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Protein

Liprin-alpha-3

Gene

PPFIA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha-3
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3
Short name:
PTPRF-interacting protein alpha-3
Gene namesi
Name:PPFIA3
Synonyms:KIAA0654
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000177380.13
HGNCiHGNC:9247 PPFIA3
MIMi603144 gene
neXtProtiNX_O75145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177380
PharmGKBiPA33568

Polymorphism and mutation databases

BioMutaiPPFIA3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910291 – 1194Liprin-alpha-3Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei431PhosphoserineBy similarity1
Modified residuei508PhosphoserineBy similarity1
Modified residuei640PhosphoserineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei683PhosphoserineCombined sources1
Modified residuei714PhosphothreonineCombined sources1
Modified residuei737PhosphoserineBy similarity1
Modified residuei792PhosphothreonineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1164PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75145
PaxDbiO75145
PeptideAtlasiO75145
PRIDEiO75145

PTM databases

iPTMnetiO75145
PhosphoSitePlusiO75145

Expressioni

Tissue specificityi

Predominantly expressed in brain (PubMed:9624153). Also detected in sperm (at protein level) (PubMed:23124857).2 Publications

Gene expression databases

BgeeiENSG00000177380
CleanExiHS_PPFIA3
ExpressionAtlasiO75145 baseline and differential
GenevisibleiO75145 HS

Organism-specific databases

HPAiHPA043567
HPA050340

Interactioni

Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta (PubMed:9624153). Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS (PubMed:9624153). Binds RIMS1, RIMS2, RIMS3 and RIMS4 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi114111, 19 interactors
IntActiO75145, 10 interactors
STRINGi9606.ENSP00000335614

Structurei

3D structure databases

ProteinModelPortaliO75145
SMRiO75145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini838 – 904SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini953 – 1017SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1041 – 1110SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 133Sequence analysisAdd BLAST108
Coiled coili161 – 501Sequence analysisAdd BLAST341
Coiled coili596 – 644Sequence analysisAdd BLAST49
Coiled coili1014 – 1040Sequence analysisAdd BLAST27

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.1 Publication

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000017513
HOVERGENiHBG052330
InParanoidiO75145
OMAiSNIWMTH
OrthoDBiEOG091G14UK
PhylomeDBiO75145
TreeFamiTF314207

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030440 PPFIA3
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF4 PTHR12587:SF4, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCEVMPTIS EDGRRGSALG PDEAGGELER LMVTMLTERE RLLETLREAQ
60 70 80 90 100
DGLATAQLRL RELGHEKDSL QRQLSIALPQ EFAALTKELN LCREQLLERE
110 120 130 140 150
EEIAELKAER NNTRLLLEHL ECLVSRHERS LRMTVVKRQA QSPGGVSSEV
160 170 180 190 200
EVLKALKSLF EHHKALDEKV RERLRMALER VAVLEEELEL SNQETLNLRE
210 220 230 240 250
QLSRRRSGLE EPGKDGDGQT LANGLGPGGD SNRRTAELEE ALERQRAEVC
260 270 280 290 300
QLRERLAVLC RQMSQLEEEL GTAHRELGKA EEANSKLQRD LKEALAQRED
310 320 330 340 350
MEERITTLEK RYLSAQREAT SLHDANDKLE NELASKESLY RQSEEKSRQL
360 370 380 390 400
AEWLDDAKQK LQQTLQKAET LPEIEAQLAQ RVAALNKAEE RHGNFEERLR
410 420 430 440 450
QLEAQLEEKN QELQRARQRE KMNDDHNKRL SETVDKLLSE SNERLQLHLK
460 470 480 490 500
ERMGALEEKN SLSEEIANMK KLQDELLLNK EQLLAEMERM QMEIDQLRGR
510 520 530 540 550
PPSSYSRSLP GSALELRYSQ APTLPSGAHL DPYVAGSGRA GKRGRWSGVK
560 570 580 590 600
EEPSKDWERS APAGSIPPPF PGELDGSDEE EAEGMFGAEL LSPSGQADVQ
610 620 630 640 650
TLAIMLQEQL EAINKEIKLI QEEKETTEQR AEELESRVSS SGLDSLGRYR
660 670 680 690 700
SSCSLPPSLT TSTLASPSPP SSGHSTPRLA PPSPAREGTD KANHVPKEEA
710 720 730 740 750
GAPRGEGPAI PGDTPPPTPR SARLERMTQA LALQAGSLED GGPPRGSEGT
760 770 780 790 800
PDSLHKAPKK KSIKSSIGRL FGKKEKGRMG PPGRDSSSLA GTPSDETLAT
810 820 830 840 850
DPLGLAKLTG PGDKDRRNKR KHELLEEACR QGLPFAAWDG PTVVSWLELW
860 870 880 890 900
VGMPAWYVAA CRANVKSGAI MANLSDTEIQ REIGISNPLH RLKLRLAIQE
910 920 930 940 950
MVSLTSPSAP ASSRTSTGNV WMTHEEMESL TATTKPETKE ISWEQILAYG
960 970 980 990 1000
DMNHEWVGND WLPSLGLPQY RSYFMESLVD ARMLDHLNKK ELRGQLKMVD
1010 1020 1030 1040 1050
SFHRVSLHYG IMCLKRLNYD RKDLERRREE SQTQIRDVMV WSNERVMGWV
1060 1070 1080 1090 1100
SGLGLKEFAT NLTESGVHGA LLALDETFDY SDLALLLQIP TQNAQARQLL
1110 1120 1130 1140 1150
EKEFSNLISL GTDRRLDEDS AKSFSRSPSW RKMFREKDLR GVTPDSAEML
1160 1170 1180 1190
PPNFRSAAAG ALGSPGLPLR KLQPEGQTSG SSRADGVSVR TYSC
Length:1,194
Mass (Da):133,496
Last modified:February 16, 2004 - v3
Checksum:i4DD92531AD8AE12D
GO
Isoform 2 (identifier: O75145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     937-945: Missing.

Note: May be due to exon skipping.
Show »
Length:1,185
Mass (Da):132,365
Checksum:i2D4AAB5416E93397
GO

Sequence cautioni

The sequence BAA31629 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti878E → K in AAC26101 (PubMed:9624153).Curated1
Sequence conflicti1011I → V in AAC26101 (PubMed:9624153).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017757563A → S3 PublicationsCorresponds to variant dbSNP:rs2303053Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009392937 – 945Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014554 mRNA Translation: BAA31629.2 Different initiation.
AK023850 mRNA Translation: BAB14702.1
AK025972 mRNA No translation available.
AK289757 mRNA Translation: BAF82446.1
CH471177 Genomic DNA Translation: EAW52457.1
BC021255 mRNA Translation: AAH21255.2
BC101518 mRNA Translation: AAI01519.1
BC101520 mRNA Translation: AAI01521.1
AF034800 mRNA Translation: AAC26101.1
CCDSiCCDS12758.1 [O75145-1]
RefSeqiNP_003651.1, NM_003660.3 [O75145-1]
XP_016882896.1, XM_017027407.1 [O75145-2]
UniGeneiHs.413748
Hs.604638

Genome annotation databases

EnsembliENST00000334186; ENSP00000335614; ENSG00000177380 [O75145-1]
ENST00000602351; ENSP00000473622; ENSG00000177380 [O75145-2]
GeneIDi8541
KEGGihsa:8541
UCSCiuc002pmr.5 human [O75145-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIPA3_HUMAN
AccessioniPrimary (citable) accession number: O75145
Secondary accession number(s): A8K142
, Q3MJA0, Q9H8B5, Q9UEW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: May 23, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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