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Protein

Cullin-associated NEDD8-dissociated protein 2

Gene

CAND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144712-MONOMER.
SIGNORiO75155.

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 2
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 2
Epididymis tissue protein Li 169
TBP-interacting protein of 120 kDa B
Short name:
TBP-interacting protein 120B
p120 CAND2
Gene namesi
Name:CAND2
Synonyms:KIAA0667, TIP120B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30689. CAND2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23066.
OpenTargetsiENSG00000144712.
PharmGKBiPA142672208.

Polymorphism and mutation databases

BioMutaiCAND2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000892972 – 1236Cullin-associated NEDD8-dissociated protein 2Add BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine2 Publications1

Post-translational modificationi

Ubiquitinated and targeted for proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiO75155.
MaxQBiO75155.
PaxDbiO75155.
PeptideAtlasiO75155.
PRIDEiO75155.

PTM databases

iPTMnetiO75155.
PhosphoSitePlusiO75155.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000144712.
CleanExiHS_CAND2.
ExpressionAtlasiO75155. baseline and differential.
GenevisibleiO75155. HS.

Organism-specific databases

HPAiHPA005777.

Interactioni

Subunit structurei

Binds TBP, CNOT3 and UBE3C.By similarity

Protein-protein interaction databases

BioGridi116701. 33 interactors.
IntActiO75155. 3 interactors.
STRINGi9606.ENSP00000387641.

Structurei

3D structure databases

ProteinModelPortaliO75155.
SMRiO75155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 39HEAT 1Add BLAST38
Repeati44 – 81HEAT 2Add BLAST38
Repeati83 – 119HEAT 3Add BLAST37
Repeati129 – 167HEAT 4Add BLAST39
Repeati171 – 208HEAT 5Add BLAST38
Repeati210 – 246HEAT 6Add BLAST37
Repeati254 – 291HEAT 7Add BLAST38
Repeati327 – 368HEAT 8Add BLAST42
Repeati372 – 409HEAT 9Add BLAST38
Repeati432 – 469HEAT 10Add BLAST38
Repeati517 – 554HEAT 11Add BLAST38
Repeati565 – 604HEAT 12Add BLAST40
Repeati608 – 645HEAT 13Add BLAST38
Repeati648 – 685HEAT 14Add BLAST38
Repeati690 – 727HEAT 15Add BLAST38
Repeati731 – 770HEAT 16Add BLAST40
Repeati772 – 813HEAT 17Add BLAST42
Repeati857 – 894HEAT 18Add BLAST38
Repeati896 – 931HEAT 19Add BLAST36
Repeati933 – 966HEAT 20Add BLAST34
Repeati967 – 1003HEAT 21Add BLAST37
Repeati1007 – 1044HEAT 22Add BLAST38
Repeati1048 – 1084HEAT 23Add BLAST37
Repeati1105 – 1141HEAT 24Add BLAST37
Repeati1157 – 1194HEAT 25Add BLAST38
Repeati1204 – 1236HEAT 26Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 346Poly-Asp4
Compositional biasi490 – 493Poly-Ser4
Compositional biasi614 – 618Poly-Leu5

Sequence similaritiesi

Belongs to the CAND family.Curated
Contains 26 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1824. Eukaryota.
ENOG410XPK4. LUCA.
GeneTreeiENSGT00390000017740.
HOGENOMiHOG000264713.
HOVERGENiHBG053467.
InParanoidiO75155.
OMAiCNLDDDE.
OrthoDBiEOG091G017Q.
PhylomeDBiO75155.
TreeFamiTF300355.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view]
PfamiPF08623. TIP120. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV
60 70 80 90 100
KMLLRLLEDK NGEVQNLAVK CLGPLVVKVK EYQVETIVDT LCTNMRSDKE
110 120 130 140 150
QLRDIAGIGL KTVLSELPPA ATGSGLATNV CRKITGQLTS AIAQQEDVAV
160 170 180 190 200
QLEALDILSD MLSRLGVPLG AFHASLLHCL LPQLSSPRLA VRKRAVGALG
210 220 230 240 250
HLAAACSTDL FVELADHLLD RLPGPRVPTS PTAIRTLIQC LGSVGRQAGH
260 270 280 290 300
RLGAHLDRLV PLVEDFCNLD DDELRESCLQ AFEAFLRKCP KEMGPHVPNV
310 320 330 340 350
TSLCLQYIKH DPNYNYDSDE DEEQMETEDS EFSEQESEDE YSDDDDMSWK
360 370 380 390 400
VRRAAAKCIA ALISSRPDLL PDFHCTLAPV LIRRFKEREE NVKADVFTAY
410 420 430 440 450
IVLLRQTQPP KGWLEAMEEP TQTGSNLHML RGQVPLVVKA LQRQLKDRSV
460 470 480 490 500
RARQGCFSLL TELAGVLPGS LAEHMPVLVS GIIFSLADRS SSSTIRMDAL
510 520 530 540 550
AFLQGLLGTE PAEAFHPHLP ILLPPVMACV ADSFYKIAAE ALVVLQELVR
560 570 580 590 600
ALWPLHRPRM LDPEPYVGEM SAVTLARLRA TDLDQEVKER AISCMGHLVG
610 620 630 640 650
HLGDRLGDDL EPTLLLLLDR LRNEITRLPA IKALTLVAVS PLQLDLQPIL
660 670 680 690 700
AEALHILASF LRKNQRALRL ATLAALDALA QSQGLSLPPS AVQAVLAELP
710 720 730 740 750
ALVNESDMHV AQLAVDFLAT VTQAQPASLV EVSGPVLSEL LRLLRSPLLP
760 770 780 790 800
AGVLAAAEGF LQALVGTRPP CVDYAKLISL LTAPVYEQAV DGGPGLHKQV
810 820 830 840 850
FHSLARCVAA LSAACPQEAA STASRLVCDA RSPHSSTGVK VLAFLSLAEV
860 870 880 890 900
GQVAGPGHQR ELKAVLLEAL GSPSEDVRAA ASYALGRVGA GSLPDFLPFL
910 920 930 940 950
LEQIEAEPRR QYLLLHSLRE ALGAAQPDSL KPYAEDIWAL LFQRCEGAEE
960 970 980 990 1000
GTRGVVAECI GKLVLVNPSF LLPRLRKQLA AGRPHTRSTV ITAVKFLISD
1010 1020 1030 1040 1050
QPHPIDPLLK SFIGEFMESL QDPDLNVRRA TLAFFNSAVH NKPSLVRDLL
1060 1070 1080 1090 1100
DDILPLLYQE TKIRRDLIRE VEMGPFKHTV DDGLDVRKAA FECMYSLLES
1110 1120 1130 1140 1150
CLGQLDICEF LNHVEDGLKD HYDIRMLTFI MVARLATLCP APVLQRVDRL
1160 1170 1180 1190 1200
IEPLRATCTA KVKAGSVKQE FEKQDELKRS AMRAVAALLT IPEVGKSPIM
1210 1220 1230
ADFSSQIRSN PELAALFESI QKDSASAPST DSMELS
Length:1,236
Mass (Da):135,256
Last modified:May 5, 2009 - v3
Checksum:i38F43A7C1B8322A8
GO
Isoform 2 (identifier: O75155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-71: C → W
     72-164: Missing.
     1014-1037: Missing.

Show »
Length:1,119
Mass (Da):122,664
Checksum:i8206517AA2F8DBD4
GO

Sequence cautioni

The sequence AAI36593 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204A → T in BAA31642 (PubMed:9734811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055023408Q → R.1 PublicationCorresponds to variant rs2305398dbSNPEnsembl.1
Natural variantiVAR_055024476P → L.Corresponds to variant rs2305397dbSNPEnsembl.1
Natural variantiVAR_055025533S → P.Corresponds to variant rs3732675dbSNPEnsembl.1
Natural variantiVAR_055026655H → R.Corresponds to variant rs9838943dbSNPEnsembl.1
Natural variantiVAR_055027845L → F.Corresponds to variant rs17037287dbSNPEnsembl.1
Natural variantiVAR_055028858H → P.2 PublicationsCorresponds to variant rs3732678dbSNPEnsembl.1
Natural variantiVAR_055029990V → I.Corresponds to variant rs3817121dbSNPEnsembl.1
Natural variantiVAR_0550301225A → T.1 PublicationCorresponds to variant rs12629133dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03724071C → W in isoform 2. 1 Publication1
Alternative sequenceiVSP_03724172 – 164Missing in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0372421014 – 1037Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727621 mRNA. Translation: ADU87623.1.
AC034198 Genomic DNA. No translation available.
BC136592 mRNA. Translation: AAI36593.1. Different initiation.
AB014567 mRNA. Translation: BAA31642.1.
CCDSiCCDS43053.1. [O75155-2]
CCDS54554.1. [O75155-1]
PIRiT01239.
RefSeqiNP_001155971.1. NM_001162499.1. [O75155-1]
NP_036430.1. NM_012298.2. [O75155-2]
UniGeneiHs.343664.

Genome annotation databases

EnsembliENST00000295989; ENSP00000295989; ENSG00000144712. [O75155-2]
ENST00000456430; ENSP00000387641; ENSG00000144712. [O75155-1]
GeneIDi23066.
KEGGihsa:23066.
UCSCiuc003bxj.3. human. [O75155-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727621 mRNA. Translation: ADU87623.1.
AC034198 Genomic DNA. No translation available.
BC136592 mRNA. Translation: AAI36593.1. Different initiation.
AB014567 mRNA. Translation: BAA31642.1.
CCDSiCCDS43053.1. [O75155-2]
CCDS54554.1. [O75155-1]
PIRiT01239.
RefSeqiNP_001155971.1. NM_001162499.1. [O75155-1]
NP_036430.1. NM_012298.2. [O75155-2]
UniGeneiHs.343664.

3D structure databases

ProteinModelPortaliO75155.
SMRiO75155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116701. 33 interactors.
IntActiO75155. 3 interactors.
STRINGi9606.ENSP00000387641.

PTM databases

iPTMnetiO75155.
PhosphoSitePlusiO75155.

Polymorphism and mutation databases

BioMutaiCAND2.

Proteomic databases

EPDiO75155.
MaxQBiO75155.
PaxDbiO75155.
PeptideAtlasiO75155.
PRIDEiO75155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295989; ENSP00000295989; ENSG00000144712. [O75155-2]
ENST00000456430; ENSP00000387641; ENSG00000144712. [O75155-1]
GeneIDi23066.
KEGGihsa:23066.
UCSCiuc003bxj.3. human. [O75155-1]

Organism-specific databases

CTDi23066.
DisGeNETi23066.
GeneCardsiCAND2.
HGNCiHGNC:30689. CAND2.
HPAiHPA005777.
MIMi610403. gene.
neXtProtiNX_O75155.
OpenTargetsiENSG00000144712.
PharmGKBiPA142672208.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1824. Eukaryota.
ENOG410XPK4. LUCA.
GeneTreeiENSGT00390000017740.
HOGENOMiHOG000264713.
HOVERGENiHBG053467.
InParanoidiO75155.
OMAiCNLDDDE.
OrthoDBiEOG091G017Q.
PhylomeDBiO75155.
TreeFamiTF300355.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144712-MONOMER.
SIGNORiO75155.

Miscellaneous databases

ChiTaRSiCAND2. human.
GenomeRNAii23066.
PROiO75155.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144712.
CleanExiHS_CAND2.
ExpressionAtlasiO75155. baseline and differential.
GenevisibleiO75155. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013932. TATA-bd_TIP120.
[Graphical view]
PfamiPF08623. TIP120. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAND2_HUMAN
AccessioniPrimary (citable) accession number: O75155
Secondary accession number(s): B9EGM9, E9KL24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.