O75200 (NPPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex-interacting protein-like 1

Gene names

Name:

NPIPL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the NPIP family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Coiled coil Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 221	203	Nuclear pore complex-interacting protein-like 1		PRO_0000326066
Regions
	Coiled coil	114 – 139	26	Potential
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O75200 [UniParc]. Last modified March 24, 2009. Version 2. Checksum: 57F79CA7E3B41BC2	FASTA	221	26,096
	10 20 30 40 50 60 MRLRFWLLIW LLLGFISHQP TPVSFLKTIF WSRNGHDGSM DVQQRAWRSN RSRQKGLRSI 70 80 90 100 110 120 CMHTKKRVSS FRGNKIGLKD VITLRRHVET KVRAKIRKRK VTTKINRHDK INGKRKTARK 130 140 150 160 170 180 QKMFQRAQEL RRRAEDYHKC KIPPSARKPL CNWVSLFVFL AFEHSLPGQD MDTFFSLQLC 190 200 210 220 AQALQREMAE RKAAYRHHSP IPVGNRVVQK HLHPHPVGPL I

References

[1]

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002544 Genomic DNA. Translation: AAC27429.1. AC138894 Genomic DNA. No translation available.
IPI	IPI00736575.
3D structure databases
ProteinModelPortal	O75200.
ModBase	Search...
PTM databases
PhosphoSite	O75200.
Proteomic databases
PaxDb	O75200.
PRIDE	O75200.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc002dpe.2. human.
Organism-specific databases
GeneCards	GC16M028468. GC16P016470. GC16P028767.
H-InvDB	HIX0038977.
HGNC	HGNC:33832. NPIPL1.
HPA	HPA026924.
neXtProt	NX_O75200.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG250343.
HOGENOM	HOG000293160.
HOVERGEN	HBG052821.
InParanoid	O75200.
OrthoDB	EOG4DZ1W9.
PhylomeDB	O75200.
Gene expression databases
Genevestigator	O75200.
Family and domain databases
InterPro	IPR009443. NPIP. [Graphical view]
PANTHER	PTHR15438. PTHR15438. 1 hit.
Pfam	PF06409. NPIP. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NPIPL1. human.

Entry information

Entry name

NPPL1_HUMAN

Accession

Primary (citable) accession number: O75200

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.