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Protein

NEDD4-binding protein 1

Gene

N4BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 1
Short name:
N4BP1
Gene namesi
Name:N4BP1
Synonyms:KIAA0615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102921.7
HGNCiHGNC:29850 N4BP1
neXtProtiNX_O75113

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9683
OpenTargetsiENSG00000102921
PharmGKBiPA162396561

Polymorphism and mutation databases

BioMutaiN4BP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966801 – 896NEDD4-binding protein 1Add BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphoserineCombined sources1
Modified residuei242PhosphothreonineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei562PhosphoserineBy similarity1

Post-translational modificationi

Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75113
MaxQBiO75113
PaxDbiO75113
PeptideAtlasiO75113
PRIDEiO75113

PTM databases

iPTMnetiO75113
PhosphoSitePlusiO75113

Miscellaneous databases

PMAP-CutDBiO75113

Expressioni

Tissue specificityi

Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000102921
CleanExiHS_N4BP1
ExpressionAtlasiO75113 baseline and differential
GenevisibleiO75113 HS

Organism-specific databases

HPAiHPA040849
HPA041080

Interactioni

Subunit structurei

Interacts with NEDD4. Interacts with ITCH (via WW domain 2) (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115036, 10 interactors
DIPiDIP-41205N
IntActiO75113, 6 interactors
MINTiO75113
STRINGi9606.ENSP00000262384

Structurei

3D structure databases

ProteinModelPortaliO75113
SMRiO75113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N4BP1 family.Curated

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00750000117218
HOGENOMiHOG000113716
HOVERGENiHBG059944
InParanoidiO75113
OMAiTEQHFLT
OrthoDBiEOG091G03B2
PhylomeDBiO75113
TreeFamiTF315783

Family and domain databases

InterProiView protein in InterPro
IPR021869 RNase_Zc3h12_NYN
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit

Sequencei

Sequence statusi: Complete.

O75113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARAVLDEF TAPAEKAELL EQSRGRIEGL FGVSLAVLGA LGAEEPLPAR
60 70 80 90 100
IWLQLCGAQE AVHSAKEYIK GICEPELEER ECYPKDMHCI FVGAESLFLK
110 120 130 140 150
SLIQDTCADL CILDIGLLGI RGSAEAVVMA RSHIQQFVKL FENKENLPSS
160 170 180 190 200
QKESEVKREF KQFVEAHADN YTMDLLILPT SLKKELLTLT QGEENLFETG
210 220 230 240 250
DDEVIEMRDS QQTEFTQNAA TGLNISRDET VLQEEARNKA GTPVSELTKQ
260 270 280 290 300
MDTVLSSSPD VLFDPINGLT PDEEALSNER ICQKRRFSDS EERHTKKQFS
310 320 330 340 350
LENVQEGEIL HDAKTLAGNV IADLSDSSAD SENLSPDIKE TTEEMEYNIL
360 370 380 390 400
VNFFKTMGYS QEIVEKVIKV YGPSTEPLLL LEEIEKENKR FQEDREFSAG
410 420 430 440 450
TVYPETNKTK NKGVYSSTNE LTTDSTPKKT QAHTQQNMVE KFSQLPFKVE
460 470 480 490 500
AKPCTSNCRI NTFRTVPIEQ KHEVWGSNQN YICNTDPETD GLSPSVASPS
510 520 530 540 550
PKEVNFVSRG ASSHQPRVPL FPENGLHQQP EPLLPNNMKS ACEKRLGCCS
560 570 580 590 600
SPHSKPNCST LSPPMPLPQL LPSVTDARSA GPSDHIDSSV TGVQRFRDTL
610 620 630 640 650
KIPYKLELKN EPGRTDLKHI VIDGSNVAIT HGLKKFFSCR GIAIAVEYFW
660 670 680 690 700
KLGNRNITVF VPQWRTRRDP NVTEQHFLTQ LQELGILSLT PARMVFGERI
710 720 730 740 750
ASHDDRFLLH LADKTGGIIV TNDNFREFVN ESVSWREIIT KRLLQYTFVG
760 770 780 790 800
DIFMVPDDPL GRSGPRLEEF LQKEVCLRDM QPLLSALPNV GMFDPSFRVP
810 820 830 840 850
GTQAASTSHQ PPTRIQGAPS SHWLPQQPHF PLLPALPSLQ QNLPMPAQRS
860 870 880 890
SAETNELREA LLKIFPDSEQ RLKIDQILVA HPYMKDLNAL SAMVLD
Length:896
Mass (Da):100,379
Last modified:November 24, 2009 - v4
Checksum:i171EDCC9D3BCF3D3
GO

Sequence cautioni

The sequence BAA31590 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62V → E in BAA31590 (PubMed:9734811).Curated1
Sequence conflicti62V → E in AAI52473 (PubMed:15489334).Curated1
Sequence conflicti600L → P in AAI08289 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014515 mRNA Translation: BAA31590.2 Different initiation.
AC023813 Genomic DNA No translation available.
AC026470 Genomic DNA No translation available.
BC108288 mRNA Translation: AAI08289.1
BC152472 mRNA Translation: AAI52473.1
CCDSiCCDS45479.1
PIRiT00389
RefSeqiNP_694574.3, NM_153029.3
UniGeneiHs.511839

Genome annotation databases

EnsembliENST00000262384; ENSP00000262384; ENSG00000102921
GeneIDi9683
KEGGihsa:9683
UCSCiuc002efp.3 human

Similar proteinsi

Entry informationi

Entry nameiN4BP1_HUMAN
AccessioniPrimary (citable) accession number: O75113
Secondary accession number(s): A7MD49, Q2YDX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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