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Protein

Slit homolog 3 protein

Gene

SLIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Roundabout binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process involved in luteolysis Source: UniProtKB
  2. axon extension involved in axon guidance Source: UniProtKB
  3. axon guidance Source: UniProtKB
  4. cellular response to hormone stimulus Source: UniProtKB
  5. negative chemotaxis Source: UniProtKB
  6. negative regulation of cell growth Source: BHF-UCL
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of chemokine-mediated signaling pathway Source: BHF-UCL
  9. negative regulation of gene expression Source: Ensembl
  10. organ morphogenesis Source: Ensembl
  11. response to cortisol Source: UniProtKB
  12. Roundabout signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_22237. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 3 protein
Short name:
Slit-3
Alternative name(s):
Multiple epidermal growth factor-like domains protein 5
Short name:
Multiple EGF-like domains protein 5
Gene namesi
Name:SLIT3
Synonyms:KIAA0814, MEGF5, SLIL2
ORF Names:UNQ691/PRO1336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11087. SLIT3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 15231490Slit homolog 3 proteinPRO_0000007732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi284 ↔ 293By similarity
Disulfide bondi441 ↔ 464By similarity
Disulfide bondi443 ↔ 485By similarity
Disulfide bondi505 ↔ 511By similarity
Disulfide bondi509 ↔ 518By similarity
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi667 ↔ 690By similarity
Disulfide bondi669 ↔ 711By similarity
Glycosylationi784 – 7841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi920 ↔ 931By similarity
Disulfide bondi925 ↔ 941By similarity
Glycosylationi928 – 9281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi943 ↔ 952By similarity
Disulfide bondi959 ↔ 970By similarity
Disulfide bondi964 ↔ 982By similarity
Disulfide bondi984 ↔ 993By similarity
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1005 ↔ 1020By similarity
Glycosylationi1008 – 10081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1022 ↔ 1031By similarity
Glycosylationi1025 – 10251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1038 ↔ 1051By similarity
Disulfide bondi1045 ↔ 1060By similarity
Disulfide bondi1062 ↔ 1071By similarity
Disulfide bondi1078 ↔ 1089By similarity
Disulfide bondi1083 ↔ 1098By similarity
Disulfide bondi1100 ↔ 1109By similarity
Disulfide bondi1123 ↔ 1134By similarity
Disulfide bondi1128 ↔ 1143By similarity
Disulfide bondi1145 ↔ 1154By similarity
Glycosylationi1181 – 11811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1247 – 12471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1305 ↔ 1332By similarity
Disulfide bondi1355 ↔ 1364By similarity
Disulfide bondi1372 ↔ 1382By similarity
Disulfide bondi1377 ↔ 1391By similarity
Disulfide bondi1393 ↔ 1402By similarity
Glycosylationi1406 – 14061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1412 ↔ 1422By similarity
Disulfide bondi1417 ↔ 1432By similarity
Disulfide bondi1434 ↔ 1443By similarity
Disulfide bondi1449 ↔ 1487By similarity
Disulfide bondi1467 ↔ 1501By similarity
Disulfide bondi1478 ↔ 1517By similarity
Disulfide bondi1482 ↔ 1519By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75094.
PaxDbiO75094.
PRIDEiO75094.

PTM databases

PhosphoSiteiO75094.

Expressioni

Tissue specificityi

Predominantly expressed in thyroid.1 Publication

Gene expression databases

BgeeiO75094.
CleanExiHS_SLIT3.
GenevestigatoriO75094.

Organism-specific databases

HPAiHPA051630.

Interactioni

Protein-protein interaction databases

BioGridi112473. 1 interaction.
IntActiO75094. 2 interactions.
MINTiMINT-2797284.
STRINGi9606.ENSP00000332164.

Structurei

3D structure databases

ProteinModelPortaliO75094.
SMRiO75094. Positions 277-485, 505-712, 725-905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Domaini215 – 26551LRRCT 1Add
BLAST
Domaini271 – 30737LRRNT 2Add
BLAST
Repeati308 – 32922LRR 7Add
BLAST
Repeati332 – 35322LRR 8Add
BLAST
Repeati356 – 37722LRR 9Add
BLAST
Repeati380 – 40122LRR 10Add
BLAST
Repeati404 – 42522LRR 11Add
BLAST
Domaini437 – 48751LRRCT 2Add
BLAST
Domaini496 – 53237LRRNT 3Add
BLAST
Repeati533 – 55422LRR 12Add
BLAST
Repeati558 – 57922LRR 13Add
BLAST
Repeati582 – 60322LRR 14Add
BLAST
Repeati606 – 62722LRR 15Add
BLAST
Repeati630 – 65122LRR 16Add
BLAST
Domaini663 – 71351LRRCT 3Add
BLAST
Domaini716 – 75237LRRNT 4Add
BLAST
Repeati753 – 77523LRR 17Add
BLAST
Repeati776 – 79722LRR 18Add
BLAST
Repeati800 – 82122LRR 19Add
BLAST
Repeati824 – 84522LRR 20Add
BLAST
Domaini857 – 90751LRRCT 4Add
BLAST
Domaini918 – 95336EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini955 – 99440EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini996 – 103237EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1034 – 107239EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini1074 – 111037EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1119 – 115537EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini1158 – 1332175Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini1340 – 136526EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini1368 – 140336EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini1408 – 144437EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini1449 – 152375CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00780000121836.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75094.
KOiK06850.
OMAiEYVCPGP.
OrthoDBiEOG78WKQW.
PhylomeDBiO75094.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 6 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75094-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL
60 70 80 90 100
GLRAVPRGIP RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI
110 120 130 140 150
ERGAFQDLKQ LERLRLNKNK LQVLPELLFQ STPKLTRLDL SENQIQGIPR
160 170 180 190 200
KAFRGITDVK NLQLDNNHIS CIEDGAFRAL RDLEILTLNN NNISRILVTS
210 220 230 240 250
FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT LCMAPVHLRG
260 270 280 290 300
FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME
310 320 330 340 350
IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA
360 370 380 390 400
FQGLKSLTSL VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ
410 420 430 440 450
DLQNLNLLSL YDNKLQTISK GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD
460 470 480 490 500
YLQDNPIETS GARCSSPRRL ANKRISQIKS KKFRCSGSED YRSRFSSECF
510 520 530 540 550
MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN DNEVSVLEAT
560 570 580 590 600
GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV
610 620 630 640 650
FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT
660 670 680 690 700
TLVSLSTINL LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP
710 720 730 740 750
IQDVAIQDFT CDGNEESSCQ LSPRCPEQCT CMETVVRCSN KGLRALPRGM
760 770 780 790 800
PKDVTELYLE GNHLTAVPRE LSALRHLTLI DLSNNSISML TNYTFSNMSH
810 820 830 840 850
LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE GSFNDLTSLS
860 870 880 890 900
HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT
910 920 930 940 950
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK
960 970 980 990 1000
DCTVPINTCI QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC
1010 1020 1030 1040 1050
EDNDCENNAT CVDGINNYVC ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK
1060 1070 1080 1090 1100
CIPLDKGFSC ECVPGYSGKL CETDNDDCVA HKCRHGAQCV DTINGYTCTC
1110 1120 1130 1140 1150
PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE PTCRCPPGFA
1160 1170 1180 1190 1200
GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD
1210 1220 1230 1240 1250
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL
1260 1270 1280 1290 1300
NLVVDKGTPK SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG
1310 1320 1330 1340 1350
GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS
1360 1370 1380 1390 1400
VVCECRPGWT GPLCDQEARD PCLGHRCHHG KCVATGTSYM CKCAEGYGGD
1410 1420 1430 1440 1450
LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG EHCQQENPCL
1460 1470 1480 1490 1500
GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ
1510 1520
CTDGSSFVEE VERHLECGCL ACS
Length:1,523
Mass (Da):167,713
Last modified:November 2, 2010 - v3
Checksum:iCEB00887F6908554
GO
Isoform 2 (identifier: O75094-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1216: Missing.

Show »
Length:1,423
Mass (Da):156,766
Checksum:i4A5F62D857F47D19
GO
Isoform 3 (identifier: O75094-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

Show »
Length:1,472
Mass (Da):162,157
Checksum:i6BF26D278F72D157
GO
Isoform 4 (identifier: O75094-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     906-906: K → KVLWFCCP

Note: No experimental confirmation available.

Show »
Length:1,530
Mass (Da):168,562
Checksum:iC5DBA4B7B0D5221D
GO

Sequence cautioni

The sequence BAA32466.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB59249.1 differs from that shown.Intron retention.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti371 – 3711V → A.5 Publications
Corresponds to variant rs891921 [ dbSNP | Ensembl ].
VAR_049004
Natural varianti395 – 3951R → Q.
Corresponds to variant rs2288792 [ dbSNP | Ensembl ].
VAR_021905
Natural varianti618 – 6181G → S.1 Publication
Corresponds to variant rs10036727 [ dbSNP | Ensembl ].
VAR_024265
Natural varianti810 – 8101R → Q.
Corresponds to variant rs36052924 [ dbSNP | Ensembl ].
VAR_049005
Natural varianti994 – 9941E → G.
Corresponds to variant rs2305993 [ dbSNP | Ensembl ].
VAR_020168
Natural varianti1064 – 10641P → A.
Corresponds to variant rs10072243 [ dbSNP | Ensembl ].
VAR_049006

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei906 – 9061K → KVLWFCCP in isoform 4. CuratedVSP_054798
Alternative sequencei1117 – 1216100Missing in isoform 2. 2 PublicationsVSP_009714Add
BLAST
Alternative sequencei1446 – 152378ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3. 1 PublicationVSP_009715Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017169 mRNA. Translation: BAA35186.1.
AB011538 mRNA. Translation: BAA32466.2. Different initiation.
AY358884 mRNA. Translation: AAQ89243.1.
AC008409 Genomic DNA. No translation available.
AC008479 Genomic DNA. No translation available.
AC011365 Genomic DNA. No translation available.
AC011389 Genomic DNA. No translation available.
AC027311 Genomic DNA. No translation available.
AC094081 Genomic DNA. No translation available.
AC112165 Genomic DNA. No translation available.
BC146759 mRNA. Translation: AAI46760.1.
AL122074 mRNA. Translation: CAB59249.1. Sequence problems.
AF075240 mRNA. Translation: AAD19336.1.
CCDSiCCDS4369.1. [O75094-1]
CCDS64311.1. [O75094-4]
PIRiT34555.
RefSeqiNP_001258875.1. NM_001271946.1.
NP_003053.1. NM_003062.3.
UniGeneiHs.552087.

Genome annotation databases

EnsembliENST00000332966; ENSP00000332164; ENSG00000184347. [O75094-4]
ENST00000519560; ENSP00000430333; ENSG00000184347. [O75094-1]
GeneIDi6586.
KEGGihsa:6586.
UCSCiuc003mab.4. human. [O75094-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017169 mRNA. Translation: BAA35186.1.
AB011538 mRNA. Translation: BAA32466.2. Different initiation.
AY358884 mRNA. Translation: AAQ89243.1.
AC008409 Genomic DNA. No translation available.
AC008479 Genomic DNA. No translation available.
AC011365 Genomic DNA. No translation available.
AC011389 Genomic DNA. No translation available.
AC027311 Genomic DNA. No translation available.
AC094081 Genomic DNA. No translation available.
AC112165 Genomic DNA. No translation available.
BC146759 mRNA. Translation: AAI46760.1.
AL122074 mRNA. Translation: CAB59249.1. Sequence problems.
AF075240 mRNA. Translation: AAD19336.1.
CCDSiCCDS4369.1. [O75094-1]
CCDS64311.1. [O75094-4]
PIRiT34555.
RefSeqiNP_001258875.1. NM_001271946.1.
NP_003053.1. NM_003062.3.
UniGeneiHs.552087.

3D structure databases

ProteinModelPortaliO75094.
SMRiO75094. Positions 277-485, 505-712, 725-905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112473. 1 interaction.
IntActiO75094. 2 interactions.
MINTiMINT-2797284.
STRINGi9606.ENSP00000332164.

PTM databases

PhosphoSiteiO75094.

Proteomic databases

MaxQBiO75094.
PaxDbiO75094.
PRIDEiO75094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332966; ENSP00000332164; ENSG00000184347. [O75094-4]
ENST00000519560; ENSP00000430333; ENSG00000184347. [O75094-1]
GeneIDi6586.
KEGGihsa:6586.
UCSCiuc003mab.4. human. [O75094-1]

Organism-specific databases

CTDi6586.
GeneCardsiGC05M168088.
H-InvDBHIX0005394.
HGNCiHGNC:11087. SLIT3.
HPAiHPA051630.
MIMi603745. gene.
neXtProtiNX_O75094.
PharmGKBiPA35940.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00780000121836.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75094.
KOiK06850.
OMAiEYVCPGP.
OrthoDBiEOG78WKQW.
PhylomeDBiO75094.
TreeFamiTF332887.

Enzyme and pathway databases

ReactomeiREACT_22237. Netrin-1 signaling.

Miscellaneous databases

ChiTaRSiSLIT3. human.
GeneWikiiSLIT3.
GenomeRNAii6586.
NextBioi25629.
PROiO75094.
SOURCEiSearch...

Gene expression databases

BgeeiO75094.
CleanExiHS_SLIT3.
GenevestigatoriO75094.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 6 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
    Itoh A., Miyabayashi T., Ohno M., Sakano S.
    Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANT ALA-371.
  2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-371.
    Tissue: Brain.
  3. Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-371 AND SER-618.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-371.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, VARIANT ALA-371.
    Tissue: Testis.
  8. "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis."
    Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T., Little M.H.
    Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).

Entry informationi

Entry nameiSLIT3_HUMAN
AccessioniPrimary (citable) accession number: O75094
Secondary accession number(s): A6H8U9
, J3KNP3, O95804, Q9UFH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 2, 2010
Last modified: February 4, 2015
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.