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Protein

Paired amphipathic helix protein Sin3b

Gene

SIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127511-MONOMER.
ReactomeiR-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-427413. NoRC negatively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3b
Alternative name(s):
Histone deacetylase complex subunit Sin3b
Transcriptional corepressor Sin3b
Gene namesi
Name:SIN3BImported
Synonyms:KIAA0700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19354. SIN3B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23309.
OpenTargetsiENSG00000127511.
PharmGKBiPA134909030.

Polymorphism and mutation databases

BioMutaiSIN3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215391 – 1162Paired amphipathic helix protein Sin3bAdd BLAST1162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by RNF220 that leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75182.
MaxQBiO75182.
PaxDbiO75182.
PeptideAtlasiO75182.
PRIDEiO75182.

PTM databases

iPTMnetiO75182.
PhosphoSitePlusiO75182.

Expressioni

Gene expression databases

BgeeiENSG00000127511.
CleanExiHS_SIN3B.
ExpressionAtlasiO75182. baseline and differential.
GenevisibleiO75182. HS.

Organism-specific databases

HPAiHPA050329.

Interactioni

Subunit structurei

Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89 (PubMed:23460338).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011067EBI-540462,EBI-447544

Protein-protein interaction databases

BioGridi116901. 60 interactors.
IntActiO75182. 26 interactors.
STRINGi9606.ENSP00000369131.

Structurei

3D structure databases

ProteinModelPortaliO75182.
SMRiO75182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 107PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini153 – 238PAH 2PROSITE-ProRule annotationAdd BLAST86
Domaini292 – 369PAH 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 308Interaction with CRY1By similarityAdd BLAST308
Regioni59 – 105Interaction with RESTBy similarityAdd BLAST47
Regioni284 – 540Interaction with NCOR1By similarityAdd BLAST257
Regioni392 – 591Interaction with SUDS3 and HDAC1By similarityAdd BLAST200

Sequence similaritiesi

Contains 3 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4204. Eukaryota.
COG5602. LUCA.
GeneTreeiENSGT00390000007239.
HOGENOMiHOG000230688.
HOVERGENiHBG060425.
InParanoidiO75182.
OMAiAPHKPLD.
OrthoDBiEOG091G03HY.
PhylomeDBiO75182.
TreeFamiTF106187.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 2 hits.
PF16879. Sin3a_C. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75182-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHAGGGSGG SGAGGPAGRG LSGARWGRSG SAGHEKLPVH VEDALTYLDQ
60 70 80 90 100
VKIRFGSDPA TYNGFLEIMK EFKSQSIDTP GVIRRVSQLF HEHPDLIVGF
110 120 130 140 150
NAFLPLGYRI DIPKNGKLNI QSPLTSQENS HNHGDGAEDF KQQVPYKEDK
160 170 180 190 200
PQVPLESDSV EFNNAISYVN KIKTRFLDHP EIYRSFLEIL HTYQKEQLNT
210 220 230 240 250
RGRPFRGMSE EEVFTEVANL FRGQEDLLSE FGQFLPEAKR SLFTGNGPCE
260 270 280 290 300
MHSVQKNEHD KTPEHSRKRS RPSLLRPVSA PAKKKMKLRG TKDLSIAAVG
310 320 330 340 350
KYGTLQEFSF FDKVRRVLKS QEVYENFLRC IALFNQELVS GSELLQLVSP
360 370 380 390 400
FLGKFPELFA QFKSFLGVKE LSFAPPMSDR SGDGISREID YASCKRIGSS
410 420 430 440 450
YRALPKTYQQ PKCSGRTAIC KELDHWTLLQ GSWTDDYCMS KFKNTCWIPG
460 470 480 490 500
YSAGVLNDTW VSFPSWSEDS TFVSSKKTPY EEQLHRCEDE RFELDVVLET
510 520 530 540 550
NLATIRVLES VQKKLSRMAP EDQEKFRLDD SLGGTSEVIQ RRAIYRIYGD
560 570 580 590 600
KAPEIIESLK KNPVTAVPVV LKRLKAKEEE WREAQQGFNK IWREQYEKAY
610 620 630 640 650
LKSLDHQAVN FKQNDTKALR SKSLLNEIES VYDEHQEQHS EGRSAPSSEP
660 670 680 690 700
HLIFVYEDRQ ILEDAAALIS YYVKRQPAIQ KEDQGTIHQL LHQFVPSLFF
710 720 730 740 750
SQQLDLGASE ESADEDRDSP QGQTTDPSER KKPAPGPHSS PPEEKGAFGD
760 770 780 790 800
APATEQPPLP PPAPHKPLDD VYSLFFANNN WYFFLRLHQT LCSRLLKIYR
810 820 830 840 850
QAQKQLLEYR TEKEREKLLC EGRREKGSDP AMELRLKQPS EVELEEYYPA
860 870 880 890 900
FLDMVRSLLE GSIDPTQYED TLREMFTIHA YVGFTMDKLV QNIARQLHHL
910 920 930 940 950
VSDDVCLKVV ELYLNEKKRG AAGGNLSSRC VRAARETSYQ WKAERCMADE
960 970 980 990 1000
NCFKVMFLQR KGQVIMTIEL LDTEEAQTED PVEVQHLARY VEQYVGTEGA
1010 1020 1030 1040 1050
SSSPTEGFLL KPVFLQRNLK KFRRRWQSEQ ARALRGEARS SWKRLVGVES
1060 1070 1080 1090 1100
ACDVDCRFKL STHKMVFIVN SEDYMYRRGT LCRAKQVQPL VLLRHHQHFE
1110 1120 1130 1140 1150
EWHSRWLEDN VTVEAASLVQ DWLMGEEDED MVPCKTLCET VHVHGLPVTR
1160
YRVQYSRRPA SP
Note: No experimental confirmation available.Curated
Length:1,162
Mass (Da):133,066
Last modified:June 21, 2005 - v2
Checksum:i03D3B24AF1CF40B6
GO
Isoform 21 Publication (identifier: O75182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-454: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,130
Mass (Da):129,359
Checksum:iB767339317ECC96D
GO
Isoform 31 Publication (identifier: O75182-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-1162: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:353
Mass (Da):39,507
Checksum:i95056B3DCF6C0D53
GO

Sequence cautioni

The sequence BAA31675 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014185354 – 1162Missing in isoform 3. 1 PublicationAdd BLAST809
Alternative sequenceiVSP_014186423 – 454Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706204 mRNA. Translation: AAU01916.1.
AB014600 mRNA. Translation: BAA31675.2. Different initiation.
CH471106 Genomic DNA. Translation: EAW84565.1.
BC005113 mRNA. Translation: AAH05113.1.
BC025026 mRNA. Translation: AAH25026.1.
BC063531 mRNA. Translation: AAH63531.1.
BC110821 mRNA. Translation: AAI10822.1.
CCDSiCCDS32946.1. [O75182-1]
CCDS74308.1. [O75182-2]
RefSeqiNP_001284524.1. NM_001297595.1. [O75182-2]
NP_001284526.1. NM_001297597.1.
NP_056075.1. NM_015260.3. [O75182-1]
UniGeneiHs.13999.

Genome annotation databases

EnsembliENST00000248054; ENSP00000248054; ENSG00000127511. [O75182-2]
ENST00000379803; ENSP00000369131; ENSG00000127511. [O75182-1]
ENST00000596802; ENSP00000473039; ENSG00000127511. [O75182-3]
GeneIDi23309.
KEGGihsa:23309.
UCSCiuc002new.4. human. [O75182-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706204 mRNA. Translation: AAU01916.1.
AB014600 mRNA. Translation: BAA31675.2. Different initiation.
CH471106 Genomic DNA. Translation: EAW84565.1.
BC005113 mRNA. Translation: AAH05113.1.
BC025026 mRNA. Translation: AAH25026.1.
BC063531 mRNA. Translation: AAH63531.1.
BC110821 mRNA. Translation: AAI10822.1.
CCDSiCCDS32946.1. [O75182-1]
CCDS74308.1. [O75182-2]
RefSeqiNP_001284524.1. NM_001297595.1. [O75182-2]
NP_001284526.1. NM_001297597.1.
NP_056075.1. NM_015260.3. [O75182-1]
UniGeneiHs.13999.

3D structure databases

ProteinModelPortaliO75182.
SMRiO75182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116901. 60 interactors.
IntActiO75182. 26 interactors.
STRINGi9606.ENSP00000369131.

PTM databases

iPTMnetiO75182.
PhosphoSitePlusiO75182.

Polymorphism and mutation databases

BioMutaiSIN3B.

Proteomic databases

EPDiO75182.
MaxQBiO75182.
PaxDbiO75182.
PeptideAtlasiO75182.
PRIDEiO75182.

Protocols and materials databases

DNASUi23309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248054; ENSP00000248054; ENSG00000127511. [O75182-2]
ENST00000379803; ENSP00000369131; ENSG00000127511. [O75182-1]
ENST00000596802; ENSP00000473039; ENSG00000127511. [O75182-3]
GeneIDi23309.
KEGGihsa:23309.
UCSCiuc002new.4. human. [O75182-1]

Organism-specific databases

CTDi23309.
DisGeNETi23309.
GeneCardsiSIN3B.
HGNCiHGNC:19354. SIN3B.
HPAiHPA050329.
MIMi607777. gene.
neXtProtiNX_O75182.
OpenTargetsiENSG00000127511.
PharmGKBiPA134909030.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4204. Eukaryota.
COG5602. LUCA.
GeneTreeiENSGT00390000007239.
HOGENOMiHOG000230688.
HOVERGENiHBG060425.
InParanoidiO75182.
OMAiAPHKPLD.
OrthoDBiEOG091G03HY.
PhylomeDBiO75182.
TreeFamiTF106187.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127511-MONOMER.
ReactomeiR-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-427413. NoRC negatively regulates rRNA expression.

Miscellaneous databases

ChiTaRSiSIN3B. human.
GeneWikiiSIN3B.
GenomeRNAii23309.
PROiO75182.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127511.
CleanExiHS_SIN3B.
ExpressionAtlasiO75182. baseline and differential.
GenevisibleiO75182. HS.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 2 hits.
PF16879. Sin3a_C. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIN3B_HUMAN
AccessioniPrimary (citable) accession number: O75182
Secondary accession number(s): Q2NL91
, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.