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Protein

Cadherin-16

Gene

CDH16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166589-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:CDH16
ORF Names:UNQ695/PRO1340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1755. CDH16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 786ExtracellularSequence analysisAdd BLAST768
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 829CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1014.
OpenTargetsiENSG00000166589.
PharmGKBiPA26289.

Polymorphism and mutation databases

BioMutaiCDH16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000380919 – 829Cadherin-16Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1
Glycosylationi602N-linked (GlcNAc...)Sequence analysis1
Glycosylationi722N-linked (GlcNAc...)Sequence analysis1
Modified residuei822PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75309.
PeptideAtlasiO75309.
PRIDEiO75309.

PTM databases

iPTMnetiO75309.
PhosphoSitePlusiO75309.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiENSG00000166589.
CleanExiHS_CDH16.
ExpressionAtlasiO75309. baseline and differential.
GenevisibleiO75309. HS.

Organism-specific databases

HPAiCAB013526.
HPA036260.

Interactioni

Protein-protein interaction databases

BioGridi107449. 3 interactors.
IntActiO75309. 2 interactors.
STRINGi9606.ENSP00000299752.

Structurei

3D structure databases

ProteinModelPortaliO75309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Cadherin 1PROSITE-ProRule annotationAdd BLAST102
Domaini131 – 235Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini242 – 336Cadherin 3PROSITE-ProRule annotationAdd BLAST95
Domaini341 – 449Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini455 – 564Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini569 – 665Cadherin 6PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni666 – 786Ectodomain GAdd BLAST121

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO75309.
KOiK06810.
OMAiHWVEPRE.
OrthoDBiEOG091G03CL.
PhylomeDBiO75309.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75309-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG
60 70 80 90 100
AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM
110 120 130 140 150
QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA
160 170 180 190 200
SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD
210 220 230 240 250
HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL
260 270 280 290 300
KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
310 320 330 340 350
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP
360 370 380 390 400
PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV
410 420 430 440 450
TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI
460 470 480 490 500
TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG
510 520 530 540 550
LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT
560 570 580 590 600
VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
610 620 630 640 650
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA
660 670 680 690 700
PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG
710 720 730 740 750
PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA
760 770 780 790 800
QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF
810 820
LILIFTHWTM SRKKDPDQPA DSVPLKATV
Length:829
Mass (Da):89,923
Last modified:November 1, 1998 - v1
Checksum:i41966915E4BFC891
GO
Isoform 2 (identifier: O75309-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-663: Missing.

Note: No experimental confirmation available.
Show »
Length:807
Mass (Da):87,614
Checksum:iB41914FE7B643744
GO
Isoform 3 (identifier: O75309-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-217: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):79,196
Checksum:i7A91F3743DD857BF
GO
Isoform 4 (identifier: O75309-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-680: Missing.

Note: No experimental confirmation available.
Show »
Length:790
Mass (Da):85,774
Checksum:iF4F26806CF6FE2EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021870191L → F.Corresponds to variant rs2271024dbSNPEnsembl.1
Natural variantiVAR_021871257H → Y.Corresponds to variant rs2271023dbSNPEnsembl.1
Natural variantiVAR_061058717R → H.Corresponds to variant rs34621310dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046027121 – 217Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046467642 – 680Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_013354642 – 663Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016272 mRNA. Translation: AAC34255.1.
AY358911 mRNA. Translation: AAQ89270.1.
AK225544 mRNA. No translation available.
AK298255 mRNA. Translation: BAG60520.1.
AC009084 Genomic DNA. No translation available.
BC027912 mRNA. Translation: AAH27912.1.
CCDSiCCDS10823.1. [O75309-1]
CCDS56002.1. [O75309-2]
CCDS58471.1. [O75309-4]
CCDS58472.1. [O75309-3]
RefSeqiNP_001191673.1. NM_001204744.1. [O75309-2]
NP_001191674.1. NM_001204745.1. [O75309-4]
NP_001191675.1. NM_001204746.1. [O75309-3]
NP_004053.1. NM_004062.3. [O75309-1]
UniGeneiHs.513660.

Genome annotation databases

EnsembliENST00000299752; ENSP00000299752; ENSG00000166589. [O75309-1]
ENST00000394055; ENSP00000377619; ENSG00000166589. [O75309-2]
ENST00000565796; ENSP00000454784; ENSG00000166589. [O75309-4]
ENST00000568632; ENSP00000455263; ENSG00000166589. [O75309-3]
GeneIDi1014.
KEGGihsa:1014.
UCSCiuc002eql.3. human. [O75309-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016272 mRNA. Translation: AAC34255.1.
AY358911 mRNA. Translation: AAQ89270.1.
AK225544 mRNA. No translation available.
AK298255 mRNA. Translation: BAG60520.1.
AC009084 Genomic DNA. No translation available.
BC027912 mRNA. Translation: AAH27912.1.
CCDSiCCDS10823.1. [O75309-1]
CCDS56002.1. [O75309-2]
CCDS58471.1. [O75309-4]
CCDS58472.1. [O75309-3]
RefSeqiNP_001191673.1. NM_001204744.1. [O75309-2]
NP_001191674.1. NM_001204745.1. [O75309-4]
NP_001191675.1. NM_001204746.1. [O75309-3]
NP_004053.1. NM_004062.3. [O75309-1]
UniGeneiHs.513660.

3D structure databases

ProteinModelPortaliO75309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107449. 3 interactors.
IntActiO75309. 2 interactors.
STRINGi9606.ENSP00000299752.

PTM databases

iPTMnetiO75309.
PhosphoSitePlusiO75309.

Polymorphism and mutation databases

BioMutaiCDH16.

Proteomic databases

PaxDbiO75309.
PeptideAtlasiO75309.
PRIDEiO75309.

Protocols and materials databases

DNASUi1014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299752; ENSP00000299752; ENSG00000166589. [O75309-1]
ENST00000394055; ENSP00000377619; ENSG00000166589. [O75309-2]
ENST00000565796; ENSP00000454784; ENSG00000166589. [O75309-4]
ENST00000568632; ENSP00000455263; ENSG00000166589. [O75309-3]
GeneIDi1014.
KEGGihsa:1014.
UCSCiuc002eql.3. human. [O75309-1]

Organism-specific databases

CTDi1014.
DisGeNETi1014.
GeneCardsiCDH16.
HGNCiHGNC:1755. CDH16.
HPAiCAB013526.
HPA036260.
MIMi603118. gene.
neXtProtiNX_O75309.
OpenTargetsiENSG00000166589.
PharmGKBiPA26289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050766.
InParanoidiO75309.
KOiK06810.
OMAiHWVEPRE.
OrthoDBiEOG091G03CL.
PhylomeDBiO75309.
TreeFamiTF316817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166589-MONOMER.

Miscellaneous databases

GeneWikiiCDH16.
GenomeRNAii1014.
PROiO75309.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166589.
CleanExiHS_CDH16.
ExpressionAtlasiO75309. baseline and differential.
GenevisibleiO75309. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR030721. Cadherin-16.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PANTHERiPTHR24028:SF1. PTHR24028:SF1. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD16_HUMAN
AccessioniPrimary (citable) accession number: O75309
Secondary accession number(s): B4DPA8, H3BPD3, Q6UW93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.