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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 2

Gene

PPP6R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 2
Alternative name(s):
SAPS domain family member 2
Gene namesi
Name:PPP6R2
Synonyms:KIAA0685, PP6R2, SAPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:19253. PPP6R2.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165378360.

Polymorphism and mutation databases

BioMutaiPPP6R2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Serine/threonine-protein phosphatase 6 regulatory subunit 2PRO_0000046098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891PhosphoserineCombined sources
Modified residuei771 – 7711PhosphoserineBy similarity
Modified residuei828 – 8281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75170.
MaxQBiO75170.
PaxDbiO75170.
PeptideAtlasiO75170.
PRIDEiO75170.

PTM databases

iPTMnetiO75170.
PhosphoSiteiO75170.

Expressioni

Tissue specificityi

Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000100239.
CleanExiHS_SAPS2.
ExpressionAtlasiO75170. baseline and differential.
GenevisibleiO75170. HS.

Organism-specific databases

HPAiCAB034919.
HPA030656.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD28O150847EBI-359739,EBI-359567
NFKBIEO002212EBI-359739,EBI-355098
PPP6CO007438EBI-359739,EBI-359751

Protein-protein interaction databases

BioGridi115053. 65 interactions.
DIPiDIP-27539N.
IntActiO75170. 30 interactions.
MINTiMINT-1140941.
STRINGi9606.ENSP00000379090.

Structurei

3D structure databases

ProteinModelPortaliO75170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi820 – 8256Poly-Ser

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiO75170.
KOiK15500.
OMAiQDPPLDM.
OrthoDBiEOG091G0893.
PhylomeDBiO75170.
TreeFamiTF313227.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 2 hits.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR
60 70 80 90 100
QQCMEELVSL ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE
110 120 130 140 150
SLLSLLYDFL DHEPPLNPLL ASFFSKTIGN LIARKTEQVI TFLKKKDKFI
160 170 180 190 200
SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ DVLHWLNEEK VIQRLVELIH
210 220 230 240 250
PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT ALESQDCVEQ
260 270 280 290 300
LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
310 320 330 340 350
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM
360 370 380 390 400
AALLHTNTPS INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS
410 420 430 440 450
HAAREERTEA SGSESRVEPP HENGNRSLET PQPAASLPDN TMVTHLFQKC
460 470 480 490 500
CLVQRILEAW EANDHTQAAG GMRRGNMGHL TRIANAVVQN LERGPVQTHI
510 520 530 540 550
SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL HSSSEDEDIE
560 570 580 590 600
GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
610 620 630 640 650
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV
660 670 680 690 700
MARPRFGAPH ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE
710 720 730 740 750
APPVEGDSEG AMWTAVFDEP ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG
760 770 780 790 800
WAKFTDFQPF CCSESGPRCS SPVDTECSHA EGSRSQGPEK ASQASYFAVS
810 820 830 840 850
PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA MDAVSRGPGR
860 870 880 890 900
EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
910 920 930 940 950
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD
960
GKTDAPPEGA ALNGPV
Note: No experimental confirmation available.
Length:966
Mass (Da):104,942
Last modified:January 15, 2008 - v2
Checksum:iD3BC10EADB98FB62
GO
Isoform 2 (identifier: O75170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     709-709: E → EA
     792-799: SQASYFAV → F
     952-966: KTDAPPEGAALNGPV → QMPRQKELP

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):101,007
Checksum:iDE1A1A4F2F66A0F9
GO
Isoform 3 (identifier: O75170-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: S → SR
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:933
Mass (Da):101,402
Checksum:iD74E382158135767
GO
Isoform 4 (identifier: O75170-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:932
Mass (Da):101,246
Checksum:i0E22A2912F2A1F2A
GO
Isoform 5 (identifier: O75170-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     792-799: SQASYFAV → F

Show »
Length:959
Mass (Da):104,235
Checksum:i6C9F6F32B2768517
GO
Isoform 6 (identifier: O75170-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-84: Missing.
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:905
Mass (Da):98,126
Checksum:i2B49E60FADD6D84D
GO

Sequence cautioni

The sequence BAA31660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241D → G in BAH13719 (PubMed:14702039).Curated
Sequence conflicti806 – 8061A → T in BAH13719 (PubMed:14702039).Curated
Sequence conflicti835 – 8351Q → H in AAH52995 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti633 – 6331D → E.
Corresponds to variant rs11555194 [ dbSNP | Ensembl ].
VAR_058402
Natural varianti732 – 7321R → K.
Corresponds to variant rs13057311 [ dbSNP | Ensembl ].
VAR_058403

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 8427Missing in isoform 6. 1 PublicationVSP_037767Add
BLAST
Alternative sequencei244 – 2441S → SR in isoform 3. 1 PublicationVSP_037768
Alternative sequencei535 – 56127Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 2 PublicationsVSP_030758Add
BLAST
Alternative sequencei709 – 7091E → EA in isoform 2. 1 PublicationVSP_030759
Alternative sequencei792 – 7998SQASYFAV → F in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_030760
Alternative sequencei952 – 96615KTDAP…LNGPV → QMPRQKELP in isoform 2. 1 PublicationVSP_030761Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014585 mRNA. Translation: BAA31660.2. Different initiation.
AK302472 mRNA. Translation: BAH13719.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03456.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03457.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03458.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03459.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03561.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03562.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03563.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03564.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03642.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03643.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03644.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03645.1.
BC000976 mRNA. Translation: AAH00976.2.
BC006568 mRNA. Translation: AAH06568.1.
BC032664 mRNA. Translation: AAH32664.1.
BC041698 mRNA. Translation: AAH41698.1.
BC052995 mRNA. Translation: AAH52995.1.
CCDSiCCDS33681.1. [O75170-4]
CCDS56235.1. [O75170-3]
CCDS56236.1. [O75170-2]
CCDS74881.1. [O75170-5]
PIRiT00357.
RefSeqiNP_001229827.1. NM_001242898.1. [O75170-5]
NP_001229828.1. NM_001242899.1. [O75170-3]
NP_001229829.1. NM_001242900.1. [O75170-2]
NP_055493.2. NM_014678.4. [O75170-4]
XP_006724497.1. XM_006724434.1. [O75170-1]
UniGeneiHs.449098.
Hs.733531.
Hs.740776.

Genome annotation databases

EnsembliENST00000216061; ENSP00000216061; ENSG00000100239. [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239. [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239. [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239. [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239. [O75170-5]
GeneIDi9701.
KEGGihsa:9701.
UCSCiuc003bky.3. human. [O75170-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014585 mRNA. Translation: BAA31660.2. Different initiation.
AK302472 mRNA. Translation: BAH13719.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03456.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03457.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03458.1.
AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03459.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03561.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03562.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03563.1.
AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03564.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03642.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03643.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03644.1.
AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03645.1.
BC000976 mRNA. Translation: AAH00976.2.
BC006568 mRNA. Translation: AAH06568.1.
BC032664 mRNA. Translation: AAH32664.1.
BC041698 mRNA. Translation: AAH41698.1.
BC052995 mRNA. Translation: AAH52995.1.
CCDSiCCDS33681.1. [O75170-4]
CCDS56235.1. [O75170-3]
CCDS56236.1. [O75170-2]
CCDS74881.1. [O75170-5]
PIRiT00357.
RefSeqiNP_001229827.1. NM_001242898.1. [O75170-5]
NP_001229828.1. NM_001242899.1. [O75170-3]
NP_001229829.1. NM_001242900.1. [O75170-2]
NP_055493.2. NM_014678.4. [O75170-4]
XP_006724497.1. XM_006724434.1. [O75170-1]
UniGeneiHs.449098.
Hs.733531.
Hs.740776.

3D structure databases

ProteinModelPortaliO75170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115053. 65 interactions.
DIPiDIP-27539N.
IntActiO75170. 30 interactions.
MINTiMINT-1140941.
STRINGi9606.ENSP00000379090.

PTM databases

iPTMnetiO75170.
PhosphoSiteiO75170.

Polymorphism and mutation databases

BioMutaiPPP6R2.

Proteomic databases

EPDiO75170.
MaxQBiO75170.
PaxDbiO75170.
PeptideAtlasiO75170.
PRIDEiO75170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216061; ENSP00000216061; ENSG00000100239. [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239. [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239. [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239. [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239. [O75170-5]
GeneIDi9701.
KEGGihsa:9701.
UCSCiuc003bky.3. human. [O75170-1]

Organism-specific databases

CTDi9701.
GeneCardsiPPP6R2.
HGNCiHGNC:19253. PPP6R2.
HPAiCAB034919.
HPA030656.
MIMi610877. gene.
neXtProtiNX_O75170.
PharmGKBiPA165378360.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiO75170.
KOiK15500.
OMAiQDPPLDM.
OrthoDBiEOG091G0893.
PhylomeDBiO75170.
TreeFamiTF313227.

Miscellaneous databases

ChiTaRSiPPP6R2. human.
GenomeRNAii9701.
PROiO75170.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100239.
CleanExiHS_SAPS2.
ExpressionAtlasiO75170. baseline and differential.
GenevisibleiO75170. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 2 hits.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPP6R2_HUMAN
AccessioniPrimary (citable) accession number: O75170
Secondary accession number(s): A6PVG3
, B7Z7T3, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.