O75191 (XYLB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylulose kinase
Short name=Xylulokinase
EC=2.7.1.17

Gene names

Name:

XYLB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Sequence similarities	Belongs to the FGGY kinase family.
Sequence caution	The sequence BAA31527.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW generation of precursor metabolites and energy Traceable author statement Ref.5. Source: ProtInc xylulose catabolic process Traceable author statement Ref.5. Source: BHF-UCL
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 536

536

Xylulose kinase

PRO_0000230985

Natural variations

Natural variant

85

1

D → E. Ref.1 Ref.3 Ref.5
Corresponds to variant rs17118 [ dbSNP | Ensembl ].

VAR_055151

Natural variant

133

1

D → N.
Corresponds to variant rs2234610 [ dbSNP | Ensembl ].

VAR_055152

Natural variant

139

1

D → E.
Corresponds to variant rs151611 [ dbSNP | Ensembl ].

VAR_055153

Natural variant

262

1

Y → N. Ref.5
Corresponds to variant rs196380 [ dbSNP | Ensembl ].

VAR_055154

Natural variant

348

1

N → D.
Corresponds to variant rs2234622 [ dbSNP | Ensembl ].

VAR_055155

Secondary structure

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536

Helix Strand Turn

Details...

Beta strand

9 – 15

7

Beta strand

17 – 26

10

Beta strand

31 – 38

8

Helix

39 – 42

4

Helix

44 – 46

3

Beta strand

52 – 54

3

Beta strand

61 – 64

4

Helix

65 – 81

17

Helix

86 – 88

3

Beta strand

89 – 96

8

Beta strand

101 – 105

5

Helix

108 – 113

6

Helix

121 – 125

5

Beta strand

132 – 135

4

Helix

143 – 153

11

Helix

156 – 163

8

Helix

172 – 182

11

Helix

184 – 188

5

Beta strand

190 – 195

6

Helix

196 – 205

10

Helix

213 – 216

4

Beta strand

218 – 220

3

Turn

224 – 227

4

Helix

231 – 237

7

Helix

241 – 245

5

Beta strand

254 – 257

4

Helix

260 – 266

7

Beta strand

273 – 275

3

Helix

280 – 287

8

Beta strand

295 – 311

17

Beta strand

316 – 323

8

Beta strand

326 – 339

14

Helix

340 – 350

11

Helix

355 – 363

9

Helix

369 – 371

3

Beta strand

373 – 379

7

Beta strand

382 – 384

3

Beta strand

388 – 392

5

Beta strand

398 – 400

3

Helix

404 – 425

22

Beta strand

436 – 440

5

Helix

441 – 444

4

Helix

446 – 456

11

Beta strand

460 – 462

3

Helix

468 – 481

14

Helix

484 – 486

3

Helix

489 – 493

5

Beta strand

500 – 503

4

Helix

509 – 530

22

Sequences

	Sequence		Length	Mass (Da)
	O75191 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: E2FC1C45308D71A8	FASTA	536	58,382
	10 20 30 40 50 60 MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG GVHVHKDGLT 70 80 90 100 110 120 VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SIYWKAGAQQ ALTSLSPDLR 130 140 150 160 170 180 LHQQLQDCFS ISDCPVWMDS STTAQCRQLE AAVGGAQALS CLTGSRAYER FTGNQIAKIY 190 200 210 220 230 240 QQNPEAYSHT ERISLVSSFA ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH 250 260 270 280 290 300 LEEKLSPPVP SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG 310 320 330 340 350 360 TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES VSRSWSDFSK 370 380 390 400 410 420 ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA AFPGDVEVRA LIEGQFMAKR 430 440 450 460 470 480 IHAEGLGYRV MSKTKILATG GASHNREILQ VLADVFDAPV YVIDTANSAC VGSAYRAFHG 490 500 510 520 530 LAGGTDVPFS EVVKLAPNPR LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-85. Tissue: Kidney.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-85.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Testis.
[5]	"Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein." Tamari M., Daigo Y., Ishikawa S., Nakamura Y. Cytogenet. Cell Genet. 82:101-104(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-512, VARIANTS GLU-85 AND ASN-262. Tissue: Liver.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK314386 mRNA. Translation: BAG37011.1.
AP006191 Genomic DNA. No translation available.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64532.1.
BC137076 mRNA. Translation: AAI37077.1.
BC137080 mRNA. Translation: AAI37081.1.
AB015046 mRNA. Translation: BAA31527.1. Sequence problems.

IPI

IPI00021107.

RefSeq

NP_005099.2. NM_005108.3.

UniGene

Hs.659985.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4BC2	X-ray	1.97	A/B/C	1-536	[»]
4BC3	X-ray	1.68	A/B/C	1-536	[»]
4BC4	X-ray	1.79	A/B/C	1-536	[»]
4BC5	X-ray	1.98	A/B/C	1-536	[»]

ProteinModelPortal

O75191.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000207870.

PTM databases

PhosphoSite

O75191.

Proteomic databases

PaxDb

O75191.

PRIDE

O75191.

Protocols and materials databases

DNASU

9942.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000207870; ENSP00000207870; ENSG00000093217.

GeneID

9942.

KEGG

hsa:9942.

UCSC

uc003cic.2. human.

Organism-specific databases

CTD

9942.

GeneCards

GC03P038363.

H-InvDB

HIX0003180.

HGNC

HGNC:12839. XYLB.

HPA

HPA037863.
HPA038415.

MIM

604049. gene.

neXtProt

NX_O75191.

PharmGKB

PA37430.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1070.

HOGENOM

HOG000174850.

HOVERGEN

HBG053124.

InParanoid

O75191.

KO

K00854.

OMA

SYSPIDY.

PhylomeDB

O75191.

Gene expression databases

ArrayExpress

O75191.

Bgee

O75191.

CleanEx

HS_XYLB.

Genevestigator

O75191.

Family and domain databases

InterPro

IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]

Pfam

PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

9942.

NextBio

37512.

SOURCE

Search...

Entry information

Entry name

XYLB_HUMAN

Accession

Primary (citable) accession number: O75191
Secondary accession number(s): B2RAW4, B9EH64

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.