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O75191 (XYLB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylulose kinase

Short name=Xylulokinase
EC=2.7.1.17
Gene names
Name:XYLB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. Ref.7

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate. Ref.7

Subunit structure

Monomer. Ref.7

Sequence similarities

Belongs to the FGGY kinase family.

Biophysicochemical properties

Kinetic parameters:

KM=24 µM for D-xylulose Ref.7

Sequence caution

The sequence BAA31527.1 differs from that shown. Reason: Probable cloning artifact.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Xylulose kinase
PRO_0000230985

Regions

Nucleotide binding441 – 4422ATP

Sites

Binding site991Substrate
Binding site1701Substrate
Binding site2801Substrate
Binding site2811Substrate
Binding site3551ATP
Binding site4451ATP

Natural variations

Natural variant851D → E. Ref.1 Ref.3 Ref.5
Corresponds to variant rs17118 [ dbSNP | Ensembl ].
VAR_055151
Natural variant1331D → N.
Corresponds to variant rs2234610 [ dbSNP | Ensembl ].
VAR_055152
Natural variant1391D → E.
Corresponds to variant rs151611 [ dbSNP | Ensembl ].
VAR_055153
Natural variant2621Y → N. Ref.5
Corresponds to variant rs196380 [ dbSNP | Ensembl ].
VAR_055154
Natural variant3481N → D.
Corresponds to variant rs2234622 [ dbSNP | Ensembl ].
VAR_055155

Secondary structure

............................................................................................. 536
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O75191 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: E2FC1C45308D71A8

FASTA53658,382
        10         20         30         40         50         60 
MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG GVHVHKDGLT 

        70         80         90        100        110        120 
VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SIYWKAGAQQ ALTSLSPDLR 

       130        140        150        160        170        180 
LHQQLQDCFS ISDCPVWMDS STTAQCRQLE AAVGGAQALS CLTGSRAYER FTGNQIAKIY 

       190        200        210        220        230        240 
QQNPEAYSHT ERISLVSSFA ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH 

       250        260        270        280        290        300 
LEEKLSPPVP SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG 

       310        320        330        340        350        360 
TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES VSRSWSDFSK 

       370        380        390        400        410        420 
ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA AFPGDVEVRA LIEGQFMAKR 

       430        440        450        460        470        480 
IHAEGLGYRV MSKTKILATG GASHNREILQ VLADVFDAPV YVIDTANSAC VGSAYRAFHG 

       490        500        510        520        530 
LAGGTDVPFS EVVKLAPNPR LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-85.
Tissue: Kidney.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-85.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Testis.
[5]"Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein."
Tamari M., Daigo Y., Ishikawa S., Nakamura Y.
Cytogenet. Cell Genet. 82:101-104(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-512, VARIANTS GLU-85 AND ASN-262.
Tissue: Liver.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism."
Bunker R.D., Bulloch E.M., Dickson J.M., Loomes K.M., Baker E.N.
J. Biol. Chem. 288:1643-1652(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) IN COMPLEX WITH D-XYLULOSE AND ADP, CATALYTIC ACTIVITY, FUNCTION, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK314386 mRNA. Translation: BAG37011.1.
AP006191 Genomic DNA. No translation available.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64532.1.
BC137076 mRNA. Translation: AAI37077.1.
BC137080 mRNA. Translation: AAI37081.1.
AB015046 mRNA. Translation: BAA31527.1. Sequence problems.
CCDSCCDS2678.1.
RefSeqNP_005099.2. NM_005108.3.
UniGeneHs.659985.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BC2X-ray1.97A/B/C1-536[»]
4BC3X-ray1.68A/B/C1-536[»]
4BC4X-ray1.79A/B/C1-536[»]
4BC5X-ray1.98A/B/C1-536[»]
ProteinModelPortalO75191.
SMRO75191. Positions 6-531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115268. 2 interactions.
STRING9606.ENSP00000207870.

PTM databases

PhosphoSiteO75191.

Proteomic databases

MaxQBO75191.
PaxDbO75191.
PRIDEO75191.

Protocols and materials databases

DNASU9942.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000207870; ENSP00000207870; ENSG00000093217.
GeneID9942.
KEGGhsa:9942.
UCSCuc003cic.2. human.

Organism-specific databases

CTD9942.
GeneCardsGC03P038363.
H-InvDBHIX0003180.
HGNCHGNC:12839. XYLB.
HPAHPA037863.
HPA038415.
MIM604049. gene.
neXtProtNX_O75191.
PharmGKBPA37430.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1070.
HOGENOMHOG000174850.
HOVERGENHBG053124.
InParanoidO75191.
KOK00854.
OMAGSYSPID.
PhylomeDBO75191.
TreeFamTF313643.

Gene expression databases

ArrayExpressO75191.
BgeeO75191.
CleanExHS_XYLB.
GenevestigatorO75191.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9942.
NextBio37512.
PROO75191.
SOURCESearch...

Entry information

Entry nameXYLB_HUMAN
AccessionPrimary (citable) accession number: O75191
Secondary accession number(s): B2RAW4, B9EH64
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM