ID   SLIT3_HUMAN             Reviewed;        1523 AA.
AC   O75094; A6H8U9; J3KNP3; O95804; Q9UFH5;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 3.
DT   27-MAR-2024, entry version 202.
DE   RecName: Full=Slit homolog 3 protein;
DE            Short=Slit-3;
DE   AltName: Full=Multiple epidermal growth factor-like domains protein 5;
DE            Short=Multiple EGF-like domains protein 5;
DE   Flags: Precursor;
GN   Name=SLIT3; Synonyms=KIAA0814, MEGF5, SLIL2; ORFNames=UNQ691/PRO1336;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, AND
RP   VARIANT ALA-371.
RX   PubMed=9813312; DOI=10.1016/s0169-328x(98)00224-1;
RA   Itoh A., Miyabayashi T., Ohno M., Sakano S.;
RT   "Cloning and expressions of three mammalian homologues of Drosophila slit
RT   suggest possible roles for Slit in the formation and maintenance of the
RT   nervous system.";
RL   Brain Res. Mol. Brain Res. 62:175-186(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-371.
RC   TISSUE=Brain;
RX   PubMed=9693030; DOI=10.1006/geno.1998.5341;
RA   Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.;
RT   "Identification of high-molecular-weight proteins with multiple EGF-like
RT   motifs by motif-trap screening.";
RL   Genomics 51:27-34(1998).
RN   [3]
RP   SEQUENCE REVISION.
RA   Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ALA-371
RP   AND SER-618.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-371.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, AND VARIANT ALA-371.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).
RX   PubMed=10349621; DOI=10.1016/s0925-4773(98)00174-9;
RA   Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T.,
RA   Little M.H.;
RT   "Distinct but overlapping expression patterns of two vertebrate slit
RT   homologs implies functional roles in CNS development and organogenesis.";
RL   Mech. Dev. 79:57-72(1998).
CC   -!- FUNCTION: May act as molecular guidance cue in cellular migration, and
CC       function may be mediated by interaction with roundabout homolog
CC       receptors.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=O75094-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75094-2; Sequence=VSP_009714;
CC       Name=3;
CC         IsoId=O75094-3; Sequence=VSP_009715;
CC       Name=4;
CC         IsoId=O75094-4; Sequence=VSP_054798;
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in thyroid.
CC       {ECO:0000269|PubMed:9813312}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA32466.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAB59249.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/50515/SLIT3";
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DR   EMBL; AB017169; BAA35186.1; -; mRNA.
DR   EMBL; AB011538; BAA32466.2; ALT_INIT; mRNA.
DR   EMBL; AY358884; AAQ89243.1; -; mRNA.
DR   EMBL; AC008409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC094081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC146759; AAI46760.1; -; mRNA.
DR   EMBL; AL122074; CAB59249.1; ALT_SEQ; mRNA.
DR   EMBL; AF075240; AAD19336.1; -; mRNA.
DR   CCDS; CCDS4369.1; -. [O75094-1]
DR   CCDS; CCDS64311.1; -. [O75094-4]
DR   PIR; T34555; T34555.
DR   RefSeq; NP_001258875.1; NM_001271946.1. [O75094-4]
DR   RefSeq; NP_003053.1; NM_003062.3. [O75094-1]
DR   AlphaFoldDB; O75094; -.
DR   SMR; O75094; -.
DR   BioGRID; 112473; 6.
DR   IntAct; O75094; 7.
DR   MINT; O75094; -.
DR   STRING; 9606.ENSP00000332164; -.
DR   TCDB; 9.B.87.1.41; the selenoprotein p receptor (selp-receptor) family.
DR   GlyConnect; 1750; 1 N-Linked glycan (1 site).
DR   GlyCosmos; O75094; 14 sites, 2 glycans.
DR   GlyGen; O75094; 16 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (3 sites).
DR   iPTMnet; O75094; -.
DR   PhosphoSitePlus; O75094; -.
DR   BioMuta; SLIT3; -.
DR   jPOST; O75094; -.
DR   MassIVE; O75094; -.
DR   MaxQB; O75094; -.
DR   PaxDb; 9606-ENSP00000332164; -.
DR   PeptideAtlas; O75094; -.
DR   ProteomicsDB; 49755; -. [O75094-1]
DR   ProteomicsDB; 49756; -. [O75094-2]
DR   ProteomicsDB; 49757; -. [O75094-3]
DR   Antibodypedia; 16807; 255 antibodies from 31 providers.
DR   DNASU; 6586; -.
DR   Ensembl; ENST00000332966.8; ENSP00000332164.8; ENSG00000184347.16. [O75094-4]
DR   Ensembl; ENST00000519560.6; ENSP00000430333.2; ENSG00000184347.16. [O75094-1]
DR   GeneID; 6586; -.
DR   KEGG; hsa:6586; -.
DR   MANE-Select; ENST00000519560.6; ENSP00000430333.2; NM_003062.4; NP_003053.2.
DR   UCSC; uc003mab.5; human. [O75094-1]
DR   AGR; HGNC:11087; -.
DR   CTD; 6586; -.
DR   DisGeNET; 6586; -.
DR   GeneCards; SLIT3; -.
DR   HGNC; HGNC:11087; SLIT3.
DR   HPA; ENSG00000184347; Low tissue specificity.
DR   MIM; 603745; gene.
DR   neXtProt; NX_O75094; -.
DR   OpenTargets; ENSG00000184347; -.
DR   PharmGKB; PA35940; -.
DR   VEuPathDB; HostDB:ENSG00000184347; -.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000159322; -.
DR   InParanoid; O75094; -.
DR   OMA; PACNANS; -.
DR   OrthoDB; 5475408at2759; -.
DR   PhylomeDB; O75094; -.
DR   TreeFam; TF332887; -.
DR   PathwayCommons; O75094; -.
DR   Reactome; R-HSA-373752; Netrin-1 signaling.
DR   Reactome; R-HSA-376176; Signaling by ROBO receptors.
DR   Reactome; R-HSA-428542; Regulation of commissural axon pathfinding by SLIT and ROBO.
DR   SignaLink; O75094; -.
DR   BioGRID-ORCS; 6586; 5 hits in 1144 CRISPR screens.
DR   ChiTaRS; SLIT3; human.
DR   GeneWiki; SLIT3; -.
DR   GenomeRNAi; 6586; -.
DR   Pharos; O75094; Tbio.
DR   PRO; PR:O75094; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; O75094; Protein.
DR   Bgee; ENSG00000184347; Expressed in right coronary artery and 189 other cell types or tissues.
DR   ExpressionAtlas; O75094; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; NAS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB.
DR   GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR   GO; GO:0048495; F:Roundabout binding; IPI:UniProtKB.
DR   GO; GO:0003180; P:aortic valve morphogenesis; ISS:BHF-UCL.
DR   GO; GO:0061364; P:apoptotic process involved in luteolysis; IEP:UniProtKB.
DR   GO; GO:0003181; P:atrioventricular valve morphogenesis; ISS:BHF-UCL.
DR   GO; GO:0048846; P:axon extension involved in axon guidance; IDA:UniProtKB.
DR   GO; GO:0007411; P:axon guidance; IDA:UniProtKB.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEP:UniProtKB.
DR   GO; GO:0050919; P:negative chemotaxis; IDA:UniProtKB.
DR   GO; GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0051414; P:response to cortisol; IEP:UniProtKB.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0060412; P:ventricular septum morphogenesis; ISS:BHF-UCL.
DR   CDD; cd00054; EGF_CA; 5.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 9.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR   Pfam; PF00008; EGF; 5.
DR   Pfam; PF12661; hEGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF01463; LRRCT; 4.
DR   Pfam; PF01462; LRRNT; 3.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00179; EGF_CA; 9.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00364; LRR_BAC; 5.
DR   SMART; SM00368; LRR_RI; 5.
DR   SMART; SM00365; LRR_SD22; 9.
DR   SMART; SM00369; LRR_TYP; 18.
DR   SMART; SM00082; LRRCT; 4.
DR   SMART; SM00013; LRRNT; 4.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 4.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS00022; EGF_1; 9.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 9.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 20.
DR   Genevisible; O75094; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Differentiation;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Leucine-rich repeat;
KW   Neurogenesis; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..1523
FT                   /note="Slit homolog 3 protein"
FT                   /id="PRO_0000007732"
FT   DOMAIN          34..61
FT                   /note="LRRNT"
FT   REPEAT          62..83
FT                   /note="LRR 1"
FT   REPEAT          86..107
FT                   /note="LRR 2"
FT   REPEAT          110..131
FT                   /note="LRR 3"
FT   REPEAT          134..155
FT                   /note="LRR 4"
FT   REPEAT          158..179
FT                   /note="LRR 5"
FT   REPEAT          182..203
FT                   /note="LRR 6"
FT   DOMAIN          215..265
FT                   /note="LRRCT 1"
FT   DOMAIN          271..307
FT                   /note="LRRNT 2"
FT   REPEAT          308..329
FT                   /note="LRR 7"
FT   REPEAT          332..353
FT                   /note="LRR 8"
FT   REPEAT          356..377
FT                   /note="LRR 9"
FT   REPEAT          380..401
FT                   /note="LRR 10"
FT   REPEAT          404..425
FT                   /note="LRR 11"
FT   DOMAIN          437..487
FT                   /note="LRRCT 2"
FT   DOMAIN          496..532
FT                   /note="LRRNT 3"
FT   REPEAT          533..554
FT                   /note="LRR 12"
FT   REPEAT          558..579
FT                   /note="LRR 13"
FT   REPEAT          582..603
FT                   /note="LRR 14"
FT   REPEAT          606..627
FT                   /note="LRR 15"
FT   REPEAT          630..651
FT                   /note="LRR 16"
FT   DOMAIN          663..713
FT                   /note="LRRCT 3"
FT   DOMAIN          716..752
FT                   /note="LRRNT 4"
FT   REPEAT          753..775
FT                   /note="LRR 17"
FT   REPEAT          776..797
FT                   /note="LRR 18"
FT   REPEAT          800..821
FT                   /note="LRR 19"
FT   REPEAT          824..845
FT                   /note="LRR 20"
FT   DOMAIN          857..907
FT                   /note="LRRCT 4"
FT   DOMAIN          918..953
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          955..994
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          996..1032
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1034..1072
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1074..1110
FT                   /note="EGF-like 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1119..1155
FT                   /note="EGF-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1158..1332
FT                   /note="Laminin G-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          1340..1365
FT                   /note="EGF-like 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1368..1403
FT                   /note="EGF-like 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1408..1444
FT                   /note="EGF-like 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1449..1523
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        563
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        622
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        784
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        792
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        797
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        928
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1008
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1025
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1181
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1247
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1406
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        284..293
FT                   /evidence="ECO:0000250"
FT   DISULFID        441..464
FT                   /evidence="ECO:0000250"
FT   DISULFID        443..485
FT                   /evidence="ECO:0000250"
FT   DISULFID        505..511
FT                   /evidence="ECO:0000250"
FT   DISULFID        509..518
FT                   /evidence="ECO:0000250"
FT   DISULFID        667..690
FT                   /evidence="ECO:0000250"
FT   DISULFID        669..711
FT                   /evidence="ECO:0000250"
FT   DISULFID        920..931
FT                   /evidence="ECO:0000250"
FT   DISULFID        925..941
FT                   /evidence="ECO:0000250"
FT   DISULFID        943..952
FT                   /evidence="ECO:0000250"
FT   DISULFID        959..970
FT                   /evidence="ECO:0000250"
FT   DISULFID        964..982
FT                   /evidence="ECO:0000250"
FT   DISULFID        984..993
FT                   /evidence="ECO:0000250"
FT   DISULFID        1000..1011
FT                   /evidence="ECO:0000250"
FT   DISULFID        1005..1020
FT                   /evidence="ECO:0000250"
FT   DISULFID        1022..1031
FT                   /evidence="ECO:0000250"
FT   DISULFID        1038..1051
FT                   /evidence="ECO:0000250"
FT   DISULFID        1045..1060
FT                   /evidence="ECO:0000250"
FT   DISULFID        1062..1071
FT                   /evidence="ECO:0000250"
FT   DISULFID        1078..1089
FT                   /evidence="ECO:0000250"
FT   DISULFID        1083..1098
FT                   /evidence="ECO:0000250"
FT   DISULFID        1100..1109
FT                   /evidence="ECO:0000250"
FT   DISULFID        1123..1134
FT                   /evidence="ECO:0000250"
FT   DISULFID        1128..1143
FT                   /evidence="ECO:0000250"
FT   DISULFID        1145..1154
FT                   /evidence="ECO:0000250"
FT   DISULFID        1305..1332
FT                   /evidence="ECO:0000250"
FT   DISULFID        1355..1364
FT                   /evidence="ECO:0000250"
FT   DISULFID        1372..1382
FT                   /evidence="ECO:0000250"
FT   DISULFID        1377..1391
FT                   /evidence="ECO:0000250"
FT   DISULFID        1393..1402
FT                   /evidence="ECO:0000250"
FT   DISULFID        1412..1422
FT                   /evidence="ECO:0000250"
FT   DISULFID        1417..1432
FT                   /evidence="ECO:0000250"
FT   DISULFID        1434..1443
FT                   /evidence="ECO:0000250"
FT   DISULFID        1449..1487
FT                   /evidence="ECO:0000250"
FT   DISULFID        1467..1501
FT                   /evidence="ECO:0000250"
FT   DISULFID        1478..1517
FT                   /evidence="ECO:0000250"
FT   DISULFID        1482..1519
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         906
FT                   /note="K -> KVLWFCCP (in isoform 4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054798"
FT   VAR_SEQ         1117..1216
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10349621,
FT                   ECO:0000303|PubMed:9813312"
FT                   /id="VSP_009714"
FT   VAR_SEQ         1446..1523
FT                   /note="ENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKY
FT                   VFQCTDGSSFVEEVERHLECGCLACS -> VFRAQVFQSSLPGNCSWSCWPPRPPMP
FT                   (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:9813312"
FT                   /id="VSP_009715"
FT   VARIANT         371
FT                   /note="V -> A (in dbSNP:rs891921)"
FT                   /evidence="ECO:0000269|PubMed:12975309,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT                   ECO:0000269|PubMed:9693030, ECO:0000269|PubMed:9813312"
FT                   /id="VAR_049004"
FT   VARIANT         395
FT                   /note="R -> Q (in dbSNP:rs2288792)"
FT                   /id="VAR_021905"
FT   VARIANT         618
FT                   /note="G -> S (in dbSNP:rs10036727)"
FT                   /evidence="ECO:0000269|PubMed:12975309"
FT                   /id="VAR_024265"
FT   VARIANT         810
FT                   /note="R -> Q (in dbSNP:rs36052924)"
FT                   /id="VAR_049005"
FT   VARIANT         994
FT                   /note="E -> G (in dbSNP:rs2305993)"
FT                   /id="VAR_020168"
FT   VARIANT         1064
FT                   /note="P -> A (in dbSNP:rs10072243)"
FT                   /id="VAR_049006"
SQ   SEQUENCE   1523 AA;  167713 MW;  CEB00887F6908554 CRC64;
     MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP
     RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK
     LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL
     RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT
     LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME
     IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL
     VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK
     GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS
     KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN
     DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV
     FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL
     LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ
     LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI
     DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE
     GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT
     HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI
     QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC
     ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA
     HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE
     PTCRCPPGFA GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD
     NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL NLVVDKGTPK
     SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG GFHGCIHEVR INNELQDFKA
     LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT GPLCDQEARD PCLGHRCHHG
     KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG
     EHCQQENPCL GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ
     CTDGSSFVEE VERHLECGCL ACS
//