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O75152

- ZC11A_HUMAN

UniProt

O75152 - ZC11A_HUMAN

Protein

Zinc finger CCCH domain-containing protein 11A

Gene

ZC3H11A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2 – 2928C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri31 – 5727C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 8627C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. poly(A)+ mRNA export from nucleus Source: UniProtKB

    Keywords - Biological processi

    mRNA transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCCH domain-containing protein 11A
    Gene namesi
    Name:ZC3H11A
    Synonyms:KIAA0663, ZC3HDC11A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29093. ZC3H11A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670535.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 810810Zinc finger CCCH domain-containing protein 11APRO_0000213905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei108 – 1081Phosphoserine5 Publications
    Modified residuei132 – 1321Phosphoserine2 Publications
    Modified residuei171 – 1711Phosphoserine1 Publication
    Modified residuei290 – 2901Phosphoserine1 Publication
    Modified residuei321 – 3211Phosphothreonine1 Publication
    Modified residuei738 – 7381Phosphoserine1 Publication
    Modified residuei758 – 7581Phosphoserine2 Publications
    Modified residuei764 – 7641N6-acetyllysine1 Publication
    Modified residuei768 – 7681Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75152.
    PaxDbiO75152.
    PRIDEiO75152.

    PTM databases

    PhosphoSiteiO75152.

    Expressioni

    Gene expression databases

    ArrayExpressiO75152.
    BgeeiO75152.
    CleanExiHS_ZC3H11A.
    GenevestigatoriO75152.

    Organism-specific databases

    HPAiHPA026439.
    HPA028490.
    HPA028526.

    Interactioni

    Subunit structurei

    Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MLH1P406923EBI-748480,EBI-744248

    Protein-protein interaction databases

    BioGridi115208. 29 interactions.
    IntActiO75152. 6 interactions.
    MINTiMINT-1444822.
    STRINGi9606.ENSP00000333253.

    Structurei

    3D structure databases

    ProteinModelPortaliO75152.
    SMRiO75152. Positions 6-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili362 – 42362Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi161 – 1688Poly-Asp

    Sequence similaritiesi

    Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2 – 2928C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri31 – 5727C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 8627C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG306637.
    HOVERGENiHBG082979.
    InParanoidiO75152.
    OMAiITRHLTK.
    OrthoDBiEOG72G19F.
    PhylomeDBiO75152.
    TreeFamiTF335608.

    Family and domain databases

    InterProiIPR000571. Znf_CCCH.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 3 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75152-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC    50
    RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT 100
    VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP 150
    THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP 200
    AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP 250
    GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK 300
    RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV 350
    NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST 400
    IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV 450
    ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE 500
    ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD 550
    ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA 600
    VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK 650
    VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA 700
    AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM 750
    SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL 800
    LLELSEMIDS 810
    Length:810
    Mass (Da):89,131
    Last modified:August 16, 2005 - v3
    Checksum:i9048ABC7F4A372FB
    GO

    Sequence cautioni

    The sequence CAH10553.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA31638.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801C → Y in CAH10553. (PubMed:17974005)Curated
    Sequence conflicti246 – 2461P → L in CAH10530. (PubMed:17974005)Curated
    Sequence conflicti266 – 2661L → P in CAH10525. (PubMed:17974005)Curated
    Sequence conflicti277 – 2771R → G in CAH10530. (PubMed:17974005)Curated
    Sequence conflicti409 – 4091V → G in CAH10525. (PubMed:17974005)Curated
    Sequence conflicti412 – 4121E → K in CAH10525. (PubMed:17974005)Curated
    Sequence conflicti616 – 6161S → P in CAH10566. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti640 – 6401T → N.
    Corresponds to variant rs11240604 [ dbSNP | Ensembl ].
    VAR_052967

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014563 mRNA. Translation: BAA31638.2. Different initiation.
    CR627439 mRNA. Translation: CAH10525.1.
    CR627446 mRNA. Translation: CAH10530.1.
    BX648271 mRNA. Translation: CAH10553.1. Sequence problems.
    BX649148 mRNA. Translation: CAH10566.1.
    BC014268 mRNA. Translation: AAH14268.1.
    CCDSiCCDS30978.1.
    PIRiT00368.
    RefSeqiNP_055642.3. NM_014827.4.
    XP_005245700.1. XM_005245643.1.
    XP_005245701.1. XM_005245644.2.
    XP_006711736.1. XM_006711673.1.
    UniGeneiHs.532399.

    Genome annotation databases

    EnsembliENST00000332127; ENSP00000333253; ENSG00000058673.
    ENST00000367210; ENSP00000356179; ENSG00000058673.
    ENST00000367212; ENSP00000356181; ENSG00000058673.
    ENST00000367214; ENSP00000356183; ENSG00000058673.
    ENST00000545588; ENSP00000438527; ENSG00000058673.
    GeneIDi9877.
    KEGGihsa:9877.
    UCSCiuc001hac.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014563 mRNA. Translation: BAA31638.2 . Different initiation.
    CR627439 mRNA. Translation: CAH10525.1 .
    CR627446 mRNA. Translation: CAH10530.1 .
    BX648271 mRNA. Translation: CAH10553.1 . Sequence problems.
    BX649148 mRNA. Translation: CAH10566.1 .
    BC014268 mRNA. Translation: AAH14268.1 .
    CCDSi CCDS30978.1.
    PIRi T00368.
    RefSeqi NP_055642.3. NM_014827.4.
    XP_005245700.1. XM_005245643.1.
    XP_005245701.1. XM_005245644.2.
    XP_006711736.1. XM_006711673.1.
    UniGenei Hs.532399.

    3D structure databases

    ProteinModelPortali O75152.
    SMRi O75152. Positions 6-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115208. 29 interactions.
    IntActi O75152. 6 interactions.
    MINTi MINT-1444822.
    STRINGi 9606.ENSP00000333253.

    PTM databases

    PhosphoSitei O75152.

    Proteomic databases

    MaxQBi O75152.
    PaxDbi O75152.
    PRIDEi O75152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332127 ; ENSP00000333253 ; ENSG00000058673 .
    ENST00000367210 ; ENSP00000356179 ; ENSG00000058673 .
    ENST00000367212 ; ENSP00000356181 ; ENSG00000058673 .
    ENST00000367214 ; ENSP00000356183 ; ENSG00000058673 .
    ENST00000545588 ; ENSP00000438527 ; ENSG00000058673 .
    GeneIDi 9877.
    KEGGi hsa:9877.
    UCSCi uc001hac.3. human.

    Organism-specific databases

    CTDi 9877.
    GeneCardsi GC01P203765.
    H-InvDB HIX0123107.
    HGNCi HGNC:29093. ZC3H11A.
    HPAi HPA026439.
    HPA028490.
    HPA028526.
    MIMi 613513. gene.
    neXtProti NX_O75152.
    PharmGKBi PA142670535.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306637.
    HOVERGENi HBG082979.
    InParanoidi O75152.
    OMAi ITRHLTK.
    OrthoDBi EOG72G19F.
    PhylomeDBi O75152.
    TreeFami TF335608.

    Miscellaneous databases

    ChiTaRSi ZC3H11A. human.
    GeneWikii ZC3H11A.
    GenomeRNAii 9877.
    NextBioi 37225.
    PROi O75152.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75152.
    Bgeei O75152.
    CleanExi HS_ZC3H11A.
    Genevestigatori O75152.

    Family and domain databases

    InterProi IPR000571. Znf_CCCH.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 3 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Ohara O., Suyama M., Nagase T., Ishikawa K.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal kidney and Retina.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Placenta.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-132; SER-171; SER-290; THR-321; SER-758 AND SER-768, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-764, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex."
      Dufu K., Livingstone M.J., Seebacher J., Gygi S.P., Wilson S.A., Reed R.
      Genes Dev. 24:2043-2053(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH THE TREX COMPLEX.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-132 AND SER-758, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export."
      Folco E.G., Lee C.S., Dufu K., Yamazaki T., Reed R.
      PLoS ONE 7:E43804-E43804(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH THOC2; DDX39B AND POLDIP3, ASSOCIATION WITH THE TREX COMPLEX.

    Entry informationi

    Entry nameiZC11A_HUMAN
    AccessioniPrimary (citable) accession number: O75152
    Secondary accession number(s): Q6AHY4
    , Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3