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Protein

Clustered mitochondria protein homolog

Gene

CLUH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.UniRule annotation1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB

GO - Biological processi

  • intracellular distribution of mitochondria Source: UniProtKB
  • mitochondrion organization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
Gene namesi
Name:CLUH
Synonyms:KIAA0664
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29094. CLUH.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671614.

Polymorphism and mutation databases

BioMutaiCLUH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13091309Clustered mitochondria protein homologPRO_0000123553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei281 – 2811PhosphoserineCombined sources
Modified residuei654 – 6541PhosphoserineCombined sources
Modified residuei664 – 6641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75153.
MaxQBiO75153.
PaxDbiO75153.
PRIDEiO75153.

PTM databases

iPTMnetiO75153.
PhosphoSiteiO75153.

Expressioni

Gene expression databases

BgeeiO75153.
CleanExiHS_KIAA0664.
ExpressionAtlasiO75153. baseline and differential.
GenevisibleiO75153. HS.

Organism-specific databases

HPAiHPA044346.

Interactioni

Protein-protein interaction databases

BioGridi116878. 38 interactions.
IntActiO75153. 3 interactions.
STRINGi9606.ENSP00000388872.

Structurei

3D structure databases

ProteinModelPortaliO75153.
SMRiO75153. Positions 991-1213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati978 – 101134TPR 1Add
BLAST
Repeati1020 – 105334TPR 2Add
BLAST
Repeati1104 – 113734TPR 3Add
BLAST
Repeati1146 – 117934TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the CLU family.UniRule annotation
Contains 4 TPR repeats.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
GeneTreeiENSGT00390000012485.
HOGENOMiHOG000113156.
HOVERGENiHBG108020.
InParanoidiO75153.
KOiK03255.
OMAiCVSHFLN.
OrthoDBiEOG72RMX5.
PhylomeDBiO75153.
TreeFamiTF300565.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

O75153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLNGDCPES LKKEAAAAEP PRENGLDEAG PGDETTGQEV IVIQDTGFSV
60 70 80 90 100
KILAPGIEPF SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNVLDH
110 120 130 140 150
FSELRSVEGL QEGSVLRVVE EPYTVREARI HVRHVRDLLK SLDPSDAFNG
160 170 180 190 200
VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD PIDCTPPEYI LPGSRERPLC
210 220 230 240 250
PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF VITAEDRQVS
260 270 280 290 300
ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
310 320 330 340 350
QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI
360 370 380 390 400
PGQTRDWNEE LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV
410 420 430 440 450
IDGNVMAINP SEETKMQMFI WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT
460 470 480 490 500
NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY RVTAQSIIPG ILERDQEQSV
510 520 530 540 550
IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHQVLNDRD EEVELCSSVE
560 570 580 590 600
CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECAR AGFPRAHRHK
610 620 630 640 650
LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QNASQLETPS SLENGGPSSL
660 670 680 690 700
ESKSEDPPGQ EAGSEEEGSS ASGLAKVKEL AETIAADDGT DPRSREVIRN
710 720 730 740 750
ACKAVGSISS TAFDIRFNPD IFSPGVRFPE SCQDEVRDQK QLLKDAAAFL
760 770 780 790 800
LSCQIPGLVK DCMEHAVLPV DGATLAEVMR QRGINMRYLG KVLELVLRSP
810 820 830 840 850
ARHQLDHVFK IGIGELITRS AKHIFKTYLQ GVELSGLSAA ISHFLNCFLS
860 870 880 890 900
SYPNPVAHLP ADELVSKKRN KRRKNRPPGA ADNTAWAVMT PQELWKNICQ
910 920 930 940 950
EAKNYFDFDL ECETVDQAVE TYGLQKITLL REISLKTGIQ VLLKEYSFDS
960 970 980 990 1000
RHKPAFTEED VLNIFPVVKH VNPKASDAFH FFQSGQAKVQ QGFLKEGCEL
1010 1020 1030 1040 1050
INEALNLFNN VYGAMHVETC ACLRLLARLH YIMGDYAEAL SNQQKAVLMS
1060 1070 1080 1090 1100
ERVMGTEHPN TIQEYMHLAL YCFASSQLST ALSLLYRARY LMLLVFGEDH
1110 1120 1130 1140 1150
PEMALLDNNI GLVLHGVMEY DLSLRFLENA LAVSTKYHGP KALKVALSHH
1160 1170 1180 1190 1200
LVARVYESKA EFRSALQHEK EGYTIYKTQL GEDHEKTKES SEYLKCLTQQ
1210 1220 1230 1240 1250
AVALQRTMNE IYRNGSSANI PPLKFTAPSM ASVLEQLNVI NGILFIPLSQ
1260 1270 1280 1290 1300
KDLENLKAEV ARRHQLQEAS RNRDRAEEPM ATEPAPAGAP GDLGSQPPAA

KDPSPSVQG
Length:1,309
Mass (Da):146,670
Last modified:February 15, 2005 - v2
Checksum:i715A7BA3A9874D2E
GO

Sequence cautioni

The sequence AK023003 differs from that shown. Reason: Frameshift at position 1105. Curated
The sequence AK125717 differs from that shown. Reason: Frameshift at position 875. Curated
The sequence CAH10532.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201M → T in AK125717 (PubMed:14702039).Curated
Sequence conflicti432 – 4321V → A in AAH63786 (PubMed:15489334).Curated
Sequence conflicti610 – 6101D → G in AK125717 (PubMed:14702039).Curated
Sequence conflicti690 – 6901T → TA in AK023003 (PubMed:14702039).Curated
Sequence conflicti690 – 6901T → TA in CAH10532 (PubMed:17974005).Curated
Sequence conflicti690 – 6901T → TA in AAH63786 (PubMed:15489334).Curated
Sequence conflicti868 – 8681K → E in AK125717 (PubMed:14702039).Curated
Sequence conflicti1104 – 11041A → G in AK023003 (PubMed:14702039).Curated
Sequence conflicti1134 – 11341S → N in CAH10532 (PubMed:17974005).Curated
Sequence conflicti1209 – 12091N → S in AK125717 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti633 – 6331A → V.1 Publication
Corresponds to variant rs11078312 [ dbSNP | Ensembl ].
VAR_034008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125717 mRNA. No translation available.
AK023003 mRNA. No translation available.
CR627449 mRNA. Translation: CAH10532.1. Different initiation.
AB014564 mRNA. Translation: BAA31639.1.
BC004266 mRNA. Translation: AAH04266.1.
BC033614 mRNA. Translation: AAH33614.1.
BC063786 mRNA. Translation: AAH63786.1.
CCDSiCCDS45572.1.
RefSeqiNP_056044.3. NM_015229.3.
UniGeneiHs.22616.

Genome annotation databases

EnsembliENST00000435359; ENSP00000388872; ENSG00000132361.
ENST00000570628; ENSP00000458986; ENSG00000132361.
GeneIDi23277.
KEGGihsa:23277.
UCSCiuc002fuy.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125717 mRNA. No translation available.
AK023003 mRNA. No translation available.
CR627449 mRNA. Translation: CAH10532.1. Different initiation.
AB014564 mRNA. Translation: BAA31639.1.
BC004266 mRNA. Translation: AAH04266.1.
BC033614 mRNA. Translation: AAH33614.1.
BC063786 mRNA. Translation: AAH63786.1.
CCDSiCCDS45572.1.
RefSeqiNP_056044.3. NM_015229.3.
UniGeneiHs.22616.

3D structure databases

ProteinModelPortaliO75153.
SMRiO75153. Positions 991-1213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116878. 38 interactions.
IntActiO75153. 3 interactions.
STRINGi9606.ENSP00000388872.

PTM databases

iPTMnetiO75153.
PhosphoSiteiO75153.

Polymorphism and mutation databases

BioMutaiCLUH.

Proteomic databases

EPDiO75153.
MaxQBiO75153.
PaxDbiO75153.
PRIDEiO75153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435359; ENSP00000388872; ENSG00000132361.
ENST00000570628; ENSP00000458986; ENSG00000132361.
GeneIDi23277.
KEGGihsa:23277.
UCSCiuc002fuy.1. human.

Organism-specific databases

CTDi23277.
GeneCardsiCLUH.
HGNCiHGNC:29094. CLUH.
HPAiHPA044346.
MIMi616184. gene.
neXtProtiNX_O75153.
PharmGKBiPA142671614.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
GeneTreeiENSGT00390000012485.
HOGENOMiHOG000113156.
HOVERGENiHBG108020.
InParanoidiO75153.
KOiK03255.
OMAiCVSHFLN.
OrthoDBiEOG72RMX5.
PhylomeDBiO75153.
TreeFamiTF300565.

Miscellaneous databases

GenomeRNAii23277.
PROiO75153.
SOURCEiSearch...

Gene expression databases

BgeeiO75153.
CleanExiHS_KIAA0664.
ExpressionAtlasiO75153. baseline and differential.
GenevisibleiO75153. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-1309.
    Tissue: Salivary gland.
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-1309.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 280-1309, VARIANT VAL-633.
    Tissue: Blood, PNS and Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279; SER-281 AND SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-654 AND SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins."
    Gao J., Schatton D., Martinelli P., Hansen H., Pla-Martin D., Barth E., Becker C., Altmueller J., Frommolt P., Sardiello M., Rugarli E.I.
    J. Cell Biol. 207:213-223(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLU_HUMAN
AccessioniPrimary (citable) accession number: O75153
Secondary accession number(s): Q6AHY2
, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.