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O75165 (DJC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily C member 13
Alternative name(s):
Required for receptor-mediated endocytosis 8
Short name=RME-8
Gene names
Name:DNAJC13
Synonyms:KIAA0678, RME8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2243 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 J domain.

Sequence caution

The sequence AAH43583.1 differs from that shown. Reason: Probable cloning artifact.

The sequence BAA31653.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC86133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86835.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86835.1 differs from that shown. Reason: Erroneous termination at position 1651. Translated as Glu.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionChaperone
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processosteoblast differentiation

Inferred from direct assay PubMed 16210410. Source: UniProt

   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

lysosomal membrane

Inferred from direct assay PubMed 17897319. Source: UniProtKB

membrane

Inferred from direct assay PubMed 16210410. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22432243DnaJ homolog subfamily C member 13
PRO_0000071072

Regions

Domain1301 – 136666J

Amino acid modifications

Modified residue841N6-acetyllysine Ref.8

Natural variations

Natural variant14631A → S. Ref.2 Ref.6
Corresponds to variant rs3762672 [ dbSNP | Ensembl ].
VAR_047458
Natural variant14871F → C.
Corresponds to variant rs4405917 [ dbSNP | Ensembl ].
VAR_047459
Natural variant15151P → S.
Corresponds to variant rs55825559 [ dbSNP | Ensembl ].
VAR_061144
Natural variant19951V → I.
Corresponds to variant rs10935014 [ dbSNP | Ensembl ].
VAR_047460

Experimental info

Sequence conflict4761D → E in BAA31653. Ref.2
Sequence conflict5621N → D in AAH43583. Ref.5
Sequence conflict10971I → T in BAC86133. Ref.6
Sequence conflict11481T → I in BAC86835. Ref.6
Sequence conflict12271Q → H in BAA31653. Ref.2
Sequence conflict12301T → A in BAC86835. Ref.6
Sequence conflict12691D → N in BAC86133. Ref.6
Sequence conflict20411L → P in BAC86835. Ref.6
Sequence conflict20911T → A in BAC86835. Ref.6

Sequences

Sequence LengthMass (Da)Tools
O75165 [UniParc].

Last modified November 2, 2010. Version 5.
Checksum: C6D292837DE1F170

FASTA2,243254,415
        10         20         30         40         50         60 
MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAITTYNP NTLEVTNQWP YGDICSISPV 

        70         80         90        100        110        120 
GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF RTDFSEGKIT GRRYNCYKHH 

       130        140        150        160        170        180 
WSDSRKPVIL EVTPGGFDQI NPATNRVLCS YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH 

       190        200        210        220        230        240 
LFASEQREEI IKSAIDHAGN YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV 

       250        260        270        280        290        300 
QKISPRHSEP VKRVLALTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK 

       310        320        330        340        350        360 
GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMTPTHKG QRWGLLSMPV DEEVESLHLR 

       370        380        390        400        410        420 
FLATPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK EKLINNAITA LLSQEGDVVA 

       430        440        450        460        470        480 
SNAELESQFQ AVRRLVASKA GFLAFTQLPK FRERLGVKVV KALKRSNNGI IHAAVDMLCA 

       490        500        510        520        530        540 
LMCPMHDDYD LRQEQLNKAS LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC 

       550        560        570        580        590        600 
APYSETTEGQ QFDMLLEMVA SNGRTLFKLF QHPSMAIIKG AGLVMKAIIE EGDKEIATKM 

       610        620        630        640        650        660 
QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNATATN LLKRILPPGL 

       670        680        690        700        710        720 
LAYLESSDLV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW QRLAGKAAKE VEKFAKEKVD 

       730        740        750        760        770        780 
LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ RIKIEANWDL FYYRFGQDHA RSNLIWNFKT 

       790        800        810        820        830        840 
REELKDTLES EMRAFNIDRE LGSANVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE 

       850        860        870        880        890        900 
NEESGSIKRS YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM 

       910        920        930        940        950        960 
LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV SRATVPLQSN 

       970        980        990       1000       1010       1020 
VIEAAPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWTK GMLNAKTRCW AQGMDGWRPL 

      1030       1040       1050       1060       1070       1080 
QSIPQLKWCL LASGQAVLNE TDLATLILNM LITMCGYFPS RDQDNAIIRP LPKVKRLLSD 

      1090       1100       1110       1120       1130       1140 
STCLPHIIQL LLTFDPILVE KVAILLYHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA 

      1150       1160       1170       1180       1190       1200 
RFLKYTHTKQ AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE 

      1210       1220       1230       1240       1250       1260 
AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP IINYPQLENE LFCNIYYLKQ 

      1270       1280       1290       1300       1310       1320 
LCDTLRFPDW PIKDPVKLLK DTLDAWKKEV EKKPPMMSID DAYEVLNLPQ GQGPHDESKI 

      1330       1340       1350       1360       1370       1380 
RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY EFLCTKSAKI VDGPDPENII LILKTQSILF 

      1390       1400       1410       1420       1430       1440 
NRHKEDLQPY KYAGYPMLIR TITMETSDDL LFSKESPLLP AATELAFHTV NCSALNAEEL 

      1450       1460       1470       1480       1490       1500 
RRENGLEVLQ EAFSRCVAVL TRASKPSDMS VQVCGYISKC YSVAAQFEEC REKITEMPSI 

      1510       1520       1530       1540       1550       1560 
IKDLCRVLYF GKSIPRVAAL GVECVSSFAV DFWLQTHLFQ AGILWYLLGF LFNYDYTLEE 

      1570       1580       1590       1600       1610       1620 
SGIQKSEETN QQEVANSLAK LSVHALSRLG GYLAEEQATP ENPTIRKSLA GMLTPYVARK 

      1630       1640       1650       1660       1670       1680 
LAVASVTEIL KMLNSNTESP YLIWNNSTRA ELLEFLESQQ ENMIKKGDCD KTYGSEFVYS 

      1690       1700       1710       1720       1730       1740 
DHAKELIVGE IFVRVYNEVP TFQLEVPKAF AASLLDYIGS QAQYLHTFMA ITHAAKVESE 

      1750       1760       1770       1780       1790       1800 
QHGDRLPRVE MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV 

      1810       1820       1830       1840       1850       1860 
TSNQDCVNNI AESMVLSSLL ALLHSLPSSR QLVLETLYAL TSSTKIIKEA MAKGALIYLL 

      1870       1880       1890       1900       1910       1920 
DMFCNSTHPQ VRAQTAELFA KMTADKLIGP KVRITLMKFL PSVFMDAMRD NPEAAVHIFE 

      1930       1940       1950       1960       1970       1980 
GTHENPELIW NDNSRDKVST TVREMMLEHF KNQQDNPEAN WKLPEDFAVV FGEAEGELAV 

      1990       2000       2010       2020       2030       2040 
GGVFLRIFIA QPAWVLRKPR EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ 

      2050       2060       2070       2080       2090       2100 
LADQVPPLGH LPKVIQAMNH RNNAIPKSAI RVIHALSENE LCVRAMASLE TIGPLMNGMK 

      2110       2120       2130       2140       2150       2160 
KRADTVGLAC EAINRMFQKE QSELVAQALK ADLVPYLLKL LEGIGLENLD SPAATKAQIV 

      2170       2180       2190       2200       2210       2220 
KALKAMTRSL QYGEQVNEIL CRSSVWSAFK DQKHDLFISE SQTAGYLTGP GVAGYLTAGT 

      2230       2240 
STSVMSNLPP PVDHEAGDLG YQT 

« Hide

References

« Hide 'large scale' references
[1]"The DnaJ-domain protein RME-8 functions in endosomal trafficking."
Girard M., Poupon V., Blondeau F., McPherson P.S.
J. Biol. Chem. 280:40135-40143(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1463.
Tissue: Brain.
[3]Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
Tissue: Aortic endothelium.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-736 AND 1819-2243.
Tissue: Cervix, Placenta and Uterus.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-2243, VARIANT SER-1463.
Tissue: Brain.
[7]Chang H.C., Hull M.J., Mellman I.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 672-1098.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY779857 mRNA. Translation: AAV41096.1.
AB014578 mRNA. Translation: BAA31653.2. Different initiation.
AC020632 Genomic DNA. No translation available.
AC020633 Genomic DNA. No translation available.
AC026374 Genomic DNA. No translation available.
BC000164 mRNA. Translation: AAH00164.2.
BC009630 mRNA. Translation: AAH09630.1.
BC040638 mRNA. Translation: AAH40638.1.
BC043583 mRNA. Translation: AAH43583.1. Sequence problems.
AK125330 mRNA. Translation: BAC86133.1. Different initiation.
AK127112 mRNA. Translation: BAC86835.1. Sequence problems.
AY369172 mRNA. Translation: AAQ57271.1.
CCDSCCDS33857.1.
PIRT00361.
RefSeqNP_056083.3. NM_015268.3.
UniGeneHs.12707.

3D structure databases

ProteinModelPortalO75165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116908. 12 interactions.
IntActO75165. 8 interactions.
MINTMINT-6772191.

PTM databases

PhosphoSiteO75165.

Proteomic databases

MaxQBO75165.
PaxDbO75165.
PRIDEO75165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260818; ENSP00000260818; ENSG00000138246.
GeneID23317.
KEGGhsa:23317.
UCSCuc003eor.3. human.

Organism-specific databases

CTD23317.
GeneCardsGC03P132136.
H-InvDBHIX0003688.
HGNCHGNC:30343. DNAJC13.
HPAHPA036923.
MIM614334. gene.
neXtProtNX_O75165.
Orphanet2828. Young adult-onset Parkinsonism.
PharmGKBPA134947358.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299042.
HOVERGENHBG081459.
InParanoidO75165.
KOK09533.
OMAFEVKYEC.
OrthoDBEOG7TBC15.
PhylomeDBO75165.
TreeFamTF105172.

Gene expression databases

ArrayExpressO75165.
BgeeO75165.
CleanExHS_DNAJC13.
GenevestigatorO75165.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001623. DnaJ_domain.
IPR025640. DUF4339.
IPR003169. GYF.
[Graphical view]
PfamPF00226. DnaJ. 1 hit.
PF14237. DUF4339. 1 hit.
[Graphical view]
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
SSF48371. SSF48371. 7 hits.
SSF55277. SSF55277. 1 hit.
PROSITEPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNAJC13. human.
GeneWikiDNAJC13.
GenomeRNAi23317.
NextBio45204.
PROO75165.
SOURCESearch...

Entry information

Entry nameDJC13_HUMAN
AccessionPrimary (citable) accession number: O75165
Secondary accession number(s): Q3L0T1 expand/collapse secondary AC list , Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 110 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM