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Protein

Zinc finger CCCH domain-containing protein 11A

Gene

ZC3H11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 2928C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri31 – 5727C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 8627C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 11A
Gene namesi
Name:ZC3H11A
Synonyms:KIAA0663, ZC3HDC11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29093. ZC3H11A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670535.

Polymorphism and mutation databases

BioMutaiZC3H11A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Zinc finger CCCH domain-containing protein 11APRO_0000213905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei171 – 1711PhosphoserineCombined sources
Modified residuei290 – 2901PhosphoserineCombined sources
Modified residuei321 – 3211PhosphothreonineCombined sources
Modified residuei370 – 3701PhosphoserineCombined sources
Cross-linki478 – 478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei495 – 4951PhosphoserineCombined sources
Modified residuei738 – 7381PhosphoserineCombined sources
Modified residuei758 – 7581PhosphoserineCombined sources
Modified residuei761 – 7611PhosphoserineCombined sources
Modified residuei762 – 7621PhosphothreonineCombined sources
Modified residuei764 – 7641N6-acetyllysineCombined sources
Modified residuei768 – 7681PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75152.
MaxQBiO75152.
PaxDbiO75152.
PeptideAtlasiO75152.
PRIDEiO75152.

PTM databases

iPTMnetiO75152.
PhosphoSiteiO75152.

Expressioni

Gene expression databases

BgeeiENSG00000058673.
CleanExiHS_ZC3H11A.
ExpressionAtlasiO75152. baseline and differential.
GenevisibleiO75152. HS.

Organism-specific databases

HPAiHPA026439.
HPA028490.
HPA028526.

Interactioni

Subunit structurei

Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXM1Q080502EBI-748480,EBI-866480
MLH1P406923EBI-748480,EBI-744248

Protein-protein interaction databases

BioGridi115208. 53 interactions.
IntActiO75152. 19 interactions.
MINTiMINT-1444822.
STRINGi9606.ENSP00000333253.

Structurei

3D structure databases

ProteinModelPortaliO75152.
SMRiO75152. Positions 6-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili362 – 42362Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi161 – 1688Poly-Asp

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 2928C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri31 – 5727C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 8627C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4791. Eukaryota.
ENOG41101ZI. LUCA.
GeneTreeiENSGT00730000111062.
HOVERGENiHBG082979.
InParanoidiO75152.
OMAiDVTCIKL.
OrthoDBiEOG091G0KPN.
PhylomeDBiO75152.
TreeFamiTF335608.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC
60 70 80 90 100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT
110 120 130 140 150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP
160 170 180 190 200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP
210 220 230 240 250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP
260 270 280 290 300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK
310 320 330 340 350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV
360 370 380 390 400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST
410 420 430 440 450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV
460 470 480 490 500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE
510 520 530 540 550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD
560 570 580 590 600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA
610 620 630 640 650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK
660 670 680 690 700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA
710 720 730 740 750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM
760 770 780 790 800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL
810
LLELSEMIDS
Length:810
Mass (Da):89,131
Last modified:August 16, 2005 - v3
Checksum:i9048ABC7F4A372FB
GO

Sequence cautioni

The sequence BAA31638 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH10553 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801C → Y in CAH10553 (PubMed:17974005).Curated
Sequence conflicti246 – 2461P → L in CAH10530 (PubMed:17974005).Curated
Sequence conflicti266 – 2661L → P in CAH10525 (PubMed:17974005).Curated
Sequence conflicti277 – 2771R → G in CAH10530 (PubMed:17974005).Curated
Sequence conflicti409 – 4091V → G in CAH10525 (PubMed:17974005).Curated
Sequence conflicti412 – 4121E → K in CAH10525 (PubMed:17974005).Curated
Sequence conflicti616 – 6161S → P in CAH10566 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti640 – 6401T → N.
Corresponds to variant rs11240604 [ dbSNP | Ensembl ].
VAR_052967

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014563 mRNA. Translation: BAA31638.2. Different initiation.
CR627439 mRNA. Translation: CAH10525.1.
CR627446 mRNA. Translation: CAH10530.1.
BX648271 mRNA. Translation: CAH10553.1. Sequence problems.
BX649148 mRNA. Translation: CAH10566.1.
BC014268 mRNA. Translation: AAH14268.1.
CCDSiCCDS30978.1.
PIRiT00368.
RefSeqiNP_001306167.1. NM_001319238.1.
NP_001306168.1. NM_001319239.1.
NP_055642.3. NM_014827.5.
XP_005245700.1. XM_005245643.2.
XP_005245701.1. XM_005245644.3.
XP_006711736.1. XM_006711673.2.
XP_011508501.1. XM_011510199.1.
XP_011508502.1. XM_011510200.1.
XP_011508503.1. XM_011510201.1.
XP_011508504.1. XM_011510202.1.
UniGeneiHs.532399.

Genome annotation databases

EnsembliENST00000332127; ENSP00000333253; ENSG00000058673.
ENST00000367210; ENSP00000356179; ENSG00000058673.
ENST00000367212; ENSP00000356181; ENSG00000058673.
ENST00000367214; ENSP00000356183; ENSG00000058673.
ENST00000545588; ENSP00000438527; ENSG00000058673.
GeneIDi9877.
KEGGihsa:9877.
UCSCiuc001hac.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014563 mRNA. Translation: BAA31638.2. Different initiation.
CR627439 mRNA. Translation: CAH10525.1.
CR627446 mRNA. Translation: CAH10530.1.
BX648271 mRNA. Translation: CAH10553.1. Sequence problems.
BX649148 mRNA. Translation: CAH10566.1.
BC014268 mRNA. Translation: AAH14268.1.
CCDSiCCDS30978.1.
PIRiT00368.
RefSeqiNP_001306167.1. NM_001319238.1.
NP_001306168.1. NM_001319239.1.
NP_055642.3. NM_014827.5.
XP_005245700.1. XM_005245643.2.
XP_005245701.1. XM_005245644.3.
XP_006711736.1. XM_006711673.2.
XP_011508501.1. XM_011510199.1.
XP_011508502.1. XM_011510200.1.
XP_011508503.1. XM_011510201.1.
XP_011508504.1. XM_011510202.1.
UniGeneiHs.532399.

3D structure databases

ProteinModelPortaliO75152.
SMRiO75152. Positions 6-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115208. 53 interactions.
IntActiO75152. 19 interactions.
MINTiMINT-1444822.
STRINGi9606.ENSP00000333253.

PTM databases

iPTMnetiO75152.
PhosphoSiteiO75152.

Polymorphism and mutation databases

BioMutaiZC3H11A.

Proteomic databases

EPDiO75152.
MaxQBiO75152.
PaxDbiO75152.
PeptideAtlasiO75152.
PRIDEiO75152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332127; ENSP00000333253; ENSG00000058673.
ENST00000367210; ENSP00000356179; ENSG00000058673.
ENST00000367212; ENSP00000356181; ENSG00000058673.
ENST00000367214; ENSP00000356183; ENSG00000058673.
ENST00000545588; ENSP00000438527; ENSG00000058673.
GeneIDi9877.
KEGGihsa:9877.
UCSCiuc001hac.4. human.

Organism-specific databases

CTDi9877.
GeneCardsiZC3H11A.
H-InvDBHIX0123107.
HGNCiHGNC:29093. ZC3H11A.
HPAiHPA026439.
HPA028490.
HPA028526.
MIMi613513. gene.
neXtProtiNX_O75152.
PharmGKBiPA142670535.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4791. Eukaryota.
ENOG41101ZI. LUCA.
GeneTreeiENSGT00730000111062.
HOVERGENiHBG082979.
InParanoidiO75152.
OMAiDVTCIKL.
OrthoDBiEOG091G0KPN.
PhylomeDBiO75152.
TreeFamiTF335608.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiZC3H11A. human.
GeneWikiiZC3H11A.
GenomeRNAii9877.
PROiO75152.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000058673.
CleanExiHS_ZC3H11A.
ExpressionAtlasiO75152. baseline and differential.
GenevisibleiO75152. HS.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC11A_HUMAN
AccessioniPrimary (citable) accession number: O75152
Secondary accession number(s): Q6AHY4
, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 7, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.