Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth arrest and DNA damage-inducible protein GADD45 beta

Gene

GADD45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Enzyme and pathway databases

SignaLinkiO75293
SIGNORiO75293

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 beta
Alternative name(s):
Myeloid differentiation primary response protein MyD118
Negative growth regulatory protein MyD118
Gene namesi
Name:GADD45B
Synonyms:MYD118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099860.8
HGNCiHGNC:4096 GADD45B
MIMi604948 gene
neXtProtiNX_O75293

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4616
OpenTargetsiENSG00000099860
PharmGKBiPA28511

Polymorphism and mutation databases

BioMutaiGADD45B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483341 – 160Growth arrest and DNA damage-inducible protein GADD45 betaAdd BLAST160

Proteomic databases

PaxDbiO75293
PeptideAtlasiO75293
PRIDEiO75293

PTM databases

iPTMnetiO75293
PhosphoSitePlusiO75293

Expressioni

Gene expression databases

BgeeiENSG00000099860
CleanExiHS_GADD45B
ExpressionAtlasiO75293 baseline and differential
GenevisibleiO75293 HS

Organism-specific databases

HPAiHPA029816

Interactioni

Subunit structurei

Interacts with GADD45GIP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110701, 22 interactors
CORUMiO75293
DIPiDIP-24219N
IntActiO75293, 4 interactors
MINTiO75293
STRINGi9606.ENSP00000215631

Structurei

3D structure databases

ProteinModelPortaliO75293
SMRiO75293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IH6M Eukaryota
ENOG4111K8B LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiO75293
KOiK04402
OMAiAQRQDCL
PhylomeDBiO75293
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

O75293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD
60 70 80 90 100
PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ
110 120 130 140 150
LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ
160
WVPYISLQER
Length:160
Mass (Da):17,818
Last modified:November 1, 1998 - v1
Checksum:i52712E307B322D46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95 – 96MQ → NA in AAC36361 (Ref. 1) Curated2
Sequence conflicti121 – 123LVT → PFLQ in AAC36361 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090950 mRNA Translation: AAC36361.1
AF078077 mRNA Translation: AAC83328.1
AF087853 mRNA Translation: AAG48366.1
AF533019 Genomic DNA Translation: AAM92794.1
AK293087 mRNA Translation: BAF85776.1
AC005624 Genomic DNA Translation: AAC34572.1
CH471139 Genomic DNA Translation: EAW69376.1
BC113466 mRNA Translation: AAI13467.1
BC117469 mRNA Translation: AAI17470.1
CCDSiCCDS32868.1
RefSeqiNP_056490.2, NM_015675.3
UniGeneiHs.110571

Genome annotation databases

EnsembliENST00000215631; ENSP00000215631; ENSG00000099860
GeneIDi4616
KEGGihsa:4616
UCSCiuc002lwb.3 human

Similar proteinsi

Entry informationi

Entry nameiGA45B_HUMAN
AccessioniPrimary (citable) accession number: O75293
Secondary accession number(s): A8KAM2, O75960, Q17R46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health