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O75182

- SIN3B_HUMAN

UniProt

O75182 - SIN3B_HUMAN

Protein

Paired amphipathic helix protein Sin3b

Gene

SIN3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. cardiac muscle tissue development Source: Ensembl
    2. cellular lipid metabolic process Source: Reactome
    3. negative regulation of transcription, DNA-templated Source: Ensembl
    4. rhythmic process Source: UniProtKB-KW
    5. skeletal muscle tissue development Source: Ensembl
    6. small molecule metabolic process Source: Reactome
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200856. NoRC negatively regulates rRNA expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired amphipathic helix protein Sin3b
    Alternative name(s):
    Histone deacetylase complex subunit Sin3b
    Transcriptional corepressor Sin3b
    Gene namesi
    Name:SIN3BImported
    Synonyms:KIAA0700
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19354. SIN3B.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. autosome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB
    5. X chromosome Source: Ensembl
    6. XY body Source: Ensembl
    7. Y chromosome Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11621162Paired amphipathic helix protein Sin3bPRO_0000121539Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by RNF220 that leads to proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiO75182.
    PaxDbiO75182.
    PRIDEiO75182.

    PTM databases

    PhosphoSiteiO75182.

    Expressioni

    Gene expression databases

    ArrayExpressiO75182.
    BgeeiO75182.
    CleanExiHS_SIN3B.
    GenevestigatoriO75182.

    Organism-specific databases

    HPAiHPA050329.

    Interactioni

    Subunit structurei

    Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1.1 Publication

    Protein-protein interaction databases

    BioGridi116901. 44 interactions.
    IntActiO75182. 7 interactions.
    STRINGi9606.ENSP00000369131.

    Structurei

    3D structure databases

    ProteinModelPortaliO75182.
    SMRiO75182. Positions 38-114, 156-240, 301-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 10771PAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini153 – 23886PAH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini292 – 36978PAH 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 308308Interaction with CRY1By similarityAdd
    BLAST
    Regioni59 – 10547Interaction with RESTBy similarityAdd
    BLAST
    Regioni284 – 540257Interaction with NCOR1By similarityAdd
    BLAST
    Regioni392 – 591200Interaction with SUDS3 and HDAC1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5602.
    HOGENOMiHOG000230688.
    HOVERGENiHBG060425.
    InParanoidiO75182.
    OMAiGEARSSW.
    PhylomeDBiO75182.
    TreeFamiTF106187.

    Family and domain databases

    Gene3Di1.20.1160.11. 3 hits.
    InterProiIPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view]
    PfamiPF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 2 hits.
    [Graphical view]
    SMARTiSM00761. HDAC_interact. 1 hit.
    [Graphical view]
    SUPFAMiSSF47762. SSF47762. 3 hits.
    PROSITEiPS51477. PAH. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75182-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHAGGGSGG SGAGGPAGRG LSGARWGRSG SAGHEKLPVH VEDALTYLDQ     50
    VKIRFGSDPA TYNGFLEIMK EFKSQSIDTP GVIRRVSQLF HEHPDLIVGF 100
    NAFLPLGYRI DIPKNGKLNI QSPLTSQENS HNHGDGAEDF KQQVPYKEDK 150
    PQVPLESDSV EFNNAISYVN KIKTRFLDHP EIYRSFLEIL HTYQKEQLNT 200
    RGRPFRGMSE EEVFTEVANL FRGQEDLLSE FGQFLPEAKR SLFTGNGPCE 250
    MHSVQKNEHD KTPEHSRKRS RPSLLRPVSA PAKKKMKLRG TKDLSIAAVG 300
    KYGTLQEFSF FDKVRRVLKS QEVYENFLRC IALFNQELVS GSELLQLVSP 350
    FLGKFPELFA QFKSFLGVKE LSFAPPMSDR SGDGISREID YASCKRIGSS 400
    YRALPKTYQQ PKCSGRTAIC KELDHWTLLQ GSWTDDYCMS KFKNTCWIPG 450
    YSAGVLNDTW VSFPSWSEDS TFVSSKKTPY EEQLHRCEDE RFELDVVLET 500
    NLATIRVLES VQKKLSRMAP EDQEKFRLDD SLGGTSEVIQ RRAIYRIYGD 550
    KAPEIIESLK KNPVTAVPVV LKRLKAKEEE WREAQQGFNK IWREQYEKAY 600
    LKSLDHQAVN FKQNDTKALR SKSLLNEIES VYDEHQEQHS EGRSAPSSEP 650
    HLIFVYEDRQ ILEDAAALIS YYVKRQPAIQ KEDQGTIHQL LHQFVPSLFF 700
    SQQLDLGASE ESADEDRDSP QGQTTDPSER KKPAPGPHSS PPEEKGAFGD 750
    APATEQPPLP PPAPHKPLDD VYSLFFANNN WYFFLRLHQT LCSRLLKIYR 800
    QAQKQLLEYR TEKEREKLLC EGRREKGSDP AMELRLKQPS EVELEEYYPA 850
    FLDMVRSLLE GSIDPTQYED TLREMFTIHA YVGFTMDKLV QNIARQLHHL 900
    VSDDVCLKVV ELYLNEKKRG AAGGNLSSRC VRAARETSYQ WKAERCMADE 950
    NCFKVMFLQR KGQVIMTIEL LDTEEAQTED PVEVQHLARY VEQYVGTEGA 1000
    SSSPTEGFLL KPVFLQRNLK KFRRRWQSEQ ARALRGEARS SWKRLVGVES 1050
    ACDVDCRFKL STHKMVFIVN SEDYMYRRGT LCRAKQVQPL VLLRHHQHFE 1100
    EWHSRWLEDN VTVEAASLVQ DWLMGEEDED MVPCKTLCET VHVHGLPVTR 1150
    YRVQYSRRPA SP 1162

    Note: No experimental confirmation available.Curated

    Length:1,162
    Mass (Da):133,066
    Last modified:June 21, 2005 - v2
    Checksum:i03D3B24AF1CF40B6
    GO
    Isoform 21 Publication (identifier: O75182-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         423-454: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:1,130
    Mass (Da):129,359
    Checksum:iB767339317ECC96D
    GO
    Isoform 31 Publication (identifier: O75182-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-1162: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:353
    Mass (Da):39,507
    Checksum:i95056B3DCF6C0D53
    GO

    Sequence cautioni

    The sequence BAA31675.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei354 – 1162809Missing in isoform 3. 1 PublicationVSP_014185Add
    BLAST
    Alternative sequencei423 – 45432Missing in isoform 2. 1 PublicationVSP_014186Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY706204 mRNA. Translation: AAU01916.1.
    AB014600 mRNA. Translation: BAA31675.2. Different initiation.
    CH471106 Genomic DNA. Translation: EAW84565.1.
    BC005113 mRNA. Translation: AAH05113.1.
    BC025026 mRNA. Translation: AAH25026.1.
    BC063531 mRNA. Translation: AAH63531.1.
    BC110821 mRNA. Translation: AAI10822.1.
    CCDSiCCDS32946.1. [O75182-1]
    RefSeqiNP_056075.1. NM_015260.2. [O75182-1]
    XP_005259889.1. XM_005259832.2. [O75182-2]
    UniGeneiHs.13999.

    Genome annotation databases

    EnsembliENST00000248054; ENSP00000248054; ENSG00000127511. [O75182-2]
    ENST00000379803; ENSP00000369131; ENSG00000127511. [O75182-1]
    ENST00000596802; ENSP00000473039; ENSG00000127511. [O75182-3]
    GeneIDi23309.
    KEGGihsa:23309.
    UCSCiuc002new.3. human. [O75182-3]
    uc002ney.2. human. [O75182-1]
    uc002nez.2. human. [O75182-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY706204 mRNA. Translation: AAU01916.1 .
    AB014600 mRNA. Translation: BAA31675.2 . Different initiation.
    CH471106 Genomic DNA. Translation: EAW84565.1 .
    BC005113 mRNA. Translation: AAH05113.1 .
    BC025026 mRNA. Translation: AAH25026.1 .
    BC063531 mRNA. Translation: AAH63531.1 .
    BC110821 mRNA. Translation: AAI10822.1 .
    CCDSi CCDS32946.1. [O75182-1 ]
    RefSeqi NP_056075.1. NM_015260.2. [O75182-1 ]
    XP_005259889.1. XM_005259832.2. [O75182-2 ]
    UniGenei Hs.13999.

    3D structure databases

    ProteinModelPortali O75182.
    SMRi O75182. Positions 38-114, 156-240, 301-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116901. 44 interactions.
    IntActi O75182. 7 interactions.
    STRINGi 9606.ENSP00000369131.

    PTM databases

    PhosphoSitei O75182.

    Proteomic databases

    MaxQBi O75182.
    PaxDbi O75182.
    PRIDEi O75182.

    Protocols and materials databases

    DNASUi 23309.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248054 ; ENSP00000248054 ; ENSG00000127511 . [O75182-2 ]
    ENST00000379803 ; ENSP00000369131 ; ENSG00000127511 . [O75182-1 ]
    ENST00000596802 ; ENSP00000473039 ; ENSG00000127511 . [O75182-3 ]
    GeneIDi 23309.
    KEGGi hsa:23309.
    UCSCi uc002new.3. human. [O75182-3 ]
    uc002ney.2. human. [O75182-1 ]
    uc002nez.2. human. [O75182-2 ]

    Organism-specific databases

    CTDi 23309.
    GeneCardsi GC19P016940.
    HGNCi HGNC:19354. SIN3B.
    HPAi HPA050329.
    MIMi 607777. gene.
    neXtProti NX_O75182.
    PharmGKBi PA134909030.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5602.
    HOGENOMi HOG000230688.
    HOVERGENi HBG060425.
    InParanoidi O75182.
    OMAi GEARSSW.
    PhylomeDBi O75182.
    TreeFami TF106187.

    Enzyme and pathway databases

    Reactomei REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200856. NoRC negatively regulates rRNA expression.

    Miscellaneous databases

    GeneWikii SIN3B.
    GenomeRNAii 23309.
    NextBioi 45174.
    PROi O75182.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75182.
    Bgeei O75182.
    CleanExi HS_SIN3B.
    Genevestigatori O75182.

    Family and domain databases

    Gene3Di 1.20.1160.11. 3 hits.
    InterProi IPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view ]
    Pfami PF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 2 hits.
    [Graphical view ]
    SMARTi SM00761. HDAC_interact. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47762. SSF47762. 3 hits.
    PROSITEi PS51477. PAH. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ali M., Batra H., Saluja D.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 743-1162 (ISOFORMS 1/2).
      Tissue: DuodenumImported, LungImported, Lymph and SkinImported.
    5. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
      Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.
      Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCFC1.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSIN3B_HUMAN
    AccessioniPrimary (citable) accession number: O75182
    Secondary accession number(s): Q2NL91
    , Q68GC2, Q6P4B8, Q8TB34, Q9BSC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3