Reviewed, UniProtKB/Swiss-Prot O75177 (S18L1_HUMAN)

Names and origin

Protein names

Recommended name:
    SS18-like protein 1
Alternative name(s):
    SYT homolog 1

Gene names

Name:	SS18L1
Synonyms:	KIAA0693

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Ubiquitous; with lowest levels in spleen.
Sequence similarities	Belongs to the SS18 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	SS18-like protein 1		PRO_0000181825
Regions
	Motif	50 – 53	4	SH2-binding Potential
	Motif	353 – 356	4	SH2-binding Potential
	Motif	371 – 379	9	SH3-binding Potential
	Motif	391 – 394	4	SH2-binding Potential
	Compositional bias	190 – 396	207	Gln-rich
Natural variations
	Natural variant	321	1	A → T: dbSNP rs36106901.		VAR_053691
Experimental info
	Sequence conflict	189	1	M → I in AAH34494. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O75177-1 [UniParc]. Last modified January 31, 2002. Version 2. Checksum: B76B7D61C7DF5592	FASTA	396	42,990
	10 20 30 40 50 60 MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCILEYQS KGKTAECTQY QQILHRNLVY 70 80 90 100 110 120 LATIADSNQN MQSLLPAPPT QNMNLGPGAL TQSGSSQGLH SQGSLSDAIS TGLPPSSLLQ 130 140 150 160 170 180 GQIGNGPSHV SMQQTAPNTL PTTSMSISGP GYSHAGPASQ GVPMQGQGTI GNYVSRTNIN 190 200 210 220 230 240 MQSNPVSMMQ QQAATSHYSS AQGGSQHYQG QSSIAMMGQG SQGSSMMGQR PMAPYRPSQQ 250 260 270 280 290 300 GSSQQYLGQE EYYGEQYSHS QGAAEPMGQQ YYPDGHGDYA YQQSSYTEQS YDRSFEESTQ 310 320 330 340 350 360 HYYEGGNSQY SQQQAGYQQG AAQQQTYSQQ QYPSQQSYPG QQQGYGSAQG APSQYPGYQQ 370 380 390 GQGQQYGSYR APQTAPSAQQ QRPYGYEQGQ YGNYQQ

References

[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB014593 mRNA. Translation: BAA31668.1. Different initiation. AL078633 Genomic DNA. Translation: CAI18836.1. BC034494 mRNA. Translation: AAH34494.1.
IPI	IPI00747811.
RefSeq	NP_945173.1.
UniGene	Hs.154429
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75177. 2 interactions.
STRING	O75177.
Proteomic databases
PRIDE	O75177.
Genome annotation databases
Ensembl	ENST00000331758; ENSP00000333012; ENSG00000184402; Homo sapiens. [Genome view] ENST00000370848; ENSP00000359885; ENSG00000184402; Homo sapiens. [Genome view] ENST00000421564; ENSP00000393999; ENSG00000184402; Homo sapiens. [Genome view] ENST00000450482; ENSP00000398634; ENSG00000184402; Homo sapiens. [Genome view]
GeneID	26039.
KEGG	hsa:26039.
UCSC	uc002ycb.1. human.
Organism-specific databases
CTD	26039.
GeneCards	GC20P060152.
HGNC	HGNC:15592. SS18L1.
HPA	CAB011827.
MIM	606472. gene.
PharmGKB	PA37989.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O75177.
OMA	EEYYSEQ.
Gene expression databases
ArrayExpress	O75177.
Bgee	O75177.
CleanEx	HS_SS18L1.
Genevestigator	O75177.
GermOnline	ENSG00000184402. Homo sapiens.
Family and domain databases
InterPro	IPR007726. SSXT. [Graphical view]
PANTHER	PTHR23107. SSXT. 1 hit.
Pfam	PF05030. SSXT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47867.
SOURCE	Search...

Entry information

Entry name

S18L1_HUMAN

Accession

Primary (citable) accession number: O75177
Secondary accession number(s): Q5JXJ3 , Q8NE69, Q9BR55, Q9H4K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	January 31, 2002
Last modified:	November 3, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.