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Protein

TSC22 domain family protein 2

Gene

TSC22D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 2
Alternative name(s):
TSC22-related-inducible leucine zipper protein 4
Gene namesi
Name:TSC22D2
Synonyms:KIAA0669, TILZ4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196428.12
HGNCiHGNC:29095 TSC22D2
MIMi617724 gene
neXtProtiNX_O75157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196428
PharmGKBiPA142670697

Polymorphism and mutation databases

BioMutaiTSC22D2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193691 – 780TSC22 domain family protein 2Add BLAST780

Proteomic databases

EPDiO75157
MaxQBiO75157
PaxDbiO75157
PeptideAtlasiO75157
PRIDEiO75157

PTM databases

iPTMnetiO75157
PhosphoSitePlusiO75157

Expressioni

Gene expression databases

BgeeiENSG00000196428
CleanExiHS_TSC22D2
ExpressionAtlasiO75157 baseline and differential
GenevisibleiO75157 HS

Organism-specific databases

HPAiHPA004926

Interactioni

Protein-protein interaction databases

BioGridi115158, 49 interactors
IntActiO75157, 2 interactors
STRINGi9606.ENSP00000354543

Structurei

3D structure databases

ProteinModelPortaliO75157
SMRiO75157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiENOG410IRQY Eukaryota
ENOG410YCNM LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000121773
HOVERGENiHBG060969
InParanoidiO75157
OMAiTSVTMPN
OrthoDBiEOG091G06PM
PhylomeDBiO75157
TreeFamiTF318837

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75157-1) [UniParc]FASTAAdd to basket
Also known as: TILZ4a, TILZ4c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD
60 70 80 90 100
VSRATDYGPE EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA
110 120 130 140 150
PANGGGVVSA RSVSGALAST LAAAATSAPA PGAPGGPQLA GSSAGPVTAA
160 170 180 190 200
PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW TCMEYYERDS DSSVLTRSGD
210 220 230 240 250
CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES GTDSSLTAVS
260 270 280 290 300
QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
310 320 330 340 350
GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA
360 370 380 390 400
AQQPQQFAYP QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG
410 420 430 440 450
AAASPATAAT LPVGTGQNAS SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA
460 470 480 490 500
PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS VPPPQMGGSG PLSAVPGGPH
510 520 530 540 550
AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ LSSHTPVSRS
560 570 580 590 600
SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
610 620 630 640 650
LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD
660 670 680 690 700
EDRNPSTAFY QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH
710 720 730 740 750
LMYAVREEVE VLKEQIKELV ERNSLLEREN ALLKSLSSND QLSQLPTQQA
760 770 780
NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
Length:780
Mass (Da):79,228
Last modified:March 29, 2005 - v3
Checksum:i5ED799E741944A01
GO
Isoform 2 (identifier: O75157-2) [UniParc]FASTAAdd to basket
Also known as: TILZ4b

The sequence of this isoform differs from the canonical sequence as follows:
     653-676: Missing.

Show »
Length:756
Mass (Da):76,392
Checksum:iDBCE734DEBC0D962
GO

Sequence cautioni

The sequence BAA31644 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052408419A → T. Corresponds to variant dbSNP:rs879634Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013202653 – 676Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014569 mRNA Translation: BAA31644.2 Different initiation.
CH471052 Genomic DNA Translation: EAW78838.1
CH471052 Genomic DNA Translation: EAW78839.1
BC044643 mRNA Translation: AAH44643.1
AF201290 mRNA Translation: AAG41223.1
AF201291 mRNA Translation: AAG41224.1
AF201292 mRNA Translation: AAG41225.1
CCDSiCCDS3149.1 [O75157-1]
PIRiT00366
RefSeqiNP_001290193.1, NM_001303264.1 [O75157-2]
NP_055594.1, NM_014779.3 [O75157-1]
UniGeneiHs.722470
Hs.730710

Genome annotation databases

EnsembliENST00000361875; ENSP00000354543; ENSG00000196428 [O75157-1]
GeneIDi9819
KEGGihsa:9819
UCSCiuc003exv.4 human [O75157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT22D2_HUMAN
AccessioniPrimary (citable) accession number: O75157
Secondary accession number(s): D3DNI5
, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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