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Protein

Paired amphipathic helix protein Sin3b

Gene

SIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3b
Alternative name(s):
Histone deacetylase complex subunit Sin3b
Transcriptional corepressor Sin3b
Gene namesi
Name:SIN3BImported
Synonyms:KIAA0700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127511.9
HGNCiHGNC:19354 SIN3B
MIMi607777 gene
neXtProtiNX_O75182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23309
OpenTargetsiENSG00000127511
PharmGKBiPA134909030

Polymorphism and mutation databases

BioMutaiSIN3B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215391 – 1162Paired amphipathic helix protein Sin3bAdd BLAST1162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by RNF220 that leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75182
MaxQBiO75182
PaxDbiO75182
PeptideAtlasiO75182
PRIDEiO75182

PTM databases

iPTMnetiO75182
PhosphoSitePlusiO75182

Expressioni

Gene expression databases

BgeeiENSG00000127511
CleanExiHS_SIN3B
ExpressionAtlasiO75182 baseline and differential
GenevisibleiO75182 HS

Organism-specific databases

HPAiHPA050329

Interactioni

Subunit structurei

Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89 (PubMed:23460338). Interacts with MYT1L (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011067EBI-540462,EBI-447544

Protein-protein interaction databases

BioGridi116901, 66 interactors
CORUMiO75182
IntActiO75182, 26 interactors
MINTiO75182
STRINGi9606.ENSP00000369131

Structurei

3D structure databases

ProteinModelPortaliO75182
SMRiO75182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 107PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini153 – 238PAH 2PROSITE-ProRule annotationAdd BLAST86
Domaini292 – 369PAH 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 308Interaction with CRY1By similarityAdd BLAST308
Regioni59 – 105Interaction with RESTBy similarityAdd BLAST47
Regioni284 – 540Interaction with NCOR1By similarityAdd BLAST257
Regioni392 – 591Interaction with SUDS3 and HDAC1By similarityAdd BLAST200

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00390000007239
HOGENOMiHOG000230688
HOVERGENiHBG060425
InParanoidiO75182
OMAiVQDWLMG
OrthoDBiEOG091G03HY
PhylomeDBiO75182
TreeFamiTF106187

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR031693 Sin3_C
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 2 hits
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75182-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHAGGGSGG SGAGGPAGRG LSGARWGRSG SAGHEKLPVH VEDALTYLDQ
60 70 80 90 100
VKIRFGSDPA TYNGFLEIMK EFKSQSIDTP GVIRRVSQLF HEHPDLIVGF
110 120 130 140 150
NAFLPLGYRI DIPKNGKLNI QSPLTSQENS HNHGDGAEDF KQQVPYKEDK
160 170 180 190 200
PQVPLESDSV EFNNAISYVN KIKTRFLDHP EIYRSFLEIL HTYQKEQLNT
210 220 230 240 250
RGRPFRGMSE EEVFTEVANL FRGQEDLLSE FGQFLPEAKR SLFTGNGPCE
260 270 280 290 300
MHSVQKNEHD KTPEHSRKRS RPSLLRPVSA PAKKKMKLRG TKDLSIAAVG
310 320 330 340 350
KYGTLQEFSF FDKVRRVLKS QEVYENFLRC IALFNQELVS GSELLQLVSP
360 370 380 390 400
FLGKFPELFA QFKSFLGVKE LSFAPPMSDR SGDGISREID YASCKRIGSS
410 420 430 440 450
YRALPKTYQQ PKCSGRTAIC KELDHWTLLQ GSWTDDYCMS KFKNTCWIPG
460 470 480 490 500
YSAGVLNDTW VSFPSWSEDS TFVSSKKTPY EEQLHRCEDE RFELDVVLET
510 520 530 540 550
NLATIRVLES VQKKLSRMAP EDQEKFRLDD SLGGTSEVIQ RRAIYRIYGD
560 570 580 590 600
KAPEIIESLK KNPVTAVPVV LKRLKAKEEE WREAQQGFNK IWREQYEKAY
610 620 630 640 650
LKSLDHQAVN FKQNDTKALR SKSLLNEIES VYDEHQEQHS EGRSAPSSEP
660 670 680 690 700
HLIFVYEDRQ ILEDAAALIS YYVKRQPAIQ KEDQGTIHQL LHQFVPSLFF
710 720 730 740 750
SQQLDLGASE ESADEDRDSP QGQTTDPSER KKPAPGPHSS PPEEKGAFGD
760 770 780 790 800
APATEQPPLP PPAPHKPLDD VYSLFFANNN WYFFLRLHQT LCSRLLKIYR
810 820 830 840 850
QAQKQLLEYR TEKEREKLLC EGRREKGSDP AMELRLKQPS EVELEEYYPA
860 870 880 890 900
FLDMVRSLLE GSIDPTQYED TLREMFTIHA YVGFTMDKLV QNIARQLHHL
910 920 930 940 950
VSDDVCLKVV ELYLNEKKRG AAGGNLSSRC VRAARETSYQ WKAERCMADE
960 970 980 990 1000
NCFKVMFLQR KGQVIMTIEL LDTEEAQTED PVEVQHLARY VEQYVGTEGA
1010 1020 1030 1040 1050
SSSPTEGFLL KPVFLQRNLK KFRRRWQSEQ ARALRGEARS SWKRLVGVES
1060 1070 1080 1090 1100
ACDVDCRFKL STHKMVFIVN SEDYMYRRGT LCRAKQVQPL VLLRHHQHFE
1110 1120 1130 1140 1150
EWHSRWLEDN VTVEAASLVQ DWLMGEEDED MVPCKTLCET VHVHGLPVTR
1160
YRVQYSRRPA SP
Note: No experimental confirmation available.Curated
Length:1,162
Mass (Da):133,066
Last modified:June 21, 2005 - v2
Checksum:i03D3B24AF1CF40B6
GO
Isoform 21 Publication (identifier: O75182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-454: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,130
Mass (Da):129,359
Checksum:iB767339317ECC96D
GO
Isoform 31 Publication (identifier: O75182-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-1162: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:353
Mass (Da):39,507
Checksum:i95056B3DCF6C0D53
GO

Sequence cautioni

The sequence BAA31675 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014185354 – 1162Missing in isoform 3. 1 PublicationAdd BLAST809
Alternative sequenceiVSP_014186423 – 454Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706204 mRNA Translation: AAU01916.1
AB014600 mRNA Translation: BAA31675.2 Different initiation.
CH471106 Genomic DNA Translation: EAW84565.1
BC005113 mRNA Translation: AAH05113.1
BC025026 mRNA Translation: AAH25026.1
BC063531 mRNA Translation: AAH63531.1
BC110821 mRNA Translation: AAI10822.1
CCDSiCCDS32946.1 [O75182-1]
CCDS74308.1 [O75182-2]
RefSeqiNP_001284524.1, NM_001297595.1 [O75182-2]
NP_001284526.1, NM_001297597.1
NP_056075.1, NM_015260.3 [O75182-1]
UniGeneiHs.13999

Genome annotation databases

EnsembliENST00000248054; ENSP00000248054; ENSG00000127511 [O75182-2]
ENST00000379803; ENSP00000369131; ENSG00000127511 [O75182-1]
ENST00000596802; ENSP00000473039; ENSG00000127511 [O75182-3]
GeneIDi23309
KEGGihsa:23309
UCSCiuc002new.4 human [O75182-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSIN3B_HUMAN
AccessioniPrimary (citable) accession number: O75182
Secondary accession number(s): Q2NL91
, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health