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Protein

Zinc finger CCCH domain-containing protein 11A

Gene

ZC3H11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 29C3H1-type 1IEP:Add BLAST28
Zinc fingeri31 – 57C3H1-type 2IEP:Add BLAST27
Zinc fingeri60 – 86C3H1-type 3IEP:Add BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 11A
Gene namesi
Name:ZC3H11A
Synonyms:KIAA0663, ZC3HDC11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000058673.15.
HGNCiHGNC:29093. ZC3H11A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9877.
OpenTargetsiENSG00000058673.
ENSG00000257315.
PharmGKBiPA142670535.

Polymorphism and mutation databases

BioMutaiZC3H11A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139051 – 810Zinc finger CCCH domain-containing protein 11AAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineND:1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:
Modified residuei132PhosphoserineND:1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:
Modified residuei149PhosphoserineND:1
Modified residuei171PhosphoserineND:1
Modified residuei290PhosphoserineND:1
Modified residuei321PhosphothreonineND:1
Modified residuei370PhosphoserineND:1
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:
Cross-linki619Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75152.
MaxQBiO75152.
PaxDbiO75152.
PeptideAtlasiO75152.
PRIDEiO75152.

PTM databases

iPTMnetiO75152.
PhosphoSitePlusiO75152.

Expressioni

Gene expression databases

BgeeiENSG00000058673.
CleanExiHS_ZC3H11A.
ExpressionAtlasiO75152. baseline and differential.
GenevisibleiO75152. HS.

Organism-specific databases

HPAiHPA026439.
HPA028490.
HPA028526.

Interactioni

Subunit structurei

Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115208. 59 interactors.
IntActiO75152. 20 interactors.
MINTiMINT-1444822.
STRINGi9606.ENSP00000333253.

Structurei

3D structure databases

ProteinModelPortaliO75152.
SMRiO75152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili362 – 423IEP:Add BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 168Poly-Asp8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 29C3H1-type 1IEP:Add BLAST28
Zinc fingeri31 – 57C3H1-type 2IEP:Add BLAST27
Zinc fingeri60 – 86C3H1-type 3IEP:Add BLAST27

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4791. Eukaryota.
ENOG41101ZI. LUCA.
GeneTreeiENSGT00530000063354.
ENSGT00900000141027.
HOVERGENiHBG082979.
InParanoidiO75152.
OMAiDVTCIKL.
OrthoDBiEOG091G0KPN.
PhylomeDBiO75152.
TreeFamiTF335608.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiView protein in InterPro
IPR000571. Znf_CCCH.
IPR036855. Znf_CCCH_sf.
SMARTiView protein in SMART
SM00356. ZnF_C3H1. 3 hits.
PROSITEiView protein in PROSITE
PS50103. ZF_C3H1. 2 hits.

Sequencei

Sequence statusi: Complete.

O75152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC
60 70 80 90 100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT
110 120 130 140 150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP
160 170 180 190 200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP
210 220 230 240 250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP
260 270 280 290 300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK
310 320 330 340 350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV
360 370 380 390 400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST
410 420 430 440 450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV
460 470 480 490 500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE
510 520 530 540 550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD
560 570 580 590 600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA
610 620 630 640 650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK
660 670 680 690 700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA
710 720 730 740 750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM
760 770 780 790 800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL
810
LLELSEMIDS
Length:810
Mass (Da):89,131
Last modified:August 16, 2005 - v3
Checksum:i9048ABC7F4A372FB
GO

Sequence cautioni

The sequence BAA31638 differs from that shown. Reason: Erroneous initiation.IKR:
The sequence CAH10553 differs from that shown. Contaminating sequence. Potential poly-A sequence.IKR:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80C → Y in CAH10553 (PubMed:17974005).IKR:1
Sequence conflicti246P → L in CAH10530 (PubMed:17974005).IKR:1
Sequence conflicti266L → P in CAH10525 (PubMed:17974005).IKR:1
Sequence conflicti277R → G in CAH10530 (PubMed:17974005).IKR:1
Sequence conflicti409V → G in CAH10525 (PubMed:17974005).IKR:1
Sequence conflicti412E → K in CAH10525 (PubMed:17974005).IKR:1
Sequence conflicti616S → P in CAH10566 (PubMed:17974005).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052967640T → N. Corresponds to variant dbSNP:rs11240604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014563 mRNA. Translation: BAA31638.2. Different initiation.
CR627439 mRNA. Translation: CAH10525.1.
CR627446 mRNA. Translation: CAH10530.1.
BX648271 mRNA. Translation: CAH10553.1. Sequence problems.
BX649148 mRNA. Translation: CAH10566.1.
BC014268 mRNA. Translation: AAH14268.1.
CCDSiCCDS30978.1.
PIRiT00368.
RefSeqiNP_001306167.1. NM_001319238.1.
NP_001306168.1. NM_001319239.1.
NP_055642.3. NM_014827.5.
XP_005245700.1. XM_005245643.2.
XP_005245701.1. XM_005245644.3.
XP_006711736.1. XM_006711673.2.
XP_011508501.1. XM_011510199.1.
XP_011508502.1. XM_011510200.1.
XP_011508503.1. XM_011510201.1.
XP_011508504.1. XM_011510202.1.
XP_016858445.1. XM_017002956.1.
XP_016858446.1. XM_017002957.1.
XP_016858447.1. XM_017002958.1.
XP_016858448.1. XM_017002959.1.
UniGeneiHs.532399.
Hs.732801.

Genome annotation databases

EnsembliENST00000332127; ENSP00000333253; ENSG00000058673.
ENST00000367210; ENSP00000356179; ENSG00000058673.
ENST00000367212; ENSP00000356181; ENSG00000058673.
ENST00000367214; ENSP00000356183; ENSG00000058673.
ENST00000639812; ENSP00000491830; ENSG00000058673.
GeneIDi9877.
KEGGihsa:9877.
UCSCiuc001hac.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZC11A_HUMAN
AccessioniPrimary (citable) accession number: O75152
Secondary accession number(s): Q6AHY4
, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 25, 2017
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot