O75094 (SLIT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Slit homolog 3 protein
Short name=Slit-3

Alternative name(s):
Multiple epidermal growth factor-like domains protein 5
Short name=Multiple EGF-like domains protein 5

Gene names

Name:	SLIT3
Synonyms:	KIAA0814, MEGF5, SLIL2
ORF Names:	UNQ691/PRO1336

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Subcellular location	Secreted By similarity.
Tissue specificity	Predominantly expressed in thyroid. Ref.1
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 9 EGF-like domains. Contains 1 laminin G-like domain. Contains 20 LRR (leucine-rich) repeats. Contains 4 LRRCT domains. Contains 4 LRRNT domains.
Sequence caution	The sequence BAA32466.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAB59249.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Leucine-rich repeat Repeat Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Roundabout signaling pathway Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL apoptotic process involved in luteolysis Inferred from expression pattern PubMed 18566128. Source: UniProtKB axon extension involved in axon guidance Inferred from direct assay PubMed 16840550. Source: UniProtKB cellular response to hormone stimulus Inferred from expression pattern PubMed 18566128. Source: UniProtKB negative chemotaxis Inferred from direct assay PubMed 11748139. Source: UniProtKB negative regulation of cell growth Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of chemokine-mediated signaling pathway Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL negative regulation of gene expression Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara response to cortisol stimulus Inferred from expression pattern PubMed 18566128. Source: UniProtKB
Cellular_component	extracellular space Inferred from direct assay PubMed 19741192. Source: UniProtKB mitochondrion Non-traceable author statement PubMed 11443047. Source: UniProtKB
Molecular_function	calcium ion binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75094-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75094-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1216: Missing.

Isoform 3 (identifier: O75094-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1523	1490	Slit homolog 3 protein		PRO_0000007732
Regions
	Domain	34 – 61	28	LRRNT
	Repeat	62 – 83	22	LRR 1
	Repeat	86 – 107	22	LRR 2
	Repeat	110 – 131	22	LRR 3
	Repeat	134 – 155	22	LRR 4
	Repeat	158 – 179	22	LRR 5
	Repeat	182 – 203	22	LRR 6
	Domain	215 – 265	51	LRRCT 1
	Domain	271 – 307	37	LRRNT 2
	Repeat	308 – 329	22	LRR 7
	Repeat	332 – 353	22	LRR 8
	Repeat	356 – 377	22	LRR 9
	Repeat	380 – 401	22	LRR 10
	Repeat	404 – 425	22	LRR 11
	Domain	437 – 487	51	LRRCT 2
	Domain	496 – 532	37	LRRNT 3
	Repeat	533 – 554	22	LRR 12
	Repeat	558 – 579	22	LRR 13
	Repeat	582 – 603	22	LRR 14
	Repeat	606 – 627	22	LRR 15
	Repeat	630 – 651	22	LRR 16
	Domain	663 – 713	51	LRRCT 3
	Domain	716 – 752	37	LRRNT 4
	Repeat	753 – 775	23	LRR 17
	Repeat	776 – 797	22	LRR 18
	Repeat	800 – 821	22	LRR 19
	Repeat	824 – 845	22	LRR 20
	Domain	857 – 907	51	LRRCT 4
	Domain	918 – 953	36	EGF-like 1
	Domain	955 – 994	40	EGF-like 2
	Domain	996 – 1032	37	EGF-like 3
	Domain	1034 – 1072	39	EGF-like 4
	Domain	1074 – 1110	37	EGF-like 5
	Domain	1119 – 1155	37	EGF-like 6
	Domain	1158 – 1332	175	Laminin G-like
	Domain	1340 – 1365	26	EGF-like 7
	Domain	1368 – 1403	36	EGF-like 8
	Domain	1408 – 1444	37	EGF-like 9
	Domain	1449 – 1523	75	CTCK
Amino acid modifications
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	563	1	N-linked (GlcNAc...) Potential
	Glycosylation	622	1	N-linked (GlcNAc...) Potential
	Glycosylation	784	1	N-linked (GlcNAc...) Potential
	Glycosylation	792	1	N-linked (GlcNAc...) Potential
	Glycosylation	797	1	N-linked (GlcNAc...) Potential
	Glycosylation	928	1	N-linked (GlcNAc...) Potential
	Glycosylation	1008	1	N-linked (GlcNAc...) Potential
	Glycosylation	1025	1	N-linked (GlcNAc...) Potential
	Glycosylation	1181	1	N-linked (GlcNAc...) Potential
	Glycosylation	1247	1	N-linked (GlcNAc...) Potential
	Glycosylation	1406	1	N-linked (GlcNAc...) Potential
	Disulfide bond	284 ↔ 293		By similarity
	Disulfide bond	441 ↔ 464		By similarity
	Disulfide bond	443 ↔ 485		By similarity
	Disulfide bond	505 ↔ 511		By similarity
	Disulfide bond	509 ↔ 518		By similarity
	Disulfide bond	667 ↔ 690		By similarity
	Disulfide bond	669 ↔ 711		By similarity
	Disulfide bond	920 ↔ 931		By similarity
	Disulfide bond	925 ↔ 941		By similarity
	Disulfide bond	943 ↔ 952		By similarity
	Disulfide bond	959 ↔ 970		By similarity
	Disulfide bond	964 ↔ 982		By similarity
	Disulfide bond	984 ↔ 993		By similarity
	Disulfide bond	1000 ↔ 1011		By similarity
	Disulfide bond	1005 ↔ 1020		By similarity
	Disulfide bond	1022 ↔ 1031		By similarity
	Disulfide bond	1038 ↔ 1051		By similarity
	Disulfide bond	1045 ↔ 1060		By similarity
	Disulfide bond	1062 ↔ 1071		By similarity
	Disulfide bond	1078 ↔ 1089		By similarity
	Disulfide bond	1083 ↔ 1098		By similarity
	Disulfide bond	1100 ↔ 1109		By similarity
	Disulfide bond	1123 ↔ 1134		By similarity
	Disulfide bond	1128 ↔ 1143		By similarity
	Disulfide bond	1145 ↔ 1154		By similarity
	Disulfide bond	1305 ↔ 1332		By similarity
	Disulfide bond	1355 ↔ 1364		By similarity
	Disulfide bond	1372 ↔ 1382		By similarity
	Disulfide bond	1377 ↔ 1391		By similarity
	Disulfide bond	1393 ↔ 1402		By similarity
	Disulfide bond	1412 ↔ 1422		By similarity
	Disulfide bond	1417 ↔ 1432		By similarity
	Disulfide bond	1434 ↔ 1443		By similarity
	Disulfide bond	1449 ↔ 1487		By similarity
	Disulfide bond	1467 ↔ 1501		By similarity
	Disulfide bond	1478 ↔ 1517		By similarity
	Disulfide bond	1482 ↔ 1519		By similarity
Natural variations
	Alternative sequence	1117 – 1216	100	Missing in isoform 2.		VSP_009714
	Alternative sequence	1446 – 1523	78	ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3.		VSP_009715
	Natural variant	371	1	V → A. Ref.1 Ref.2 Ref.4 Ref.6 Ref.7 Corresponds to variant rs891921 [ dbSNP | Ensembl ].		VAR_049004
	Natural variant	395	1	R → Q. Corresponds to variant rs2288792 [ dbSNP | Ensembl ].		VAR_021905
	Natural variant	618	1	G → S. Ref.4 Corresponds to variant rs10036727 [ dbSNP | Ensembl ].		VAR_024265
	Natural variant	810	1	R → Q. Corresponds to variant rs36052924 [ dbSNP | Ensembl ].		VAR_049005
	Natural variant	994	1	E → G. Corresponds to variant rs2305993 [ dbSNP | Ensembl ].		VAR_020168
	Natural variant	1064	1	P → A. Corresponds to variant rs10072243 [ dbSNP | Ensembl ].		VAR_049006

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: CEB00887F6908554	FASTA	1,523	167,713
	10 20 30 40 50 60 MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP 70 80 90 100 110 120 RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK 130 140 150 160 170 180 LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL 190 200 210 220 230 240 RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT 250 260 270 280 290 300 LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 310 320 330 340 350 360 IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL 370 380 390 400 410 420 VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK 430 440 450 460 470 480 GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS 490 500 510 520 530 540 KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN 550 560 570 580 590 600 DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 610 620 630 640 650 660 FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL 670 680 690 700 710 720 LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ 730 740 750 760 770 780 LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI 790 800 810 820 830 840 DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE 850 860 870 880 890 900 GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 910 920 930 940 950 960 HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI 970 980 990 1000 1010 1020 QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC 1030 1040 1050 1060 1070 1080 ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA 1090 1100 1110 1120 1130 1140 HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE 1150 1160 1170 1180 1190 1200 PTCRCPPGFA GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 1210 1220 1230 1240 1250 1260 NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL NLVVDKGTPK 1270 1280 1290 1300 1310 1320 SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG GFHGCIHEVR INNELQDFKA 1330 1340 1350 1360 1370 1380 LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT GPLCDQEARD PCLGHRCHHG 1390 1400 1410 1420 1430 1440 KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG 1450 1460 1470 1480 1490 1500 EHCQQENPCL GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ 1510 1520 CTDGSSFVEE VERHLECGCL ACS
	Isoform 2 [UniParc]. Checksum: 4A5F62D857F47D19	FASTA	1,423	156,766
	10 20 30 40 50 60 MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP 70 80 90 100 110 120 RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK 130 140 150 160 170 180 LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL 190 200 210 220 230 240 RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT 250 260 270 280 290 300 LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 310 320 330 340 350 360 IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL 370 380 390 400 410 420 VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK 430 440 450 460 470 480 GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS 490 500 510 520 530 540 KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN 550 560 570 580 590 600 DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 610 620 630 640 650 660 FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL 670 680 690 700 710 720 LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ 730 740 750 760 770 780 LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI 790 800 810 820 830 840 DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE 850 860 870 880 890 900 GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 910 920 930 940 950 960 HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI 970 980 990 1000 1010 1020 QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC 1030 1040 1050 1060 1070 1080 ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA 1090 1100 1110 1120 1130 1140 HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVYDSL SSPPTTVYSV ETVNDGQFHS 1150 1160 1170 1180 1190 1200 VELVTLNQTL NLVVDKGTPK SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG 1210 1220 1230 1240 1250 1260 GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT 1270 1280 1290 1300 1310 1320 GPLCDQEARD PCLGHRCHHG KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG 1330 1340 1350 1360 1370 1380 QCHISDQGEP YCLCQPGFSG EHCQQENPCL GQVVREVIRR QKGYASCATA SKVPIMECRG 1390 1400 1410 1420 GCGPQCCQPT RSKRRKYVFQ CTDGSSFVEE VERHLECGCL ACS
	Isoform 3 [UniParc]. Checksum: 6BF26D278F72D157	FASTA	1,472	162,157
	10 20 30 40 50 60 MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP 70 80 90 100 110 120 RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK 130 140 150 160 170 180 LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL 190 200 210 220 230 240 RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT 250 260 270 280 290 300 LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 310 320 330 340 350 360 IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL 370 380 390 400 410 420 VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK 430 440 450 460 470 480 GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS 490 500 510 520 530 540 KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN 550 560 570 580 590 600 DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 610 620 630 640 650 660 FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL 670 680 690 700 710 720 LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ 730 740 750 760 770 780 LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI 790 800 810 820 830 840 DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE 850 860 870 880 890 900 GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 910 920 930 940 950 960 HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI 970 980 990 1000 1010 1020 QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC 1030 1040 1050 1060 1070 1080 ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA 1090 1100 1110 1120 1130 1140 HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE 1150 1160 1170 1180 1190 1200 PTCRCPPGFA GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 1210 1220 1230 1240 1250 1260 NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL NLVVDKGTPK 1270 1280 1290 1300 1310 1320 SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG GFHGCIHEVR INNELQDFKA 1330 1340 1350 1360 1370 1380 LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT GPLCDQEARD PCLGHRCHHG 1390 1400 1410 1420 1430 1440 KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG 1450 1460 1470 EHCQQVFRAQ VFQSSLPGNC SWSCWPPRPP MP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system." Itoh A., Miyabayashi T., Ohno M., Sakano S. Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANT ALA-371.
[2]	"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening." Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O. Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-371. Tissue: Brain.
[3]	Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-371 AND SER-618.
[5]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-371.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, VARIANT ALA-371. Tissue: Testis.
[8]	"Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis." Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T., Little M.H. Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB017169 mRNA. Translation: BAA35186.1. AB011538 mRNA. Translation: BAA32466.2. Different initiation. AY358884 mRNA. Translation: AAQ89243.1. AC008409 Genomic DNA. No translation available. AC008479 Genomic DNA. No translation available. AC011365 Genomic DNA. No translation available. AC011389 Genomic DNA. No translation available. AC027311 Genomic DNA. No translation available. AC094081 Genomic DNA. No translation available. AC112165 Genomic DNA. No translation available. BC146759 mRNA. Translation: AAI46760.1. AL122074 mRNA. Translation: CAB59249.1. Sequence problems. AF075240 mRNA. Translation: AAD19336.1.
IPI	IPI00409709. IPI00409710. IPI00983148.
PIR	T34555.
RefSeq	NP_001258875.1. NM_001271946.1. NP_003053.1. NM_003062.3.
UniGene	Hs.604116.
3D structure databases
ProteinModelPortal	O75094.
SMR	O75094. Positions 277-485, 505-712, 725-905.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75094. 1 interaction.
MINT	MINT-2797284.
STRING	9606.ENSP00000332164.
PTM databases
PhosphoSite	O75094.
Proteomic databases
PaxDb	O75094.
PRIDE	O75094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000404867; ENSP00000384890; ENSG00000184347. ENST00000519560; ENSP00000430333; ENSG00000184347.
GeneID	6586.
KEGG	hsa:6586.
UCSC	uc003mab.3. human.
Organism-specific databases
CTD	6586.
GeneCards	GC05M168021.
H-InvDB	HIX0005394.
HGNC	HGNC:11087. SLIT3.
HPA	HPA051630.
MIM	603745. gene.
neXtProt	NX_O75094.
PharmGKB	PA35940.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000116120.
HOVERGEN	HBG057959.
InParanoid	O75094.
KO	K06850.
OrthoDB	EOG4D7Z4T.
PhylomeDB	O75094.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
Bgee	O75094.
CleanEx	HS_SLIT3.
Genevestigator	O75094.
GermOnline	ENSG00000184347. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000483. Cys-rich_flank_reg_C. IPR006207. Cys_knot_C. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR001791. Laminin_G. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00008. EGF. 6 hits. PF12661. hEGF. 2 hits. PF02210. Laminin_G_2. 1 hit. PF01463. LRRCT. 4 hits. PF01462. LRRNT. 4 hits. [Graphical view]
SMART	SM00041. CT. 1 hit. SM00181. EGF. 8 hits. SM00179. EGF_CA. 1 hit. SM00282. LamG. 1 hit. SM00369. LRR_TYP. 9 hits. SM00082. LRRCT. 4 hits. SM00013. LRRNT. 4 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00022. EGF_1. 9 hits. PS01186. EGF_2. 7 hits. PS50026. EGF_3. 9 hits. PS01187. EGF_CA. 2 hits. PS50025. LAM_G_DOMAIN. 1 hit. PS51450. LRR. 20 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLIT3. human.
GenomeRNAi	6586.
NextBio	25629.
SOURCE	Search...

Entry information

Entry name

SLIT3_HUMAN

Accession

Primary (citable) accession number: O75094
Secondary accession number(s): A6H8U9, O95804, Q9UFH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.