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Protein

DnaJ homolog subfamily C member 13

Gene

DNAJC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).3 Publications

GO - Biological processi

  • endosome organization Source: UniProtKB
  • osteoblast differentiation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of early endosome to late endosome transport Source: UniProtKB
  • regulation of early endosome to recycling endosome transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138246-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 13
Alternative name(s):
Required for receptor-mediated endocytosis 8
Short name:
RME-8
Gene namesi
Name:DNAJC13
Synonyms:KIAA0678, RME8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30343. DNAJC13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • early endosome membrane Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Parkinson disease (PARK)2 Publications
The gene represented in this entry may be involved in disease pathogenesis. Genetic variants in DNAJC13 (PubMed:24218364, PubMed:25393719) and TMEM230 (PubMed:27270108) have been found in the same large multigenerational family with adult-onset Parkinson disease. The pathological role of each gene and therefore the exact molecular basis of the disease is unclear.1 Publication
Disease descriptionA complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.
See also OMIM:168600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076718722V → L in PARK; unknown pathological significance. 1 Publication1
Natural variantiVAR_073785855N → S in PARK; unknown pathological significance; affects regulation of endosomal membrane trafficking as indicated by accumulation of transferrin in endosomal compartments. 2 PublicationsCorresponds to variant rs387907571dbSNPEnsembl.1
Natural variantiVAR_0767221266R → Q in PARK; sporadic case; unknown pathological significance. 1 Publication1
Natural variantiVAR_0767261895T → M in PARK; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNETi23317.
MalaCardsiDNAJC13.
MIMi168600. phenotype.
OpenTargetsiENSG00000138246.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA134947358.

Polymorphism and mutation databases

BioMutaiDNAJC13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710721 – 2243DnaJ homolog subfamily C member 13Add BLAST2243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75165.
MaxQBiO75165.
PaxDbiO75165.
PeptideAtlasiO75165.
PRIDEiO75165.

PTM databases

iPTMnetiO75165.
PhosphoSitePlusiO75165.

Expressioni

Gene expression databases

BgeeiENSG00000138246.
CleanExiHS_DNAJC13.
ExpressionAtlasiO75165. baseline and differential.
GenevisibleiO75165. HS.

Organism-specific databases

HPAiHPA036923.
HPA036924.

Interactioni

Subunit structurei

Interacts with FAM21C; mediates the association with the WASH complex (PubMed:24643499).1 Publication

Protein-protein interaction databases

BioGridi116908. 45 interactors.
IntActiO75165. 19 interactors.
MINTiMINT-6772191.
STRINGi9606.ENSP00000260818.

Structurei

3D structure databases

ProteinModelPortaliO75165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1301 – 1366JPROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 453Involved in membrane association1 PublicationAdd BLAST453

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1789. Eukaryota.
ENOG410XRI2. LUCA.
GeneTreeiENSGT00390000017582.
HOVERGENiHBG081459.
InParanoidiO75165.
KOiK09533.
OMAiFEVKYEC.
OrthoDBiEOG091G005A.
PhylomeDBiO75165.
TreeFamiTF105172.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001623. DnaJ_domain.
IPR025640. DUF4339.
IPR003169. GYF.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14237. DUF4339. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF48371. SSF48371. 7 hits.
SSF55277. SSF55277. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAITTYNP NTLEVTNQWP
60 70 80 90 100
YGDICSISPV GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF
110 120 130 140 150
RTDFSEGKIT GRRYNCYKHH WSDSRKPVIL EVTPGGFDQI NPATNRVLCS
160 170 180 190 200
YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH LFASEQREEI IKSAIDHAGN
210 220 230 240 250
YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV QKISPRHSEP
260 270 280 290 300
VKRVLALTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK
310 320 330 340 350
GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMTPTHKG QRWGLLSMPV
360 370 380 390 400
DEEVESLHLR FLATPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK
410 420 430 440 450
EKLINNAITA LLSQEGDVVA SNAELESQFQ AVRRLVASKA GFLAFTQLPK
460 470 480 490 500
FRERLGVKVV KALKRSNNGI IHAAVDMLCA LMCPMHDDYD LRQEQLNKAS
510 520 530 540 550
LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC APYSETTEGQ
560 570 580 590 600
QFDMLLEMVA SNGRTLFKLF QHPSMAIIKG AGLVMKAIIE EGDKEIATKM
610 620 630 640 650
QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNATATN
660 670 680 690 700
LLKRILPPGL LAYLESSDLV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW
710 720 730 740 750
QRLAGKAAKE VEKFAKEKVD LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ
760 770 780 790 800
RIKIEANWDL FYYRFGQDHA RSNLIWNFKT REELKDTLES EMRAFNIDRE
810 820 830 840 850
LGSANVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE NEESGSIKRS
860 870 880 890 900
YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM
910 920 930 940 950
LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV
960 970 980 990 1000
SRATVPLQSN VIEAAPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWTK
1010 1020 1030 1040 1050
GMLNAKTRCW AQGMDGWRPL QSIPQLKWCL LASGQAVLNE TDLATLILNM
1060 1070 1080 1090 1100
LITMCGYFPS RDQDNAIIRP LPKVKRLLSD STCLPHIIQL LLTFDPILVE
1110 1120 1130 1140 1150
KVAILLYHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA RFLKYTHTKQ
1160 1170 1180 1190 1200
AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE
1210 1220 1230 1240 1250
AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP IINYPQLENE
1260 1270 1280 1290 1300
LFCNIYYLKQ LCDTLRFPDW PIKDPVKLLK DTLDAWKKEV EKKPPMMSID
1310 1320 1330 1340 1350
DAYEVLNLPQ GQGPHDESKI RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY
1360 1370 1380 1390 1400
EFLCTKSAKI VDGPDPENII LILKTQSILF NRHKEDLQPY KYAGYPMLIR
1410 1420 1430 1440 1450
TITMETSDDL LFSKESPLLP AATELAFHTV NCSALNAEEL RRENGLEVLQ
1460 1470 1480 1490 1500
EAFSRCVAVL TRASKPSDMS VQVCGYISKC YSVAAQFEEC REKITEMPSI
1510 1520 1530 1540 1550
IKDLCRVLYF GKSIPRVAAL GVECVSSFAV DFWLQTHLFQ AGILWYLLGF
1560 1570 1580 1590 1600
LFNYDYTLEE SGIQKSEETN QQEVANSLAK LSVHALSRLG GYLAEEQATP
1610 1620 1630 1640 1650
ENPTIRKSLA GMLTPYVARK LAVASVTEIL KMLNSNTESP YLIWNNSTRA
1660 1670 1680 1690 1700
ELLEFLESQQ ENMIKKGDCD KTYGSEFVYS DHAKELIVGE IFVRVYNEVP
1710 1720 1730 1740 1750
TFQLEVPKAF AASLLDYIGS QAQYLHTFMA ITHAAKVESE QHGDRLPRVE
1760 1770 1780 1790 1800
MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV
1810 1820 1830 1840 1850
TSNQDCVNNI AESMVLSSLL ALLHSLPSSR QLVLETLYAL TSSTKIIKEA
1860 1870 1880 1890 1900
MAKGALIYLL DMFCNSTHPQ VRAQTAELFA KMTADKLIGP KVRITLMKFL
1910 1920 1930 1940 1950
PSVFMDAMRD NPEAAVHIFE GTHENPELIW NDNSRDKVST TVREMMLEHF
1960 1970 1980 1990 2000
KNQQDNPEAN WKLPEDFAVV FGEAEGELAV GGVFLRIFIA QPAWVLRKPR
2010 2020 2030 2040 2050
EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ LADQVPPLGH
2060 2070 2080 2090 2100
LPKVIQAMNH RNNAIPKSAI RVIHALSENE LCVRAMASLE TIGPLMNGMK
2110 2120 2130 2140 2150
KRADTVGLAC EAINRMFQKE QSELVAQALK ADLVPYLLKL LEGIGLENLD
2160 2170 2180 2190 2200
SPAATKAQIV KALKAMTRSL QYGEQVNEIL CRSSVWSAFK DQKHDLFISE
2210 2220 2230 2240
SQTAGYLTGP GVAGYLTAGT STSVMSNLPP PVDHEAGDLG YQT
Length:2,243
Mass (Da):254,415
Last modified:November 2, 2010 - v5
Checksum:iC6D292837DE1F170
GO

Sequence cautioni

The sequence AAH43583 differs from that shown. Probable cloning artifact.Curated
The sequence BAA31653 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86835 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86835 differs from that shown. Reason: Erroneous termination at position 1651. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476D → E in BAA31653 (PubMed:9734811).Curated1
Sequence conflicti562N → D in AAH43583 (PubMed:15489334).Curated1
Sequence conflicti1097I → T in BAC86133 (PubMed:14702039).Curated1
Sequence conflicti1148T → I in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti1227Q → H in BAA31653 (PubMed:9734811).Curated1
Sequence conflicti1230T → A in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti1269D → N in BAC86133 (PubMed:14702039).Curated1
Sequence conflicti2041L → P in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti2091T → A in BAC86835 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073784264E → Q.1 Publication1
Natural variantiVAR_076716556L → S.1 Publication1
Natural variantiVAR_076717674D → A.1 Publication1
Natural variantiVAR_076718722V → L in PARK; unknown pathological significance. 1 Publication1
Natural variantiVAR_073785855N → S in PARK; unknown pathological significance; affects regulation of endosomal membrane trafficking as indicated by accumulation of transferrin in endosomal compartments. 2 PublicationsCorresponds to variant rs387907571dbSNPEnsembl.1
Natural variantiVAR_076719903R → K.1 Publication1
Natural variantiVAR_076720997L → F.1 Publication1
Natural variantiVAR_0737861082T → I.1 PublicationCorresponds to variant rs202127368dbSNPEnsembl.1
Natural variantiVAR_0767211135N → S.1 Publication1
Natural variantiVAR_0767221266R → Q in PARK; sporadic case; unknown pathological significance. 1 Publication1
Natural variantiVAR_0767231291E → G.1 Publication1
Natural variantiVAR_0474581463A → S.2 PublicationsCorresponds to variant rs3762672dbSNPEnsembl.1
Natural variantiVAR_0474591487F → C.Corresponds to variant rs4405917dbSNPEnsembl.1
Natural variantiVAR_0611441515P → S.Corresponds to variant rs55825559dbSNPEnsembl.1
Natural variantiVAR_0767241516R → H.1 Publication1
Natural variantiVAR_0767251740E → Q.1 Publication1
Natural variantiVAR_0767261895T → M in PARK; unknown pathological significance. 1 Publication1
Natural variantiVAR_0474601995V → I.Corresponds to variant rs10935014dbSNPEnsembl.1
Natural variantiVAR_0767272057A → S.1 Publication1
Natural variantiVAR_0737872115R → L.1 Publication1
Natural variantiVAR_0767282170L → W.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY779857 mRNA. Translation: AAV41096.1.
AB014578 mRNA. Translation: BAA31653.2. Different initiation.
AC020632 Genomic DNA. No translation available.
AC020633 Genomic DNA. No translation available.
AC026374 Genomic DNA. No translation available.
BC000164 mRNA. Translation: AAH00164.2.
BC009630 mRNA. Translation: AAH09630.1.
BC040638 mRNA. Translation: AAH40638.1.
BC043583 mRNA. Translation: AAH43583.1. Sequence problems.
AK125330 mRNA. Translation: BAC86133.1. Different initiation.
AK127112 mRNA. Translation: BAC86835.1. Sequence problems.
AY369172 mRNA. Translation: AAQ57271.1.
CCDSiCCDS33857.1.
PIRiT00361.
RefSeqiNP_056083.3. NM_015268.3.
UniGeneiHs.12707.

Genome annotation databases

EnsembliENST00000260818; ENSP00000260818; ENSG00000138246.
GeneIDi23317.
KEGGihsa:23317.
UCSCiuc003eor.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY779857 mRNA. Translation: AAV41096.1.
AB014578 mRNA. Translation: BAA31653.2. Different initiation.
AC020632 Genomic DNA. No translation available.
AC020633 Genomic DNA. No translation available.
AC026374 Genomic DNA. No translation available.
BC000164 mRNA. Translation: AAH00164.2.
BC009630 mRNA. Translation: AAH09630.1.
BC040638 mRNA. Translation: AAH40638.1.
BC043583 mRNA. Translation: AAH43583.1. Sequence problems.
AK125330 mRNA. Translation: BAC86133.1. Different initiation.
AK127112 mRNA. Translation: BAC86835.1. Sequence problems.
AY369172 mRNA. Translation: AAQ57271.1.
CCDSiCCDS33857.1.
PIRiT00361.
RefSeqiNP_056083.3. NM_015268.3.
UniGeneiHs.12707.

3D structure databases

ProteinModelPortaliO75165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116908. 45 interactors.
IntActiO75165. 19 interactors.
MINTiMINT-6772191.
STRINGi9606.ENSP00000260818.

PTM databases

iPTMnetiO75165.
PhosphoSitePlusiO75165.

Polymorphism and mutation databases

BioMutaiDNAJC13.

Proteomic databases

EPDiO75165.
MaxQBiO75165.
PaxDbiO75165.
PeptideAtlasiO75165.
PRIDEiO75165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260818; ENSP00000260818; ENSG00000138246.
GeneIDi23317.
KEGGihsa:23317.
UCSCiuc003eor.4. human.

Organism-specific databases

CTDi23317.
DisGeNETi23317.
GeneCardsiDNAJC13.
H-InvDBHIX0003688.
HGNCiHGNC:30343. DNAJC13.
HPAiHPA036923.
HPA036924.
MalaCardsiDNAJC13.
MIMi168600. phenotype.
614334. gene.
neXtProtiNX_O75165.
OpenTargetsiENSG00000138246.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA134947358.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1789. Eukaryota.
ENOG410XRI2. LUCA.
GeneTreeiENSGT00390000017582.
HOVERGENiHBG081459.
InParanoidiO75165.
KOiK09533.
OMAiFEVKYEC.
OrthoDBiEOG091G005A.
PhylomeDBiO75165.
TreeFamiTF105172.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138246-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiDNAJC13. human.
GeneWikiiDNAJC13.
GenomeRNAii23317.
PROiO75165.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138246.
CleanExiHS_DNAJC13.
ExpressionAtlasiO75165. baseline and differential.
GenevisibleiO75165. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001623. DnaJ_domain.
IPR025640. DUF4339.
IPR003169. GYF.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14237. DUF4339. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF48371. SSF48371. 7 hits.
SSF55277. SSF55277. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC13_HUMAN
AccessioniPrimary (citable) accession number: O75165
Secondary accession number(s): Q3L0T1
, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 134 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In human, FAM21 has undergone evolutionary duplication giving rise to highly homologous family members. A FAM21C construct with FAM21A-specific sequence insertions (of 2 aa and 21 aa length resulting in a construct length of 1341 aa similar to FAM21A length) has been used to demonstrate the interaction with FAM21 (PubMed:24643499).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.