Reviewed, UniProtKB/Swiss-Prot O75293 (GA45B_HUMAN)

Names and origin

Protein names

Recommended name:
    Growth arrest and DNA-damage-inducible protein GADD45 beta
Alternative name(s):
    Myeloid differentiation primary response protein MyD118
    Negative growth regulatory protein MyD118

Gene names

Name:	GADD45B
Synonyms:	MYD118

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Subunit structure	Interacts with GADD45GIP1. Ref.7
Sequence similarities	Belongs to the GADD45 family.

Ontologies

Keywords
Biological process	Apoptosis Differentiation
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	activation of MAPKKK activity Ref.2 Traceable author statement. Source: ProtInc apoptosis Ref.2 Traceable author statement. Source: ProtInc cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW response to stress Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Growth arrest and DNA-damage-inducible protein GADD45 beta		PRO_0000148334
Experimental info
	Sequence conflict	95 – 96	2	MQ → NA in AAC36361. Ref.1
	Sequence conflict	121 – 123	3	LVT → PFLQ Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75293-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 52712E307B322D46	FASTA	160	17,818
	10 20 30 40 50 60 MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA 70 80 90 100 110 120 IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL 130 140 150 160 LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Posttranscriptional regulation of MyD118 and GADD45 during apoptosis in human lung carcinoma cell lines by the synthetic retinoid AHPN." Sakaue M., Adachi H., Jetten A.M. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung carcinoma.
[2]	"A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK." Takekawa M., Saito H. Cell 95:521-530(1998) [PubMed: 9827804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping." Gong R., Yu L., Zhang H., Tu Q., Zhao Y., Yang J., Xu Y., Zhao S. Cytogenet. Cell Genet. 88:95-96(2000) [PubMed: 10773677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	NIEHS SNPs program Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle." Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M. J. Biol. Chem. 278:28079-28088(2003) [PubMed: 12716909] [Abstract] Cited for: INTERACTION WITH GADD45GIP1. Tissue: Colon carcinoma.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF090950 mRNA. Translation: AAC36361.1. AF078077 mRNA. Translation: AAC83328.1. AF087853 mRNA. Translation: AAG48366.1. AF533019 Genomic DNA. Translation: AAM92794.1. AC005624 Genomic DNA. Translation: AAC34572.1. BC113466 mRNA. Translation: AAI13467.1. BC117469 mRNA. Translation: AAI17470.1.
IPI	IPI00307805.
RefSeq	NP_056490.2.
UniGene	Hs.110571
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24219N.
Proteomic databases
PRIDE	O75293.
Genome annotation databases
Ensembl	ENSG00000099860. Homo sapiens. [Contig view]
GeneID	4616.
KEGG	hsa:4616.
Organism-specific databases
GeneCards	GC19P002427.
H-InvDB	HIX0014620.
HGNC	HGNC:4096. GADD45B.
MIM	604948. gene.
PharmGKB	PA28511.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O75293.
HOVERGEN	O75293.
OMA	O75293. CDNDIDI.
Enzyme and pathway databases
Pathway_Interaction_DB	il12_2pathway. IL12-mediated signaling events. p38_mkk3_6pathway. p38 MAPK signaling pathway.
Gene expression databases
ArrayExpress	O75293.
Bgee	O75293.
CleanEx	HS_GADD45B.
GermOnline	ENSG00000099860. Homo sapiens.
Family and domain databases
InterPro	IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45. [Graphical view]
Pfam	PF01248. Ribosomal_L7Ae. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17768.
SOURCE	Search...

Entry information

Entry name

GA45B_HUMAN

Accession

Primary (citable) accession number: O75293
Secondary accession number(s): O75960, Q17R46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)