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O75150

- BRE1B_HUMAN

UniProt

O75150 - BRE1B_HUMAN

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Protein
E3 ubiquitin-protein ligase BRE1B
Gene
RNF40, BRE1B, KIAA0661
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri948 – 98740RING-type
Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. ubiquitin protein ligase binding Source: UniProtKB
  5. ubiquitin-protein transferase activity Source: Ensembl
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H2B ubiquitination Source: UniProtKB
  2. histone monoubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase BRE1B (EC:6.3.2.-)
Short name:
BRE1-B
Alternative name(s):
95 kDa retinoblastoma-associated protein
Short name:
RBP95
RING finger protein 40
Gene namesi
Name:RNF40
Synonyms:BRE1B, KIAA0661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:16867. RNF40.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. HULC complex Source: UniProtKB
  2. neuron projection Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091L → S: Abolishes interaction with RB1. 1 Publication
Mutagenesisi111 – 1111C → M: Abolishes interaction with RB1. 1 Publication
Mutagenesisi113 – 1131E → Q: Abolishes interaction with RB1. 1 Publication

Organism-specific databases

PharmGKBiPA34440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001E3 ubiquitin-protein ligase BRE1B
PRO_0000055839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201N6-acetyllysine By similarity
Modified residuei517 – 5171N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO75150.
PaxDbiO75150.
PRIDEiO75150.

PTM databases

PhosphoSiteiO75150.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.1 Publication

Gene expression databases

ArrayExpressiO75150.
BgeeiO75150.
CleanExiHS_RNF40.
GenevestigatoriO75150.

Organism-specific databases

HPAiHPA041330.

Interactioni

Subunit structurei

Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-744408,EBI-466029
RB1P064003EBI-744408,EBI-491274
RNF20Q5VTR210EBI-744408,EBI-2372238

Protein-protein interaction databases

BioGridi115149. 39 interactions.
IntActiO75150. 13 interactions.
MINTiMINT-1466706.
STRINGi9606.ENSP00000325677.

Structurei

3D structure databases

ProteinModelPortaliO75150.
SMRiO75150. Positions 943-993.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 9148 Reviewed prediction
Add
BLAST
Coiled coili189 – 377189 Reviewed prediction
Add
BLAST
Coiled coili437 – 52589 Reviewed prediction
Add
BLAST
Coiled coili627 – 946320 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the BRE1 family.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG263074.
HOVERGENiHBG080312.
InParanoidiO75150.
KOiK10696.
OMAiYSELQDK.
OrthoDBiEOG7DVD99.
PhylomeDBiO75150.
TreeFamiTF323183.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75150-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK     50
VLQFKNKKLA ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ 100
LDETVEALLR CHESQGELSS APEAPGTQEG PTCDGTPLPE PGTSELRDPL 150
LMQLRPPLSE PALAFVVALG ASSSEEVELE LQGRMEFSKA AVSRVVEASD 200
RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL QDLATQLQEK 250
HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL 300
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM 350
AELEKLQAEL QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN 400
ESLQVKTQLD EARGLLLATK NSHLRHIEHM ESDELGLQKK LRTEVIQLED 450
TLAQVRKEYE MLRIEFEQNL AANEQAGPIN REMRHLISSL QNHNHQLKGD 500
AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV SAPAPGKEEG 550
GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS 600
SRGREPEARP KRELQEREGP SLGPPPVASA LSRADREKAK VEETKRKESE 650
LLKGLRAELK KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV 700
DELRSRIREL EERDRRESKK IADEDALRRI RQAEEQIEHL QRKLGATKQE 750
EEALLSEMDV TGQAFEDMQE QNGRLLQQLR EKDDANFKLM SERIKANQIH 800
KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG SLGGVEKELT 850
LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK 900
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC 950
CNTRKKDAVL TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI 1000
S 1001
Length:1,001
Mass (Da):113,650
Last modified:November 30, 2010 - v4
Checksum:i82D7CD183EDD5EFC
GO
Isoform 3 (identifier: O75150-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-838: DAQLLTVQKLEEKERAL → WPPPACRLELERWGSWP
     839-1001: Missing.

Note: No experimental confirmation available.

Show »
Length:838
Mass (Da):94,796
Checksum:i87B68E08B358A730
GO
Isoform 4 (identifier: O75150-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-431: Missing.

Note: No experimental confirmation available.

Show »
Length:901
Mass (Da):102,046
Checksum:i445DD31CF7511205
GO

Sequence cautioni

The sequence CAE45869.1 differs from that shown. Reason: Aberrant splicing.
The sequence BAA31636.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti463 – 4631R → H.
Corresponds to variant rs11556801 [ dbSNP | Ensembl ].
VAR_055021
Natural varianti615 – 6151Q → R.5 Publications
Corresponds to variant rs7195142 [ dbSNP | Ensembl ].
VAR_055022

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei332 – 431100Missing in isoform 4.
VSP_016681Add
BLAST
Alternative sequencei822 – 83817DAQLL…KERAL → WPPPACRLELERWGSWP in isoform 3.
VSP_016682Add
BLAST
Alternative sequencei839 – 1001163Missing in isoform 3.
VSP_016683Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561N → D in BAB55092. 1 Publication
Sequence conflicti96 – 961R → L in AAG13723. 1 Publication
Sequence conflicti108 – 1081L → P in BAB55092. 1 Publication
Sequence conflicti172 – 1721S → G in BAB55092. 1 Publication
Sequence conflicti387 – 3871E → K in CAH10518. 1 Publication
Sequence conflicti562 – 5621K → E in CAE45869. 1 Publication
Sequence conflicti600 – 6001S → F in CAE45869. 1 Publication
Sequence conflicti714 – 7141D → N in BAB55092. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF122819 mRNA. Translation: AAG13723.1.
AB014561 mRNA. Translation: BAA31636.2. Different initiation.
AK027406 mRNA. Translation: BAB55092.1.
BX640763 mRNA. Translation: CAE45869.1. Sequence problems.
CR627431 mRNA. Translation: CAH10518.1.
AC106886 Genomic DNA. No translation available.
BC004527 mRNA. Translation: AAH04527.2.
BC006133 mRNA. Translation: AAH06133.1.
BC011769 mRNA. Translation: AAH11769.1.
BC018647 mRNA. Translation: AAH18647.1.
BC030802 mRNA. Translation: AAH30802.2.
CCDSiCCDS10691.1. [O75150-1]
CCDS55994.1. [O75150-4]
PIRiJC7363.
RefSeqiNP_001193962.1. NM_001207033.1.
NP_001193963.1. NM_001207034.1.
NP_001273501.1. NM_001286572.2.
NP_055586.1. NM_014771.3.
UniGeneiHs.65238.

Genome annotation databases

EnsembliENST00000324685; ENSP00000325677; ENSG00000103549. [O75150-1]
ENST00000357890; ENSP00000350563; ENSG00000103549. [O75150-4]
GeneIDi9810.
KEGGihsa:9810.
UCSCiuc002dzq.3. human. [O75150-1]
uc010cab.3. human. [O75150-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF122819 mRNA. Translation: AAG13723.1 .
AB014561 mRNA. Translation: BAA31636.2 . Different initiation.
AK027406 mRNA. Translation: BAB55092.1 .
BX640763 mRNA. Translation: CAE45869.1 . Sequence problems.
CR627431 mRNA. Translation: CAH10518.1 .
AC106886 Genomic DNA. No translation available.
BC004527 mRNA. Translation: AAH04527.2 .
BC006133 mRNA. Translation: AAH06133.1 .
BC011769 mRNA. Translation: AAH11769.1 .
BC018647 mRNA. Translation: AAH18647.1 .
BC030802 mRNA. Translation: AAH30802.2 .
CCDSi CCDS10691.1. [O75150-1 ]
CCDS55994.1. [O75150-4 ]
PIRi JC7363.
RefSeqi NP_001193962.1. NM_001207033.1.
NP_001193963.1. NM_001207034.1.
NP_001273501.1. NM_001286572.2.
NP_055586.1. NM_014771.3.
UniGenei Hs.65238.

3D structure databases

ProteinModelPortali O75150.
SMRi O75150. Positions 943-993.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115149. 39 interactions.
IntActi O75150. 13 interactions.
MINTi MINT-1466706.
STRINGi 9606.ENSP00000325677.

PTM databases

PhosphoSitei O75150.

Proteomic databases

MaxQBi O75150.
PaxDbi O75150.
PRIDEi O75150.

Protocols and materials databases

DNASUi 9810.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324685 ; ENSP00000325677 ; ENSG00000103549 . [O75150-1 ]
ENST00000357890 ; ENSP00000350563 ; ENSG00000103549 . [O75150-4 ]
GeneIDi 9810.
KEGGi hsa:9810.
UCSCi uc002dzq.3. human. [O75150-1 ]
uc010cab.3. human. [O75150-4 ]

Organism-specific databases

CTDi 9810.
GeneCardsi GC16P030775.
HGNCi HGNC:16867. RNF40.
HPAi HPA041330.
MIMi 607700. gene.
neXtProti NX_O75150.
PharmGKBi PA34440.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263074.
HOVERGENi HBG080312.
InParanoidi O75150.
KOi K10696.
OMAi YSELQDK.
OrthoDBi EOG7DVD99.
PhylomeDBi O75150.
TreeFami TF323183.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GeneWikii RNF40.
GenomeRNAii 9810.
NextBioi 36932.
PROi O75150.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75150.
Bgeei O75150.
CleanExi HS_RNF40.
Genevestigatori O75150.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein."
    Wen H., Ao S.
    Biochem. Biophys. Res. Commun. 275:141-148(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, INTERACTION WITH RB1, MUTAGENESIS OF LEU-109; CYS-111 AND GLU-113, VARIANT ARG-615.
    Tissue: Fetal brain.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-615.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ARG-615.
    Tissue: Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-615.
    Tissue: Cervix and Rectum tumor.
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-615.
    Tissue: Brain, Mammary gland, Skin and Uterus.
  7. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."
    Zhu B., Zheng Y., Pham A.-D., Mandal S.S., Erdjument-Bromage H., Tempst P., Reinberg D.
    Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, IDENTIFICATION IN A COMPLEX WITH RNF20 AND UBE2E1.
  8. "RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells."
    Kim J., Guermah M., McGinty R.K., Lee J.S., Tang Z., Milne T.A., Shilatifard A., Muir T.W., Roeder R.G.
    Cell 137:459-471(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."
    Zhang F., Yu X.
    Mol. Cell 41:384-397(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WAC.

Entry informationi

Entry nameiBRE1B_HUMAN
AccessioniPrimary (citable) accession number: O75150
Secondary accession number(s): Q6AHZ6
, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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