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Protein

Growth arrest and DNA damage-inducible protein GADD45 beta

Gene

GADD45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation

Enzyme and pathway databases

SignaLinkiO75293.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 beta
Alternative name(s):
Myeloid differentiation primary response protein MyD118
Negative growth regulatory protein MyD118
Gene namesi
Name:GADD45B
Synonyms:MYD118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4096. GADD45B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28511.

Polymorphism and mutation databases

BioMutaiGADD45B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Growth arrest and DNA damage-inducible protein GADD45 betaPRO_0000148334Add
BLAST

Proteomic databases

PaxDbiO75293.
PeptideAtlasiO75293.
PRIDEiO75293.

PTM databases

iPTMnetiO75293.

Expressioni

Gene expression databases

BgeeiO75293.
CleanExiHS_GADD45B.
ExpressionAtlasiO75293. baseline and differential.
GenevisibleiO75293. HS.

Organism-specific databases

HPAiHPA029816.

Interactioni

Subunit structurei

Interacts with GADD45GIP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP2K7O147338EBI-448187,EBI-492605
MAP3K4Q9Y6R42EBI-448187,EBI-448104

Protein-protein interaction databases

BioGridi110701. 22 interactions.
DIPiDIP-24219N.
IntActiO75293. 3 interactions.
MINTiMINT-265075.
STRINGi9606.ENSP00000215631.

Structurei

3D structure databases

ProteinModelPortaliO75293.
SMRiO75293. Positions 12-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IH6M. Eukaryota.
ENOG4111K8B. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiO75293.
KOiK04402.
OMAiCDIDINI.
OrthoDBiEOG7J1819.
PhylomeDBiO75293.
TreeFamiTF300196.

Family and domain databases

InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

O75293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD
60 70 80 90 100
PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ
110 120 130 140 150
LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ
160
WVPYISLQER
Length:160
Mass (Da):17,818
Last modified:November 1, 1998 - v1
Checksum:i52712E307B322D46
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 962MQ → NA in AAC36361 (Ref. 1) Curated
Sequence conflicti121 – 1233LVT → PFLQ in AAC36361 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090950 mRNA. Translation: AAC36361.1.
AF078077 mRNA. Translation: AAC83328.1.
AF087853 mRNA. Translation: AAG48366.1.
AF533019 Genomic DNA. Translation: AAM92794.1.
AK293087 mRNA. Translation: BAF85776.1.
AC005624 Genomic DNA. Translation: AAC34572.1.
CH471139 Genomic DNA. Translation: EAW69376.1.
BC113466 mRNA. Translation: AAI13467.1.
BC117469 mRNA. Translation: AAI17470.1.
CCDSiCCDS32868.1.
RefSeqiNP_056490.2. NM_015675.3.
UniGeneiHs.110571.

Genome annotation databases

EnsembliENST00000215631; ENSP00000215631; ENSG00000099860.
GeneIDi4616.
KEGGihsa:4616.
UCSCiuc002lwb.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

GADD45B entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090950 mRNA. Translation: AAC36361.1.
AF078077 mRNA. Translation: AAC83328.1.
AF087853 mRNA. Translation: AAG48366.1.
AF533019 Genomic DNA. Translation: AAM92794.1.
AK293087 mRNA. Translation: BAF85776.1.
AC005624 Genomic DNA. Translation: AAC34572.1.
CH471139 Genomic DNA. Translation: EAW69376.1.
BC113466 mRNA. Translation: AAI13467.1.
BC117469 mRNA. Translation: AAI17470.1.
CCDSiCCDS32868.1.
RefSeqiNP_056490.2. NM_015675.3.
UniGeneiHs.110571.

3D structure databases

ProteinModelPortaliO75293.
SMRiO75293. Positions 12-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110701. 22 interactions.
DIPiDIP-24219N.
IntActiO75293. 3 interactions.
MINTiMINT-265075.
STRINGi9606.ENSP00000215631.

PTM databases

iPTMnetiO75293.

Polymorphism and mutation databases

BioMutaiGADD45B.

Proteomic databases

PaxDbiO75293.
PeptideAtlasiO75293.
PRIDEiO75293.

Protocols and materials databases

DNASUi4616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215631; ENSP00000215631; ENSG00000099860.
GeneIDi4616.
KEGGihsa:4616.
UCSCiuc002lwb.3. human.

Organism-specific databases

CTDi4616.
GeneCardsiGADD45B.
H-InvDBHIX0174390.
HGNCiHGNC:4096. GADD45B.
HPAiHPA029816.
MIMi604948. gene.
neXtProtiNX_O75293.
PharmGKBiPA28511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH6M. Eukaryota.
ENOG4111K8B. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiO75293.
KOiK04402.
OMAiCDIDINI.
OrthoDBiEOG7J1819.
PhylomeDBiO75293.
TreeFamiTF300196.

Enzyme and pathway databases

SignaLinkiO75293.

Miscellaneous databases

GeneWikiiGADD45B.
GenomeRNAii4616.
PROiO75293.
SOURCEiSearch...

Gene expression databases

BgeeiO75293.
CleanExiHS_GADD45B.
ExpressionAtlasiO75293. baseline and differential.
GenevisibleiO75293. HS.

Family and domain databases

InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Posttranscriptional regulation of MyD118 and GADD45 during apoptosis in human lung carcinoma cell lines by the synthetic retinoid AHPN."
    Sakaue M., Adachi H., Jetten A.M.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung carcinoma.
  2. "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK."
    Takekawa M., Saito H.
    Cell 95:521-530(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping."
    Gong R., Yu L., Zhang H., Tu Q., Zhao Y., Yang J., Xu Y., Zhao S.
    Cytogenet. Cell Genet. 88:95-96(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. NIEHS SNPs program
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."
    Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.
    J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GADD45GIP1.
    Tissue: Colon carcinoma.

Entry informationi

Entry nameiGA45B_HUMAN
AccessioniPrimary (citable) accession number: O75293
Secondary accession number(s): A8KAM2, O75960, Q17R46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.