O75170 (PP6R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 2

Alternative name(s):
SAPS domain family member 2

Gene names

Name:	PPP6R2
Synonyms:	KIAA0685, PP6R2, SAPS2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	966 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Ref.5
Subunit structure	Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28. Ref.5 Ref.6
Subcellular location	Cytoplasm Ref.5.
Tissue specificity	Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta. Ref.5
Sequence similarities	Belongs to the SAPS family.
Sequence caution	The sequence BAA31660.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from physical interaction Ref.6. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PPP6C	O00743	2	EBI-359739,EBI-359751

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75170-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: O75170-2)

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     709-709: E → EA
     792-799: SQASYFAV → F
     952-966: KTDAPPEGAALNGPV → QMPRQKELP

Note: No experimental confirmation available.

Isoform 3 (identifier: O75170-3)

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: S → SR
     535-561: Missing.
     792-799: SQASYFAV → F

Isoform 4 (identifier: O75170-4)

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     792-799: SQASYFAV → F

Isoform 5 (identifier: O75170-5)

The sequence of this isoform differs from the canonical sequence as follows:
     792-799: SQASYFAV → F

Isoform 6 (identifier: O75170-6)

The sequence of this isoform differs from the canonical sequence as follows:
     58-84: Missing.
     535-561: Missing.
     792-799: SQASYFAV → F

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 966	966	Serine/threonine-protein phosphatase 6 regulatory subunit 2		PRO_0000046098
Regions
	Compositional bias	820 – 825	6	Poly-Ser
Amino acid modifications
	Modified residue	289	1	Phosphoserine Ref.7 Ref.8 Ref.9 Ref.10
	Modified residue	770	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	58 – 84	27	Missing in isoform 6.		VSP_037767
	Alternative sequence	244	1	S → SR in isoform 3.		VSP_037768
	Alternative sequence	535 – 561	27	Missing in isoform 2, isoform 3, isoform 4 and isoform 6.		VSP_030758
	Alternative sequence	709	1	E → EA in isoform 2.		VSP_030759
	Alternative sequence	792 – 799	8	SQASYFAV → F in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.		VSP_030760
	Alternative sequence	952 – 966	15	KTDAP…LNGPV → QMPRQKELP in isoform 2.		VSP_030761
	Natural variant	633	1	D → E. Corresponds to variant rs11555194 [ dbSNP | Ensembl ].		VAR_058402
	Natural variant	732	1	R → K. Corresponds to variant rs13057311 [ dbSNP | Ensembl ].		VAR_058403
Experimental info
	Sequence conflict	224	1	D → G in BAH13719. Ref.2
	Sequence conflict	806	1	A → T in BAH13719. Ref.2
	Sequence conflict	835	1	Q → H in AAH52995. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: D3BC10EADB98FB62	FASTA	966	104,942
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 70 80 90 100 110 120 ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 130 140 150 160 170 180 ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 190 200 210 220 230 240 DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 250 260 270 280 290 300 ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV 310 320 330 340 350 360 SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS 370 380 390 400 410 420 INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP 430 440 450 460 470 480 HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL 490 500 510 520 530 540 TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL 550 560 570 580 590 600 HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI 610 620 630 640 650 660 AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH 670 680 690 700 710 720 ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP 730 740 750 760 770 780 ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA 790 800 810 820 830 840 EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA 850 860 870 880 890 900 MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV 910 920 930 940 950 960 AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA ALNGPV
	Isoform 2 [UniParc]. Checksum: DE1A1A4F2F66A0F9	FASTA	927	101,007
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 70 80 90 100 110 120 ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 130 140 150 160 170 180 ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 190 200 210 220 230 240 DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 250 260 270 280 290 300 ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV 310 320 330 340 350 360 SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS 370 380 390 400 410 420 INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP 430 440 450 460 470 480 HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL 490 500 510 520 530 540 TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLAFSDYQ 550 560 570 580 590 600 IQQMTANFVD QFGFNDEEFA DQDDNINAPF DRIAEINFNI DADEDSPSAA LFEACCSDRI 610 620 630 640 650 660 QPFDDDEDED IWEDSDTRCA ARVMARPRFG APHASESCSK NGPERGGQDG KASLEAHRDA 670 680 690 700 710 720 PGAGAPPAPG KKEAPPVEGD SEAGAMWTAV FDEPANSTPT APGVVRDVGS SVWAAGTSAP 730 740 750 760 770 780 EEKGWAKFTD FQPFCCSESG PRCSSPVDTE CSHAEGSRSQ GPEKAFSPAS PCAWNVCVTR 790 800 810 820 830 840 KAPLLASDSS SSGGSHSEDG DQKAASAMDA VSRGPGREAP PLPTVARTEE AVGRVGCADS 850 860 870 880 890 900 RLLSPACPAP KEVTAAPAVA VPPEATVAIT TALSKAGPAI PTPAVSSALA VAVPLGPIMA 910 920 VTAAPAMVAT LGTVTKDGQM PRQKELP
	Isoform 3 [UniParc]. Checksum: D74E382158135767	FASTA	933	101,402
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 70 80 90 100 110 120 ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 130 140 150 160 170 180 ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 190 200 210 220 230 240 DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 250 260 270 280 290 300 ALESRQDCVE QLLKNMFDGD RTESCLVSGT QVLLTLLETR RVGTEGLVDS FSQGLERSYA 310 320 330 340 350 360 VSSSVLHGIE PRLKDFHQLL LNPPKKKAIL TTIGVLEEPL GNARLHGARL MAALLHTNTP 370 380 390 400 410 420 SINQELCRLN TMDLLLDLFF KYTWNNFLHF QVELCIAAIL SHAAREERTE ASGSESRVEP 430 440 450 460 470 480 PHENGNRSLE TPQPAASLPD NTMVTHLFQK CCLVQRILEA WEANDHTQAA GGMRRGNMGH 490 500 510 520 530 540 LTRIANAVVQ NLERGPVQTH ISEVIRGLPA DCRGRWESFV EETLTETNRR NTVDLAFSDY 550 560 570 580 590 600 QIQQMTANFV DQFGFNDEEF ADQDDNINAP FDRIAEINFN IDADEDSPSA ALFEACCSDR 610 620 630 640 650 660 IQPFDDDEDE DIWEDSDTRC AARVMARPRF GAPHASESCS KNGPERGGQD GKASLEAHRD 670 680 690 700 710 720 APGAGAPPAP GKKEAPPVEG DSEGAMWTAV FDEPANSTPT APGVVRDVGS SVWAAGTSAP 730 740 750 760 770 780 EEKGWAKFTD FQPFCCSESG PRCSSPVDTE CSHAEGSRSQ GPEKAFSPAS PCAWNVCVTR 790 800 810 820 830 840 KAPLLASDSS SSGGSHSEDG DQKAASAMDA VSRGPGREAP PLPTVARTEE AVGRVGCADS 850 860 870 880 890 900 RLLSPACPAP KEVTAAPAVA VPPEATVAIT TALSKAGPAI PTPAVSSALA VAVPLGPIMA 910 920 930 VTAAPAMVAT LGTVTKDGKT DAPPEGAALN GPV
	Isoform 4 [UniParc]. Checksum: 0E22A2912F2A1F2A	FASTA	932	101,246
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 70 80 90 100 110 120 ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 130 140 150 160 170 180 ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 190 200 210 220 230 240 DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 250 260 270 280 290 300 ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV 310 320 330 340 350 360 SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS 370 380 390 400 410 420 INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP 430 440 450 460 470 480 HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL 490 500 510 520 530 540 TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLAFSDYQ 550 560 570 580 590 600 IQQMTANFVD QFGFNDEEFA DQDDNINAPF DRIAEINFNI DADEDSPSAA LFEACCSDRI 610 620 630 640 650 660 QPFDDDEDED IWEDSDTRCA ARVMARPRFG APHASESCSK NGPERGGQDG KASLEAHRDA 670 680 690 700 710 720 PGAGAPPAPG KKEAPPVEGD SEGAMWTAVF DEPANSTPTA PGVVRDVGSS VWAAGTSAPE 730 740 750 760 770 780 EKGWAKFTDF QPFCCSESGP RCSSPVDTEC SHAEGSRSQG PEKAFSPASP CAWNVCVTRK 790 800 810 820 830 840 APLLASDSSS SGGSHSEDGD QKAASAMDAV SRGPGREAPP LPTVARTEEA VGRVGCADSR 850 860 870 880 890 900 LLSPACPAPK EVTAAPAVAV PPEATVAITT ALSKAGPAIP TPAVSSALAV AVPLGPIMAV 910 920 930 TAAPAMVATL GTVTKDGKTD APPEGAALNG PV
	Isoform 5 [UniParc]. Checksum: 6C9F6F32B2768517	FASTA	959	104,235
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 70 80 90 100 110 120 ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 130 140 150 160 170 180 ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 190 200 210 220 230 240 DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 250 260 270 280 290 300 ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV 310 320 330 340 350 360 SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS 370 380 390 400 410 420 INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP 430 440 450 460 470 480 HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL 490 500 510 520 530 540 TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL 550 560 570 580 590 600 HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI 610 620 630 640 650 660 AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH 670 680 690 700 710 720 ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP 730 740 750 760 770 780 ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA 790 800 810 820 830 840 EGSRSQGPEK AFSPASPCAW NVCVTRKAPL LASDSSSSGG SHSEDGDQKA ASAMDAVSRG 850 860 870 880 890 900 PGREAPPLPT VARTEEAVGR VGCADSRLLS PACPAPKEVT AAPAVAVPPE ATVAITTALS 910 920 930 940 950 KAGPAIPTPA VSSALAVAVP LGPIMAVTAA PAMVATLGTV TKDGKTDAPP EGAALNGPV
	Isoform 6 [UniParc]. Checksum: 2B49E60FADD6D84D	FASTA	905	98,126
	10 20 30 40 50 60 MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELLTC 70 80 90 100 110 120 DVPQISDRLG GDESLLSLLY DFLDHEPPLN PLLASFFSKT IGNLIARKTE QVITFLKKKD 130 140 150 160 170 180 KFISLVLKHI GTSALMDLLL RLVSCVEPAG LRQDVLHWLN EEKVIQRLVE LIHPSQDEDR 190 200 210 220 230 240 QSNASQTLCD IVRLGRDQGS QLQEALEPDP LLTALESQDC VEQLLKNMFD GDRTESCLVS 250 260 270 280 290 300 GTQVLLTLLE TRRVGTEGLV DSFSQGLERS YAVSSSVLHG IEPRLKDFHQ LLLNPPKKKA 310 320 330 340 350 360 ILTTIGVLEE PLGNARLHGA RLMAALLHTN TPSINQELCR LNTMDLLLDL FFKYTWNNFL 370 380 390 400 410 420 HFQVELCIAA ILSHAAREER TEASGSESRV EPPHENGNRS LETPQPAASL PDNTMVTHLF 430 440 450 460 470 480 QKCCLVQRIL EAWEANDHTQ AAGGMRRGNM GHLTRIANAV VQNLERGPVQ THISEVIRGL 490 500 510 520 530 540 PADCRGRWES FVEETLTETN RRNTVDLAFS DYQIQQMTAN FVDQFGFNDE EFADQDDNIN 550 560 570 580 590 600 APFDRIAEIN FNIDADEDSP SAALFEACCS DRIQPFDDDE DEDIWEDSDT RCAARVMARP 610 620 630 640 650 660 RFGAPHASES CSKNGPERGG QDGKASLEAH RDAPGAGAPP APGKKEAPPV EGDSEGAMWT 670 680 690 700 710 720 AVFDEPANST PTAPGVVRDV GSSVWAAGTS APEEKGWAKF TDFQPFCCSE SGPRCSSPVD 730 740 750 760 770 780 TECSHAEGSR SQGPEKAFSP ASPCAWNVCV TRKAPLLASD SSSSGGSHSE DGDQKAASAM 790 800 810 820 830 840 DAVSRGPGRE APPLPTVART EEAVGRVGCA DSRLLSPACP APKEVTAAPA VAVPPEATVA 850 860 870 880 890 900 ITTALSKAGP AIPTPAVSSA LAVAVPLGPI MAVTAAPAMV ATLGTVTKDG KTDAPPEGAA LNGPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 6). Tissue: Brain, Lymph, Muscle, Placenta and Skin.
[5]	"Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon." Stefansson B., Brautigan D.L. J. Biol. Chem. 281:22624-22634(2006) [PubMed: 16769727] [Abstract] Cited for: FUNCTION, INTERACTION WITH PPP6C AND NFKBIE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]	"Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains." Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L. Biochemistry 47:1442-1451(2008) [PubMed: 18186651] [Abstract] Cited for: INTERACTION WITH PPP6C AND ANKRD28.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-770, MASS SPECTROMETRY.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB014585 mRNA. Translation: BAA31660.2. Different initiation. AK302472 mRNA. Translation: BAH13719.1. AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03456.1. AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03457.1. AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03458.1. AL096767, AL671545, AL954743 Genomic DNA. Translation: CAO03459.1. AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03561.1. AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03562.1. AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03563.1. AL954743, AL096767, AL671545 Genomic DNA. Translation: CAO03564.1. AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03642.1. AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03643.1. AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03644.1. AL671545, AL096767, AL954743 Genomic DNA. Translation: CAO03645.1. BC000976 mRNA. Translation: AAH00976.2. BC006568 mRNA. Translation: AAH06568.1. BC032664 mRNA. Translation: AAH32664.1. BC041698 mRNA. Translation: AAH41698.1. BC052995 mRNA. Translation: AAH52995.1.
IPI	IPI00375638. IPI00414872. IPI00853540. IPI00853587. IPI00939295. IPI00942736.
PIR	T00357.
RefSeq	NP_001229827.1. NM_001242898.1. NP_001229828.1. NM_001242899.1. NP_001229829.1. NM_001242900.1. NP_055493.2. NM_014678.4.
UniGene	Hs.449098. Hs.729287.
3D structure databases
ProteinModelPortal	O75170.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27539N.
IntAct	O75170. 6 interactions.
MINT	MINT-2867235.
STRING	O75170.
PTM databases
PhosphoSite	O75170.
Proteomic databases
PRIDE	O75170.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216061; ENSP00000216061; ENSG00000100239. ENST00000395746; ENSP00000379095; ENSG00000100239.
GeneID	9701.
KEGG	hsa:9701.
UCSC	uc003bky.1. human. uc003blb.1. human.
Organism-specific databases
CTD	9701.
GeneCards	GC22P050782.
HGNC	HGNC:19253. PPP6R2.
HPA	HPA030656.
MIM	610877. gene.
neXtProt	NX_O75170.
PharmGKB	PA165378360.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13592.
GeneTree	ENSGT00390000009899.
HOVERGEN	HBG069733.
InParanoid	O75170.
OMA	PPKKKAI.
PhylomeDB	O75170.
Gene expression databases
ArrayExpress	O75170.
Bgee	O75170.
CleanEx	HS_SAPS2.
Genevestigator	O75170.
GermOnline	ENSG00000100239. Homo sapiens.
Family and domain databases
InterPro	IPR007587. SAPS. [Graphical view]
KO	K15500.
PANTHER	PTHR12634. SAPS. 1 hit.
Pfam	PF04499. SAPS. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PP6R2_HUMAN

Accession

Primary (citable) accession number: O75170
Secondary accession number(s): A6PVG3 , B7Z7T3, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.