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Protein

Zinc finger protein 623

Gene

ZNF623

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri123 – 145C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri151 – 173C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33063-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 623
Gene namesi
Name:ZNF623
Synonyms:KIAA0628
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29084. ZNF623.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969295.

Polymorphism and mutation databases

BioMutaiZNF623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476941 – 536Zinc finger protein 623Add BLAST536

Proteomic databases

MaxQBiO75123.
PaxDbiO75123.
PeptideAtlasiO75123.
PRIDEiO75123.

PTM databases

iPTMnetiO75123.
PhosphoSitePlusiO75123.

Expressioni

Gene expression databases

BgeeiENSG00000183309.
CleanExiHS_ZNF623.
ExpressionAtlasiO75123. baseline and differential.
GenevisibleiO75123. HS.

Organism-specific databases

HPAiHPA044372.

Interactioni

Protein-protein interaction databases

BioGridi115169. 4 interactors.
STRINGi9606.ENSP00000434258.

Structurei

3D structure databases

ProteinModelPortaliO75123.
SMRiO75123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri123 – 145C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri151 – 173C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75123.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiO75123.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLSFVSDS NVGTGEKKVT EAWISEDENS HRTTSDRLTV MELPSPESEE
60 70 80 90 100
VHEPRLGELL GNPEGQSLGS SPSQDRGCKQ VTVTHWKIQT GETAQVCTKS
110 120 130 140 150
GRNHILNSDL LLLQRELIEG EANPCNICGK TFTFNSDLVR HRISHAGEKP
160 170 180 190 200
YTCDQCGKGF GQSSHLMEHQ RIHTGERLYV CNVCGKDFIH YSGLIEHQRV
210 220 230 240 250
HSGEKPFKCA QCGKAFCHSS DLIRHQRVHT RERPFECKEC GKGFSQSSLL
260 270 280 290 300
IRHQRIHTGE RPYECNECGK SFIRSSSLIR HYQIHTEVKQ YECKECGKAF
310 320 330 340 350
RHRSDLIEHQ RIHTGERPFE CNECGKAFIR SSKLIQHQRI HTGERPYVCN
360 370 380 390 400
ECGKRFSQTS NFTQHQRIHT GEKLYECNEC GKAFFLSSYL IRHQKIHTGE
410 420 430 440 450
RVYECKECGK AFLQKAHLTE HQKIHSGDRP FECKDCGKAF IQSSKLLLHQ
460 470 480 490 500
IIHTGEKPYV CSYCGKGFIQ RSNFLQHQKI HTEEKLYECS QYGRDFNSTT
510 520 530
NVKNNQRVHQ EGLSLSKAPI HLGERSVDKG EHTGNL
Length:536
Mass (Da):61,392
Last modified:November 30, 2010 - v2
Checksum:i798EB7EC0F0A4366
GO
Isoform 2 (identifier: O75123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):56,956
Checksum:i4D439CB2E91BA7DD
GO

Sequence cautioni

The sequence BAA31603 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG57854 differs from that shown. Reason: Frameshift at position 467.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052881126N → D.2 PublicationsCorresponds to variant rs4874084dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535011 – 40Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014528 mRNA. Translation: BAA31603.2. Different initiation.
AK294695 mRNA. Translation: BAG57854.1. Frameshift.
AC067930 Genomic DNA. No translation available.
AC105210 Genomic DNA. No translation available.
BC067516 mRNA. Translation: AAH67516.1.
BC067517 mRNA. Translation: AAH67517.1.
BC067518 mRNA. Translation: AAH67518.1.
BC075056 mRNA. Translation: AAH75056.1.
BC075057 mRNA. Translation: AAH75057.1.
BC112899 mRNA. Translation: AAI12900.1.
CCDSiCCDS34957.1. [O75123-1]
CCDS47931.1. [O75123-2]
RefSeqiNP_001075949.1. NM_001082480.2.
NP_001248772.1. NM_001261843.1.
NP_055604.3. NM_014789.3.
UniGeneiHs.43133.
Hs.694018.
Hs.745418.

Genome annotation databases

EnsembliENST00000501748; ENSP00000445979; ENSG00000183309.
GeneIDi9831.
KEGGihsa:9831.
UCSCiuc003yzd.3. human. [O75123-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014528 mRNA. Translation: BAA31603.2. Different initiation.
AK294695 mRNA. Translation: BAG57854.1. Frameshift.
AC067930 Genomic DNA. No translation available.
AC105210 Genomic DNA. No translation available.
BC067516 mRNA. Translation: AAH67516.1.
BC067517 mRNA. Translation: AAH67517.1.
BC067518 mRNA. Translation: AAH67518.1.
BC075056 mRNA. Translation: AAH75056.1.
BC075057 mRNA. Translation: AAH75057.1.
BC112899 mRNA. Translation: AAI12900.1.
CCDSiCCDS34957.1. [O75123-1]
CCDS47931.1. [O75123-2]
RefSeqiNP_001075949.1. NM_001082480.2.
NP_001248772.1. NM_001261843.1.
NP_055604.3. NM_014789.3.
UniGeneiHs.43133.
Hs.694018.
Hs.745418.

3D structure databases

ProteinModelPortaliO75123.
SMRiO75123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115169. 4 interactors.
STRINGi9606.ENSP00000434258.

PTM databases

iPTMnetiO75123.
PhosphoSitePlusiO75123.

Polymorphism and mutation databases

BioMutaiZNF623.

Proteomic databases

MaxQBiO75123.
PaxDbiO75123.
PeptideAtlasiO75123.
PRIDEiO75123.

Protocols and materials databases

DNASUi9831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000501748; ENSP00000445979; ENSG00000183309.
GeneIDi9831.
KEGGihsa:9831.
UCSCiuc003yzd.3. human. [O75123-1]

Organism-specific databases

CTDi9831.
GeneCardsiZNF623.
HGNCiHGNC:29084. ZNF623.
HPAiHPA044372.
neXtProtiNX_O75123.
PharmGKBiPA134969295.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75123.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiO75123.
TreeFamiTF337005.

Enzyme and pathway databases

BioCyciZFISH:G66-33063-MONOMER.

Miscellaneous databases

ChiTaRSiZNF623. human.
GenomeRNAii9831.
PROiO75123.

Gene expression databases

BgeeiENSG00000183309.
CleanExiHS_ZNF623.
ExpressionAtlasiO75123. baseline and differential.
GenevisibleiO75123. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN623_HUMAN
AccessioniPrimary (citable) accession number: O75123
Secondary accession number(s): A4FU80, B4DGP3, E7ENV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.