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O75094

- SLIT3_HUMAN

UniProt

O75094 - SLIT3_HUMAN

Protein

Slit homolog 3 protein

Gene

SLIT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. Roundabout binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process involved in luteolysis Source: UniProtKB
    2. axon extension involved in axon guidance Source: UniProtKB
    3. axon guidance Source: UniProtKB
    4. cellular response to hormone stimulus Source: UniProtKB
    5. negative chemotaxis Source: UniProtKB
    6. negative regulation of cell growth Source: BHF-UCL
    7. negative regulation of cell proliferation Source: Ensembl
    8. negative regulation of chemokine-mediated signaling pathway Source: BHF-UCL
    9. negative regulation of gene expression Source: Ensembl
    10. organ morphogenesis Source: Ensembl
    11. response to cortisol Source: UniProtKB
    12. Roundabout signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_22237. Netrin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Slit homolog 3 protein
    Short name:
    Slit-3
    Alternative name(s):
    Multiple epidermal growth factor-like domains protein 5
    Short name:
    Multiple EGF-like domains protein 5
    Gene namesi
    Name:SLIT3
    Synonyms:KIAA0814, MEGF5, SLIL2
    ORF Names:UNQ691/PRO1336
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11087. SLIT3.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 15231490Slit homolog 3 proteinPRO_0000007732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi284 ↔ 293By similarity
    Disulfide bondi441 ↔ 464By similarity
    Disulfide bondi443 ↔ 485By similarity
    Disulfide bondi505 ↔ 511By similarity
    Disulfide bondi509 ↔ 518By similarity
    Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi667 ↔ 690By similarity
    Disulfide bondi669 ↔ 711By similarity
    Glycosylationi784 – 7841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi920 ↔ 931By similarity
    Disulfide bondi925 ↔ 941By similarity
    Glycosylationi928 – 9281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi943 ↔ 952By similarity
    Disulfide bondi959 ↔ 970By similarity
    Disulfide bondi964 ↔ 982By similarity
    Disulfide bondi984 ↔ 993By similarity
    Disulfide bondi1000 ↔ 1011By similarity
    Disulfide bondi1005 ↔ 1020By similarity
    Glycosylationi1008 – 10081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1022 ↔ 1031By similarity
    Glycosylationi1025 – 10251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1038 ↔ 1051By similarity
    Disulfide bondi1045 ↔ 1060By similarity
    Disulfide bondi1062 ↔ 1071By similarity
    Disulfide bondi1078 ↔ 1089By similarity
    Disulfide bondi1083 ↔ 1098By similarity
    Disulfide bondi1100 ↔ 1109By similarity
    Disulfide bondi1123 ↔ 1134By similarity
    Disulfide bondi1128 ↔ 1143By similarity
    Disulfide bondi1145 ↔ 1154By similarity
    Glycosylationi1181 – 11811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1247 – 12471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1305 ↔ 1332By similarity
    Disulfide bondi1355 ↔ 1364By similarity
    Disulfide bondi1372 ↔ 1382By similarity
    Disulfide bondi1377 ↔ 1391By similarity
    Disulfide bondi1393 ↔ 1402By similarity
    Glycosylationi1406 – 14061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1412 ↔ 1422By similarity
    Disulfide bondi1417 ↔ 1432By similarity
    Disulfide bondi1434 ↔ 1443By similarity
    Disulfide bondi1449 ↔ 1487By similarity
    Disulfide bondi1467 ↔ 1501By similarity
    Disulfide bondi1478 ↔ 1517By similarity
    Disulfide bondi1482 ↔ 1519By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO75094.
    PaxDbiO75094.
    PRIDEiO75094.

    PTM databases

    PhosphoSiteiO75094.

    Expressioni

    Tissue specificityi

    Predominantly expressed in thyroid.1 Publication

    Gene expression databases

    ArrayExpressiO75094.
    BgeeiO75094.
    CleanExiHS_SLIT3.
    GenevestigatoriO75094.

    Organism-specific databases

    HPAiHPA051630.

    Interactioni

    Protein-protein interaction databases

    BioGridi112473. 1 interaction.
    IntActiO75094. 3 interactions.
    MINTiMINT-2797284.
    STRINGi9606.ENSP00000332164.

    Structurei

    3D structure databases

    ProteinModelPortaliO75094.
    SMRiO75094. Positions 277-485, 505-712, 725-905.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 6128LRRNTAdd
    BLAST
    Repeati62 – 8322LRR 1Add
    BLAST
    Repeati86 – 10722LRR 2Add
    BLAST
    Repeati110 – 13122LRR 3Add
    BLAST
    Repeati134 – 15522LRR 4Add
    BLAST
    Repeati158 – 17922LRR 5Add
    BLAST
    Repeati182 – 20322LRR 6Add
    BLAST
    Domaini215 – 26551LRRCT 1Add
    BLAST
    Domaini271 – 30737LRRNT 2Add
    BLAST
    Repeati308 – 32922LRR 7Add
    BLAST
    Repeati332 – 35322LRR 8Add
    BLAST
    Repeati356 – 37722LRR 9Add
    BLAST
    Repeati380 – 40122LRR 10Add
    BLAST
    Repeati404 – 42522LRR 11Add
    BLAST
    Domaini437 – 48751LRRCT 2Add
    BLAST
    Domaini496 – 53237LRRNT 3Add
    BLAST
    Repeati533 – 55422LRR 12Add
    BLAST
    Repeati558 – 57922LRR 13Add
    BLAST
    Repeati582 – 60322LRR 14Add
    BLAST
    Repeati606 – 62722LRR 15Add
    BLAST
    Repeati630 – 65122LRR 16Add
    BLAST
    Domaini663 – 71351LRRCT 3Add
    BLAST
    Domaini716 – 75237LRRNT 4Add
    BLAST
    Repeati753 – 77523LRR 17Add
    BLAST
    Repeati776 – 79722LRR 18Add
    BLAST
    Repeati800 – 82122LRR 19Add
    BLAST
    Repeati824 – 84522LRR 20Add
    BLAST
    Domaini857 – 90751LRRCT 4Add
    BLAST
    Domaini918 – 95336EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini955 – 99440EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini996 – 103237EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1034 – 107239EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1074 – 111037EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1119 – 115537EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1158 – 1332175Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini1340 – 136526EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1368 – 140336EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1408 – 144437EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1449 – 152375CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 9 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 20 LRR (leucine-rich) repeats.Curated
    Contains 4 LRRCT domains.Curated
    Contains 4 LRRNT domains.Curated

    Keywords - Domaini

    EGF-like domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116120.
    HOVERGENiHBG057959.
    InParanoidiO75094.
    KOiK06850.
    OrthoDBiEOG78WKQW.
    PhylomeDBiO75094.
    TreeFamiTF332887.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00008. EGF. 6 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view]
    SMARTiSM00041. CT. 1 hit.
    SM00181. EGF. 8 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 9 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 7 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 20 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75094-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL     50
    GLRAVPRGIP RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI 100
    ERGAFQDLKQ LERLRLNKNK LQVLPELLFQ STPKLTRLDL SENQIQGIPR 150
    KAFRGITDVK NLQLDNNHIS CIEDGAFRAL RDLEILTLNN NNISRILVTS 200
    FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT LCMAPVHLRG 250
    FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 300
    IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA 350
    FQGLKSLTSL VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ 400
    DLQNLNLLSL YDNKLQTISK GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD 450
    YLQDNPIETS GARCSSPRRL ANKRISQIKS KKFRCSGSED YRSRFSSECF 500
    MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN DNEVSVLEAT 550
    GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 600
    FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT 650
    TLVSLSTINL LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP 700
    IQDVAIQDFT CDGNEESSCQ LSPRCPEQCT CMETVVRCSN KGLRALPRGM 750
    PKDVTELYLE GNHLTAVPRE LSALRHLTLI DLSNNSISML TNYTFSNMSH 800
    LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE GSFNDLTSLS 850
    HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 900
    HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK 950
    DCTVPINTCI QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC 1000
    EDNDCENNAT CVDGINNYVC ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK 1050
    CIPLDKGFSC ECVPGYSGKL CETDNDDCVA HKCRHGAQCV DTINGYTCTC 1100
    PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE PTCRCPPGFA 1150
    GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 1200
    NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL 1250
    NLVVDKGTPK SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG 1300
    GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS 1350
    VVCECRPGWT GPLCDQEARD PCLGHRCHHG KCVATGTSYM CKCAEGYGGD 1400
    LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG EHCQQENPCL 1450
    GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ 1500
    CTDGSSFVEE VERHLECGCL ACS 1523
    Length:1,523
    Mass (Da):167,713
    Last modified:November 2, 2010 - v3
    Checksum:iCEB00887F6908554
    GO
    Isoform 2 (identifier: O75094-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1117-1216: Missing.

    Show »
    Length:1,423
    Mass (Da):156,766
    Checksum:i4A5F62D857F47D19
    GO
    Isoform 3 (identifier: O75094-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

    Show »
    Length:1,472
    Mass (Da):162,157
    Checksum:i6BF26D278F72D157
    GO
    Isoform 4 (identifier: O75094-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         906-906: K → KVLWFCCP

    Note: No experimental confirmation available.

    Show »
    Length:1,530
    Mass (Da):168,562
    Checksum:iC5DBA4B7B0D5221D
    GO

    Sequence cautioni

    The sequence CAB59249.1 differs from that shown. Reason: Intron retention.
    The sequence BAA32466.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti371 – 3711V → A.5 Publications
    Corresponds to variant rs891921 [ dbSNP | Ensembl ].
    VAR_049004
    Natural varianti395 – 3951R → Q.
    Corresponds to variant rs2288792 [ dbSNP | Ensembl ].
    VAR_021905
    Natural varianti618 – 6181G → S.1 Publication
    Corresponds to variant rs10036727 [ dbSNP | Ensembl ].
    VAR_024265
    Natural varianti810 – 8101R → Q.
    Corresponds to variant rs36052924 [ dbSNP | Ensembl ].
    VAR_049005
    Natural varianti994 – 9941E → G.
    Corresponds to variant rs2305993 [ dbSNP | Ensembl ].
    VAR_020168
    Natural varianti1064 – 10641P → A.
    Corresponds to variant rs10072243 [ dbSNP | Ensembl ].
    VAR_049006

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei906 – 9061K → KVLWFCCP in isoform 4. CuratedVSP_054798
    Alternative sequencei1117 – 1216100Missing in isoform 2. 2 PublicationsVSP_009714Add
    BLAST
    Alternative sequencei1446 – 152378ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3. 1 PublicationVSP_009715Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017169 mRNA. Translation: BAA35186.1.
    AB011538 mRNA. Translation: BAA32466.2. Different initiation.
    AY358884 mRNA. Translation: AAQ89243.1.
    AC008409 Genomic DNA. No translation available.
    AC008479 Genomic DNA. No translation available.
    AC011365 Genomic DNA. No translation available.
    AC011389 Genomic DNA. No translation available.
    AC027311 Genomic DNA. No translation available.
    AC094081 Genomic DNA. No translation available.
    AC112165 Genomic DNA. No translation available.
    BC146759 mRNA. Translation: AAI46760.1.
    AL122074 mRNA. Translation: CAB59249.1. Sequence problems.
    AF075240 mRNA. Translation: AAD19336.1.
    CCDSiCCDS4369.1. [O75094-1]
    CCDS64311.1. [O75094-4]
    PIRiT34555.
    RefSeqiNP_001258875.1. NM_001271946.1.
    NP_003053.1. NM_003062.3.
    UniGeneiHs.552087.

    Genome annotation databases

    EnsembliENST00000332966; ENSP00000332164; ENSG00000184347. [O75094-4]
    ENST00000404867; ENSP00000384890; ENSG00000184347. [O75094-3]
    ENST00000519560; ENSP00000430333; ENSG00000184347. [O75094-1]
    GeneIDi6586.
    KEGGihsa:6586.
    UCSCiuc003mab.4. human. [O75094-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017169 mRNA. Translation: BAA35186.1 .
    AB011538 mRNA. Translation: BAA32466.2 . Different initiation.
    AY358884 mRNA. Translation: AAQ89243.1 .
    AC008409 Genomic DNA. No translation available.
    AC008479 Genomic DNA. No translation available.
    AC011365 Genomic DNA. No translation available.
    AC011389 Genomic DNA. No translation available.
    AC027311 Genomic DNA. No translation available.
    AC094081 Genomic DNA. No translation available.
    AC112165 Genomic DNA. No translation available.
    BC146759 mRNA. Translation: AAI46760.1 .
    AL122074 mRNA. Translation: CAB59249.1 . Sequence problems.
    AF075240 mRNA. Translation: AAD19336.1 .
    CCDSi CCDS4369.1. [O75094-1 ]
    CCDS64311.1. [O75094-4 ]
    PIRi T34555.
    RefSeqi NP_001258875.1. NM_001271946.1.
    NP_003053.1. NM_003062.3.
    UniGenei Hs.552087.

    3D structure databases

    ProteinModelPortali O75094.
    SMRi O75094. Positions 277-485, 505-712, 725-905.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112473. 1 interaction.
    IntActi O75094. 3 interactions.
    MINTi MINT-2797284.
    STRINGi 9606.ENSP00000332164.

    PTM databases

    PhosphoSitei O75094.

    Proteomic databases

    MaxQBi O75094.
    PaxDbi O75094.
    PRIDEi O75094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332966 ; ENSP00000332164 ; ENSG00000184347 . [O75094-4 ]
    ENST00000404867 ; ENSP00000384890 ; ENSG00000184347 . [O75094-3 ]
    ENST00000519560 ; ENSP00000430333 ; ENSG00000184347 . [O75094-1 ]
    GeneIDi 6586.
    KEGGi hsa:6586.
    UCSCi uc003mab.4. human. [O75094-1 ]

    Organism-specific databases

    CTDi 6586.
    GeneCardsi GC05M168021.
    H-InvDB HIX0005394.
    HGNCi HGNC:11087. SLIT3.
    HPAi HPA051630.
    MIMi 603745. gene.
    neXtProti NX_O75094.
    PharmGKBi PA35940.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116120.
    HOVERGENi HBG057959.
    InParanoidi O75094.
    KOi K06850.
    OrthoDBi EOG78WKQW.
    PhylomeDBi O75094.
    TreeFami TF332887.

    Enzyme and pathway databases

    Reactomei REACT_22237. Netrin-1 signaling.

    Miscellaneous databases

    ChiTaRSi SLIT3. human.
    GeneWikii SLIT3.
    GenomeRNAii 6586.
    NextBioi 25629.
    PROi O75094.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75094.
    Bgeei O75094.
    CleanExi HS_SLIT3.
    Genevestigatori O75094.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00008. EGF. 6 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view ]
    SMARTi SM00041. CT. 1 hit.
    SM00181. EGF. 8 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 9 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 7 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 20 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
      Itoh A., Miyabayashi T., Ohno M., Sakano S.
      Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANT ALA-371.
    2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-371.
      Tissue: Brain.
    3. Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-371 AND SER-618.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-371.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, VARIANT ALA-371.
      Tissue: Testis.
    8. "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis."
      Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T., Little M.H.
      Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).

    Entry informationi

    Entry nameiSLIT3_HUMAN
    AccessioniPrimary (citable) accession number: O75094
    Secondary accession number(s): A6H8U9
    , J3KNP3, O95804, Q9UFH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3