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Protein

TSC22 domain family protein 2

Gene

TSC22D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 2
Alternative name(s):
TSC22-related-inducible leucine zipper protein 4
Gene namesi
Name:TSC22D2
Synonyms:KIAA0669, TILZ4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29095. TSC22D2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670697.

Polymorphism and mutation databases

BioMutaiTSC22D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780TSC22 domain family protein 2PRO_0000219369Add
BLAST

Proteomic databases

EPDiO75157.
MaxQBiO75157.
PaxDbiO75157.
PRIDEiO75157.

PTM databases

iPTMnetiO75157.
PhosphoSiteiO75157.

Expressioni

Gene expression databases

BgeeiO75157.
CleanExiHS_TSC22D2.
ExpressionAtlasiO75157. baseline and differential.
GenevisibleiO75157. HS.

Organism-specific databases

HPAiHPA004926.

Interactioni

Protein-protein interaction databases

BioGridi115158. 4 interactions.
IntActiO75157. 2 interactions.
STRINGi9606.ENSP00000354543.

Structurei

3D structure databases

ProteinModelPortaliO75157.
SMRiO75157. Positions 694-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiENOG410IRQY. Eukaryota.
ENOG410YCNM. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000121773.
HOVERGENiHBG060969.
InParanoidiO75157.
OMAiSMQGAHG.
OrthoDBiEOG7RZ5PT.
PhylomeDBiO75157.
TreeFamiTF318837.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75157-1) [UniParc]FASTAAdd to basket

Also known as: TILZ4a, TILZ4c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD
60 70 80 90 100
VSRATDYGPE EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA
110 120 130 140 150
PANGGGVVSA RSVSGALAST LAAAATSAPA PGAPGGPQLA GSSAGPVTAA
160 170 180 190 200
PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW TCMEYYERDS DSSVLTRSGD
210 220 230 240 250
CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES GTDSSLTAVS
260 270 280 290 300
QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
310 320 330 340 350
GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA
360 370 380 390 400
AQQPQQFAYP QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG
410 420 430 440 450
AAASPATAAT LPVGTGQNAS SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA
460 470 480 490 500
PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS VPPPQMGGSG PLSAVPGGPH
510 520 530 540 550
AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ LSSHTPVSRS
560 570 580 590 600
SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
610 620 630 640 650
LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD
660 670 680 690 700
EDRNPSTAFY QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH
710 720 730 740 750
LMYAVREEVE VLKEQIKELV ERNSLLEREN ALLKSLSSND QLSQLPTQQA
760 770 780
NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
Length:780
Mass (Da):79,228
Last modified:March 29, 2005 - v3
Checksum:i5ED799E741944A01
GO
Isoform 2 (identifier: O75157-2) [UniParc]FASTAAdd to basket

Also known as: TILZ4b

The sequence of this isoform differs from the canonical sequence as follows:
     653-676: Missing.

Show »
Length:756
Mass (Da):76,392
Checksum:iDBCE734DEBC0D962
GO

Sequence cautioni

The sequence BAA31644.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti419 – 4191A → T.
Corresponds to variant rs879634 [ dbSNP | Ensembl ].
VAR_052408

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei653 – 67624Missing in isoform 2. 1 PublicationVSP_013202Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014569 mRNA. Translation: BAA31644.2. Different initiation.
CH471052 Genomic DNA. Translation: EAW78838.1.
CH471052 Genomic DNA. Translation: EAW78839.1.
BC044643 mRNA. Translation: AAH44643.1.
AF201290 mRNA. Translation: AAG41223.1.
AF201291 mRNA. Translation: AAG41224.1.
AF201292 mRNA. Translation: AAG41225.1.
CCDSiCCDS3149.1. [O75157-1]
PIRiT00366.
RefSeqiNP_001290193.1. NM_001303264.1. [O75157-2]
NP_055594.1. NM_014779.3. [O75157-1]
UniGeneiHs.722470.
Hs.730710.

Genome annotation databases

EnsembliENST00000361875; ENSP00000354543; ENSG00000196428. [O75157-1]
GeneIDi9819.
KEGGihsa:9819.
UCSCiuc003exv.4. human. [O75157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014569 mRNA. Translation: BAA31644.2. Different initiation.
CH471052 Genomic DNA. Translation: EAW78838.1.
CH471052 Genomic DNA. Translation: EAW78839.1.
BC044643 mRNA. Translation: AAH44643.1.
AF201290 mRNA. Translation: AAG41223.1.
AF201291 mRNA. Translation: AAG41224.1.
AF201292 mRNA. Translation: AAG41225.1.
CCDSiCCDS3149.1. [O75157-1]
PIRiT00366.
RefSeqiNP_001290193.1. NM_001303264.1. [O75157-2]
NP_055594.1. NM_014779.3. [O75157-1]
UniGeneiHs.722470.
Hs.730710.

3D structure databases

ProteinModelPortaliO75157.
SMRiO75157. Positions 694-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115158. 4 interactions.
IntActiO75157. 2 interactions.
STRINGi9606.ENSP00000354543.

PTM databases

iPTMnetiO75157.
PhosphoSiteiO75157.

Polymorphism and mutation databases

BioMutaiTSC22D2.

Proteomic databases

EPDiO75157.
MaxQBiO75157.
PaxDbiO75157.
PRIDEiO75157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361875; ENSP00000354543; ENSG00000196428. [O75157-1]
GeneIDi9819.
KEGGihsa:9819.
UCSCiuc003exv.4. human. [O75157-1]

Organism-specific databases

CTDi9819.
GeneCardsiTSC22D2.
H-InvDBHIX0031086.
HGNCiHGNC:29095. TSC22D2.
HPAiHPA004926.
neXtProtiNX_O75157.
PharmGKBiPA142670697.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRQY. Eukaryota.
ENOG410YCNM. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000121773.
HOVERGENiHBG060969.
InParanoidiO75157.
OMAiSMQGAHG.
OrthoDBiEOG7RZ5PT.
PhylomeDBiO75157.
TreeFamiTF318837.

Miscellaneous databases

ChiTaRSiTSC22D2. human.
GenomeRNAii9819.
PROiO75157.

Gene expression databases

BgeeiO75157.
CleanExiHS_TSC22D2.
ExpressionAtlasiO75157. baseline and differential.
GenevisibleiO75157. HS.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Identification and characterization of a family of leucine zipper genes related to TSC22."
    Ershler M.A., Belyavsky A.V., Visser J.W.M.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 544-780 (ISOFORMS 1 AND 2).
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiT22D2_HUMAN
AccessioniPrimary (citable) accession number: O75157
Secondary accession number(s): D3DNI5
, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 8, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.