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O75094 (SLIT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Slit homolog 3 protein

Short name=Slit-3
Alternative name(s):
Multiple epidermal growth factor-like domains protein 5
Short name=Multiple EGF-like domains protein 5
Gene names
Name:SLIT3
Synonyms:KIAA0814, MEGF5, SLIL2
ORF Names:UNQ691/PRO1336
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

Subcellular location

Secreted By similarity.

Tissue specificity

Predominantly expressed in thyroid. Ref.1

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 9 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 20 LRR (leucine-rich) repeats.

Contains 4 LRRCT domains.

Contains 4 LRRNT domains.

Sequence caution

The sequence BAA32466.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAB59249.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Leucine-rich repeat
Repeat
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRoundabout signaling pathway

Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL

apoptotic process involved in luteolysis

Inferred from expression pattern PubMed 18566128. Source: UniProtKB

axon extension involved in axon guidance

Inferred from direct assay PubMed 16840550. Source: UniProtKB

axon guidance

Inferred from direct assay PubMed 11748139. Source: UniProtKB

cellular response to hormone stimulus

Inferred from expression pattern PubMed 18566128. Source: UniProtKB

negative chemotaxis

Inferred from direct assay PubMed 11748139. Source: UniProtKB

negative regulation of cell growth

Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of chemokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

response to cortisol

Inferred from expression pattern PubMed 18566128. Source: UniProtKB

   Cellular_componentextracellular space

Inferred from direct assay PubMed 19741192. Source: UniProtKB

mitochondrion

Non-traceable author statement PubMed 11443047. Source: UniProtKB

   Molecular_functionRoundabout binding

Inferred from physical interaction PubMed 15207848. Source: UniProtKB

calcium ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75094-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75094-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1216: Missing.
Isoform 3 (identifier: O75094-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 15231490Slit homolog 3 protein
PRO_0000007732

Regions

Domain34 – 6128LRRNT
Repeat62 – 8322LRR 1
Repeat86 – 10722LRR 2
Repeat110 – 13122LRR 3
Repeat134 – 15522LRR 4
Repeat158 – 17922LRR 5
Repeat182 – 20322LRR 6
Domain215 – 26551LRRCT 1
Domain271 – 30737LRRNT 2
Repeat308 – 32922LRR 7
Repeat332 – 35322LRR 8
Repeat356 – 37722LRR 9
Repeat380 – 40122LRR 10
Repeat404 – 42522LRR 11
Domain437 – 48751LRRCT 2
Domain496 – 53237LRRNT 3
Repeat533 – 55422LRR 12
Repeat558 – 57922LRR 13
Repeat582 – 60322LRR 14
Repeat606 – 62722LRR 15
Repeat630 – 65122LRR 16
Domain663 – 71351LRRCT 3
Domain716 – 75237LRRNT 4
Repeat753 – 77523LRR 17
Repeat776 – 79722LRR 18
Repeat800 – 82122LRR 19
Repeat824 – 84522LRR 20
Domain857 – 90751LRRCT 4
Domain918 – 95336EGF-like 1
Domain955 – 99440EGF-like 2
Domain996 – 103237EGF-like 3
Domain1034 – 107239EGF-like 4
Domain1074 – 111037EGF-like 5
Domain1119 – 115537EGF-like 6
Domain1158 – 1332175Laminin G-like
Domain1340 – 136526EGF-like 7
Domain1368 – 140336EGF-like 8
Domain1408 – 144437EGF-like 9
Domain1449 – 152375CTCK

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation5631N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation7841N-linked (GlcNAc...) Potential
Glycosylation7921N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential
Glycosylation9281N-linked (GlcNAc...) Potential
Glycosylation10081N-linked (GlcNAc...) Potential
Glycosylation10251N-linked (GlcNAc...) Potential
Glycosylation11811N-linked (GlcNAc...) Potential
Glycosylation12471N-linked (GlcNAc...) Potential
Glycosylation14061N-linked (GlcNAc...) Potential
Disulfide bond284 ↔ 293 By similarity
Disulfide bond441 ↔ 464 By similarity
Disulfide bond443 ↔ 485 By similarity
Disulfide bond505 ↔ 511 By similarity
Disulfide bond509 ↔ 518 By similarity
Disulfide bond667 ↔ 690 By similarity
Disulfide bond669 ↔ 711 By similarity
Disulfide bond920 ↔ 931 By similarity
Disulfide bond925 ↔ 941 By similarity
Disulfide bond943 ↔ 952 By similarity
Disulfide bond959 ↔ 970 By similarity
Disulfide bond964 ↔ 982 By similarity
Disulfide bond984 ↔ 993 By similarity
Disulfide bond1000 ↔ 1011 By similarity
Disulfide bond1005 ↔ 1020 By similarity
Disulfide bond1022 ↔ 1031 By similarity
Disulfide bond1038 ↔ 1051 By similarity
Disulfide bond1045 ↔ 1060 By similarity
Disulfide bond1062 ↔ 1071 By similarity
Disulfide bond1078 ↔ 1089 By similarity
Disulfide bond1083 ↔ 1098 By similarity
Disulfide bond1100 ↔ 1109 By similarity
Disulfide bond1123 ↔ 1134 By similarity
Disulfide bond1128 ↔ 1143 By similarity
Disulfide bond1145 ↔ 1154 By similarity
Disulfide bond1305 ↔ 1332 By similarity
Disulfide bond1355 ↔ 1364 By similarity
Disulfide bond1372 ↔ 1382 By similarity
Disulfide bond1377 ↔ 1391 By similarity
Disulfide bond1393 ↔ 1402 By similarity
Disulfide bond1412 ↔ 1422 By similarity
Disulfide bond1417 ↔ 1432 By similarity
Disulfide bond1434 ↔ 1443 By similarity
Disulfide bond1449 ↔ 1487 By similarity
Disulfide bond1467 ↔ 1501 By similarity
Disulfide bond1478 ↔ 1517 By similarity
Disulfide bond1482 ↔ 1519 By similarity

Natural variations

Alternative sequence1117 – 1216100Missing in isoform 2.
VSP_009714
Alternative sequence1446 – 152378ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3.
VSP_009715
Natural variant3711V → A. Ref.1 Ref.2 Ref.4 Ref.6 Ref.7
Corresponds to variant rs891921 [ dbSNP | Ensembl ].
VAR_049004
Natural variant3951R → Q.
Corresponds to variant rs2288792 [ dbSNP | Ensembl ].
VAR_021905
Natural variant6181G → S. Ref.4
Corresponds to variant rs10036727 [ dbSNP | Ensembl ].
VAR_024265
Natural variant8101R → Q.
Corresponds to variant rs36052924 [ dbSNP | Ensembl ].
VAR_049005
Natural variant9941E → G.
Corresponds to variant rs2305993 [ dbSNP | Ensembl ].
VAR_020168
Natural variant10641P → A.
Corresponds to variant rs10072243 [ dbSNP | Ensembl ].
VAR_049006

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: CEB00887F6908554

FASTA1,523167,713
        10         20         30         40         50         60 
MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP 

        70         80         90        100        110        120 
RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK 

       130        140        150        160        170        180 
LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL 

       190        200        210        220        230        240 
RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT 

       250        260        270        280        290        300 
LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 

       310        320        330        340        350        360 
IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL 

       370        380        390        400        410        420 
VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK 

       430        440        450        460        470        480 
GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS 

       490        500        510        520        530        540 
KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN 

       550        560        570        580        590        600 
DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 

       610        620        630        640        650        660 
FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL 

       670        680        690        700        710        720 
LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ 

       730        740        750        760        770        780 
LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI 

       790        800        810        820        830        840 
DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE 

       850        860        870        880        890        900 
GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 

       910        920        930        940        950        960 
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI 

       970        980        990       1000       1010       1020 
QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC 

      1030       1040       1050       1060       1070       1080 
ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA 

      1090       1100       1110       1120       1130       1140 
HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE 

      1150       1160       1170       1180       1190       1200 
PTCRCPPGFA GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 

      1210       1220       1230       1240       1250       1260 
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL NLVVDKGTPK 

      1270       1280       1290       1300       1310       1320 
SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG GFHGCIHEVR INNELQDFKA 

      1330       1340       1350       1360       1370       1380 
LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT GPLCDQEARD PCLGHRCHHG 

      1390       1400       1410       1420       1430       1440 
KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG 

      1450       1460       1470       1480       1490       1500 
EHCQQENPCL GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ 

      1510       1520 
CTDGSSFVEE VERHLECGCL ACS 

« Hide

Isoform 2 [UniParc].

Checksum: 4A5F62D857F47D19
Show »

FASTA1,423156,766
Isoform 3 [UniParc].

Checksum: 6BF26D278F72D157
Show »

FASTA1,472162,157

References

« Hide 'large scale' references
[1]"Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
Itoh A., Miyabayashi T., Ohno M., Sakano S.
Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, VARIANT ALA-371.
[2]"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-371.
Tissue: Brain.
[3]Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-371 AND SER-618.
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-371.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-657, VARIANT ALA-371.
Tissue: Testis.
[8]"Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis."
Holmes G.P., Negus K., Burridge L., Raman S., Algar E., Yamada T., Little M.H.
Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-1523 (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017169 mRNA. Translation: BAA35186.1.
AB011538 mRNA. Translation: BAA32466.2. Different initiation.
AY358884 mRNA. Translation: AAQ89243.1.
AC008409 Genomic DNA. No translation available.
AC008479 Genomic DNA. No translation available.
AC011365 Genomic DNA. No translation available.
AC011389 Genomic DNA. No translation available.
AC027311 Genomic DNA. No translation available.
AC094081 Genomic DNA. No translation available.
AC112165 Genomic DNA. No translation available.
BC146759 mRNA. Translation: AAI46760.1.
AL122074 mRNA. Translation: CAB59249.1. Sequence problems.
AF075240 mRNA. Translation: AAD19336.1.
PIRT34555.
RefSeqNP_001258875.1. NM_001271946.1.
NP_003053.1. NM_003062.3.
UniGeneHs.552087.

3D structure databases

ProteinModelPortalO75094.
SMRO75094. Positions 277-485, 505-712, 725-905.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112473. 1 interaction.
IntActO75094. 2 interactions.
MINTMINT-2797284.
STRING9606.ENSP00000332164.

PTM databases

PhosphoSiteO75094.

Proteomic databases

PaxDbO75094.
PRIDEO75094.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000404867; ENSP00000384890; ENSG00000184347. [O75094-3]
ENST00000519560; ENSP00000430333; ENSG00000184347. [O75094-1]
GeneID6586.
KEGGhsa:6586.
UCSCuc003mab.4. human. [O75094-1]

Organism-specific databases

CTD6586.
GeneCardsGC05M168021.
H-InvDBHIX0005394.
HGNCHGNC:11087. SLIT3.
HPAHPA051630.
MIM603745. gene.
neXtProtNX_O75094.
PharmGKBPA35940.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116120.
HOVERGENHBG057959.
InParanoidO75094.
KOK06850.
OrthoDBEOG78WKQW.
PhylomeDBO75094.
TreeFamTF332887.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressO75094.
BgeeO75094.
CleanExHS_SLIT3.
GenevestigatorO75094.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF00008. EGF. 6 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTSM00041. CT. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLIT3. human.
GeneWikiSLIT3.
GenomeRNAi6586.
NextBio25629.
PROO75094.
SOURCESearch...

Entry information

Entry nameSLIT3_HUMAN
AccessionPrimary (citable) accession number: O75094
Secondary accession number(s): A6H8U9, O95804, Q9UFH5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM