Reviewed, UniProtKB/Swiss-Prot Q86TI2 (DPP9_HUMAN)

Names and origin

Protein names

Recommended name:
    Dipeptidyl peptidase 9
    EC=3.4.14.5
Alternative name(s):
    Dipeptidyl peptidase IX
    DP9
    Dipeptidyl peptidase-like protein 9
      Short name=DPLP9
    Dipeptidyl peptidase IV-related protein 2
      Short name=DPRP-2

Gene names

Name:	DPP9
Synonyms:	DPRP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	863 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Enzyme regulation	Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.
Subcellular location	Cytoplasm › cytosol.
Tissue specificity	Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
Sequence similarities	Belongs to the peptidase S9B family. DPPIV subfamily.
Biophysicochemical properties	Kinetic parameters: KM=161 µM for Ala-Pro-AMC KM=180 µM for Ala-Pro-AFC pH dependence: Optimum pH is 7.5-8.5. Little activity below pH 6.5.
Sequence caution	The sequence AAC33801.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC62840.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAD39039.3 differs from that shown. Reason: Frameshift at positions 432 and 460.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86TI2-1)

Also known as: Short;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86TI2-2)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → LSRRVPCVRR...FSLNSEGAER

Notes: Incomplete sequence.

Isoform 3 (identifier: Q86TI2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     650-674: QLVNNSFKGIKYLRLNTLASLGYAV → SAHLLPRPPPHHPPEDSPSPLKCQL
     675-863: Missing.

Isoform 4 (identifier: Q86TI2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     832-858: Missing.

Isoform 5 (identifier: Q86TI2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → LSRRVPCVRR...FSLNSEGAER
     3-139: Missing.

Notes: Incomplete sequence.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 863	863	Dipeptidyl peptidase 9		PRO_0000122415
Sites
	Active site	730	1	Charge relay system By similarity
	Active site	808	1	Charge relay system By similarity
	Active site	840	1	Charge relay system By similarity
Natural variations
	Alternative sequence	1	1	M → LSRRVPCVRRGCRPPLPPLP GSQSRAWSRDREAPLDPGRP AQSGRRPTSRSVSHACSWNG GSLDPLEGTPALLRSAERLM RKVKKLRLDKENTGSWRSFS LNSEGAER in isoform 2 and isoform 5.		VSP_013865
	Alternative sequence	3 – 139	137	Missing in isoform 5.		VSP_013866
	Alternative sequence	650 – 674	25	QLVNN…LGYAV → SAHLLPRPPPHHPPEDSPSP LKCQL in isoform 3.		VSP_013867
	Alternative sequence	675 – 863	189	Missing in isoform 3.		VSP_013868
	Alternative sequence	832 – 858	27	Missing in isoform 4.		VSP_013869
Experimental info
	Sequence conflict	204	1	I → N in AAO73880 and AAQ83119. Ref.3
	Sequence conflict	571	1	C → W in BAC85150. Ref.6
	Sequence conflict	709	1	L → P in BAD18643. Ref.6
	Sequence conflict	753	1	G → C in BAB70784. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Short) [UniParc]. Last modified June 7, 2005. Version 3. Checksum: 40FE0B78E26CDED5	FASTA	863	98,263
	10 20 30 40 50 60 MATTGTPTAD RGDAAATDDP AARFQVQKHS WDGLRSIIHG SRKYSGLIVN KAPHDFQFVQ 70 80 90 100 110 120 KTDESGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LLLSWKQMLD HFQATPHHGV 130 140 150 160 170 180 YSREEELLRE RKRLGVFGIT SYDFHSESGL FLFQASNSLF HCRDGGKNGF MVSPMKPLEI 190 200 210 220 230 240 KTQCSGPRMD PKICPADPAF FSFINNSDLW VANIETGEER RLTFCHQGLS NVLDDPKSAG 250 260 270 280 290 300 VATFVIQEEF DRFTGYWWCP TASWEGSEGL KTLRILYEEV DESEVEVIHV PSPALEERKT 310 320 330 340 350 360 DSYRYPRTGS KNPKIALKLA EFQTDSQGKI VSTQEKELVQ PFSSLFPKVE YIARAGWTRD 370 380 390 400 410 420 GKYAWAMFLD RPQQWLQLVL LPPALFIPST ENEEQRLASA RAVPRNVQPY VVYEEVTNVW 430 440 450 460 470 480 INVHDIFYPF PQSEGEDELC FLRANECKTG FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK 490 500 510 520 530 540 CPIKEEIALT SGEWEVLARH GSKIWVNEET KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR 550 560 570 580 590 600 LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP CVHVYKLSGP DDDPLHKQPR FWASMMEAAS 610 620 630 640 650 660 CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA LQPGKKHPTV LFVYGGPQVQ LVNNSFKGIK 670 680 690 700 710 720 YLRLNTLASL GYAVVVIDGR GSCQRGLRFE GALKNQMGQV EIEDQVEGLQ FVAEKYGFID 730 740 750 760 770 780 LSRVAIHGWS YGGFLSLMGL IHKPQVFKVA IAGAPVTVWM AYDTGYTERY MDVPENNQHG 790 800 810 820 830 840 YEAGSVALHV EKLPNEPNRL LILHGFLDEN VHFFHTNFLV SQLIRAGKPY QLQIYPNERH 850 860 SIRCPESGEH YEVTLLHFLQ EYL
	Isoform 2 (Long) [UniParc]. Checksum: 397F78903F01A7F8		970	110,114
	10 20 30 40 50 60 LSRRVPCVRR GCRPPLPPLP GSQSRAWSRD REAPLDPGRP AQSGRRPTSR SVSHACSWNG 70 80 90 100 110 120 GSLDPLEGTP ALLRSAERLM RKVKKLRLDK ENTGSWRSFS LNSEGAERAT TGTPTADRGD 130 140 150 160 170 180 AAATDDPAAR FQVQKHSWDG LRSIIHGSRK YSGLIVNKAP HDFQFVQKTD ESGPHSHRLY 190 200 210 220 230 240 YLGMPYGSRE NSLLYSEIPK KVRKEALLLL SWKQMLDHFQ ATPHHGVYSR EEELLRERKR 250 260 270 280 290 300 LGVFGITSYD FHSESGLFLF QASNSLFHCR DGGKNGFMVS PMKPLEIKTQ CSGPRMDPKI 310 320 330 340 350 360 CPADPAFFSF INNSDLWVAN IETGEERRLT FCHQGLSNVL DDPKSAGVAT FVIQEEFDRF 370 380 390 400 410 420 TGYWWCPTAS WEGSEGLKTL RILYEEVDES EVEVIHVPSP ALEERKTDSY RYPRTGSKNP 430 440 450 460 470 480 KIALKLAEFQ TDSQGKIVST QEKELVQPFS SLFPKVEYIA RAGWTRDGKY AWAMFLDRPQ 490 500 510 520 530 540 QWLQLVLLPP ALFIPSTENE EQRLASARAV PRNVQPYVVY EEVTNVWINV HDIFYPFPQS 550 560 570 580 590 600 EGEDELCFLR ANECKTGFCH LYKVTAVLKS QGYDWSEPFS PGEDEFKCPI KEEIALTSGE 610 620 630 640 650 660 WEVLARHGSK IWVNEETKLV YFQGTKDTPL EHHLYVVSYE AAGEIVRLTT PGFSHSCSMS 670 680 690 700 710 720 QNFDMFVSHY SSVSTPPCVH VYKLSGPDDD PLHKQPRFWA SMMEAASCPP DYVPPEIFHF 730 740 750 760 770 780 HTRSDVRLYG MIYKPHALQP GKKHPTVLFV YGGPQVQLVN NSFKGIKYLR LNTLASLGYA 790 800 810 820 830 840 VVVIDGRGSC QRGLRFEGAL KNQMGQVEIE DQVEGLQFVA EKYGFIDLSR VAIHGWSYGG 850 860 870 880 890 900 FLSLMGLIHK PQVFKVAIAG APVTVWMAYD TGYTERYMDV PENNQHGYEA GSVALHVEKL 910 920 930 940 950 960 PNEPNRLLIL HGFLDENVHF FHTNFLVSQL IRAGKPYQLQ IYPNERHSIR CPESGEHYEV 970 TLLHFLQEYL
	Isoform 3 [UniParc]. Checksum: 8C5A7E386929CAA5		674	76,702
	10 20 30 40 50 60 MATTGTPTAD RGDAAATDDP AARFQVQKHS WDGLRSIIHG SRKYSGLIVN KAPHDFQFVQ 70 80 90 100 110 120 KTDESGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LLLSWKQMLD HFQATPHHGV 130 140 150 160 170 180 YSREEELLRE RKRLGVFGIT SYDFHSESGL FLFQASNSLF HCRDGGKNGF MVSPMKPLEI 190 200 210 220 230 240 KTQCSGPRMD PKICPADPAF FSFINNSDLW VANIETGEER RLTFCHQGLS NVLDDPKSAG 250 260 270 280 290 300 VATFVIQEEF DRFTGYWWCP TASWEGSEGL KTLRILYEEV DESEVEVIHV PSPALEERKT 310 320 330 340 350 360 DSYRYPRTGS KNPKIALKLA EFQTDSQGKI VSTQEKELVQ PFSSLFPKVE YIARAGWTRD 370 380 390 400 410 420 GKYAWAMFLD RPQQWLQLVL LPPALFIPST ENEEQRLASA RAVPRNVQPY VVYEEVTNVW 430 440 450 460 470 480 INVHDIFYPF PQSEGEDELC FLRANECKTG FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK 490 500 510 520 530 540 CPIKEEIALT SGEWEVLARH GSKIWVNEET KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR 550 560 570 580 590 600 LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP CVHVYKLSGP DDDPLHKQPR FWASMMEAAS 610 620 630 640 650 660 CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA LQPGKKHPTV LFVYGGPQVS AHLLPRPPPH 670 HPPEDSPSPL KCQL
	Isoform 4 [UniParc]. Checksum: EF3B224CF112B857		836	95,013
	10 20 30 40 50 60 MATTGTPTAD RGDAAATDDP AARFQVQKHS WDGLRSIIHG SRKYSGLIVN KAPHDFQFVQ 70 80 90 100 110 120 KTDESGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LLLSWKQMLD HFQATPHHGV 130 140 150 160 170 180 YSREEELLRE RKRLGVFGIT SYDFHSESGL FLFQASNSLF HCRDGGKNGF MVSPMKPLEI 190 200 210 220 230 240 KTQCSGPRMD PKICPADPAF FSFINNSDLW VANIETGEER RLTFCHQGLS NVLDDPKSAG 250 260 270 280 290 300 VATFVIQEEF DRFTGYWWCP TASWEGSEGL KTLRILYEEV DESEVEVIHV PSPALEERKT 310 320 330 340 350 360 DSYRYPRTGS KNPKIALKLA EFQTDSQGKI VSTQEKELVQ PFSSLFPKVE YIARAGWTRD 370 380 390 400 410 420 GKYAWAMFLD RPQQWLQLVL LPPALFIPST ENEEQRLASA RAVPRNVQPY VVYEEVTNVW 430 440 450 460 470 480 INVHDIFYPF PQSEGEDELC FLRANECKTG FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK 490 500 510 520 530 540 CPIKEEIALT SGEWEVLARH GSKIWVNEET KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR 550 560 570 580 590 600 LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP CVHVYKLSGP DDDPLHKQPR FWASMMEAAS 610 620 630 640 650 660 CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA LQPGKKHPTV LFVYGGPQVQ LVNNSFKGIK 670 680 690 700 710 720 YLRLNTLASL GYAVVVIDGR GSCQRGLRFE GALKNQMGQV EIEDQVEGLQ FVAEKYGFID 730 740 750 760 770 780 LSRVAIHGWS YGGFLSLMGL IHKPQVFKVA IAGAPVTVWM AYDTGYTERY MDVPENNQHG 790 800 810 820 830 YEAGSVALHV EKLPNEPNRL LILHGFLDEN VHFFHTNFLV SQLIRAGKPY QLQEYL
	Isoform 5 [UniParc]. Checksum: E83D994DAEBC8C5B		833	94,487
	10 20 30 40 50 60 LSRRVPCVRR GCRPPLPPLP GSQSRAWSRD REAPLDPGRP AQSGRRPTSR SVSHACSWNG 70 80 90 100 110 120 GSLDPLEGTP ALLRSAERLM RKVKKLRLDK ENTGSWRSFS LNSEGAERAT SYDFHSESGL 130 140 150 160 170 180 FLFQASNSLF HCRDGGKNGF MVSPMKPLEI KTQCSGPRMD PKICPADPAF FSFINNSDLW 190 200 210 220 230 240 VANIETGEER RLTFCHQGLS NVLDDPKSAG VATFVIQEEF DRFTGYWWCP TASWEGSEGL 250 260 270 280 290 300 KTLRILYEEV DESEVEVIHV PSPALEERKT DSYRYPRTGS KNPKIALKLA EFQTDSQGKI 310 320 330 340 350 360 VSTQEKELVQ PFSSLFPKVE YIARAGWTRD GKYAWAMFLD RPQQWLQLVL LPPALFIPST 370 380 390 400 410 420 ENEEQRLASA RAVPRNVQPY VVYEEVTNVW INVHDIFYPF PQSEGEDELC FLRANECKTG 430 440 450 460 470 480 FCHLYKVTAV LKSQGYDWSE PFSPGEDEFK CPIKEEIALT SGEWEVLARH GSKIWVNEET 490 500 510 520 530 540 KLVYFQGTKD TPLEHHLYVV SYEAAGEIVR LTTPGFSHSC SMSQNFDMFV SHYSSVSTPP 550 560 570 580 590 600 CVHVYKLSGP DDDPLHKQPR FWASMMEAAS CPPDYVPPEI FHFHTRSDVR LYGMIYKPHA 610 620 630 640 650 660 LQPGKKHPTV LFVYGGPQVQ LVNNSFKGIK YLRLNTLASL GYAVVVIDGR GSCQRGLRFE 670 680 690 700 710 720 GALKNQMGQV EIEDQVEGLQ FVAEKYGFID LSRVAIHGWS YGGFLSLMGL IHKPQVFKVA 730 740 750 760 770 780 IAGAPVTVWM AYDTGYTERY MDVPENNQHG YEAGSVALHV EKLPNEPNRL LILHGFLDEN 790 800 810 820 830 VHFFHTNFLV SQLIRAGKPY QLQIYPNERH SIRCPESGEH YEVTLLHFLQ EYL

References

[1]	"Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV." Olsen C., Wagtmann N. Gene 299:185-193(2002) [PubMed: 12459266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases." Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O. Biochem. J. 373:179-189(2003) [PubMed: 12662155] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Colon.
[3]	"Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity." Ajami K., Abbott C.A., McCaughan G.W., Gorrell M.D. Biochim. Biophys. Acta 1679:18-28(2004) [PubMed: 15245913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta and Skin.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-863 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 272-863 (ISOFORM 2), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Glial tumor, Ovary, Spleen and Trachea.
[7]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-863 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-863 (ISOFORM 2). Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF452102 mRNA. Translation: AAL47179.1. AY172660 mRNA. Translation: AAO17262.1. AF542510 mRNA. Translation: AAO73880.2. AY374518 mRNA. Translation: AAQ83119.1. AC005594 Genomic DNA. Translation: AAC33801.1. Sequence problems. AC005783 Genomic DNA. Translation: AAC62840.1. Sequence problems. BC000970 mRNA. Translation: AAH00970.1. BC037948 mRNA. Translation: AAH37948.1. AK054656 mRNA. Translation: BAB70784.1. Different initiation. AK075030 mRNA. Translation: BAC11362.1. AK131100 mRNA. Translation: BAC85150.1. AK131499 mRNA. Translation: BAD18643.1. Different initiation. AL834376 mRNA. Translation: CAD39039.3. Frameshift. CR627380 mRNA. Translation: CAH10477.1.
UniGene	Hs.515081
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S09.019.
PTM databases
PhosphoSite	Q86TI2.
Genome annotation databases
Ensembl	ENSG00000142002. Homo sapiens. [Contig view]
KEGG	hsa:91039.
Organism-specific databases
H-InvDB	HIX0022644.
HGNC	HGNC:18648. DPP9.
MIM	608258. gene.
PharmGKB	PA38620.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q86TI2.
Gene expression databases
ArrayExpress	Q86TI2.
GermOnline	ENSG00000142002. Homo sapiens.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77078.
SOURCE	Search...

Entry information

Entry name

DPP9_HUMAN

Accession

Primary (citable) accession number: Q86TI2
Secondary accession number(s): O75273 , O75868, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	November 25, 2008
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)