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Protein

Probable phospholipid-transporting ATPase IIA

Gene

ATP9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3914-aspartylphosphate intermediateBy similarity1
Metal bindingi785MagnesiumBy similarity1
Metal bindingi789MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: GO_Central
  • phospholipid translocation Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00675-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.8.16. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIA (EC:3.6.3.1)
Alternative name(s):
ATPase class II type 9A
Gene namesi
Name:ATP9A
Synonyms:ATPIIA, KIAA0611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13540. ATP9A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 69CytoplasmicSequence analysisAdd BLAST68
Transmembranei70 – 91HelicalSequence analysisAdd BLAST22
Topological domaini92 – 96ExtracellularSequence analysis5
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Topological domaini120 – 303CytoplasmicSequence analysisAdd BLAST184
Transmembranei304 – 325HelicalSequence analysisAdd BLAST22
Topological domaini326 – 332ExtracellularSequence analysis7
Transmembranei333 – 354HelicalSequence analysisAdd BLAST22
Topological domaini355 – 841CytoplasmicSequence analysisAdd BLAST487
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Topological domaini863 – 874ExtracellularSequence analysisAdd BLAST12
Transmembranei875 – 893HelicalSequence analysisAdd BLAST19
Topological domaini894 – 923CytoplasmicSequence analysisAdd BLAST30
Transmembranei924 – 942HelicalSequence analysisAdd BLAST19
Topological domaini943 – 949ExtracellularSequence analysis7
Transmembranei950 – 972HelicalSequence analysisAdd BLAST23
Topological domaini973 – 978CytoplasmicSequence analysis6
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Topological domaini1000 – 1006ExtracellularSequence analysis7
Transmembranei1007 – 1030HelicalSequence analysisAdd BLAST24
Topological domaini1031 – 1047CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: GO_Central
  • recycling endosome Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10079.
OpenTargetsiENSG00000054793.
PharmGKBiPA25171.

Polymorphism and mutation databases

BioMutaiATP9A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000463752 – 1047Probable phospholipid-transporting ATPase IIAAdd BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO75110.
PaxDbiO75110.
PeptideAtlasiO75110.
PRIDEiO75110.

PTM databases

iPTMnetiO75110.
PhosphoSitePlusiO75110.
SwissPalmiO75110.

Expressioni

Gene expression databases

BgeeiENSG00000054793.
CleanExiHS_ATP9A.
ExpressionAtlasiO75110. baseline and differential.
GenevisibleiO75110. HS.

Organism-specific databases

HPAiCAB020699.
HPA035630.
HPA055795.

Interactioni

Protein-protein interaction databases

BioGridi115389. 33 interactors.
IntActiO75110. 11 interactors.
STRINGi9606.ENSP00000342481.

Structurei

3D structure databases

ProteinModelPortaliO75110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0210. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00550000074723.
HOVERGENiHBG050617.
InParanoidiO75110.
KOiK01530.
OMAiTRTQDIH.
OrthoDBiEOG091G076A.
PhylomeDBiO75110.
TreeFamiTF300590.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030356. ATP9A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF49. PTHR24092:SF49. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O75110-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDNIPLQPV RQKKRMDSRP RAGCCEWLRC CGGGEARPRT VWLGHPEKRD
60 70 80 90 100
QRYPRNVINN QKYNFFTFLP GVLFNQFKYF FNLYFLLLAC SQFVPEMRLG
110 120 130 140 150
ALYTYWVPLG FVLAVTVIRE AVEEIRCYVR DKEVNSQVYS RLTARGTVKV
160 170 180 190 200
KSSNIQVGDL IIVEKNQRVP ADMIFLRTSE KNGSCFLRTD QLDGETDWKL
210 220 230 240 250
RLPVACTQRL PTAADLLQIR SYVYAEEPNI DIHNFVGTFT REDSDPPISE
260 270 280 290 300
SLSIENTLWA GTVVASGTVV GVVLYTGREL RSVMNTSNPR SKIGLFDLEV
310 320 330 340 350
NCLTKILFGA LVVVSLVMVA LQHFAGRWYL QIIRFLLLFS NIIPISLRVN
360 370 380 390 400
LDMGKIVYSW VIRRDSKIPG TVVRSSTIPE QLGRISYLLT DKTGTLTQNE
410 420 430 440 450
MIFKRLHLGT VAYGLDSMDE VQSHIFSIYT QQSQDPPAQK GPTLTTKVRR
460 470 480 490 500
TMSSRVHEAV KAIALCHNVT PVYESNGVTD QAEAEKQYED SCRVYQASSP
510 520 530 540 550
DEVALVQWTE SVGLTLVGRD QSSMQLRTPG DQILNFTILQ IFPFTYESKR
560 570 580 590 600
MGIIVRDEST GEITFYMKGA DVVMAGIVQY NDWLEEECGN MAREGLRVLV
610 620 630 640 650
VAKKSLAEEQ YQDFEARYVQ AKLSVHDRSL KVATVIESLE MEMELLCLTG
660 670 680 690 700
VEDQLQADVR PTLETLRNAG IKVWMLTGDK LETATCTAKN AHLVTRNQDI
710 720 730 740 750
HVFRLVTNRG EAHLELNAFR RKHDCALVIS GDSLEVCLKY YEYEFMELAC
760 770 780 790 800
QCPAVVCCRC APTQKAQIVR LLQERTGKLT CAVGDGGNDV SMIQESDCGV
810 820 830 840 850
GVEGKEGKQA SLAADFSITQ FKHLGRLLMV HGRNSYKRSA ALSQFVIHRS
860 870 880 890 900
LCISTMQAVF SSVFYFASVP LYQGFLIIGY STIYTMFPVF SLVLDKDVKS
910 920 930 940 950
EVAMLYPELY KDLLKGRPLS YKTFLIWVLI SIYQGSTIMY GALLLFESEF
960 970 980 990 1000
VHIVAISFTS LILTELLMVA LTIQTWHWLM TVAELLSLAC YIASLVFLHE
1010 1020 1030 1040
FIDVYFIATL SFLWKVSVIT LVSCLPLYVL KYLRRRFSPP SYSKLTS
Length:1,047
Mass (Da):118,583
Last modified:January 24, 2001 - v3
Checksum:i80C307CF5A396755
GO
Isoform Short (identifier: O75110-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-269: Missing.

Show »
Length:926
Mass (Da):105,133
Checksum:iF2F66A97B9000AA4
GO

Sequence cautioni

The sequence BAD18775 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI18889 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19203 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186F → S in BAD18775 (PubMed:14702039).Curated1
Sequence conflicti415L → P in BAD18775 (PubMed:14702039).Curated1
Sequence conflicti957S → P in BAD18775 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000432149 – 269Missing in isoform Short. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353799, AL138807, AL035684 Genomic DNA. Translation: CAI18889.1. Sequence problems.
AL353799, AL035684, AL138807 Genomic DNA. Translation: CAI18890.1.
AL035684, AL138807, AL353799 Genomic DNA. Translation: CAI19202.1.
AL035684, AL138807, AL353799 Genomic DNA. Translation: CAI19203.1. Sequence problems.
AL138807, AL035684, AL353799 Genomic DNA. Translation: CAI22924.1. Sequence problems.
AL138807, AL035684, AL353799 Genomic DNA. Translation: CAI22925.1.
CH471077 Genomic DNA. Translation: EAW75597.1.
CH471077 Genomic DNA. Translation: EAW75598.1.
CH471077 Genomic DNA. Translation: EAW75599.1.
CH471077 Genomic DNA. Translation: EAW75600.1.
AB014511 mRNA. Translation: BAA31586.1.
AK172802 mRNA. Translation: BAD18775.1. Different initiation.
CCDSiCCDS33489.1. [O75110-1]
RefSeqiNP_006036.1. NM_006045.2. [O75110-1]
UniGeneiHs.649234.

Genome annotation databases

EnsembliENST00000338821; ENSP00000342481; ENSG00000054793. [O75110-1]
GeneIDi10079.
KEGGihsa:10079.
UCSCiuc002xwg.2. human. [O75110-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353799, AL138807, AL035684 Genomic DNA. Translation: CAI18889.1. Sequence problems.
AL353799, AL035684, AL138807 Genomic DNA. Translation: CAI18890.1.
AL035684, AL138807, AL353799 Genomic DNA. Translation: CAI19202.1.
AL035684, AL138807, AL353799 Genomic DNA. Translation: CAI19203.1. Sequence problems.
AL138807, AL035684, AL353799 Genomic DNA. Translation: CAI22924.1. Sequence problems.
AL138807, AL035684, AL353799 Genomic DNA. Translation: CAI22925.1.
CH471077 Genomic DNA. Translation: EAW75597.1.
CH471077 Genomic DNA. Translation: EAW75598.1.
CH471077 Genomic DNA. Translation: EAW75599.1.
CH471077 Genomic DNA. Translation: EAW75600.1.
AB014511 mRNA. Translation: BAA31586.1.
AK172802 mRNA. Translation: BAD18775.1. Different initiation.
CCDSiCCDS33489.1. [O75110-1]
RefSeqiNP_006036.1. NM_006045.2. [O75110-1]
UniGeneiHs.649234.

3D structure databases

ProteinModelPortaliO75110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115389. 33 interactors.
IntActiO75110. 11 interactors.
STRINGi9606.ENSP00000342481.

Protein family/group databases

TCDBi3.A.3.8.16. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiO75110.
PhosphoSitePlusiO75110.
SwissPalmiO75110.

Polymorphism and mutation databases

BioMutaiATP9A.

Proteomic databases

MaxQBiO75110.
PaxDbiO75110.
PeptideAtlasiO75110.
PRIDEiO75110.

Protocols and materials databases

DNASUi10079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338821; ENSP00000342481; ENSG00000054793. [O75110-1]
GeneIDi10079.
KEGGihsa:10079.
UCSCiuc002xwg.2. human. [O75110-1]

Organism-specific databases

CTDi10079.
DisGeNETi10079.
GeneCardsiATP9A.
HGNCiHGNC:13540. ATP9A.
HPAiCAB020699.
HPA035630.
HPA055795.
MIMi609126. gene.
neXtProtiNX_O75110.
OpenTargetsiENSG00000054793.
PharmGKBiPA25171.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0210. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00550000074723.
HOVERGENiHBG050617.
InParanoidiO75110.
KOiK01530.
OMAiTRTQDIH.
OrthoDBiEOG091G076A.
PhylomeDBiO75110.
TreeFamiTF300590.

Enzyme and pathway databases

BioCyciZFISH:HS00675-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP9A. human.
GenomeRNAii10079.
PROiO75110.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054793.
CleanExiHS_ATP9A.
ExpressionAtlasiO75110. baseline and differential.
GenevisibleiO75110. HS.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030356. ATP9A.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF49. PTHR24092:SF49. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP9A_HUMAN
AccessioniPrimary (citable) accession number: O75110
Secondary accession number(s): E1P5Y3
, E1P5Y4, Q5TFW5, Q5TFW6, Q5TFW9, Q6ZMF3, Q9NQK6, Q9NQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2001
Last modified: November 2, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.