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Protein

Calcium-transporting ATPase type 2C member 2

Gene

ATP2C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi332Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi333Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi335Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi337Calcium 2By similarity1
Active sitei3794-aspartylphosphate intermediateBy similarity1
Metal bindingi674MagnesiumBy similarity1
Metal bindingi678MagnesiumBy similarity1
Metal bindingi768Calcium 2By similarity1
Metal bindingi772Calcium 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.8 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.2.9 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 2 (EC:3.6.3.8)
Short name:
ATPase 2C2
Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2
Gene namesi
Name:ATP2C2
Synonyms:KIAA0703, SPCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000064270.12
HGNCiHGNC:29103 ATP2C2
MIMi613082 gene
neXtProtiNX_O75185

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini128 – 129ExtracellularSequence analysis2
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini151 – 231CytoplasmicSequence analysisAdd BLAST81
Transmembranei232 – 252Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini253 – 293ExtracellularSequence analysisAdd BLAST41
Transmembranei294 – 314Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini315 – 331CytoplasmicSequence analysisAdd BLAST17
Transmembranei332 – 352Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini353 – 750ExtracellularSequence analysisAdd BLAST398
Transmembranei751 – 771Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini772 – 804CytoplasmicSequence analysisAdd BLAST33
Transmembranei805 – 825Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini826 – 837ExtracellularSequence analysisAdd BLAST12
Transmembranei838 – 855Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini856 – 874CytoplasmicSequence analysisAdd BLAST19
Transmembranei875 – 895Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini896 – 905ExtracellularSequence analysis10
Transmembranei906 – 926Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini927 – 946CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9914
PharmGKBiPA162377204

Polymorphism and mutation databases

BioMutaiATP2C2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462071 – 946Calcium-transporting ATPase type 2C member 2Add BLAST946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphothreonineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75185
PeptideAtlasiO75185
PRIDEiO75185

PTM databases

iPTMnetiO75185
PhosphoSitePlusiO75185

Expressioni

Gene expression databases

BgeeiENSG00000064270
CleanExiHS_ATP2C2
ExpressionAtlasiO75185 baseline and differential
GenevisibleiO75185 HS

Organism-specific databases

HPAiHPA052262
HPA075812

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ORAI1Q96D3110EBI-2939806,EBI-2291476

Protein-protein interaction databases

IntActiO75185, 1 interactor
STRINGi9606.ENSP00000262429

Structurei

3D structure databases

ProteinModelPortaliO75185
SMRiO75185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 119Poly-Leu6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
HOGENOMiHOG000265621
HOVERGENiHBG106478
InParanoidiO75185
KOiK01537
PhylomeDBiO75185
TreeFamiTF354251

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030334 ATP2C2
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF23 PTHR42861:SF23, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75185-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT
60 70 80 90 100
ALPPKEACKC QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE
110 120 130 140 150
PVWKKYLDQF KNPLILLLLG SALVSVLTKE YEDAVSIATA VLVVVTVAFI
160 170 180 190 200
QEYRSEKSLE ELTKMVPPEC NCLREGKLQH LLARELVPGD VVSLSIGDRI
210 220 230 240 250
PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT TLSNIVFMGT
260 270 280 290 300
LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL
310 320 330 340 350
FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG
360 370 380 390 400
VLRMAKKRVI VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL
410 420 430 440 450
RAEVSGVGYD GQGTVCLLPS KEVIKEFSNV SVGKLVEAGC VANNAVIRKN
460 470 480 490 500
AVMGQPTEGA LMALAMKMDL SDIKNSYIRK KEIPFSSEQK WMAVKCSLKT
510 520 530 540 550
EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC LQEEKRMGSL
560 570 580 590 600
GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT
610 620 630 640 650
GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT
660 670 680 690 700
SPKHKLKIIK ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK
710 720 730 740 750
EAANMILVDD DFSAIMNAVE EGKGIFYNIK NFVRFQLSTS ISALSLITLS
760 770 780 790 800
TVFNLPSPLN AMQILWINII MDGPPAQSLG VEPVDKDAFR QPPRSVRDTI
810 820 830 840 850
LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT MTFTCFVFFD
860 870 880 890 900
LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ
910 920 930 940
TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV
Length:946
Mass (Da):103,187
Last modified:December 16, 2008 - v2
Checksum:iAEB061210ED09D1C
GO
Isoform 2 (identifier: O75185-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MVEGRVSEFL...QKEDLARAFC → MLHFHLLKFK...SELVPDLSFQ

Show »
Length:963
Mass (Da):105,041
Checksum:iA82EA87032866F4D
GO
Isoform 3 (identifier: O75185-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-778: S → RSSQKTEVCCTAVRLGVEGRGESTWAGRAG

Note: No experimental confirmation available.Curated
Show »
Length:975
Mass (Da):106,235
Checksum:i4AD1288CAC4CD7A5
GO

Sequence cautioni

The sequence BAA31678 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171N → D in CAI46049 (PubMed:17974005).Curated1
Sequence conflicti361V → A in CAI46049 (PubMed:17974005).Curated1
Sequence conflicti880L → R in CAI46049 (PubMed:17974005).Curated1
Isoform 2 (identifier: O75185-2)
Sequence conflicti12R → I in BAA31678 (PubMed:9734811).Curated1
Isoform 3 (identifier: O75185-3)
Sequence conflicti789A → G in CAI46049 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059137165M → L2 PublicationsCorresponds to variant dbSNP:rs247818Ensembl.1
Natural variantiVAR_047935411G → S. Corresponds to variant dbSNP:rs2303853Ensembl.1
Natural variantiVAR_047936466M → L1 PublicationCorresponds to variant dbSNP:rs247897Ensembl.1
Natural variantiVAR_070929604L → Q1 PublicationCorresponds to variant dbSNP:rs62640926Ensembl.1
Natural variantiVAR_047937907L → P. Corresponds to variant dbSNP:rs16973859Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0359891 – 70MVEGR…ARAFC → MLHFHLLKFKTRVVFSAVII MVTGLCLFLLSLPHLHGVFE QVPAPWWTSLCPWPIMEAAA FQSGSLYPVASFLAAPMSEL VPDLSFQ in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_054679778S → RSSQKTEVCCTAVRLGVEGR GESTWAGRAG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY791884 mRNA Translation: AAV54193.1
AB014603 mRNA Translation: BAA31678.2 Different initiation.
AK300526 mRNA Translation: BAG62238.1
BX648333 mRNA Translation: CAI46049.1
CR749829 mRNA Translation: CAH18686.1
AC010551 Genomic DNA No translation available.
AC022165 Genomic DNA No translation available.
CCDSiCCDS42207.1 [O75185-1]
CCDS67088.1 [O75185-3]
RefSeqiNP_001273456.2, NM_001286527.2
NP_001278383.1, NM_001291454.1
NP_055676.3, NM_014861.3
UniGeneiHs.6168

Genome annotation databases

EnsembliENST00000262429; ENSP00000262429; ENSG00000064270
GeneIDi9914
KEGGihsa:9914
UCSCiuc002fhx.4 human [O75185-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAT2C2_HUMAN
AccessioniPrimary (citable) accession number: O75185
Secondary accession number(s): B4DU76
, E7ES94, Q5HYC3, Q5S053, Q68CQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health