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Protein

Phosphatase and actin regulator 2

Gene

PHACTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112419-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatase and actin regulator 2
Gene namesi
Name:PHACTR2
Synonyms:C6orf56, KIAA0680
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20956. PHACTR2.

Subcellular locationi

Isoform 2 :
Isoform 4 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9749.
OpenTargetsiENSG00000112419.
PharmGKBiPA134944445.

Polymorphism and mutation databases

BioMutaiPHACTR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266361 – 634Phosphatase and actin regulator 2Add BLAST634
Isoform 2 (identifier: O75167-2)
Initiator methionineiRemoved1 Publication
Isoform 4 (identifier: O75167-4)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei25PhosphothreonineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei522PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Isoform 2 (identifier: O75167-2)
Lipidationi2N-myristoyl glycine1 Publication1
Isoform 4 (identifier: O75167-4)
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiO75167.
PaxDbiO75167.
PeptideAtlasiO75167.
PRIDEiO75167.

PTM databases

iPTMnetiO75167.
PhosphoSitePlusiO75167.

Expressioni

Gene expression databases

BgeeiENSG00000112419.
CleanExiHS_PHACTR2.
ExpressionAtlasiO75167. baseline and differential.
GenevisibleiO75167. HS.

Organism-specific databases

HPAiHPA031719.
HPA031720.
HPA031725.

Interactioni

Subunit structurei

Binds PPP1CA and actin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1754409,EBI-389883

Protein-protein interaction databases

BioGridi115097. 9 interactors.
IntActiO75167. 6 interactors.
STRINGi9606.ENSP00000417038.

Structurei

3D structure databases

ProteinModelPortaliO75167.
SMRiO75167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 85RPEL 1Add BLAST26
Repeati477 – 502RPEL 2Add BLAST26
Repeati515 – 540RPEL 3Add BLAST26
Repeati553 – 578RPEL 4Add BLAST26

Sequence similaritiesi

Contains 4 RPEL repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4339. Eukaryota.
ENOG4111M01. LUCA.
GeneTreeiENSGT00390000004420.
HOVERGENiHBG108246.
InParanoidiO75167.
OMAiGPVLYTD.
OrthoDBiEOG091G0HBF.
PhylomeDBiO75167.
TreeFamiTF316316.

Family and domain databases

InterProiIPR029991. Phactr2.
IPR004018. RPEL_repeat.
[Graphical view]
PANTHERiPTHR12751:SF5. PTHR12751:SF5. 1 hit.
PfamiPF02755. RPEL. 4 hits.
[Graphical view]
SMARTiSM00707. RPEL. 4 hits.
[Graphical view]
PROSITEiPS51073. RPEL. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNAVDGLDK ASIANSDGPT AGSQTPPFKR KGKLSTIGKI FKPWKWRKKK
60 70 80 90 100
TSDKFRETSA VLERKISTRQ SREELIRRGV LKELPDQDGD VTVNFENSNG
110 120 130 140 150
HMIPIGEEST REENVVKSEE GNGSVSEKTP PLEEQAEDKK ENTENHSETP
160 170 180 190 200
AAPALPPSAP PKPRPKPKPK KSPVPPKGAT AGASHKGDEV PPIKKNTKAP
210 220 230 240 250
GKQAPVPPPK PASRNTTREA AGSSHSKKTT GSKASASPST SSTSSRPKAS
260 270 280 290 300
KETVSSKAGT VGTTKGKRKT DKQPITSHLS SDTTTSGTSD LKGEPAETRV
310 320 330 340 350
ESFKLEQTVP GAEEQNTGKF KSMVPPPPVA PAPSPLAPPL PLEDQCITAS
360 370 380 390 400
DTPVVLVSVG ADLPVSALDP SQLLWAEEPT NRTTLYSGTG LSVNRENAKC
410 420 430 440 450
FTTKEELGKT VPQLLTPGLM GESSESFSAS EDEGHREYQA NDSDSDGPIL
460 470 480 490 500
YTDDEDEDED EDGSGESALA SKIRRRDTLA IKLGNRPSKK ELEDKNILQR
510 520 530 540 550
TSEEERQEIR QQIGTKLVRR LSQRPTTEEL EQRNILKQKN EEEEQEAKME
560 570 580 590 600
LKRRLSRKLS LRPTVAELQA RRILRFNEYV EVTDSPDYDR RADKPWARLT
610 620 630
PADKAAIRKE LNEFKSTEME VHEESRQFTR FHRP
Length:634
Mass (Da):69,700
Last modified:July 22, 2008 - v2
Checksum:iB45A5C5F2E389779
GO
Isoform 2 (identifier: O75167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS
     141-220: Missing.

Show »
Length:565
Mass (Da):62,485
Checksum:i07F754786B22BA74
GO
Isoform 4 (identifier: O75167-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS

Show »
Length:645
Mass (Da):70,727
Checksum:iDEF58BCDD6F51EC5
GO
Isoform 5 (identifier: O75167-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-220: Missing.

Show »
Length:554
Mass (Da):61,458
Checksum:i85281EC838ED5CA4
GO

Sequence cautioni

The sequence BAA31655 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG60527 differs from that shown. Reason: Erroneous termination at position 46. Translated as Trp.Curated
The sequence CAI14133 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19814 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21446 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197T → I in AAI50631 (PubMed:15489334).Curated1
Sequence conflicti436R → K in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti558K → R in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti610E → G in BAG60138 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045628165P → S.2 PublicationsCorresponds to variant rs2073214dbSNPEnsembl.1
Natural variantiVAR_053646449I → V.Corresponds to variant rs2295201dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0122721 – 4MDNA → MGQTSVSTLSPQPGS in isoform 2 and isoform 4. 2 Publications4
Alternative sequenceiVSP_012273141 – 220Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014580 mRNA. Translation: BAA31655.2. Different initiation.
AK297799 mRNA. Translation: BAG60138.1.
AK298263 mRNA. Translation: BAG60527.1. Sequence problems.
AK300221 mRNA. Translation: BAG61989.1.
CR749345 mRNA. Translation: CAH18198.1.
AL357117, AL049844, AL078593 Genomic DNA. Translation: CAI14133.1. Sequence problems.
AL078593, AL049844, AL357117 Genomic DNA. Translation: CAI19814.1. Sequence problems.
AL049844, AL078593, AL357117 Genomic DNA. Translation: CAI21446.1. Sequence problems.
BC150630 mRNA. Translation: AAI50631.1.
BC152416 mRNA. Translation: AAI52417.1.
CCDSiCCDS43512.1. [O75167-5]
CCDS47492.1. [O75167-1]
CCDS47493.1. [O75167-4]
CCDS47494.1. [O75167-2]
PIRiT00359.
RefSeqiNP_001093634.1. NM_001100164.1. [O75167-4]
NP_001093635.1. NM_001100165.1. [O75167-2]
NP_001093636.1. NM_001100166.1. [O75167-5]
NP_055536.2. NM_014721.2. [O75167-1]
UniGeneiHs.102471.

Genome annotation databases

EnsembliENST00000305766; ENSP00000305530; ENSG00000112419. [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419. [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419. [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419. [O75167-4]
GeneIDi9749.
KEGGihsa:9749.
UCSCiuc003qjq.4. human. [O75167-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014580 mRNA. Translation: BAA31655.2. Different initiation.
AK297799 mRNA. Translation: BAG60138.1.
AK298263 mRNA. Translation: BAG60527.1. Sequence problems.
AK300221 mRNA. Translation: BAG61989.1.
CR749345 mRNA. Translation: CAH18198.1.
AL357117, AL049844, AL078593 Genomic DNA. Translation: CAI14133.1. Sequence problems.
AL078593, AL049844, AL357117 Genomic DNA. Translation: CAI19814.1. Sequence problems.
AL049844, AL078593, AL357117 Genomic DNA. Translation: CAI21446.1. Sequence problems.
BC150630 mRNA. Translation: AAI50631.1.
BC152416 mRNA. Translation: AAI52417.1.
CCDSiCCDS43512.1. [O75167-5]
CCDS47492.1. [O75167-1]
CCDS47493.1. [O75167-4]
CCDS47494.1. [O75167-2]
PIRiT00359.
RefSeqiNP_001093634.1. NM_001100164.1. [O75167-4]
NP_001093635.1. NM_001100165.1. [O75167-2]
NP_001093636.1. NM_001100166.1. [O75167-5]
NP_055536.2. NM_014721.2. [O75167-1]
UniGeneiHs.102471.

3D structure databases

ProteinModelPortaliO75167.
SMRiO75167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115097. 9 interactors.
IntActiO75167. 6 interactors.
STRINGi9606.ENSP00000417038.

PTM databases

iPTMnetiO75167.
PhosphoSitePlusiO75167.

Polymorphism and mutation databases

BioMutaiPHACTR2.

Proteomic databases

MaxQBiO75167.
PaxDbiO75167.
PeptideAtlasiO75167.
PRIDEiO75167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305766; ENSP00000305530; ENSG00000112419. [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419. [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419. [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419. [O75167-4]
GeneIDi9749.
KEGGihsa:9749.
UCSCiuc003qjq.4. human. [O75167-1]

Organism-specific databases

CTDi9749.
DisGeNETi9749.
GeneCardsiPHACTR2.
H-InvDBHIX0006269.
HGNCiHGNC:20956. PHACTR2.
HPAiHPA031719.
HPA031720.
HPA031725.
MIMi608724. gene.
neXtProtiNX_O75167.
OpenTargetsiENSG00000112419.
PharmGKBiPA134944445.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4339. Eukaryota.
ENOG4111M01. LUCA.
GeneTreeiENSGT00390000004420.
HOVERGENiHBG108246.
InParanoidiO75167.
OMAiGPVLYTD.
OrthoDBiEOG091G0HBF.
PhylomeDBiO75167.
TreeFamiTF316316.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112419-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiPHACTR2. human.
GenomeRNAii9749.
PROiO75167.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112419.
CleanExiHS_PHACTR2.
ExpressionAtlasiO75167. baseline and differential.
GenevisibleiO75167. HS.

Family and domain databases

InterProiIPR029991. Phactr2.
IPR004018. RPEL_repeat.
[Graphical view]
PANTHERiPTHR12751:SF5. PTHR12751:SF5. 1 hit.
PfamiPF02755. RPEL. 4 hits.
[Graphical view]
SMARTiSM00707. RPEL. 4 hits.
[Graphical view]
PROSITEiPS51073. RPEL. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHAR2_HUMAN
AccessioniPrimary (citable) accession number: O75167
Secondary accession number(s): A6NKP5
, A7MCZ5, A8MZC0, B2RWP7, B4DN76, B4DPB5, B4DTH7, Q5TFA0, Q68DM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.