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O75191

- XYLB_HUMAN

UniProt

O75191 - XYLB_HUMAN

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Protein

Xylulose kinase

Gene

XYLB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.1 Publication

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.1 Publication

Kineticsi

  1. KM=24 µM for D-xylulose1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Substrate
Binding sitei170 – 1701Substrate
Binding sitei280 – 2801Substrate
Binding sitei281 – 2811Substrate
Binding sitei355 – 3551ATP
Binding sitei445 – 4451ATP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi441 – 4422ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: ProtInc
  2. carbohydrate phosphorylation Source: GOC
  3. D-xylose metabolic process Source: UniProtKB-KW
  4. generation of precursor metabolites and energy Source: ProtInc
  5. xylulose catabolic process Source: BHF-UCL
  6. xylulose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:XYLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12839. XYLB.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Xylulose kinasePRO_0000230985Add
BLAST

Proteomic databases

MaxQBiO75191.
PaxDbiO75191.
PRIDEiO75191.

PTM databases

PhosphoSiteiO75191.

Expressioni

Gene expression databases

BgeeiO75191.
CleanExiHS_XYLB.
ExpressionAtlasiO75191. baseline and differential.
GenevestigatoriO75191.

Organism-specific databases

HPAiHPA037863.
HPA038415.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi115268. 2 interactions.
STRINGi9606.ENSP00000207870.

Structurei

Secondary structure

1
536
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157
Beta strandi17 – 2610
Beta strandi31 – 388
Helixi39 – 424
Helixi44 – 463
Beta strandi52 – 543
Beta strandi61 – 644
Helixi65 – 8117
Helixi86 – 883
Beta strandi89 – 968
Beta strandi101 – 1055
Helixi108 – 1136
Helixi121 – 1255
Beta strandi132 – 1354
Helixi143 – 15311
Helixi156 – 1638
Helixi172 – 18211
Helixi184 – 1885
Beta strandi190 – 1956
Helixi196 – 20510
Helixi213 – 2164
Beta strandi218 – 2203
Turni224 – 2274
Helixi231 – 2377
Helixi241 – 2455
Beta strandi254 – 2574
Helixi260 – 2667
Beta strandi273 – 2753
Helixi280 – 2878
Beta strandi295 – 31117
Beta strandi316 – 3238
Beta strandi326 – 33914
Helixi340 – 35011
Helixi355 – 3639
Helixi369 – 3713
Beta strandi373 – 3797
Beta strandi382 – 3843
Beta strandi388 – 3925
Beta strandi398 – 4003
Helixi404 – 42522
Beta strandi436 – 4405
Helixi441 – 4444
Helixi446 – 45611
Beta strandi460 – 4623
Helixi468 – 48114
Helixi484 – 4863
Helixi489 – 4935
Beta strandi500 – 5034
Helixi509 – 53022

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BC2X-ray1.97A/B/C1-536[»]
4BC3X-ray1.68A/B/C1-536[»]
4BC4X-ray1.79A/B/C1-536[»]
4BC5X-ray1.98A/B/C1-536[»]
ProteinModelPortaliO75191.
SMRiO75191. Positions 6-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiO75191.
KOiK00854.
OMAiGSYSPID.
PhylomeDBiO75191.
TreeFamiTF313643.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75191) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG
60 70 80 90 100
GVHVHKDGLT VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG
110 120 130 140 150
SIYWKAGAQQ ALTSLSPDLR LHQQLQDCFS ISDCPVWMDS STTAQCRQLE
160 170 180 190 200
AAVGGAQALS CLTGSRAYER FTGNQIAKIY QQNPEAYSHT ERISLVSSFA
210 220 230 240 250
ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH LEEKLSPPVP
260 270 280 290 300
SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG
310 320 330 340 350
TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES
360 370 380 390 400
VSRSWSDFSK ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA
410 420 430 440 450
AFPGDVEVRA LIEGQFMAKR IHAEGLGYRV MSKTKILATG GASHNREILQ
460 470 480 490 500
VLADVFDAPV YVIDTANSAC VGSAYRAFHG LAGGTDVPFS EVVKLAPNPR
510 520 530
LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE
Length:536
Mass (Da):58,382
Last modified:May 5, 2009 - v3
Checksum:iE2FC1C45308D71A8
GO
Isoform 2 (identifier: O75191-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.

Show »
Length:399
Mass (Da):43,182
Checksum:iBF7C28142BABD317
GO

Sequence cautioni

The sequence BAA31527.1 differs from that shown. Reason: Probable cloning artifact.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851D → E.3 Publications
Corresponds to variant rs17118 [ dbSNP | Ensembl ].
VAR_055151
Natural varianti133 – 1331D → N.
Corresponds to variant rs2234610 [ dbSNP | Ensembl ].
VAR_055152
Natural varianti139 – 1391D → E.
Corresponds to variant rs151611 [ dbSNP | Ensembl ].
VAR_055153
Natural varianti262 – 2621Y → N.1 Publication
Corresponds to variant rs196380 [ dbSNP | Ensembl ].
VAR_055154
Natural varianti348 – 3481N → D.
Corresponds to variant rs2234622 [ dbSNP | Ensembl ].
VAR_055155

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_055522Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293325 mRNA. Translation: BAG56843.1.
AK314386 mRNA. Translation: BAG37011.1.
AP006191 Genomic DNA. No translation available.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64532.1.
BC137076 mRNA. Translation: AAI37077.1.
BC137080 mRNA. Translation: AAI37081.1.
AB015046 mRNA. Translation: BAA31527.1. Sequence problems.
CCDSiCCDS2678.1. [O75191-1]
RefSeqiNP_005099.2. NM_005108.3. [O75191-1]
XP_006713513.1. XM_006713450.1. [O75191-2]
UniGeneiHs.659985.

Genome annotation databases

EnsembliENST00000207870; ENSP00000207870; ENSG00000093217. [O75191-1]
GeneIDi9942.
KEGGihsa:9942.
UCSCiuc003cic.2. human. [O75191-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293325 mRNA. Translation: BAG56843.1 .
AK314386 mRNA. Translation: BAG37011.1 .
AP006191 Genomic DNA. No translation available.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64532.1 .
BC137076 mRNA. Translation: AAI37077.1 .
BC137080 mRNA. Translation: AAI37081.1 .
AB015046 mRNA. Translation: BAA31527.1 . Sequence problems.
CCDSi CCDS2678.1. [O75191-1 ]
RefSeqi NP_005099.2. NM_005108.3. [O75191-1 ]
XP_006713513.1. XM_006713450.1. [O75191-2 ]
UniGenei Hs.659985.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BC2 X-ray 1.97 A/B/C 1-536 [» ]
4BC3 X-ray 1.68 A/B/C 1-536 [» ]
4BC4 X-ray 1.79 A/B/C 1-536 [» ]
4BC5 X-ray 1.98 A/B/C 1-536 [» ]
ProteinModelPortali O75191.
SMRi O75191. Positions 6-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115268. 2 interactions.
STRINGi 9606.ENSP00000207870.

PTM databases

PhosphoSitei O75191.

Proteomic databases

MaxQBi O75191.
PaxDbi O75191.
PRIDEi O75191.

Protocols and materials databases

DNASUi 9942.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000207870 ; ENSP00000207870 ; ENSG00000093217 . [O75191-1 ]
GeneIDi 9942.
KEGGi hsa:9942.
UCSCi uc003cic.2. human. [O75191-1 ]

Organism-specific databases

CTDi 9942.
GeneCardsi GC03P038363.
H-InvDB HIX0003180.
HGNCi HGNC:12839. XYLB.
HPAi HPA037863.
HPA038415.
MIMi 604049. gene.
neXtProti NX_O75191.
PharmGKBi PA37430.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1070.
GeneTreei ENSGT00390000010821.
HOGENOMi HOG000174850.
HOVERGENi HBG053124.
InParanoidi O75191.
KOi K00854.
OMAi GSYSPID.
PhylomeDBi O75191.
TreeFami TF313643.

Miscellaneous databases

GenomeRNAii 9942.
NextBioi 35471022.
PROi O75191.
SOURCEi Search...

Gene expression databases

Bgeei O75191.
CleanExi HS_XYLB.
ExpressionAtlasi O75191. baseline and differential.
Genevestigatori O75191.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLU-85.
    Tissue: Kidney and Mammary gland.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-85.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Testis.
  5. "Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein."
    Tamari M., Daigo Y., Ishikawa S., Nakamura Y.
    Cytogenet. Cell Genet. 82:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-512 (ISOFORM 1), VARIANTS GLU-85 AND ASN-262.
    Tissue: Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism."
    Bunker R.D., Bulloch E.M., Dickson J.M., Loomes K.M., Baker E.N.
    J. Biol. Chem. 288:1643-1652(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) IN COMPLEX WITH D-XYLULOSE AND ADP, CATALYTIC ACTIVITY, FUNCTION, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiXYLB_HUMAN
AccessioniPrimary (citable) accession number: O75191
Secondary accession number(s): B2RAW4, B4DDT2, B9EH64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3