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Protein

CCR4-NOT transcription complex subunit 3

Gene

CNOT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 3
Alternative name(s):
CCR4-associated factor 3
Leukocyte receptor cluster member 2
Gene namesi
Name:CNOT3
Synonyms:KIAA0691, LENG2, NOT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7879. CNOT3.

Subcellular locationi

GO - Cellular componenti

  • CCR4-NOT complex Source: UniProtKB
  • CCR4-NOT core complex Source: GO_Central
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: Reactome
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiCNOT3.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA26674.

Polymorphism and mutation databases

BioMutaiCNOT3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753CCR4-NOT transcription complex subunit 3PRO_0000198333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921PhosphothreonineCombined sources
Modified residuei299 – 2991PhosphoserineCombined sources
Modified residuei542 – 5421PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75175.
MaxQBiO75175.
PaxDbiO75175.
PRIDEiO75175.

PTM databases

iPTMnetiO75175.
PhosphoSiteiO75175.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiO75175.
CleanExiHS_CNOT3.
ExpressionAtlasiO75175. baseline and differential.
GenevisibleiO75175. HS.

Organism-specific databases

HPAiHPA006408.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cand2Q6ZQ732EBI-6504867,EBI-6504831From a different organism.
CNOT1A5YKK62EBI-743073,EBI-1222758
CNOT2Q9NZN83EBI-743073,EBI-743033
CNOT6LQ96LI52EBI-743073,EBI-1046635
CNOT8Q9UFF93EBI-743073,EBI-742299
TOB1P506162EBI-743073,EBI-723281

Protein-protein interaction databases

BioGridi110911. 39 interactions.
DIPiDIP-40297N.
IntActiO75175. 25 interactions.
MINTiMINT-1439009.
STRINGi9606.ENSP00000221232.

Structurei

Secondary structure

1
753
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi609 – 62214Combined sources
Helixi628 – 6303Combined sources
Beta strandi636 – 6383Combined sources
Helixi660 – 6656Combined sources
Helixi668 – 67710Combined sources
Helixi682 – 69312Combined sources
Beta strandi697 – 6993Combined sources
Turni700 – 7034Combined sources
Beta strandi704 – 7107Combined sources
Beta strandi713 – 7153Combined sources
Beta strandi717 – 72812Combined sources
Turni729 – 7324Combined sources
Beta strandi733 – 74311Combined sources
Helixi744 – 7463Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20C607-753[»]
4C0GX-ray2.40A/B/C/D/E/F656-753[»]
5FU6X-ray2.90C/F607-748[»]
5FU7X-ray3.10C/G607-748[»]
ProteinModelPortaliO75175.
SMRiO75175. Positions 607-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni661 – 75393Repressor domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi314 – 39582Pro-richAdd
BLAST
Compositional biasi397 – 42529Gly/Ser-richAdd
BLAST
Compositional biasi457 – 655199Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CNOT2/3/5 family.Curated

Phylogenomic databases

eggNOGiKOG2150. Eukaryota.
COG5665. LUCA.
GeneTreeiENSGT00390000014743.
HOGENOMiHOG000184850.
HOVERGENiHBG051042.
InParanoidiO75175.
KOiK12580.
OMAiELSPHHS.
PhylomeDBiO75175.
TreeFamiTF321963.

Family and domain databases

InterProiIPR012270. CCR4-NOT_su3/5.
IPR007282. NOT.
IPR007207. Not_N.
[Graphical view]
PfamiPF04153. NOT2_3_5. 1 hit.
PF04065. Not3. 1 hit.
[Graphical view]
PIRSFiPIRSF005290. NOT_su_3_5. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75175-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK
60 70 80 90 100
EIKKLQRLRD QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT
110 120 130 140 150
KAYSKEGLGL AQKVDPAQKE KEEVGQWLTN TIDTLNMQVD QFESEVESLS
160 170 180 190 200
VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV RMLETILRML DNDSILVDAI
210 220 230 240 250
RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA TSPPSHSHME
260 270 280 290 300
DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
310 320 330 340 350
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP
360 370 380 390 400
SALGPKASPA PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG
410 420 430 440 450
GGSGGGGSSS SSNSSAGGGA GKQNGATSYS SVVADSPAEV ALSSSGGNNA
460 470 480 490 500
SSQALGPPSG PHNPPPSTSK EPSAAAPTGA GGVAPGSGNN SGGPSLLVPL
510 520 530 540 550
PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL SSLKSMAERA
560 570 580 590 600
AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
610 620 630 640 650
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH
660 670 680 690 700
QMPPPHSDTV EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT
710 720 730 740 750
KYMMWFQRHE EPKTITDEFE QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR

DLQ
Length:753
Mass (Da):81,872
Last modified:November 1, 1998 - v1
Checksum:iC9D4F8B9FEF6CD90
GO
Isoform 2 (identifier: O75175-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-609: TK → PR
     610-753: Missing.

Show »
Length:609
Mass (Da):64,053
Checksum:i507FC8AF634B613C
GO
Isoform 3 (identifier: O75175-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.
     680-753: GTKAQYLAAK...YRYLEDRDLQ → PRDVRTAWVD...LSSPLPTPLL

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):58,841
Checksum:iB21FEF915F2D01F4
GO

Sequence cautioni

The sequence BAA31666.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform 3. 1 PublicationVSP_009919Add
BLAST
Alternative sequencei608 – 6092TK → PR in isoform 2. 1 PublicationVSP_009920
Alternative sequencei610 – 753144Missing in isoform 2. 1 PublicationVSP_009921Add
BLAST
Alternative sequencei680 – 75374GTKAQ…DRDLQ → PRDVRTAWVDSEAGPLRHTS APLPVAHWLTRGPSPALLQQ PQSRPTPLCSSAHSQASLET TGELSSPLPTPLL in isoform 3. 1 PublicationVSP_009922Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180474 mRNA. Translation: AAF29828.1.
AB014591 mRNA. Translation: BAA31666.2. Different initiation.
AL133647 mRNA. Translation: CAB63766.1.
BC016474 mRNA. Translation: AAH16474.1.
CCDSiCCDS12880.1. [O75175-1]
PIRiT43456.
RefSeqiNP_055331.1. NM_014516.3. [O75175-1]
UniGeneiHs.343571.

Genome annotation databases

EnsembliENST00000221232; ENSP00000221232; ENSG00000088038. [O75175-1]
ENST00000358389; ENSP00000351159; ENSG00000088038. [O75175-1]
ENST00000610829; ENSP00000480392; ENSG00000276082. [O75175-3]
ENST00000610883; ENSP00000480258; ENSG00000274941. [O75175-1]
ENST00000611252; ENSP00000483968; ENSG00000275979. [O75175-1]
ENST00000611667; ENSP00000479186; ENSG00000277615. [O75175-3]
ENST00000612924; ENSP00000480585; ENSG00000274176. [O75175-1]
ENST00000613528; ENSP00000483604; ENSG00000277615. [O75175-1]
ENST00000613636; ENSP00000478143; ENSG00000274616. [O75175-3]
ENST00000613752; ENSP00000481681; ENSG00000273943. [O75175-1]
ENST00000614598; ENSP00000483450; ENSG00000274941. [O75175-3]
ENST00000614649; ENSP00000484794; ENSG00000274176. [O75175-1]
ENST00000615030; ENSP00000480697; ENSG00000274616. [O75175-1]
ENST00000616102; ENSP00000477620; ENSG00000277114. [O75175-3]
ENST00000616359; ENSP00000484040; ENSG00000274616. [O75175-1]
ENST00000616910; ENSP00000480876; ENSG00000277615. [O75175-1]
ENST00000617218; ENSP00000481624; ENSG00000274176. [O75175-3]
ENST00000617982; ENSP00000479987; ENSG00000277600. [O75175-1]
ENST00000618405; ENSP00000481924; ENSG00000277114. [O75175-1]
ENST00000619347; ENSP00000477693; ENSG00000273943. [O75175-3]
ENST00000619557; ENSP00000484369; ENSG00000275979. [O75175-3]
ENST00000619567; ENSP00000483882; ENSG00000275979. [O75175-1]
ENST00000619854; ENSP00000483431; ENSG00000273943. [O75175-1]
ENST00000620060; ENSP00000483036; ENSG00000277114. [O75175-1]
ENST00000620419; ENSP00000478956; ENSG00000276082. [O75175-1]
ENST00000620573; ENSP00000480988; ENSG00000276082. [O75175-1]
ENST00000620970; ENSP00000483692; ENSG00000277600. [O75175-1]
ENST00000622131; ENSP00000478280; ENSG00000274941. [O75175-1]
ENST00000622193; ENSP00000478913; ENSG00000277600. [O75175-3]
GeneIDi4849.
KEGGihsa:4849.
UCSCiuc002qdj.3. human. [O75175-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180474 mRNA. Translation: AAF29828.1.
AB014591 mRNA. Translation: BAA31666.2. Different initiation.
AL133647 mRNA. Translation: CAB63766.1.
BC016474 mRNA. Translation: AAH16474.1.
CCDSiCCDS12880.1. [O75175-1]
PIRiT43456.
RefSeqiNP_055331.1. NM_014516.3. [O75175-1]
UniGeneiHs.343571.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20C607-753[»]
4C0GX-ray2.40A/B/C/D/E/F656-753[»]
5FU6X-ray2.90C/F607-748[»]
5FU7X-ray3.10C/G607-748[»]
ProteinModelPortaliO75175.
SMRiO75175. Positions 607-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110911. 39 interactions.
DIPiDIP-40297N.
IntActiO75175. 25 interactions.
MINTiMINT-1439009.
STRINGi9606.ENSP00000221232.

PTM databases

iPTMnetiO75175.
PhosphoSiteiO75175.

Polymorphism and mutation databases

BioMutaiCNOT3.

Proteomic databases

EPDiO75175.
MaxQBiO75175.
PaxDbiO75175.
PRIDEiO75175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221232; ENSP00000221232; ENSG00000088038. [O75175-1]
ENST00000358389; ENSP00000351159; ENSG00000088038. [O75175-1]
ENST00000610829; ENSP00000480392; ENSG00000276082. [O75175-3]
ENST00000610883; ENSP00000480258; ENSG00000274941. [O75175-1]
ENST00000611252; ENSP00000483968; ENSG00000275979. [O75175-1]
ENST00000611667; ENSP00000479186; ENSG00000277615. [O75175-3]
ENST00000612924; ENSP00000480585; ENSG00000274176. [O75175-1]
ENST00000613528; ENSP00000483604; ENSG00000277615. [O75175-1]
ENST00000613636; ENSP00000478143; ENSG00000274616. [O75175-3]
ENST00000613752; ENSP00000481681; ENSG00000273943. [O75175-1]
ENST00000614598; ENSP00000483450; ENSG00000274941. [O75175-3]
ENST00000614649; ENSP00000484794; ENSG00000274176. [O75175-1]
ENST00000615030; ENSP00000480697; ENSG00000274616. [O75175-1]
ENST00000616102; ENSP00000477620; ENSG00000277114. [O75175-3]
ENST00000616359; ENSP00000484040; ENSG00000274616. [O75175-1]
ENST00000616910; ENSP00000480876; ENSG00000277615. [O75175-1]
ENST00000617218; ENSP00000481624; ENSG00000274176. [O75175-3]
ENST00000617982; ENSP00000479987; ENSG00000277600. [O75175-1]
ENST00000618405; ENSP00000481924; ENSG00000277114. [O75175-1]
ENST00000619347; ENSP00000477693; ENSG00000273943. [O75175-3]
ENST00000619557; ENSP00000484369; ENSG00000275979. [O75175-3]
ENST00000619567; ENSP00000483882; ENSG00000275979. [O75175-1]
ENST00000619854; ENSP00000483431; ENSG00000273943. [O75175-1]
ENST00000620060; ENSP00000483036; ENSG00000277114. [O75175-1]
ENST00000620419; ENSP00000478956; ENSG00000276082. [O75175-1]
ENST00000620573; ENSP00000480988; ENSG00000276082. [O75175-1]
ENST00000620970; ENSP00000483692; ENSG00000277600. [O75175-1]
ENST00000622131; ENSP00000478280; ENSG00000274941. [O75175-1]
ENST00000622193; ENSP00000478913; ENSG00000277600. [O75175-3]
GeneIDi4849.
KEGGihsa:4849.
UCSCiuc002qdj.3. human. [O75175-1]

Organism-specific databases

CTDi4849.
GeneCardsiCNOT3.
HGNCiHGNC:7879. CNOT3.
HPAiHPA006408.
MalaCardsiCNOT3.
MIMi604910. gene.
neXtProtiNX_O75175.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA26674.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2150. Eukaryota.
COG5665. LUCA.
GeneTreeiENSGT00390000014743.
HOGENOMiHOG000184850.
HOVERGENiHBG051042.
InParanoidiO75175.
KOiK12580.
OMAiELSPHHS.
PhylomeDBiO75175.
TreeFamiTF321963.

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.

Miscellaneous databases

GeneWikiiCNOT3.
GenomeRNAii4849.
NextBioi18674.
PROiO75175.
SOURCEiSearch...

Gene expression databases

BgeeiO75175.
CleanExiHS_CNOT3.
ExpressionAtlasiO75175. baseline and differential.
GenevisibleiO75175. HS.

Family and domain databases

InterProiIPR012270. CCR4-NOT_su3/5.
IPR007282. NOT.
IPR007207. Not_N.
[Graphical view]
PfamiPF04153. NOT2_3_5. 1 hit.
PF04065. Not3. 1 hit.
[Graphical view]
PIRSFiPIRSF005290. NOT_su_3_5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
    Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
    Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CNOT8, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3."
    Aoki T., Okada N., Wakamatsu T., Tamura T.-A.
    Biochem. Biophys. Res. Commun. 296:1097-1103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIP120B.
  6. "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."
    Zwartjes C.G., Jayne S., van den Berg D.L., Timmers H.T.
    J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."
    Ito K., Inoue T., Yokoyama K., Morita M., Suzuki T., Yamamoto T.
    Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNOT2.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: FUNCTION.
  14. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
    Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G.
    Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCNOT3_HUMAN
AccessioniPrimary (citable) accession number: O75175
Secondary accession number(s): Q9NZN7, Q9UF76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.