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Protein

Obscurin-like protein 1

Gene

OBSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.3 Publications

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: BHF-UCL

GO - Biological processi

  • cardiac myofibril assembly Source: BHF-UCL
  • cytoskeleton organization Source: BHF-UCL
  • Golgi organization Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
  • positive regulation of dendrite morphogenesis Source: UniProtKB
  • protein localization to Golgi apparatus Source: UniProtKB
  • regulation of mitotic nuclear division Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124006-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Obscurin-like protein 1
Gene namesi
Name:OBSL1
Synonyms:KIAA0657
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29092. OBSL1.

Subcellular locationi

GO - Cellular componenti

  • 3M complex Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • intercalated disc Source: BHF-UCL
  • M band Source: BHF-UCL
  • perinuclear region of cytoplasm Source: UniProtKB
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

3M syndrome 2 (3M2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.
See also OMIM:612921

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17F → R: Diminishes binding affinity for TTN. 1 Publication1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNETi23363.
MalaCardsiOBSL1.
MIMi612921. phenotype.
OpenTargetsiENSG00000124006.
Orphaneti2616. 3M syndrome.
PharmGKBiPA142671235.

Polymorphism and mutation databases

BioMutaiOBSL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002479591 – 1896Obscurin-like protein 1Add BLAST1896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Disulfide bondi33 ↔ 84PROSITE-ProRule annotation
Disulfide bondi149 ↔ 209PROSITE-ProRule annotation
Disulfide bondi267 ↔ 319PROSITE-ProRule annotation
Disulfide bondi362 ↔ 412PROSITE-ProRule annotation
Disulfide bondi738 ↔ 788PROSITE-ProRule annotation
Disulfide bondi829 ↔ 879PROSITE-ProRule annotation
Disulfide bondi920 ↔ 970PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1061PROSITE-ProRule annotation
Disulfide bondi1103 ↔ 1153PROSITE-ProRule annotation
Disulfide bondi1195 ↔ 1245PROSITE-ProRule annotation
Disulfide bondi1381 ↔ 1522PROSITE-ProRule annotation
Disulfide bondi1650 ↔ 1700PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO75147.
PaxDbiO75147.
PeptideAtlasiO75147.
PRIDEiO75147.

PTM databases

iPTMnetiO75147.
PhosphoSitePlusiO75147.

Expressioni

Tissue specificityi

Widely expressed, with predominant levels found in the heart.1 Publication

Gene expression databases

BgeeiENSG00000124006.
CleanExiHS_OBSL1.
ExpressionAtlasiO75147. baseline and differential.
GenevisibleiO75147. HS.

Organism-specific databases

HPAiHPA036404.
HPA036405.

Interactioni

Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts with CCDC8. Interacts with CUL7; the interaction is direct. Interacts with FBXW8. Interacts (via N-terminal Ig-like domain) with TTN/titin (via C-terminal Ig-like domain); the interaction is direct.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TTNQ8WZ428EBI-1223896,EBI-681210

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi116944. 640 interactors.
DIPiDIP-38340N.
IntActiO75147. 13 interactors.
MINTiMINT-7979572.
STRINGi9606.ENSP00000385636.

Structurei

Secondary structure

11896
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 16Combined sources7
Beta strandi21 – 24Combined sources4
Beta strandi29 – 39Combined sources11
Beta strandi42 – 47Combined sources6
Beta strandi56 – 59Combined sources4
Beta strandi66 – 73Combined sources8
Helixi76 – 78Combined sources3
Beta strandi80 – 88Combined sources9
Beta strandi91 – 102Combined sources12
Beta strandi618 – 620Combined sources3
Beta strandi625 – 628Combined sources4
Beta strandi632 – 641Combined sources10
Beta strandi646 – 651Combined sources6
Beta strandi669 – 672Combined sources4
Beta strandi678 – 685Combined sources8
Beta strandi692 – 699Combined sources8
Beta strandi702 – 711Combined sources10
Beta strandi724 – 732Combined sources9
Beta strandi748 – 751Combined sources4
Beta strandi762 – 767Combined sources6
Beta strandi770 – 777Combined sources8
Turni780 – 782Combined sources3
Beta strandi784 – 789Combined sources6
Beta strandi797 – 802Combined sources6
Beta strandi815 – 818Combined sources4
Beta strandi825 – 830Combined sources6
Beta strandi839 – 842Combined sources4
Beta strandi854 – 858Combined sources5
Beta strandi861 – 868Combined sources8
Helixi871 – 873Combined sources3
Beta strandi875 – 880Combined sources6
Beta strandi885 – 891Combined sources7
Beta strandi898 – 902Combined sources5
Beta strandi906 – 911Combined sources6
Beta strandi916 – 923Combined sources8
Beta strandi930 – 933Combined sources4
Beta strandi944 – 948Combined sources5
Beta strandi950 – 959Combined sources10
Turni962 – 964Combined sources3
Beta strandi966 – 974Combined sources9
Beta strandi976 – 984Combined sources9
Beta strandi1279 – 1281Combined sources3
Beta strandi1287 – 1290Combined sources4
Beta strandi1301 – 1304Combined sources4
Beta strandi1313 – 1319Combined sources7
Beta strandi1324 – 1330Combined sources7
Beta strandi1337 – 1342Combined sources6
Turni1344 – 1346Combined sources3
Beta strandi1348 – 1354Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPCNMR-A893-992[»]
2E6PNMR-A714-804[»]
2E6QNMR-A615-713[»]
2LU7NMR-A1277-1357[»]
2LVCNMR-A805-892[»]
2WP3X-ray1.48O1-106[»]
2WWKX-ray1.70O1-106[»]
2WWMX-ray2.30C/O1-106[»]
3KNBX-ray1.40B1-105[»]
ProteinModelPortaliO75147.
SMRiO75147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 100Ig-like 1Add BLAST89
Domaini128 – 225Ig-like 2Add BLAST98
Domaini243 – 330Ig-like 3Add BLAST88
Domaini339 – 425Ig-like 4Add BLAST87
Domaini517 – 615Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99
Domaini714 – 800Ig-like 5Add BLAST87
Domaini804 – 893Ig-like 6Add BLAST90
Domaini902 – 982Ig-like 7Add BLAST81
Domaini986 – 1075Ig-like 8Add BLAST90
Domaini1078 – 1172Ig-like 9Add BLAST95
Domaini1174 – 1261Ig-like 10Add BLAST88
Domaini1265 – 1357Ig-like 11Add BLAST93
Domaini1357 – 1534Ig-like 12Add BLAST178
Domaini1628 – 1720Ig-like 13Add BLAST93
Domaini1794 – 1896Ig-like 14Add BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 19Interaction with TTN3
Regioni85 – 94Interaction with TTN10

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000263472.
HOVERGENiHBG082081.
InParanoidiO75147.
KOiK19574.
OMAiDSVFFNI.
OrthoDBiEOG091G0003.
PhylomeDBiO75147.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 20 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 13 hits.
[Graphical view]
SMARTiSM00409. IG. 19 hits.
SM00408. IGc2. 14 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 18 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 14 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75147-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKASSGDQGS PPCFLRFPRP VRVVSGAEAE LKCVVLGEPP PVVVWEKGGQ
60 70 80 90 100
QLAASERLSF PADGAEHGLL LTAALPTDAG VYVCRARNAA GEAYAAAAVT
110 120 130 140 150
VLEPPASDPE LQPAERPLPS PGSGEGAPVF LTGPRSQWVL RGAEVVLTCR
160 170 180 190 200
AGGLPEPTLY WEKDGMALDE VWDSSHFALQ PGRAEDGPGA SLALRILAAR
210 220 230 240 250
LPDSGVYVCH ARNAHGHAQA GALLQVHQPP ESPPADPDEA PAPVVEPLKC
260 270 280 290 300
APKTFWVNEG KHAKFRCYVM GKPEPEIEWH WEGRPLLPDR RRLMYRDRDG
310 320 330 340 350
GFVLKVLYCQ AKDRGLYVCA ARNSAGQTLS AVQLHVKEPR LRFTRPLQDV
360 370 380 390 400
EGREHGIAVL ECKVPNSRIP TAWFREDQRL LPCRKYEQIE EGTVRRLIIH
410 420 430 440 450
RLKADDDGIY LCEMRGRVRT VANVTVKGPI LKRLPRKLDV LEGENAVLLV
460 470 480 490 500
ETLEAGVEGR WSRDGEELPV ICQSSSGHMH ALVLPGVTRE DAGEVTFSLG
510 520 530 540 550
NSRTTTLLRV KCVKHSPPGP PILAEMFKGH KNTVLLTWKP PEPAPETPFI
560 570 580 590 600
YRLERQEVGS EDWIQCFSIE KAGAVEVPGD CVPSEGDYRF RICTVSGHGR
610 620 630 640 650
SPHVVFHGSA HLVPTARLVA GLEDVQVYDG EDAVFSLDLS TIIQGTWFLN
660 670 680 690 700
GEELKSNEPE GQVEPGALRY RIEQKGLQHR LILHAVKHQD SGALVGFSCP
710 720 730 740 750
GVQDSAALTI QESPVHILSP QDRVSLTFTT SERVVLTCEL SRVDFPATWY
760 770 780 790 800
KDGQKVEESE LLVVKMDGRK HRLILPEAKV QDSGEFECRT EGVSAFFGVT
810 820 830 840 850
VQDPPVHIVD PREHVFVHAI TSECVMLACE VDREDAPVRW YKDGQEVEES
860 870 880 890 900
DFVVLENEGP HRRLVLPATQ PSDGGEFQCV AGDECAYFTV TITDVSSWIV
910 920 930 940 950
YPSGKVYVAA VRLERVVLTC ELCRPWAEVR WTKDGEEVVE SPALLLQKED
960 970 980 990 1000
TVRRLVLPAV QLEDSGEYLC EIDDESASFT VTVTEPPVRI IYPRDEVTLI
1010 1020 1030 1040 1050
AVTLECVVLM CELSREDAPV RWYKDGLEVE ESEALVLERD GPRCRLVLPA
1060 1070 1080 1090 1100
AQPEDGGEFV CDAGDDSAFF TVTVTAPPER IVHPAARSLD LHFGAPGRVE
1110 1120 1130 1140 1150
LRCEVAPAGS QVRWYKDGLE VEASDALQLG AEGPTRTLTL PHAQPEDAGE
1160 1170 1180 1190 1200
YVCETRHEAI TFNVILAEPP VQFLALETTP SPLCVAPGEP VVLSCELSRA
1210 1220 1230 1240 1250
GAPVVWSHNG RPVQEGEGLE LHAEGPRRVL CIQAAGPAHA GLYTCQSGAA
1260 1270 1280 1290 1300
PGAPSLSFTV QVAEPPVRVV APEAAQTRVR STPGGDLELV VHLSGPGGPV
1310 1320 1330 1340 1350
RWYKDGERLA SQGRVQLEQA GARQVLRVQG ARSGDAGEYL CDAPQDSRIF
1360 1370 1380 1390 1400
LVSVEEPLLV KLVSELTPLT VHEGDDATFR CEVSPPDADV TWLRNGAVVT
1410 1420 1430 1440 1450
PGPQVEMAQN GSSRILTLRG CQLGDAGTVT LRAGSTATSA RLHVRETELL
1460 1470 1480 1490 1500
FLRRLQDVRA EEGQDVCLEV ETGRVGAAGA VRWVRGGQPL PHDSRLSMAQ
1510 1520 1530 1540 1550
DGHIHRLFIH GVILADQGTY GCESHHDRTL ARLSVRPRQL RVLRPLEDVT
1560 1570 1580 1590 1600
ISEGGSATFQ LELSQEGVTG EWARGGVQLY PGPKCHIHSD GHRHRLVLNG
1610 1620 1630 1640 1650
LGLADSGCVS FTADSLRCAA RLIVREVPVT IVRGPHDLEV TEGDTATFEC
1660 1670 1680 1690 1700
ELSQALADVT WEKDGNALTP SPRLRLQALG TRRLLQLRRC GPSDAGTYSC
1710 1720 1730 1740 1750
AVGTARAGPV RLTVRERTVA VLSELRSVSA REGDGATFEC TVSEVETTGR
1760 1770 1780 1790 1800
WELGGRPLRP GARVRIRQEG KKHILVLSEL RAEDAGEVRF QAGPAQSLAL
1810 1820 1830 1840 1850
LEVEALPLQM CRHPPREKTV LVGRRAVLEV TVSRSGGHVC WLREGAELCP
1860 1870 1880 1890
GDKYEMRSHG PTHSLVIHDV RPEDQGTYCC QAGQDSTHTR LLVEGN
Length:1,896
Mass (Da):206,947
Last modified:April 5, 2011 - v4
Checksum:i6D592AC3E30E9ACA
GO
Isoform 2 (identifier: O75147-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     986-1025: PPVRIIYPRD...EDAPVRWYKD → SYQSQDSSNN...PPWRRTAGTE
     1026-1896: Missing.

Show »
Length:1,025
Mass (Da):113,273
Checksum:iCAF2D3D8E1920335
GO
Isoform 3 (identifier: O75147-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1167: Missing.
     1405-1493: VEMAQNGSSR...VRGGQPLPHD → RQSCCSYGGC...TTIAPWPGSA
     1494-1896: Missing.

Show »
Length:1,401
Mass (Da):152,925
Checksum:i3AE3886DF8C0B8A8
GO
Isoform 4 (identifier: O75147-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1537-1543: PRQLRVL → RECPVLS
     1544-1896: Missing.

Show »
Length:1,543
Mass (Da):168,521
Checksum:i8DAB399C567C8CDD
GO

Sequence cautioni

The sequence AAH07201 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165G → R in BAA31632 (PubMed:9734811).Curated1
Sequence conflicti512C → CG in ABO42327 (PubMed:17289344).Curated1
Sequence conflicti723R → K in AAH07201 (PubMed:15489334).Curated1
Sequence conflicti723R → K in BAA31632 (PubMed:9734811).Curated1
Sequence conflicti1365E → D in BAA31632 (PubMed:9734811).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040784986 – 1025PPVRI…RWYKD → SYQSQDSSNNNPELCVLLKK PKTRRLWSRFPPWRRTAGTE in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0407851026 – 1896Missing in isoform 2. 1 PublicationAdd BLAST871
Alternative sequenceiVSP_0407861076 – 1167Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0407871405 – 1493VEMAQ…PLPHD → RQSCCSYGGCRMCGQRKART CVSKWRQAEWVQRGPCAGCE VGSPCPTTLACPWPRMGTST ASSSMVSYWPTRAPTAARAT TIAPWPGSA in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0407881494 – 1896Missing in isoform 3. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_0547551537 – 1543PRQLRVL → RECPVLS in isoform 4. 1 Publication7
Alternative sequenceiVSP_0547561544 – 1896Missing in isoform 4. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF063637 mRNA. Translation: ABO42327.1.
EF063638 mRNA. Translation: ABO42328.1.
AC009955 Genomic DNA. No translation available.
BC007201 mRNA. Translation: AAH07201.1. Different initiation.
AB014557 mRNA. Translation: BAA31632.2.
CCDSiCCDS46520.1. [O75147-3]
CCDS54433.1. [O75147-2]
CCDS63134.1. [O75147-4]
RefSeqiNP_001166879.1. NM_001173408.1. [O75147-2]
NP_001166902.1. NM_001173431.1. [O75147-4]
NP_056126.1. NM_015311.2. [O75147-3]
UniGeneiHs.526594.

Genome annotation databases

EnsembliENST00000373873; ENSP00000362980; ENSG00000124006. [O75147-2]
ENST00000404537; ENSP00000385636; ENSG00000124006. [O75147-3]
ENST00000603926; ENSP00000474519; ENSG00000124006. [O75147-4]
GeneIDi23363.
KEGGihsa:23363.
UCSCiuc002vmi.4. human. [O75147-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF063637 mRNA. Translation: ABO42327.1.
EF063638 mRNA. Translation: ABO42328.1.
AC009955 Genomic DNA. No translation available.
BC007201 mRNA. Translation: AAH07201.1. Different initiation.
AB014557 mRNA. Translation: BAA31632.2.
CCDSiCCDS46520.1. [O75147-3]
CCDS54433.1. [O75147-2]
CCDS63134.1. [O75147-4]
RefSeqiNP_001166879.1. NM_001173408.1. [O75147-2]
NP_001166902.1. NM_001173431.1. [O75147-4]
NP_056126.1. NM_015311.2. [O75147-3]
UniGeneiHs.526594.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPCNMR-A893-992[»]
2E6PNMR-A714-804[»]
2E6QNMR-A615-713[»]
2LU7NMR-A1277-1357[»]
2LVCNMR-A805-892[»]
2WP3X-ray1.48O1-106[»]
2WWKX-ray1.70O1-106[»]
2WWMX-ray2.30C/O1-106[»]
3KNBX-ray1.40B1-105[»]
ProteinModelPortaliO75147.
SMRiO75147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116944. 640 interactors.
DIPiDIP-38340N.
IntActiO75147. 13 interactors.
MINTiMINT-7979572.
STRINGi9606.ENSP00000385636.

PTM databases

iPTMnetiO75147.
PhosphoSitePlusiO75147.

Polymorphism and mutation databases

BioMutaiOBSL1.

Proteomic databases

EPDiO75147.
PaxDbiO75147.
PeptideAtlasiO75147.
PRIDEiO75147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373873; ENSP00000362980; ENSG00000124006. [O75147-2]
ENST00000404537; ENSP00000385636; ENSG00000124006. [O75147-3]
ENST00000603926; ENSP00000474519; ENSG00000124006. [O75147-4]
GeneIDi23363.
KEGGihsa:23363.
UCSCiuc002vmi.4. human. [O75147-3]

Organism-specific databases

CTDi23363.
DisGeNETi23363.
GeneCardsiOBSL1.
GeneReviewsiOBSL1.
H-InvDBHIX0002869.
HIX0161860.
HGNCiHGNC:29092. OBSL1.
HPAiHPA036404.
HPA036405.
MalaCardsiOBSL1.
MIMi610991. gene.
612921. phenotype.
neXtProtiNX_O75147.
OpenTargetsiENSG00000124006.
Orphaneti2616. 3M syndrome.
PharmGKBiPA142671235.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000263472.
HOVERGENiHBG082081.
InParanoidiO75147.
KOiK19574.
OMAiDSVFFNI.
OrthoDBiEOG091G0003.
PhylomeDBiO75147.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124006-MONOMER.

Miscellaneous databases

ChiTaRSiOBSL1. human.
EvolutionaryTraceiO75147.
GeneWikiiOBSL1.
GenomeRNAii23363.
PROiO75147.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124006.
CleanExiHS_OBSL1.
ExpressionAtlasiO75147. baseline and differential.
GenevisibleiO75147. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 20 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 13 hits.
[Graphical view]
SMARTiSM00409. IG. 19 hits.
SM00408. IGc2. 14 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 18 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOBSL1_HUMAN
AccessioniPrimary (citable) accession number: O75147
Secondary accession number(s): A4KVA4
, A4KVA5, Q96IW3, S4R3M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.