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O75144

- ICOSL_HUMAN

UniProt

O75144 - ICOSL_HUMAN

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Protein

ICOS ligand

Gene
ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function By similarity.

GO - Molecular functioni

  1. receptor binding Source: UniProtKB

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. defense response Source: UniProtKB
  3. hyperosmotic response Source: UniProtKB
  4. positive regulation of activated T cell proliferation Source: UniProtKB
  5. positive regulation of interleukin-4 biosynthetic process Source: Ensembl
  6. signal transduction Source: UniProtKB
  7. T cell activation Source: UniProtKB
  8. T cell costimulation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, B-cell activation, Immunity

Enzyme and pathway databases

ReactomeiREACT_19344. Costimulation by the CD28 family.

Names & Taxonomyi

Protein namesi
Recommended name:
ICOS ligand
Alternative name(s):
B7 homolog 2
Short name:
B7-H2
B7-like protein Gl50
B7-related protein 1
Short name:
B7RP-1
CD_antigen: CD275
Gene namesi
Name:ICOSLG
Synonyms:B7H2, B7RP1, ICOSL, KIAA0653
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:17087. ICOSLG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 256238Extracellular Reviewed predictionAdd
BLAST
Transmembranei257 – 27721Helical; Reviewed predictionAdd
BLAST
Topological domaini278 – 30225Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB
  4. integral component of plasma membrane Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 302284ICOS ligandPRO_0000014803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 113 Reviewed prediction
Glycosylationi70 – 701N-linked (GlcNAc...)1 Publication
Glycosylationi102 – 1021N-linked (GlcNAc...)1 Publication
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi158 ↔ 216 Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...)1 Publication
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75144.
PaxDbiO75144.
PRIDEiO75144.

Expressioni

Tissue specificityi

Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.1 Publication

Inductioni

Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

Gene expression databases

ArrayExpressiO75144.
BgeeiO75144.
CleanExiHS_ICOSLG.
GenevestigatoriO75144.

Organism-specific databases

HPAiCAB026037.

Interactioni

Protein-protein interaction databases

BioGridi116900. 1 interaction.
STRINGi9606.ENSP00000384432.

Structurei

3D structure databases

ProteinModelPortaliO75144.
SMRiO75144. Positions 22-225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 129111Ig-like V-typeAdd
BLAST
Domaini141 – 22787Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43300.
HOGENOMiHOG000036913.
HOVERGENiHBG106483.
KOiK06710.
OrthoDBiEOG79KPFZ.
PhylomeDBiO75144.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O75144-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV    50
YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL 100
FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS 150
QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV 200
SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD KITENPVSTG 250
EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG 300
HV 302
Length:302
Mass (Da):33,349
Last modified:August 14, 2001 - v2
Checksum:i647934E21B55E34A
GO
Isoform 2 (identifier: O75144-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-302: GHV → ESWNLLLLLS

Show »
Length:309
Mass (Da):34,225
Checksum:iD019EC5307D796A5
GO
Isoform 3 (identifier: O75144-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-134: Missing.

Show »
Length:185
Mass (Da):20,120
Checksum:i0DAD5D52E6DE5F5F
GO

Sequence cautioni

The sequence BAA31628.1 differs from that shown. Reason: The sequence differs from that shown in position 300 onward for unknown reason.
The sequence BAA31628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281V → I.
Corresponds to variant rs11558819 [ dbSNP | Ensembl ].
VAR_049880

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 134117Missing in isoform 3. VSP_054718Add
BLAST
Alternative sequencei300 – 3023GHV → ESWNLLLLLS in isoform 2. VSP_002520

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF199028 mRNA. Translation: AAF34739.1.
AF289028 mRNA. Translation: AAG01176.1.
AF216749 mRNA. Translation: AAK16241.1.
AX100595 mRNA. Translation: CAC36465.1.
AB014553 mRNA. Translation: BAA31628.1. Sequence problems.
AK090492 mRNA. Translation: BAG52170.1.
AP001058 Genomic DNA. No translation available.
AP001059 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09446.1.
BC064637 mRNA. Translation: AAH64637.1.
CCDSiCCDS42952.1. [O75144-1]
CCDS63377.1. [O75144-3]
CCDS63379.1. [O75144-2]
RefSeqiNP_001269979.1. NM_001283050.1. [O75144-2]
NP_001269980.1. NM_001283051.1. [O75144-3]
NP_056074.1. NM_015259.5. [O75144-1]
XP_006710171.1. XM_006710108.1. [O75144-1]
XP_006723963.1. XM_006723900.1. [O75144-1]
UniGeneiHs.14155.

Genome annotation databases

EnsembliENST00000344330; ENSP00000339477; ENSG00000160223. [O75144-2]
ENST00000400377; ENSP00000383228; ENSG00000160223.
ENST00000407780; ENSP00000384432; ENSG00000160223. [O75144-1]
GeneIDi102723996.
23308.
KEGGihsa:102723996.
hsa:23308.
UCSCiuc002zee.3. human. [O75144-1]
uc002zef.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF199028 mRNA. Translation: AAF34739.1 .
AF289028 mRNA. Translation: AAG01176.1 .
AF216749 mRNA. Translation: AAK16241.1 .
AX100595 mRNA. Translation: CAC36465.1 .
AB014553 mRNA. Translation: BAA31628.1 . Sequence problems.
AK090492 mRNA. Translation: BAG52170.1 .
AP001058 Genomic DNA. No translation available.
AP001059 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09446.1 .
BC064637 mRNA. Translation: AAH64637.1 .
CCDSi CCDS42952.1. [O75144-1 ]
CCDS63377.1. [O75144-3 ]
CCDS63379.1. [O75144-2 ]
RefSeqi NP_001269979.1. NM_001283050.1. [O75144-2 ]
NP_001269980.1. NM_001283051.1. [O75144-3 ]
NP_056074.1. NM_015259.5. [O75144-1 ]
XP_006710171.1. XM_006710108.1. [O75144-1 ]
XP_006723963.1. XM_006723900.1. [O75144-1 ]
UniGenei Hs.14155.

3D structure databases

ProteinModelPortali O75144.
SMRi O75144. Positions 22-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116900. 1 interaction.
STRINGi 9606.ENSP00000384432.

Proteomic databases

MaxQBi O75144.
PaxDbi O75144.
PRIDEi O75144.

Protocols and materials databases

DNASUi 23308.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344330 ; ENSP00000339477 ; ENSG00000160223 . [O75144-2 ]
ENST00000400377 ; ENSP00000383228 ; ENSG00000160223 .
ENST00000407780 ; ENSP00000384432 ; ENSG00000160223 . [O75144-1 ]
GeneIDi 102723996.
23308.
KEGGi hsa:102723996.
hsa:23308.
UCSCi uc002zee.3. human. [O75144-1 ]
uc002zef.3. human.

Organism-specific databases

CTDi 23308.
GeneCardsi GC21M045642.
H-InvDB HIX0016164.
HGNCi HGNC:17087. ICOSLG.
HPAi CAB026037.
MIMi 605717. gene.
neXtProti NX_O75144.
PharmGKBi PA134977297.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43300.
HOGENOMi HOG000036913.
HOVERGENi HBG106483.
KOi K06710.
OrthoDBi EOG79KPFZ.
PhylomeDBi O75144.
TreeFami TF331083.

Enzyme and pathway databases

Reactomei REACT_19344. Costimulation by the CD28 family.

Miscellaneous databases

GeneWikii ICOSLG.
GenomeRNAii 23308.
NextBioi 45170.
PROi O75144.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75144.
Bgeei O75144.
CleanExi HS_ICOSLG.
Genevestigatori O75144.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS."
    Wang S., Zhu G., Chapoval A.I., Dong H., Tamada K., Ni J., Chen L.
    Blood 96:2808-2813(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  2. "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS."
    Yoshinaga S.K., Zhang M., Pistillo J., Horan T., Khare S.D., Miner K., Sonnenberg M., Boone T., Brankow D., Dai T., Delaney J., Han H., Hui A., Kohno T., Manoukian R., Whoriskey J.S., Coccia M.A.
    Int. Immunol. 12:1439-1447(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Peripheral blood lymphocyte.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Leukocyte.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  7. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  10. Cited for: TISSUE SPECIFICITY.
  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-102 AND ASN-186.
    Tissue: Plasma.

Entry informationi

Entry nameiICOSL_HUMAN
AccessioniPrimary (citable) accession number: O75144
Secondary accession number(s): A8MUZ1, Q9HD18, Q9NRQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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