true2006-08-222024-03-27184OBSL1_HUMANObscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.Geisler S.B.Robinson D.Hauringa M.Raeker M.O.Borisov A.B.Westfall M.V.Russell M.W.doi:10.1016/j.ygeno.2006.12.0042007Genomics89521-531NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)TISSUE SPECIFICITYHeartGeneration and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W.Graves T.A.Fulton R.S.Fulton L.A.Pepin K.H.Minx P.Wagner-McPherson C.Layman D.Wylie K.Sekhon M.Becker M.C.Fewell G.A.Delehaunty K.D.Miner T.L.Nash W.E.Kremitzki C.Oddy L.Du H.Sun H.Bradshaw-Cordum H.Ali J.Carter J.Cordes M.Harris A.Isak A.van Brunt A.Nguyen C.Du F.Courtney L.Kalicki J.Ozersky P.Abbott S.Armstrong J.Belter E.A.Caruso L.Cedroni M.Cotton M.Davidson T.Desai A.Elliott G.Erb T.Fronick C.Gaige T.Haakenson W.Haglund K.Holmes A.Harkins R.Kim K.Kruchowski S.S.Strong C.M.Grewal N.Goyea E.Hou S.Levy A.Martinka S.Mead K.McLellan M.D.Meyer R.Randall-Maher J.Tomlinson C.Dauphin-Kohlberg S.Kozlowicz-Reilly A.Shah N.Swearengen-Shahid S.Snider J.Strong J.T.Thompson J.Yoakum M.Leonard S.Pearman C.Trani L.Radionenko M.Waligorski J.E.Wang C.Rock S.M.Tin-Wollam A.-M.Maupin R.Latreille P.Wendl M.C.Yang S.-P.Pohl C.Wallis J.W.Spieth J.Bieri T.A.Berkowicz N.Nelson J.O.Osborne J.Ding L.Meyer R.'Sabo A.Shotland Y.Sinha P.Wohldmann P.E.Cook L.L.Hickenbotham M.T.Eldred J.Williams D.Jones T.A.She X.Ciccarelli F.D.Izaurralde E.Taylor J.Schmutz J.Myers R.M.Cox D.R.Huang X.McPherson J.D.Mardis E.R.Clifton S.W.Warren W.C.Chinwalla A.T.Eddy S.R.Marra M.A.Ovcharenko I.Furey T.S.Miller W.Eichler E.E.Bork P.Suyama M.Torrents D.Waterston R.H.Wilson R.K.doi:10.1038/nature034662005Nature434724-731NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Mural R.J.Istrail S.Sutton G.G.Florea L.Halpern A.L.Mobarry C.M.Lippert R.Walenz B.Shatkay H.Dew I.Miller J.R.Flanigan M.J.Edwards N.J.Bolanos R.Fasulo D.Halldorsson B.V.Hannenhalli S.Turner R.Yooseph S.Lu F.Nusskern D.R.Shue B.C.Zheng X.H.Zhong F.Delcher A.L.Huson D.H.Kravitz S.A.Mouchard L.Reinert K.Remington K.A.Clark A.G.Waterman M.S.Eichler E.E.Adams M.D.Hunkapiller M.W.Myers E.W.Venter J.C.2005-07EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)MusclePrediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.Ishikawa K.Nagase T.Suyama M.Miyajima N.Tanaka A.Kotani H.Nomura N.Ohara O.doi:10.1093/dnares/5.3.1691998DNA Res.5169-176NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-1896 (ISOFORM 3)BrainConstruction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.Nakajima D.Okazaki N.Yamakawa H.Kikuno R.Ohara O.Nagase T.doi:10.1093/dnares/9.3.992002DNA Res.999-106SEQUENCE REVISIONA quantitative atlas of mitotic phosphorylation.Dephoure N.Zhou C.Villen J.Beausoleil S.A.Bakalarski C.E.Elledge S.J.Gygi S.P.doi:10.1073/pnas.08051391052008Proc. Natl. Acad. Sci. U.S.A.10510762-10767PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Cervix carcinomaThe primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1.Hanson D.Murray P.G.Sud A.Temtamy S.A.Aglan M.Superti-Furga A.Holder S.E.Urquhart J.Hilton E.Manson F.D.C.Scambler P.Black G.C.M.Clayton P.E.doi:10.1016/j.ajhg.2009.04.0212009Am. J. Hum. Genet.84801-806INVOLVEMENT IN 3M2Exome sequencing identifies CCDC8 mutations in 3-M syndrome, Suggesting that CCDC8 Contributes in a Pathway with CUL7 and OBSL1 to Control Human Growth.Hanson D.Murray P.G.O'Sullivan J.Urquhart J.Daly S.Bhaskar S.S.Biesecker L.G.Skae M.Smith C.Cole T.Kirk J.Chandler K.Kingston H.Donnai D.Clayton P.E.Black G.C.doi:10.1016/j.ajhg.2011.05.0282011Am. J. Hum. Genet.89148-153INTERACTION WITH CCDC8 AND CUL7An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.Litterman N.Ikeuchi Y.Gallardo G.O'Connell B.C.Sowa M.E.Gygi S.P.Harper J.W.Bonni A.doi:10.1371/journal.pbio.10010602011PLoS Biol.9E1001060FUNCTIONINTERACTION WITH FBXW8 AND CUL7SUBCELLULAR LOCATIONToward a comprehensive characterization of a human cancer cell phosphoproteome.Zhou H.Di Palma S.Preisinger C.Peng M.Polat A.N.Heck A.J.Mohammed S.doi:10.1021/pr300630k2013J. Proteome Res.12260-271PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]ErythroleukemiaThe 3M complex maintains microtubule and genome integrity.Yan J.Yan F.Li Z.Sinnott B.Cappell K.M.Yu Y.Mo J.Duncan J.A.Chen X.Cormier-Daire V.Whitehurst A.W.Xiong Y.doi:10.1016/j.molcel.2014.03.0472014Mol. Cell54791-804FUNCTIONIDENTIFICATION IN THE 3M COMPLEXSUBCELLULAR LOCATIONCUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.Li Z.Pei X.H.Yan J.Yan F.Cappell K.M.Whitehurst A.W.Xiong Y.doi:10.1016/j.molcel.2014.03.0462014Mol. Cell54805-819FUNCTIONMutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.Hanson D.Murray P.G.Coulson T.Sud A.Omokanye A.Stratta E.Sakhinia F.Bonshek C.Wilson L.C.Wakeling E.Temtamy S.A.Aglan M.Rosser E.M.Mansour S.Carcavilla A.Nampoothiri S.Khan W.I.Banerjee I.Chandler K.E.Black G.C.Clayton P.E.doi:10.1530/jme-12-00342012J. Mol. Endocrinol.49267-275INVOLVEMENT IN 3M2Solution structure of Ig-like domains from human obscurin-like protein 1.RIKEN structural genomics initiative (RSGI)2005-11PDBSTRUCTURE BY NMR OF 615-992Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.Sauer F.Vahokoski J.Song Y.H.Wilmanns M.doi:10.1038/embor.2010.652010EMBO Rep.11534-540X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-105 IN COMPLEX WITH THE C-TERMINAL IG-LIKE DOMAIN OF TTNINTERACTION WITH TTNStructural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.Pernigo S.Fukuzawa A.Bertz M.Holt M.Rief M.Steiner R.A.Gautel M.doi:10.1073/pnas.09137361072010Proc. Natl. Acad. Sci. U.S.A.1072908-2913X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 1-106 OF WILD-TYPE AND MUTANT ARG-17 IN COMPLEX WITH THE C-TERMINAL IG-LIKE DOMAIN OF TTNINTERACTION WITH TTNMUTAGENESIS OF PHE-17Solution NMR structure of Ig like domain (805-892) of obscurin-like protein 1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8578K (CASP Target).Northeast structural genomics consortium (NESG)2012-06PDBSTRUCTURE BY NMR OF 805-892Solution NMR Structure of Ig like domain (1277-1357) of Obscurin-like protein 1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8578D (CASP Target).Northeast structural genomics consortium (NESG)2012-06PDBSTRUCTURE BY NMR OF 1277-1357Different initiation.A=893-992A=714-804A=615-713A=1277-1357A=805-8921.48O=1-1061.70O=1-1062.30C/O=1-1061.40B=1-1053.10O/P=251-3399013M complex553 sites, 1 glycan4 sites, 1 O-linked glycan (4 sites)16 antibodies from 7 providershumanOBSL1Tissue enhanced (ovary)genephenotype3M syndromeEukaryotaNeddylation11 hits in 1153 CRISPR screenshumanhumanTbioProteinExpressed in right testis and 195 other cell types or tissuesbaseline and differentialFN3IgIg_Semaphorin_CIgI_C2_MyBP-C-likeImmunoglobulinsFN3_domFN3_sfIg-like_domIg-like_dom_sfIg-like_foldIg_I-setIg_subIg_sub2OBSCURIN-LIKE PROTEIN 1SI:DKEY-31G6.6I-setIg_3IGIGc2Fibronectin type IIIImmunoglobulinFN3IG_LIKEHSObscurin-like protein 1OBSL1KIAA0657Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts with CCDC8. Interacts with CUL7; the interaction is direct. Interacts with FBXW8. Interacts (via N-terminal Ig-like domain) with TTN/titin (via C-terminal Ig-like domain); the interaction is direct.Colocalizes with CUL7 at the Golgi apparatus in neurons (PubMed:21572988).Widely expressed, with predominant levels found in the heart.The disease is caused by variants affecting the gene represented in this entry.Extended N-terminus.Obscurin-like protein 120694711896Ig-like 112100Ig-like 2128225Ig-like 3243330Ig-like 4339425Fibronectin type-III517615Ig-like 5714800Ig-like 6804893Ig-like 7902982Ig-like 89861075Ig-like 910781172Ig-like 1011741261Ig-like 1112651357Ig-like 121534Ig-like 1316281720Ig-like 141794Interaction with TTN1719Interaction with TTN8594Disordered106127Phosphoserine1033841492092673193624127387888298799209701011106111031153119512451381152216501700In isoform 2.SYQSQDSSNNNPELCVLLKKPKTRRLWSRFPPWRRTAGTE1025In isoform 2.1026In isoform 3.10761167In isoform 3.RQSCCSYGGCRMCGQRKARTCVSKWRQAEWVQRGPCAGCEVGSPCPTTLACPWPRMGTSTASSSMVSYWPTRAPTAARATTIAPWPGSA14051493In isoform 3.1494In isoform 4.RECPVLS15371543In isoform 4.1544Diminishes binding affinity for TTN.RR165CG512K723KKKD1365162124293942475659667376788088911022542582612692732762812902963003063113133153223273376186206256286326416466516696726786856926997027117247327487517627677707777807827847897978028158188258308398428548588618688718738758808858918989069119169239309339449489509599629649669749769841279128112871290130113041313131913241330133713421344134613481354false13false4TTNCUL72011-04-0542069476a6fcec2ef2ab98e5547ccb971b125a31MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEGN2MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTESYQSQDSSNNNPELCVLLKKPKTRRLWSRFPPWRRTAGTE3MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQRQSCCSYGGCRMCGQRKARTCVSKWRQAEWVQRGPCAGCEVGSPCPTTLACPWPRMGTSTASSSMVSYWPTRAPTAARATTIAPWPGSA4MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRRECPVLStruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetrue