SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75159

- SOCS5_HUMAN

UniProt

O75159 - SOCS5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Suppressor of cytokine signaling 5
Gene
SOCS5, CIS6, CISH5, CISH6, KIAA0671
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.1 Publication

Pathwayi

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  1. JAK-STAT cascade Source: InterPro
  2. cell growth Source: UniProtKB
  3. cytokine-mediated signaling pathway Source: UniProtKB
  4. epidermal growth factor receptor signaling pathway Source: Ensembl
  5. negative regulation of T-helper 2 cell differentiation Source: UniProtKB
  6. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
  7. negative regulation of signal transduction Source: UniProtKB
  8. positive regulation of T-helper 1 cell differentiation Source: UniProtKB
  9. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  10. protein ubiquitination Source: UniProtKB-UniPathway
  11. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiO75159.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 5
Short name:
SOCS-5
Alternative name(s):
Cytokine-inducible SH2 protein 6
Short name:
CIS-6
Cytokine-inducible SH2-containing protein 5
Gene namesi
Name:SOCS5
Synonyms:CIS6, CISH5, CISH6, KIAA0671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16852. SOCS5.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi406 – 4061R → K: Abrogates the ability to induce EGFR degradation. 1 Publication
Mutagenesisi484 – 4841L → P: Abrogates the interaction with TCEB1 and TCEB2 and the ability to suppress EGFR signaling; when associated with F-488. 1 Publication
Mutagenesisi488 – 4881C → F: Abrogates the interaction with TCEB1 and TCEB2 and the ability to suppress EGFR signaling; when associated with P-484. 1 Publication

Organism-specific databases

PharmGKBiPA134884627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Suppressor of cytokine signaling 5
PRO_0000181249Add
BLAST

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by EGF.1 Publication

Proteomic databases

MaxQBiO75159.
PaxDbiO75159.
PRIDEiO75159.

PTM databases

PhosphoSiteiO75159.

Expressioni

Inductioni

Up-regulated by EGF (at protein level).1 Publication

Gene expression databases

ArrayExpressiO75159.
BgeeiO75159.
CleanExiHS_SOCS5.
GenevestigatoriO75159.

Organism-specific databases

HPAiCAB025510.
HPA020884.

Interactioni

Subunit structurei

Interacts with IL4R; inhibits IL4 signaling By similarity. Interacts with EGFR. Interacts with TCEB1 AND TCEB2; mediates EGFR ubiquitination and degradation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
METP085812EBI-970130,EBI-1039152

Protein-protein interaction databases

BioGridi115013. 7 interactions.
IntActiO75159. 5 interactions.
MINTiMINT-2835826.
STRINGi9606.ENSP00000305133.

Structurei

3D structure databases

ProteinModelPortaliO75159.
SMRiO75159. Positions 369-524.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini381 – 47696SH2
Add
BLAST
Domaini471 – 52050SOCS box
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050Required for interaction with IL4R By similarity
Add
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SOCS box domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG258974.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiO75159.
KOiK04698.
OMAiQVSGDSH.
OrthoDBiEOG7XH6QR.
PhylomeDBiO75159.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028413. SOCS.
IPR022252. SOCS4/SOCS5_dom.
IPR028420. SOCS5.
IPR001496. SOCS_C.
[Graphical view]
PANTHERiPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF28. PTHR10385:SF28. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75159-1 [UniParc]FASTAAdd to Basket

« Hide

MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS    50
TPQQQSSPLR ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS 100
CVTPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDADK KFGRTRSGLQ 150
RRERRYGVSS VHDMDSVSSR TVGSRSLRQR LQDTVGLCFP MRTYSKQSKP 200
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF 250
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG 300
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH 350
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE 400
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS 450
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG 500
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK 536
Length:536
Mass (Da):61,246
Last modified:November 1, 1998 - v1
Checksum:i0629CDCF2A97E9D8
GO

Sequence cautioni

The sequence BAA31646.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti478 – 4781R → M in AAH32862. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073958 mRNA. Translation: AAD40484.1.
AB014571 mRNA. Translation: BAA31646.2. Different initiation.
AL136896 mRNA. Translation: CAB66830.1.
AK290194 mRNA. Translation: BAF82883.1.
AC020604 Genomic DNA. Translation: AAY24289.1.
CH471053 Genomic DNA. Translation: EAX00236.1.
CH471053 Genomic DNA. Translation: EAX00237.1.
BC032862 mRNA. Translation: AAH32862.1.
CCDSiCCDS1830.1.
PIRiT46499.
RefSeqiNP_054730.1. NM_014011.4.
NP_659198.1. NM_144949.2.
UniGeneiHs.468426.

Genome annotation databases

EnsembliENST00000306503; ENSP00000305133; ENSG00000171150.
ENST00000394861; ENSP00000378330; ENSG00000171150.
GeneIDi9655.
KEGGihsa:9655.
UCSCiuc002rvf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073958 mRNA. Translation: AAD40484.1 .
AB014571 mRNA. Translation: BAA31646.2 . Different initiation.
AL136896 mRNA. Translation: CAB66830.1 .
AK290194 mRNA. Translation: BAF82883.1 .
AC020604 Genomic DNA. Translation: AAY24289.1 .
CH471053 Genomic DNA. Translation: EAX00236.1 .
CH471053 Genomic DNA. Translation: EAX00237.1 .
BC032862 mRNA. Translation: AAH32862.1 .
CCDSi CCDS1830.1.
PIRi T46499.
RefSeqi NP_054730.1. NM_014011.4.
NP_659198.1. NM_144949.2.
UniGenei Hs.468426.

3D structure databases

ProteinModelPortali O75159.
SMRi O75159. Positions 369-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115013. 7 interactions.
IntActi O75159. 5 interactions.
MINTi MINT-2835826.
STRINGi 9606.ENSP00000305133.

PTM databases

PhosphoSitei O75159.

Proteomic databases

MaxQBi O75159.
PaxDbi O75159.
PRIDEi O75159.

Protocols and materials databases

DNASUi 9655.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306503 ; ENSP00000305133 ; ENSG00000171150 .
ENST00000394861 ; ENSP00000378330 ; ENSG00000171150 .
GeneIDi 9655.
KEGGi hsa:9655.
UCSCi uc002rvf.3. human.

Organism-specific databases

CTDi 9655.
GeneCardsi GC02P046926.
HGNCi HGNC:16852. SOCS5.
HPAi CAB025510.
HPA020884.
MIMi 607094. gene.
neXtProti NX_O75159.
PharmGKBi PA134884627.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258974.
HOGENOMi HOG000027791.
HOVERGENi HBG054138.
InParanoidi O75159.
KOi K04698.
OMAi QVSGDSH.
OrthoDBi EOG7XH6QR.
PhylomeDBi O75159.
TreeFami TF321368.

Enzyme and pathway databases

UniPathwayi UPA00143 .
SignaLinki O75159.

Miscellaneous databases

GeneWikii SOCS5.
GenomeRNAii 9655.
NextBioi 36245.
PROi O75159.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75159.
Bgeei O75159.
CleanExi HS_SOCS5.
Genevestigatori O75159.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
IPR028413. SOCS.
IPR022252. SOCS4/SOCS5_dom.
IPR028420. SOCS5.
IPR001496. SOCS_C.
[Graphical view ]
PANTHERi PTHR10385. PTHR10385. 1 hit.
PTHR10385:SF28. PTHR10385:SF28. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of CIS6, chromosomal assignment to 3p22 and 2p21 by in situ hybridization."
    Magrangeas F., Apiou F., Denis S., Weidle U., Jacques Y., Minvielle S.
    Cytogenet. Cell Genet. 88:78-81(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
    Kario E., Marmor M.D., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G., Yarden Y.
    J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EGFR DEGRADATION, INDUCTION BY EGF, PHOSPHORYLATION, MUTAGENESIS OF ARG-406; LEU-484 AND CYS-488, INTERACTION WITH EGFR; TCEB1 AND TCEB2.

Entry informationi

Entry nameiSOCS5_HUMAN
AccessioniPrimary (citable) accession number: O75159
Secondary accession number(s): Q53SD4, Q8IYZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi