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Protein

Zinc finger protein 780A

Gene

ZNF780A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171642-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 780A
Gene namesi
Name:ZNF780A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27603. ZNF780A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197782.
ENSG00000280568.
PharmGKBiPA162410417.

Polymorphism and mutation databases

BioMutaiZNF780A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636901 – 641Zinc finger protein 780AAdd BLAST641

Proteomic databases

MaxQBiO75290.
PaxDbiO75290.
PeptideAtlasiO75290.
PRIDEiO75290.

PTM databases

iPTMnetiO75290.
PhosphoSitePlusiO75290.

Expressioni

Gene expression databases

BgeeiENSG00000197782.
CleanExiHS_ZNF780A.
ExpressionAtlasiO75290. baseline and differential.
GenevisibleiO75290. HS.

Organism-specific databases

HPAiHPA003311.
HPA038486.

Interactioni

Protein-protein interaction databases

BioGridi129827. 3 interactors.
STRINGi9606.ENSP00000400997.

Structurei

3D structure databases

ProteinModelPortaliO75290.
SMRiO75290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133979.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75290.
KOiK09228.
OMAiGMAFRYH.
OrthoDBiEOG091G02KC.
PhylomeDBiO75290.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75290-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS
60 70 80 90 100
KPDVITLLEQ EKEPWMVVRK ETSRRYPDLE LKYGPEKVSP ENDTSEVNLP
110 120 130 140 150
KQVIKQISTT LGIEAFYFRN DSEYRQFEGL QGYQEGNINQ KMISYEKLPT
160 170 180 190 200
HTPHASLICN THKPYECKEC GKYFSRSANL IQHQSIHTGE KPFECKECGK
210 220 230 240 250
AFRLHIQFTR HQKFHTGEKP FECNECGKAF SLLTLLNRHK NIHTGEKLFE
260 270 280 290 300
CKECGKSFNR SSNLVQHQSI HSGVKPYECK ECGKGFNRGA HLIQHQKIHS
310 320 330 340 350
NEKPFVCKEC GMAFRYHYQL IEHCQIHTGE KPFECKECGK AFTLLTKLVR
360 370 380 390 400
HQKIHTGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR
410 420 430 440 450
SSNLVQHQSI HAGIKPYECK ECGKGFNRGA HLIQHQKIHS NEKPFVCREC
460 470 480 490 500
EMAFRYHCQL IEHSRIHTGD KPFECQDCGK AFNRGSSLVQ HQSIHTGEKP
510 520 530 540 550
YECKECGKAF RLYLQLSQHQ KTHTGEKPFE CKECGKFFRR GSNLNQHRSI
560 570 580 590 600
HTGKKPFECK ECGKAFRLHM HLIRHQKLHT GEKPFECKEC GKAFRLHMQL
610 620 630 640
IRHQKLHTGE KPFECKECGK VFSLPTQLNR HKNIHTGEKA S
Length:641
Mass (Da):74,531
Last modified:December 16, 2008 - v3
Checksum:iFE92AF740839A86D
GO
Isoform 2 (identifier: O75290-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRSPRKIDQFCNSSNM
     103-141: VIKQISTTLG...GYQEGNINQK → ISSLASKPSF...SLVYCSLEIL
     142-641: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,256
Checksum:iE8DF8674C3FE501B
GO
Isoform 3 (identifier: O75290-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: L → LA

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:642
Mass (Da):74,602
Checksum:i84DEFC8DEBD6C736
GO

Sequence cautioni

The sequence AAC34327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104I → L in AK091274 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377181M → MGRSPRKIDQFCNSSNM in isoform 2. 1 Publication1
Alternative sequenceiVSP_04646545L → LA in isoform 3. Curated1
Alternative sequenceiVSP_037719103 – 141VIKQI…NINQK → ISSLASKPSFTAIHIQRRIH CRICIAFGYLSLVYCSLEIL in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_037720142 – 641Missing in isoform 2. 1 PublicationAdd BLAST500

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091274 mRNA. No translation available.
AK131328 mRNA. Translation: BAD18488.1.
AC005614 Genomic DNA. Translation: AAC34327.1. Sequence problems.
CCDSiCCDS33026.2. [O75290-1]
CCDS46078.1. [O75290-2]
CCDS46079.1. [O75290-3]
RefSeqiNP_001010880.2. NM_001010880.2. [O75290-1]
NP_001136050.1. NM_001142578.1. [O75290-1]
NP_001136051.1. NM_001142579.1. [O75290-2]
XP_005258830.1. XM_005258773.2. [O75290-3]
XP_006723213.1. XM_006723150.3. [O75290-3]
XP_011525073.1. XM_011526771.2. [O75290-3]
XP_011525074.1. XM_011526772.2. [O75290-3]
XP_016882106.1. XM_017026617.1. [O75290-1]
XP_016882107.1. XM_017026618.1. [O75290-1]
XP_016882108.1. XM_017026619.1. [O75290-1]
UniGeneiHs.115140.

Genome annotation databases

EnsembliENST00000340963; ENSP00000341507; ENSG00000197782. [O75290-1]
ENST00000414720; ENSP00000416294; ENSG00000197782. [O75290-2]
ENST00000455521; ENSP00000400997; ENSG00000197782. [O75290-3]
ENST00000594395; ENSP00000469786; ENSG00000197782. [O75290-3]
ENST00000595687; ENSP00000472189; ENSG00000197782. [O75290-1]
ENST00000626168; ENSP00000487366; ENSG00000280568. [O75290-3]
ENST00000626829; ENSP00000487177; ENSG00000280568. [O75290-1]
ENST00000628273; ENSP00000487520; ENSG00000280568. [O75290-1]
ENST00000630440; ENSP00000486672; ENSG00000280568. [O75290-2]
ENST00000630528; ENSP00000486345; ENSG00000280568. [O75290-3]
GeneIDi284323.
KEGGihsa:284323.
UCSCiuc002omw.5. human. [O75290-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091274 mRNA. No translation available.
AK131328 mRNA. Translation: BAD18488.1.
AC005614 Genomic DNA. Translation: AAC34327.1. Sequence problems.
CCDSiCCDS33026.2. [O75290-1]
CCDS46078.1. [O75290-2]
CCDS46079.1. [O75290-3]
RefSeqiNP_001010880.2. NM_001010880.2. [O75290-1]
NP_001136050.1. NM_001142578.1. [O75290-1]
NP_001136051.1. NM_001142579.1. [O75290-2]
XP_005258830.1. XM_005258773.2. [O75290-3]
XP_006723213.1. XM_006723150.3. [O75290-3]
XP_011525073.1. XM_011526771.2. [O75290-3]
XP_011525074.1. XM_011526772.2. [O75290-3]
XP_016882106.1. XM_017026617.1. [O75290-1]
XP_016882107.1. XM_017026618.1. [O75290-1]
XP_016882108.1. XM_017026619.1. [O75290-1]
UniGeneiHs.115140.

3D structure databases

ProteinModelPortaliO75290.
SMRiO75290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129827. 3 interactors.
STRINGi9606.ENSP00000400997.

PTM databases

iPTMnetiO75290.
PhosphoSitePlusiO75290.

Polymorphism and mutation databases

BioMutaiZNF780A.

Proteomic databases

MaxQBiO75290.
PaxDbiO75290.
PeptideAtlasiO75290.
PRIDEiO75290.

Protocols and materials databases

DNASUi284323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340963; ENSP00000341507; ENSG00000197782. [O75290-1]
ENST00000414720; ENSP00000416294; ENSG00000197782. [O75290-2]
ENST00000455521; ENSP00000400997; ENSG00000197782. [O75290-3]
ENST00000594395; ENSP00000469786; ENSG00000197782. [O75290-3]
ENST00000595687; ENSP00000472189; ENSG00000197782. [O75290-1]
ENST00000626168; ENSP00000487366; ENSG00000280568. [O75290-3]
ENST00000626829; ENSP00000487177; ENSG00000280568. [O75290-1]
ENST00000628273; ENSP00000487520; ENSG00000280568. [O75290-1]
ENST00000630440; ENSP00000486672; ENSG00000280568. [O75290-2]
ENST00000630528; ENSP00000486345; ENSG00000280568. [O75290-3]
GeneIDi284323.
KEGGihsa:284323.
UCSCiuc002omw.5. human. [O75290-1]

Organism-specific databases

CTDi284323.
GeneCardsiZNF780A.
HGNCiHGNC:27603. ZNF780A.
HPAiHPA003311.
HPA038486.
neXtProtiNX_O75290.
OpenTargetsiENSG00000197782.
ENSG00000280568.
PharmGKBiPA162410417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133979.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75290.
KOiK09228.
OMAiGMAFRYH.
OrthoDBiEOG091G02KC.
PhylomeDBiO75290.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171642-MONOMER.

Miscellaneous databases

GenomeRNAii284323.
PROiO75290.

Gene expression databases

BgeeiENSG00000197782.
CleanExiHS_ZNF780A.
ExpressionAtlasiO75290. baseline and differential.
GenevisibleiO75290. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ780A_HUMAN
AccessioniPrimary (citable) accession number: O75290
Secondary accession number(s): E9PB48, Q6ZN87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.