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Protein

Xylulose kinase

Gene

XYLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.1 Publication

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.1 Publication

Kineticsi

  1. KM=24 µM for D-xylulose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei99Substrate1
    Binding sitei170Substrate1
    Binding sitei280Substrate1
    Binding sitei281Substrate1
    Binding sitei355ATP1
    Binding sitei445ATP1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi441 – 442ATP2

    GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • xylulokinase activity Source: UniProtKB

    GO - Biological processi

    • carbohydrate metabolic process Source: ProtInc
    • D-xylose metabolic process Source: UniProtKB-KW
    • generation of precursor metabolites and energy Source: ProtInc
    • glucuronate catabolic process to xylulose 5-phosphate Source: Reactome
    • xylulose catabolic process Source: BHF-UCL
    • xylulose metabolic process Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciZFISH:HS01797-MONOMER.
    BRENDAi2.7.1.17. 2681.
    ReactomeiR-HSA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose kinase (EC:2.7.1.17)
    Short name:
    Xylulokinase
    Gene namesi
    Name:XYLB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12839. XYLB.

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: GO_Central
    • cytosol Source: Reactome
    • extracellular exosome Source: UniProtKB
    Complete GO annotation...

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi9942.
    OpenTargetsiENSG00000093217.
    PharmGKBiPA37430.

    Polymorphism and mutation databases

    BioMutaiXYLB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002309851 – 536Xylulose kinaseAdd BLAST536

    Proteomic databases

    EPDiO75191.
    MaxQBiO75191.
    PaxDbiO75191.
    PeptideAtlasiO75191.
    PRIDEiO75191.

    PTM databases

    iPTMnetiO75191.
    PhosphoSitePlusiO75191.

    Expressioni

    Gene expression databases

    BgeeiENSG00000093217.
    CleanExiHS_XYLB.
    ExpressionAtlasiO75191. baseline and differential.
    GenevisibleiO75191. HS.

    Organism-specific databases

    HPAiHPA037863.
    HPA038415.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi115268. 5 interactors.
    STRINGi9606.ENSP00000207870.

    Structurei

    Secondary structure

    1536
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi9 – 15Combined sources7
    Beta strandi17 – 26Combined sources10
    Beta strandi31 – 38Combined sources8
    Helixi39 – 42Combined sources4
    Helixi44 – 46Combined sources3
    Beta strandi52 – 54Combined sources3
    Beta strandi61 – 64Combined sources4
    Helixi65 – 81Combined sources17
    Helixi86 – 88Combined sources3
    Beta strandi89 – 96Combined sources8
    Beta strandi101 – 105Combined sources5
    Helixi108 – 113Combined sources6
    Helixi121 – 125Combined sources5
    Beta strandi132 – 135Combined sources4
    Helixi143 – 153Combined sources11
    Helixi156 – 163Combined sources8
    Helixi172 – 182Combined sources11
    Helixi184 – 188Combined sources5
    Beta strandi190 – 195Combined sources6
    Helixi196 – 205Combined sources10
    Helixi213 – 216Combined sources4
    Beta strandi218 – 220Combined sources3
    Turni224 – 227Combined sources4
    Helixi231 – 237Combined sources7
    Helixi241 – 245Combined sources5
    Beta strandi254 – 257Combined sources4
    Helixi260 – 266Combined sources7
    Beta strandi273 – 275Combined sources3
    Helixi280 – 287Combined sources8
    Beta strandi295 – 311Combined sources17
    Beta strandi316 – 323Combined sources8
    Beta strandi326 – 339Combined sources14
    Helixi340 – 350Combined sources11
    Helixi355 – 363Combined sources9
    Helixi369 – 371Combined sources3
    Beta strandi373 – 379Combined sources7
    Beta strandi382 – 384Combined sources3
    Beta strandi388 – 392Combined sources5
    Beta strandi398 – 400Combined sources3
    Helixi404 – 425Combined sources22
    Beta strandi436 – 440Combined sources5
    Helixi441 – 444Combined sources4
    Helixi446 – 456Combined sources11
    Beta strandi460 – 462Combined sources3
    Helixi468 – 481Combined sources14
    Helixi484 – 486Combined sources3
    Helixi489 – 493Combined sources5
    Beta strandi500 – 503Combined sources4
    Helixi509 – 530Combined sources22

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4BC2X-ray1.97A/B/C1-536[»]
    4BC3X-ray1.68A/B/C1-536[»]
    4BC4X-ray1.79A/B/C1-536[»]
    4BC5X-ray1.98A/B/C1-536[»]
    ProteinModelPortaliO75191.
    SMRiO75191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiKOG2531. Eukaryota.
    COG1070. LUCA.
    GeneTreeiENSGT00390000010821.
    HOGENOMiHOG000174850.
    HOVERGENiHBG053124.
    InParanoidiO75191.
    KOiK00854.
    OMAiLWLQEPM.
    OrthoDBiEOG091G07Q3.
    PhylomeDBiO75191.
    TreeFamiTF313643.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: O75191-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG
    60 70 80 90 100
    GVHVHKDGLT VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG
    110 120 130 140 150
    SIYWKAGAQQ ALTSLSPDLR LHQQLQDCFS ISDCPVWMDS STTAQCRQLE
    160 170 180 190 200
    AAVGGAQALS CLTGSRAYER FTGNQIAKIY QQNPEAYSHT ERISLVSSFA
    210 220 230 240 250
    ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH LEEKLSPPVP
    260 270 280 290 300
    SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG
    310 320 330 340 350
    TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES
    360 370 380 390 400
    VSRSWSDFSK ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA
    410 420 430 440 450
    AFPGDVEVRA LIEGQFMAKR IHAEGLGYRV MSKTKILATG GASHNREILQ
    460 470 480 490 500
    VLADVFDAPV YVIDTANSAC VGSAYRAFHG LAGGTDVPFS EVVKLAPNPR
    510 520 530
    LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE
    Length:536
    Mass (Da):58,382
    Last modified:May 5, 2009 - v3
    Checksum:iE2FC1C45308D71A8
    GO
    Isoform 2 (identifier: O75191-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:399
    Mass (Da):43,182
    Checksum:iBF7C28142BABD317
    GO

    Sequence cautioni

    The sequence BAA31527 differs from that shown. Probable cloning artifact.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05515185D → E.3 PublicationsCorresponds to variant rs17118dbSNPEnsembl.1
    Natural variantiVAR_055152133D → N.Corresponds to variant rs2234610dbSNPEnsembl.1
    Natural variantiVAR_055153139D → E.Corresponds to variant rs151611dbSNPEnsembl.1
    Natural variantiVAR_055154262Y → N.1 PublicationCorresponds to variant rs196380dbSNPEnsembl.1
    Natural variantiVAR_055155348N → D.Corresponds to variant rs2234622dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0555221 – 137Missing in isoform 2. 1 PublicationAdd BLAST137

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK293325 mRNA. Translation: BAG56843.1.
    AK314386 mRNA. Translation: BAG37011.1.
    AP006191 Genomic DNA. No translation available.
    AP006193 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64532.1.
    BC137076 mRNA. Translation: AAI37077.1.
    BC137080 mRNA. Translation: AAI37081.1.
    AB015046 mRNA. Translation: BAA31527.1. Sequence problems.
    CCDSiCCDS2678.1. [O75191-1]
    RefSeqiNP_005099.2. NM_005108.3. [O75191-1]
    UniGeneiHs.659985.

    Genome annotation databases

    EnsembliENST00000207870; ENSP00000207870; ENSG00000093217. [O75191-1]
    GeneIDi9942.
    KEGGihsa:9942.
    UCSCiuc003cic.3. human. [O75191-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK293325 mRNA. Translation: BAG56843.1.
    AK314386 mRNA. Translation: BAG37011.1.
    AP006191 Genomic DNA. No translation available.
    AP006193 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64532.1.
    BC137076 mRNA. Translation: AAI37077.1.
    BC137080 mRNA. Translation: AAI37081.1.
    AB015046 mRNA. Translation: BAA31527.1. Sequence problems.
    CCDSiCCDS2678.1. [O75191-1]
    RefSeqiNP_005099.2. NM_005108.3. [O75191-1]
    UniGeneiHs.659985.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4BC2X-ray1.97A/B/C1-536[»]
    4BC3X-ray1.68A/B/C1-536[»]
    4BC4X-ray1.79A/B/C1-536[»]
    4BC5X-ray1.98A/B/C1-536[»]
    ProteinModelPortaliO75191.
    SMRiO75191.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi115268. 5 interactors.
    STRINGi9606.ENSP00000207870.

    PTM databases

    iPTMnetiO75191.
    PhosphoSitePlusiO75191.

    Polymorphism and mutation databases

    BioMutaiXYLB.

    Proteomic databases

    EPDiO75191.
    MaxQBiO75191.
    PaxDbiO75191.
    PeptideAtlasiO75191.
    PRIDEiO75191.

    Protocols and materials databases

    DNASUi9942.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000207870; ENSP00000207870; ENSG00000093217. [O75191-1]
    GeneIDi9942.
    KEGGihsa:9942.
    UCSCiuc003cic.3. human. [O75191-1]

    Organism-specific databases

    CTDi9942.
    DisGeNETi9942.
    GeneCardsiXYLB.
    H-InvDBHIX0003180.
    HGNCiHGNC:12839. XYLB.
    HPAiHPA037863.
    HPA038415.
    MIMi604049. gene.
    neXtProtiNX_O75191.
    OpenTargetsiENSG00000093217.
    PharmGKBiPA37430.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2531. Eukaryota.
    COG1070. LUCA.
    GeneTreeiENSGT00390000010821.
    HOGENOMiHOG000174850.
    HOVERGENiHBG053124.
    InParanoidiO75191.
    KOiK00854.
    OMAiLWLQEPM.
    OrthoDBiEOG091G07Q3.
    PhylomeDBiO75191.
    TreeFamiTF313643.

    Enzyme and pathway databases

    BioCyciZFISH:HS01797-MONOMER.
    BRENDAi2.7.1.17. 2681.
    ReactomeiR-HSA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

    Miscellaneous databases

    GenomeRNAii9942.
    PROiO75191.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000093217.
    CleanExiHS_XYLB.
    ExpressionAtlasiO75191. baseline and differential.
    GenevisibleiO75191. HS.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiXYLB_HUMAN
    AccessioniPrimary (citable) accession number: O75191
    Secondary accession number(s): B2RAW4, B4DDT2, B9EH64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: May 5, 2009
    Last modified: November 2, 2016
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.