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Protein

Zinc finger BED domain-containing protein 4

Gene

ZBED4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 17258BED-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 34258BED-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 51257BED-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 61558BED-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 4
Gene namesi
Name:ZBED4
Synonyms:KIAA0637
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:20721. ZBED4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948378.

Polymorphism and mutation databases

BioMutaiZBED4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11711171Zinc finger BED domain-containing protein 4PRO_0000066563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei624 – 6241PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75132.
MaxQBiO75132.
PaxDbiO75132.
PeptideAtlasiO75132.
PRIDEiO75132.

PTM databases

iPTMnetiO75132.
PhosphoSiteiO75132.

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis, kidney and spinal cord and brain corpus callosum. Expressed in the retina, found in the cone photoreceptors, Mueller cells, cone pedicles and in the innermost retinal layer.1 Publication

Gene expression databases

BgeeiENSG00000100426.
CleanExiHS_ZBED4.
GenevisibleiO75132. HS.

Organism-specific databases

HPAiHPA045341.

Interactioni

Subunit structurei

Homodimer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-2860059,EBI-10172134

Protein-protein interaction databases

BioGridi115219. 4 interactions.
IntActiO75132. 11 interactions.
MINTiMINT-2797409.
STRINGi9606.ENSP00000216268.

Structurei

3D structure databases

ProteinModelPortaliO75132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 306Asp/Glu-rich (acidic)
Compositional biasi533 – 5364Poly-Ser

Sequence similaritiesi

Contains 4 BED-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 17258BED-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 34258BED-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 51257BED-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 61558BED-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR9V. Eukaryota.
ENOG4111I2V. LUCA.
GeneTreeiENSGT00530000063354.
HOGENOMiHOG000139424.
HOVERGENiHBG054511.
InParanoidiO75132.
OMAiHWVSFES.
OrthoDBiEOG091G0B61.
PhylomeDBiO75132.
TreeFamiTF322818.

Family and domain databases

InterProiIPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF02892. zf-BED. 4 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 4 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNLKTCPK EDGDFVSDKI KFKIEEEDDD GIPPDSLERM DFKSEQEDMK
60 70 80 90 100
QTDSGGERAG LGGTGCSCKP PGKYLSAESE DDYGALFSQY SSTLYDVAME
110 120 130 140 150
AVTQSLLSSR NMSSRKKSPA WKHFFISPRD STKAICMYCV KEFSRGKNEK
160 170 180 190 200
DLSTSCLMRH VRRAHPTVLI QENGSVSAVS SFPSPSLLLP PQPADAGDLS
210 220 230 240 250
TILSPIKLVQ KVASKIPSPD RITEESVSVV SSEEISSDMS VSEKCGREEA
260 270 280 290 300
LVGSSPHLPA LHYDEPAENL AEKSLPLPKS TSGSRRRSAV WKHFYLSPLD
310 320 330 340 350
NSKAVCIHCM NEFSRGKNGK DLGTSCLIRH MWRAHRAIVL QENGGTGIPP
360 370 380 390 400
LYSTPPTLLP SLLPPEGELS SVSSSPVKPV RESPSASSSP DRLTEDLQSH
410 420 430 440 450
LNPGDGLMED VAAFSSSDDI GEASASSPEK QQADGLSPRL FESGAIFQQN
460 470 480 490 500
KKVMKRLKSE VWHHFSLAPM DSLKAECRYC GCAISRGKKG DVGTSCLMRH
510 520 530 540 550
LYRRHPEVVG SQKGFLGASL ANSPYATLAS AESSSSKLTD LPTVVTKNNQ
560 570 580 590 600
VMFPVNSKKT SKLWNHFSIC SADSTKVVCL HCGRTISRGK KPTNLGTSCL
610 620 630 640 650
LRHLQRFHSN VLKTEVSETA RPSSPDTRVP RGTELSGASS FDDTNEKFYD
660 670 680 690 700
SHPVAKKITS LIAEMIALDL QPYSFVDNVG FNRLLEYLKP QYSLPAPSYF
710 720 730 740 750
SRTAIPGMYD NVKQIIMSHL KEAESGVIHF TSGIWMSNQT REYLTLTAHW
760 770 780 790 800
VSFESPARPR CDDHHCSALL DVSQVDCDYS GNSIQKQLEC WWEAWVTSTG
810 820 830 840 850
LQVGITVTDN ASIGKTLNEG EHSSVQCFSH TVNLIVSEAI KSQRMVQNLL
860 870 880 890 900
SLARKICERV HRSPKAKEKL AELQREYALP QHHLIQDVPS KWSTSFHMLE
910 920 930 940 950
RLIEQKRAIN EMSVECNFRE LISCDQWEVM QSVCRALKPF EAASREMSTQ
960 970 980 990 1000
MSTLSQVIPM VHILNRKVEM LFEETMGIDT MLRSLKEAMV SRLSATLHDP
1010 1020 1030 1040 1050
RYVFATLLDP RYKASLFTEE EAEQYKQDLI RELELMNSTS EDVAASHRCD
1060 1070 1080 1090 1100
AGSPSKDSAA EENLWSLVAK VKKKDPREKL PEAMVLAYLE EEVLEHSCDP
1110 1120 1130 1140 1150
LTYWNLKKAS WPGLSALAVR FLGCPPSIVP SEKLFNTPTE NGSLGQSRLM
1160 1170
MEHFEKLIFL KVNLPLIYFQ Y
Length:1,171
Mass (Da):130,322
Last modified:January 11, 2011 - v2
Checksum:i485746484E87B389
GO

Sequence cautioni

The sequence BAA31612 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti584 – 5841R → Q in AAI17671 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti420 – 4201I → V.3 Publications
Corresponds to variant rs910799 [ dbSNP | Ensembl ].
VAR_027809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014537 mRNA. Translation: BAA31612.2. Different initiation.
CR456387 mRNA. Translation: CAG30273.1.
AL117328 Genomic DNA. Translation: CAB62924.1.
BC117670 mRNA. Translation: AAI17671.1.
BC167155 mRNA. Translation: AAI67155.1.
CCDSiCCDS33677.1.
PIRiT00380.
RefSeqiNP_055653.2. NM_014838.2.
UniGeneiHs.475208.

Genome annotation databases

EnsembliENST00000216268; ENSP00000216268; ENSG00000100426.
GeneIDi9889.
KEGGihsa:9889.
UCSCiuc003bix.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014537 mRNA. Translation: BAA31612.2. Different initiation.
CR456387 mRNA. Translation: CAG30273.1.
AL117328 Genomic DNA. Translation: CAB62924.1.
BC117670 mRNA. Translation: AAI17671.1.
BC167155 mRNA. Translation: AAI67155.1.
CCDSiCCDS33677.1.
PIRiT00380.
RefSeqiNP_055653.2. NM_014838.2.
UniGeneiHs.475208.

3D structure databases

ProteinModelPortaliO75132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115219. 4 interactions.
IntActiO75132. 11 interactions.
MINTiMINT-2797409.
STRINGi9606.ENSP00000216268.

PTM databases

iPTMnetiO75132.
PhosphoSiteiO75132.

Polymorphism and mutation databases

BioMutaiZBED4.

Proteomic databases

EPDiO75132.
MaxQBiO75132.
PaxDbiO75132.
PeptideAtlasiO75132.
PRIDEiO75132.

Protocols and materials databases

DNASUi9889.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216268; ENSP00000216268; ENSG00000100426.
GeneIDi9889.
KEGGihsa:9889.
UCSCiuc003bix.3. human.

Organism-specific databases

CTDi9889.
GeneCardsiZBED4.
H-InvDBHIX0016602.
HGNCiHGNC:20721. ZBED4.
HPAiHPA045341.
MIMi612552. gene.
neXtProtiNX_O75132.
PharmGKBiPA134948378.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR9V. Eukaryota.
ENOG4111I2V. LUCA.
GeneTreeiENSGT00530000063354.
HOGENOMiHOG000139424.
HOVERGENiHBG054511.
InParanoidiO75132.
OMAiHWVSFES.
OrthoDBiEOG091G0B61.
PhylomeDBiO75132.
TreeFamiTF322818.

Miscellaneous databases

ChiTaRSiZBED4. human.
GenomeRNAii9889.
PROiO75132.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100426.
CleanExiHS_ZBED4.
GenevisibleiO75132. HS.

Family and domain databases

InterProiIPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF02892. zf-BED. 4 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 4 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBED4_HUMAN
AccessioniPrimary (citable) accession number: O75132
Secondary accession number(s): B2RZH1, Q1ECU0, Q9UGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.