##gff-version 3 O75151 UniProtKB Chain 1 1096 . . . ID=PRO_0000059290;Note=Lysine-specific demethylase PHF2 O75151 UniProtKB Domain 197 353 . . . Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538 O75151 UniProtKB Zinc finger 5 56 . . . Note=PHD-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146 O75151 UniProtKB Region 447 634 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Region 646 674 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Region 719 799 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Region 817 846 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Region 877 1078 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 501 516 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 518 536 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 551 565 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 581 628 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 725 753 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 776 799 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 885 902 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 959 1026 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Compositional bias 1052 1068 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75151 UniProtKB Binding site 193 193 . . . . O75151 UniProtKB Binding site 246 246 . . . . O75151 UniProtKB Binding site 249 249 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000269|PubMed:21167174;Dbxref=PMID:21167174 O75151 UniProtKB Binding site 251 251 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000269|PubMed:21167174;Dbxref=PMID:21167174 O75151 UniProtKB Binding site 259 259 . . . . O75151 UniProtKB Binding site 266 266 . . . . O75151 UniProtKB Binding site 321 321 . . . . O75151 UniProtKB Binding site 321 321 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00538,ECO:0000269|PubMed:21167174;Dbxref=PMID:21167174 O75151 UniProtKB Binding site 323 323 . . . . O75151 UniProtKB Modified residue 474 474 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:24275569;Dbxref=PMID:20068231,PMID:24275569 O75151 UniProtKB Modified residue 479 479 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O75151 UniProtKB Modified residue 539 539 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 O75151 UniProtKB Modified residue 655 655 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75151 UniProtKB Modified residue 681 681 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O75151 UniProtKB Modified residue 705 705 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 O75151 UniProtKB Modified residue 720 720 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 728 728 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 730 730 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 733 733 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 734 734 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 738 738 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 879 879 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WTU0 O75151 UniProtKB Modified residue 882 882 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569 O75151 UniProtKB Modified residue 899 899 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O75151 UniProtKB Modified residue 1056 1056 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Cross-link 711 711 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 O75151 UniProtKB Natural variant 56 56 . . . ID=VAR_047553;Note=T->P;Dbxref=dbSNP:rs34279404 O75151 UniProtKB Natural variant 1058 1058 . . . ID=VAR_051598;Note=S->L;Dbxref=dbSNP:rs35236745 O75151 UniProtKB Mutagenesis 7 7 . . . Note=Abolishes binding to H3K4me2 and H3K4me3. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20129925;Dbxref=PMID:20129925 O75151 UniProtKB Mutagenesis 29 29 . . . Note=Abolishes binding to H3K4me2 and H3K4me3. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20129925;Dbxref=PMID:20129925 O75151 UniProtKB Mutagenesis 249 249 . . . Note=Abolishes demethylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Mutagenesis 321 321 . . . Note=Does not alter iron-binding nor activates histone demethylase activity. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21167174;Dbxref=PMID:21167174 O75151 UniProtKB Mutagenesis 757 757 . . . Note=Abolishes phosphorylation by PKA and activation of demethylase activity%3B when associated with A-899%3B A-954 and A-1056. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Mutagenesis 899 899 . . . Note=Abolishes phosphorylation by PKA and activation of demethylase activity%3B when associated with A-757%3B A-954 and A-1056. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Mutagenesis 954 954 . . . Note=Abolishes phosphorylation by PKA and activation of demethylase activity%3B when associated with A-757%3B A-899 and A-1056. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Mutagenesis 1056 1056 . . . Note=Abolishes phosphorylation by PKA and activation of demethylase activity%3B when associated with A-757%3B A-899 and A-954. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21532585;Dbxref=PMID:21532585 O75151 UniProtKB Sequence conflict 19 41 . . . Note=FMIECDACKDWFHGSCVGVEEEE->PRAARPPARPGPTRAAQRRGRAT;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 75 76 . . . Note=QA->PT;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 100 100 . . . Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 106 106 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 115 115 . . . Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 621 621 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 633 633 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 642 642 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 654 654 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 664 664 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 670 670 . . . Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 698 698 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 712 719 . . . Note=AVLPTPVT->EALLMPTS;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 727 727 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 752 752 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 782 782 . . . Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 817 817 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 823 823 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 833 833 . . . Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 837 841 . . . Note=SGKSA->NKGT;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 849 849 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 857 857 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 862 862 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 888 888 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 949 950 . . . Note=SK->NR;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 954 955 . . . Note=SA->NT;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 959 960 . . . Note=LT->PA;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 964 964 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 968 968 . . . Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 972 972 . . . Note=I->ASASTGTT;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 975 975 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 978 979 . . . Note=ST->PA;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 996 996 . . . Note=T->TTPAST;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 1033 1035 . . . Note=TGA->SGS;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 1040 1040 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Sequence conflict 1063 1063 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75151 UniProtKB Beta strand 2 5 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8F8Y O75151 UniProtKB Turn 8 11 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Beta strand 20 22 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Turn 24 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Beta strand 29 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Helix 32 35 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Helix 39 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Beta strand 45 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Helix 51 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7M10 O75151 UniProtKB Helix 87 95 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 101 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 105 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 110 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 115 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 127 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Turn 133 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 146 153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 158 163 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Turn 164 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 169 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 174 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8F8Y O75151 UniProtKB Beta strand 190 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 201 205 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 210 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 217 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 236 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 245 249 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 252 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 256 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 275 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 295 298 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 303 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 312 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 320 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 339 341 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PU8 O75151 UniProtKB Helix 342 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Beta strand 359 361 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PU3 O75151 UniProtKB Helix 366 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 393 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Turn 412 414 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PU8 O75151 UniProtKB Helix 415 418 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PU8 O75151 UniProtKB Helix 419 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA O75151 UniProtKB Helix 428 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3PUA