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O75094

- SLIT3_HUMAN

UniProt

O75094 - SLIT3_HUMAN

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Protein

Slit homolog 3 protein

Gene
SLIT3, KIAA0814, MEGF5, SLIL2, UNQ691/PRO1336
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Roundabout binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process involved in luteolysis Source: UniProtKB
  2. axon extension involved in axon guidance Source: UniProtKB
  3. axon guidance Source: UniProtKB
  4. cellular response to hormone stimulus Source: UniProtKB
  5. negative chemotaxis Source: UniProtKB
  6. negative regulation of cell growth Source: BHF-UCL
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of chemokine-mediated signaling pathway Source: BHF-UCL
  9. negative regulation of gene expression Source: Ensembl
  10. organ morphogenesis Source: Ensembl
  11. response to cortisol Source: UniProtKB
  12. Roundabout signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_22237. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 3 protein
Short name:
Slit-3
Alternative name(s):
Multiple epidermal growth factor-like domains protein 5
Short name:
Multiple EGF-like domains protein 5
Gene namesi
Name:SLIT3
Synonyms:KIAA0814, MEGF5, SLIL2
ORF Names:UNQ691/PRO1336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11087. SLIT3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 15231490Slit homolog 3 proteinPRO_0000007732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi284 ↔ 293 By similarity
Disulfide bondi441 ↔ 464 By similarity
Disulfide bondi443 ↔ 485 By similarity
Disulfide bondi505 ↔ 511 By similarity
Disulfide bondi509 ↔ 518 By similarity
Glycosylationi563 – 5631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi667 ↔ 690 By similarity
Disulfide bondi669 ↔ 711 By similarity
Glycosylationi784 – 7841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi792 – 7921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi797 – 7971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi920 ↔ 931 By similarity
Disulfide bondi925 ↔ 941 By similarity
Glycosylationi928 – 9281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi943 ↔ 952 By similarity
Disulfide bondi959 ↔ 970 By similarity
Disulfide bondi964 ↔ 982 By similarity
Disulfide bondi984 ↔ 993 By similarity
Disulfide bondi1000 ↔ 1011 By similarity
Disulfide bondi1005 ↔ 1020 By similarity
Glycosylationi1008 – 10081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1022 ↔ 1031 By similarity
Glycosylationi1025 – 10251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1038 ↔ 1051 By similarity
Disulfide bondi1045 ↔ 1060 By similarity
Disulfide bondi1062 ↔ 1071 By similarity
Disulfide bondi1078 ↔ 1089 By similarity
Disulfide bondi1083 ↔ 1098 By similarity
Disulfide bondi1100 ↔ 1109 By similarity
Disulfide bondi1123 ↔ 1134 By similarity
Disulfide bondi1128 ↔ 1143 By similarity
Disulfide bondi1145 ↔ 1154 By similarity
Glycosylationi1181 – 11811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1247 – 12471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1305 ↔ 1332 By similarity
Disulfide bondi1355 ↔ 1364 By similarity
Disulfide bondi1372 ↔ 1382 By similarity
Disulfide bondi1377 ↔ 1391 By similarity
Disulfide bondi1393 ↔ 1402 By similarity
Glycosylationi1406 – 14061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1412 ↔ 1422 By similarity
Disulfide bondi1417 ↔ 1432 By similarity
Disulfide bondi1434 ↔ 1443 By similarity
Disulfide bondi1449 ↔ 1487 By similarity
Disulfide bondi1467 ↔ 1501 By similarity
Disulfide bondi1478 ↔ 1517 By similarity
Disulfide bondi1482 ↔ 1519 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75094.
PaxDbiO75094.
PRIDEiO75094.

PTM databases

PhosphoSiteiO75094.

Expressioni

Tissue specificityi

Predominantly expressed in thyroid.1 Publication

Gene expression databases

ArrayExpressiO75094.
BgeeiO75094.
CleanExiHS_SLIT3.
GenevestigatoriO75094.

Organism-specific databases

HPAiHPA051630.

Interactioni

Protein-protein interaction databases

BioGridi112473. 1 interaction.
IntActiO75094. 2 interactions.
MINTiMINT-2797284.
STRINGi9606.ENSP00000332164.

Structurei

3D structure databases

ProteinModelPortaliO75094.
SMRiO75094. Positions 277-485, 505-712, 725-905.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Domaini215 – 26551LRRCT 1Add
BLAST
Domaini271 – 30737LRRNT 2Add
BLAST
Repeati308 – 32922LRR 7Add
BLAST
Repeati332 – 35322LRR 8Add
BLAST
Repeati356 – 37722LRR 9Add
BLAST
Repeati380 – 40122LRR 10Add
BLAST
Repeati404 – 42522LRR 11Add
BLAST
Domaini437 – 48751LRRCT 2Add
BLAST
Domaini496 – 53237LRRNT 3Add
BLAST
Repeati533 – 55422LRR 12Add
BLAST
Repeati558 – 57922LRR 13Add
BLAST
Repeati582 – 60322LRR 14Add
BLAST
Repeati606 – 62722LRR 15Add
BLAST
Repeati630 – 65122LRR 16Add
BLAST
Domaini663 – 71351LRRCT 3Add
BLAST
Domaini716 – 75237LRRNT 4Add
BLAST
Repeati753 – 77523LRR 17Add
BLAST
Repeati776 – 79722LRR 18Add
BLAST
Repeati800 – 82122LRR 19Add
BLAST
Repeati824 – 84522LRR 20Add
BLAST
Domaini857 – 90751LRRCT 4Add
BLAST
Domaini918 – 95336EGF-like 1Add
BLAST
Domaini955 – 99440EGF-like 2Add
BLAST
Domaini996 – 103237EGF-like 3Add
BLAST
Domaini1034 – 107239EGF-like 4Add
BLAST
Domaini1074 – 111037EGF-like 5Add
BLAST
Domaini1119 – 115537EGF-like 6Add
BLAST
Domaini1158 – 1332175Laminin G-likeAdd
BLAST
Domaini1340 – 136526EGF-like 7Add
BLAST
Domaini1368 – 140336EGF-like 8Add
BLAST
Domaini1408 – 144437EGF-like 9Add
BLAST
Domaini1449 – 152375CTCKAdd
BLAST

Sequence similaritiesi

Contains 9 EGF-like domains.
Contains 4 LRRCT domains.
Contains 4 LRRNT domains.

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75094.
KOiK06850.
OrthoDBiEOG78WKQW.
PhylomeDBiO75094.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 6 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75094-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL     50
GLRAVPRGIP RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI 100
ERGAFQDLKQ LERLRLNKNK LQVLPELLFQ STPKLTRLDL SENQIQGIPR 150
KAFRGITDVK NLQLDNNHIS CIEDGAFRAL RDLEILTLNN NNISRILVTS 200
FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT LCMAPVHLRG 250
FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 300
IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA 350
FQGLKSLTSL VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ 400
DLQNLNLLSL YDNKLQTISK GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD 450
YLQDNPIETS GARCSSPRRL ANKRISQIKS KKFRCSGSED YRSRFSSECF 500
MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN DNEVSVLEAT 550
GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 600
FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT 650
TLVSLSTINL LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP 700
IQDVAIQDFT CDGNEESSCQ LSPRCPEQCT CMETVVRCSN KGLRALPRGM 750
PKDVTELYLE GNHLTAVPRE LSALRHLTLI DLSNNSISML TNYTFSNMSH 800
LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE GSFNDLTSLS 850
HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 900
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK 950
DCTVPINTCI QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC 1000
EDNDCENNAT CVDGINNYVC ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK 1050
CIPLDKGFSC ECVPGYSGKL CETDNDDCVA HKCRHGAQCV DTINGYTCTC 1100
PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE PTCRCPPGFA 1150
GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 1200
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL 1250
NLVVDKGTPK SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG 1300
GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS 1350
VVCECRPGWT GPLCDQEARD PCLGHRCHHG KCVATGTSYM CKCAEGYGGD 1400
LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG EHCQQENPCL 1450
GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ 1500
CTDGSSFVEE VERHLECGCL ACS 1523
Length:1,523
Mass (Da):167,713
Last modified:November 2, 2010 - v3
Checksum:iCEB00887F6908554
GO
Isoform 2 (identifier: O75094-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1216: Missing.

Show »
Length:1,423
Mass (Da):156,766
Checksum:i4A5F62D857F47D19
GO
Isoform 3 (identifier: O75094-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

Show »
Length:1,472
Mass (Da):162,157
Checksum:i6BF26D278F72D157
GO
Isoform 4 (identifier: O75094-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     906-906: K → KVLWFCCP

Note: No experimental confirmation available.

Show »
Length:1,530
Mass (Da):168,562
Checksum:iC5DBA4B7B0D5221D
GO

Sequence cautioni

The sequence CAB59249.1 differs from that shown. Reason: Intron retention.
The sequence BAA32466.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti371 – 3711V → A.5 Publications
Corresponds to variant rs891921 [ dbSNP | Ensembl ].
VAR_049004
Natural varianti395 – 3951R → Q.
Corresponds to variant rs2288792 [ dbSNP | Ensembl ].
VAR_021905
Natural varianti618 – 6181G → S.1 Publication
Corresponds to variant rs10036727 [ dbSNP | Ensembl ].
VAR_024265
Natural varianti810 – 8101R → Q.
Corresponds to variant rs36052924 [ dbSNP | Ensembl ].
VAR_049005
Natural varianti994 – 9941E → G.
Corresponds to variant rs2305993 [ dbSNP | Ensembl ].
VAR_020168
Natural varianti1064 – 10641P → A.
Corresponds to variant rs10072243 [ dbSNP | Ensembl ].
VAR_049006

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei906 – 9061K → KVLWFCCP in isoform 4. VSP_054798
Alternative sequencei1117 – 1216100Missing in isoform 2. VSP_009714Add
BLAST
Alternative sequencei1446 – 152378ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3. VSP_009715Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017169 mRNA. Translation: BAA35186.1.
AB011538 mRNA. Translation: BAA32466.2. Different initiation.
AY358884 mRNA. Translation: AAQ89243.1.
AC008409 Genomic DNA. No translation available.
AC008479 Genomic DNA. No translation available.
AC011365 Genomic DNA. No translation available.
AC011389 Genomic DNA. No translation available.
AC027311 Genomic DNA. No translation available.
AC094081 Genomic DNA. No translation available.
AC112165 Genomic DNA. No translation available.
BC146759 mRNA. Translation: AAI46760.1.
AL122074 mRNA. Translation: CAB59249.1. Sequence problems.
AF075240 mRNA. Translation: AAD19336.1.
CCDSiCCDS4369.1. [O75094-1]
CCDS64311.1. [O75094-4]
PIRiT34555.
RefSeqiNP_001258875.1. NM_001271946.1.
NP_003053.1. NM_003062.3.
UniGeneiHs.552087.

Genome annotation databases

EnsembliENST00000332966; ENSP00000332164; ENSG00000184347.
ENST00000404867; ENSP00000384890; ENSG00000184347. [O75094-3]
ENST00000519560; ENSP00000430333; ENSG00000184347. [O75094-1]
GeneIDi6586.
KEGGihsa:6586.
UCSCiuc003mab.4. human. [O75094-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017169 mRNA. Translation: BAA35186.1 .
AB011538 mRNA. Translation: BAA32466.2 . Different initiation.
AY358884 mRNA. Translation: AAQ89243.1 .
AC008409 Genomic DNA. No translation available.
AC008479 Genomic DNA. No translation available.
AC011365 Genomic DNA. No translation available.
AC011389 Genomic DNA. No translation available.
AC027311 Genomic DNA. No translation available.
AC094081 Genomic DNA. No translation available.
AC112165 Genomic DNA. No translation available.
BC146759 mRNA. Translation: AAI46760.1 .
AL122074 mRNA. Translation: CAB59249.1 . Sequence problems.
AF075240 mRNA. Translation: AAD19336.1 .
CCDSi CCDS4369.1. [O75094-1 ]
CCDS64311.1. [O75094-4 ]
PIRi T34555.
RefSeqi NP_001258875.1. NM_001271946.1.
NP_003053.1. NM_003062.3.
UniGenei Hs.552087.

3D structure databases

ProteinModelPortali O75094.
SMRi O75094. Positions 277-485, 505-712, 725-905.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112473. 1 interaction.
IntActi O75094. 2 interactions.
MINTi MINT-2797284.
STRINGi 9606.ENSP00000332164.

PTM databases

PhosphoSitei O75094.

Proteomic databases

MaxQBi O75094.
PaxDbi O75094.
PRIDEi O75094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332966 ; ENSP00000332164 ; ENSG00000184347 .
ENST00000404867 ; ENSP00000384890 ; ENSG00000184347 . [O75094-3 ]
ENST00000519560 ; ENSP00000430333 ; ENSG00000184347 . [O75094-1 ]
GeneIDi 6586.
KEGGi hsa:6586.
UCSCi uc003mab.4. human. [O75094-1 ]

Organism-specific databases

CTDi 6586.
GeneCardsi GC05M168021.
H-InvDB HIX0005394.
HGNCi HGNC:11087. SLIT3.
HPAi HPA051630.
MIMi 603745. gene.
neXtProti NX_O75094.
PharmGKBi PA35940.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000116120.
HOVERGENi HBG057959.
InParanoidi O75094.
KOi K06850.
OrthoDBi EOG78WKQW.
PhylomeDBi O75094.
TreeFami TF332887.

Enzyme and pathway databases

Reactomei REACT_22237. Netrin-1 signaling.

Miscellaneous databases

ChiTaRSi SLIT3. human.
GeneWikii SLIT3.
GenomeRNAii 6586.
NextBioi 25629.
PROi O75094.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75094.
Bgeei O75094.
CleanExi HS_SLIT3.
Genevestigatori O75094.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00008. EGF. 6 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view ]
SMARTi SM00041. CT. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
    Itoh A., Miyabayashi T., Ohno M., Sakano S.
    Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANT ALA-371.
  2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-371.
    Tissue: Brain.
  3. Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-371 AND SER-618.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-371.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, VARIANT ALA-371.
    Tissue: Testis.
  8. "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis."
    Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T., Little M.H.
    Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).

Entry informationi

Entry nameiSLIT3_HUMAN
AccessioniPrimary (citable) accession number: O75094
Secondary accession number(s): A6H8U9
, J3KNP3, O95804, Q9UFH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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