOG000231613.
HOVERGENi HBG050766.
InParanoidi O75309.
KOi K06810.
OMAi RLMDFAI.
OrthoDBi EOG7Z3F4D.
PhylomeDBi O75309.
TreeFami TF316817.

Miscellaneous databases

GeneWikii CDH16.
GenomeRNAii 1014.
NextBioi 4261.
PROi O75309.
SOURCEi Search...

Gene expression databases

Bgeei O75309.
CleanExi HS_CDH16.
ExpressionAtlasi O75309. baseline and differential.
Genevestigatori O75309.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin."
    Thomson R.B., Ward D.C., Quaggin S.E., Igarashi P., Muckler Z.E., Aronson P.S.
    Genomics 51:445-451(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Kidney.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Kidney.
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiCAD16_HUMAN
AccessioniPrimary (citable) accession number: O75309
Secondary accession number(s): B4DPA8, H3BPD3, Q6UW93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3