O75165 (DJC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 13

Alternative name(s):
Required for receptor-mediated endocytosis 8
Short name=RME-8

Gene names

Name:	DNAJC13
Synonyms:	KIAA0678, RME8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 J domain.

Sequence caution

The sequence AAH43583.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAA31653.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC86133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86835.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86835.1 differs from that shown. Reason: Erroneous termination at position 1651. Translated as Glu.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2243	2243	DnaJ homolog subfamily C member 13		PRO_0000071072
Regions
	Domain	1301 – 1366	66	J
Amino acid modifications
	Modified residue	84	1	N6-acetyllysine Ref.11
	Modified residue	1701	1	Phosphothreonine Ref.9
	Modified residue	1843	1	Phosphoserine Ref.8
	Modified residue	2151	1	Phosphoserine Ref.10
Natural variations
	Natural variant	1463	1	A → S. Ref.2 Ref.6 Corresponds to variant rs3762672 [ dbSNP | Ensembl ].		VAR_047458
	Natural variant	1487	1	F → C. Corresponds to variant rs4405917 [ dbSNP | Ensembl ].		VAR_047459
	Natural variant	1515	1	P → S. Corresponds to variant rs55825559 [ dbSNP | Ensembl ].		VAR_061144
	Natural variant	1995	1	V → I. Corresponds to variant rs10935014 [ dbSNP | Ensembl ].		VAR_047460
Experimental info
	Sequence conflict	476	1	D → E in BAA31653. Ref.2
	Sequence conflict	562	1	N → D in AAH43583. Ref.5
	Sequence conflict	1097	1	I → T in BAC86133. Ref.6
	Sequence conflict	1148	1	T → I in BAC86835. Ref.6
	Sequence conflict	1227	1	Q → H in BAA31653. Ref.2
	Sequence conflict	1230	1	T → A in BAC86835. Ref.6
	Sequence conflict	1269	1	D → N in BAC86133. Ref.6
	Sequence conflict	2041	1	L → P in BAC86835. Ref.6
	Sequence conflict	2091	1	T → A in BAC86835. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	O75165 [UniParc]. Last modified November 2, 2010. Version 5. Checksum: C6D292837DE1F170	FASTA	2,243	254,415
	10 20 30 40 50 60 MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAITTYNP NTLEVTNQWP YGDICSISPV 70 80 90 100 110 120 GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF RTDFSEGKIT GRRYNCYKHH 130 140 150 160 170 180 WSDSRKPVIL EVTPGGFDQI NPATNRVLCS YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH 190 200 210 220 230 240 LFASEQREEI IKSAIDHAGN YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV 250 260 270 280 290 300 QKISPRHSEP VKRVLALTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK 310 320 330 340 350 360 GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMTPTHKG QRWGLLSMPV DEEVESLHLR 370 380 390 400 410 420 FLATPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK EKLINNAITA LLSQEGDVVA 430 440 450 460 470 480 SNAELESQFQ AVRRLVASKA GFLAFTQLPK FRERLGVKVV KALKRSNNGI IHAAVDMLCA 490 500 510 520 530 540 LMCPMHDDYD LRQEQLNKAS LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC 550 560 570 580 590 600 APYSETTEGQ QFDMLLEMVA SNGRTLFKLF QHPSMAIIKG AGLVMKAIIE EGDKEIATKM 610 620 630 640 650 660 QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNATATN LLKRILPPGL 670 680 690 700 710 720 LAYLESSDLV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW QRLAGKAAKE VEKFAKEKVD 730 740 750 760 770 780 LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ RIKIEANWDL FYYRFGQDHA RSNLIWNFKT 790 800 810 820 830 840 REELKDTLES EMRAFNIDRE LGSANVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE 850 860 870 880 890 900 NEESGSIKRS YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM 910 920 930 940 950 960 LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV SRATVPLQSN 970 980 990 1000 1010 1020 VIEAAPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWTK GMLNAKTRCW AQGMDGWRPL 1030 1040 1050 1060 1070 1080 QSIPQLKWCL LASGQAVLNE TDLATLILNM LITMCGYFPS RDQDNAIIRP LPKVKRLLSD 1090 1100 1110 1120 1130 1140 STCLPHIIQL LLTFDPILVE KVAILLYHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA 1150 1160 1170 1180 1190 1200 RFLKYTHTKQ AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE 1210 1220 1230 1240 1250 1260 AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP IINYPQLENE LFCNIYYLKQ 1270 1280 1290 1300 1310 1320 LCDTLRFPDW PIKDPVKLLK DTLDAWKKEV EKKPPMMSID DAYEVLNLPQ GQGPHDESKI 1330 1340 1350 1360 1370 1380 RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY EFLCTKSAKI VDGPDPENII LILKTQSILF 1390 1400 1410 1420 1430 1440 NRHKEDLQPY KYAGYPMLIR TITMETSDDL LFSKESPLLP AATELAFHTV NCSALNAEEL 1450 1460 1470 1480 1490 1500 RRENGLEVLQ EAFSRCVAVL TRASKPSDMS VQVCGYISKC YSVAAQFEEC REKITEMPSI 1510 1520 1530 1540 1550 1560 IKDLCRVLYF GKSIPRVAAL GVECVSSFAV DFWLQTHLFQ AGILWYLLGF LFNYDYTLEE 1570 1580 1590 1600 1610 1620 SGIQKSEETN QQEVANSLAK LSVHALSRLG GYLAEEQATP ENPTIRKSLA GMLTPYVARK 1630 1640 1650 1660 1670 1680 LAVASVTEIL KMLNSNTESP YLIWNNSTRA ELLEFLESQQ ENMIKKGDCD KTYGSEFVYS 1690 1700 1710 1720 1730 1740 DHAKELIVGE IFVRVYNEVP TFQLEVPKAF AASLLDYIGS QAQYLHTFMA ITHAAKVESE 1750 1760 1770 1780 1790 1800 QHGDRLPRVE MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV 1810 1820 1830 1840 1850 1860 TSNQDCVNNI AESMVLSSLL ALLHSLPSSR QLVLETLYAL TSSTKIIKEA MAKGALIYLL 1870 1880 1890 1900 1910 1920 DMFCNSTHPQ VRAQTAELFA KMTADKLIGP KVRITLMKFL PSVFMDAMRD NPEAAVHIFE 1930 1940 1950 1960 1970 1980 GTHENPELIW NDNSRDKVST TVREMMLEHF KNQQDNPEAN WKLPEDFAVV FGEAEGELAV 1990 2000 2010 2020 2030 2040 GGVFLRIFIA QPAWVLRKPR EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ 2050 2060 2070 2080 2090 2100 LADQVPPLGH LPKVIQAMNH RNNAIPKSAI RVIHALSENE LCVRAMASLE TIGPLMNGMK 2110 2120 2130 2140 2150 2160 KRADTVGLAC EAINRMFQKE QSELVAQALK ADLVPYLLKL LEGIGLENLD SPAATKAQIV 2170 2180 2190 2200 2210 2220 KALKAMTRSL QYGEQVNEIL CRSSVWSAFK DQKHDLFISE SQTAGYLTGP GVAGYLTAGT 2230 2240 STSVMSNLPP PVDHEAGDLG YQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DnaJ-domain protein RME-8 functions in endosomal trafficking." Girard M., Poupon V., Blondeau F., McPherson P.S. J. Biol. Chem. 280:40135-40143(2005) [PubMed: 16179350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1463. Tissue: Brain.
[3]	Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. Tissue: Aortic endothelium.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-736 AND 1819-2243. Tissue: Cervix, Placenta and Uterus.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-2243, VARIANT SER-1463. Tissue: Brain.
[7]	Chang H.C., Hull M.J., Mellman I. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 672-1098.
[8]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1843, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1701, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2151, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-84, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY779857 mRNA. Translation: AAV41096.1. AB014578 mRNA. Translation: BAA31653.2. Different initiation. AC020632 Genomic DNA. No translation available. AC020633 Genomic DNA. No translation available. AC026374 Genomic DNA. No translation available. BC000164 mRNA. Translation: AAH00164.2. BC009630 mRNA. Translation: AAH09630.1. BC040638 mRNA. Translation: AAH40638.1. BC043583 mRNA. Translation: AAH43583.1. Sequence problems. AK125330 mRNA. Translation: BAC86133.1. Different initiation. AK127112 mRNA. Translation: BAC86835.1. Sequence problems. AY369172 mRNA. Translation: AAQ57271.1.
IPI	IPI00307259.
PIR	T00361.
RefSeq	NP_056083.3. NM_015268.3.
UniGene	Hs.12707.
3D structure databases
ProteinModelPortal	O75165.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75165. 1 interaction.
STRING	O75165.
PTM databases
PhosphoSite	O75165.
Proteomic databases
PRIDE	O75165.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260818; ENSP00000260818; ENSG00000138246.
GeneID	23317.
KEGG	hsa:23317.
Organism-specific databases
CTD	23317.
GeneCards	GC03P132136.
H-InvDB	HIX0003688.
HGNC	HGNC:30343. DNAJC13.
HPA	HPA036923.
MIM	614334. gene.
neXtProt	NX_O75165.
PharmGKB	PA134947358.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG081459.
InParanoid	O75165.
OMA	VPYSETT.
OrthoDB	EOG4WQ11M.
PhylomeDB	O75165.
Gene expression databases
ArrayExpress	O75165.
Bgee	O75165.
CleanEx	HS_DNAJC13.
Genevestigator	O75165.
GermOnline	ENSG00000138246. Homo sapiens.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR001623. DnaJ_N. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 5 hits. G3DSA:1.10.287.110. DnaJ_N. 1 hit.
KO	K09533.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

DJC13_HUMAN

Accession

Primary (citable) accession number: O75165
Secondary accession number(s): Q3L0T1 , Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	November 2, 2010
Last modified:	January 25, 2012
This is version 90 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.