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O75093

- SLIT1_HUMAN

UniProt

O75093 - SLIT1_HUMAN

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Protein

Slit homolog 1 protein

Gene

SLIT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Roundabout binding Source: UniProtKB

GO - Biological processi

  1. axon extension involved in axon guidance Source: UniProtKB
  2. axon guidance Source: UniProtKB
  3. dorsal/ventral axon guidance Source: Ensembl
  4. establishment of nucleus localization Source: Ensembl
  5. forebrain morphogenesis Source: UniProtKB
  6. motor neuron axon guidance Source: UniProtKB
  7. negative chemotaxis Source: UniProtKB
  8. negative regulation of axon extension involved in axon guidance Source: Ensembl
  9. negative regulation of synapse assembly Source: UniProtKB
  10. retinal ganglion cell axon guidance Source: Ensembl
  11. spinal cord development Source: Ensembl
  12. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_22237. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name:
Multiple EGF-like domains protein 4
Gene namesi
Name:SLIT1
Synonyms:KIAA0813, MEGF4, SLIL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11085. SLIT1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 15341501Slit homolog 1 proteinPRO_0000007722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi286 ↔ 295By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi443 ↔ 466By similarity
Disulfide bondi445 ↔ 487By similarity
Disulfide bondi513 ↔ 519By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi675 ↔ 698By similarity
Disulfide bondi677 ↔ 719By similarity
Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi929 ↔ 940By similarity
Disulfide bondi934 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 991By similarity
Disulfide bondi993 ↔ 1002By similarity
Disulfide bondi1009 ↔ 1020By similarity
Disulfide bondi1014 ↔ 1029By similarity
Glycosylationi1026 – 10261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1047 ↔ 1060By similarity
Disulfide bondi1054 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1107By similarity
Disulfide bondi1109 ↔ 1118By similarity
Disulfide bondi1131 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1151By similarity
Disulfide bondi1153 ↔ 1162By similarity
Glycosylationi1189 – 11891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1259 – 12591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1306 – 13061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1313 ↔ 1339By similarity
Disulfide bondi1342 ↔ 1352By similarity
Disulfide bondi1347 ↔ 1362By similarity
Disulfide bondi1364 ↔ 1373By similarity
Disulfide bondi1381 ↔ 1391By similarity
Disulfide bondi1386 ↔ 1401By similarity
Disulfide bondi1403 ↔ 1412By similarity
Disulfide bondi1422 ↔ 1432By similarity
Disulfide bondi1427 ↔ 1442By similarity
Disulfide bondi1444 ↔ 1453By similarity
Disulfide bondi1459 ↔ 1498By similarity
Disulfide bondi1477 ↔ 1512By similarity
Disulfide bondi1488 ↔ 1528By similarity
Disulfide bondi1492 ↔ 1530By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75093.
PaxDbiO75093.
PRIDEiO75093.

PTM databases

PhosphoSiteiO75093.

Expressioni

Tissue specificityi

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.1 Publication

Gene expression databases

BgeeiO75093.
CleanExiHS_SLIT1.
ExpressionAtlasiO75093. baseline.
GenevestigatoriO75093.

Organism-specific databases

HPAiHPA006879.

Interactioni

Subunit structurei

Interacts with ROBO1 and GREM1.By similarity

Protein-protein interaction databases

BioGridi112472. 1 interaction.
IntActiO75093. 2 interactions.
MINTiMINT-2797238.
STRINGi9606.ENSP00000266058.

Structurei

3D structure databases

ProteinModelPortaliO75093.
SMRiO75093. Positions 30-1454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Domaini215 – 26551LRRCT 1Add
BLAST
Domaini273 – 30937LRRNT 2Add
BLAST
Repeati310 – 33122LRR 7Add
BLAST
Repeati334 – 35522LRR 8Add
BLAST
Repeati358 – 37922LRR 9Add
BLAST
Repeati382 – 40322LRR 10Add
BLAST
Repeati406 – 42722LRR 11Add
BLAST
Domaini439 – 48951LRRCT 2Add
BLAST
Domaini504 – 54037LRRNT 3Add
BLAST
Repeati541 – 56222LRR 12Add
BLAST
Repeati566 – 58722LRR 13Add
BLAST
Repeati590 – 61122LRR 14Add
BLAST
Repeati614 – 63522LRR 15Add
BLAST
Repeati638 – 65922LRR 16Add
BLAST
Domaini671 – 72151LRRCT 3Add
BLAST
Domaini725 – 76137LRRNT 4Add
BLAST
Repeati762 – 78322LRR 17Add
BLAST
Repeati785 – 80622LRR 18Add
BLAST
Repeati809 – 83022LRR 19Add
BLAST
Repeati833 – 85422LRR 20Add
BLAST
Domaini866 – 91651LRRCT 4Add
BLAST
Domaini927 – 96236EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini964 – 100340EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 104137EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 108139EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini1083 – 111937EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1127 – 116337EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini1166 – 1339174Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini1340 – 137435EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini1377 – 141337EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini1418 – 145437EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini1459 – 153476CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75093.
KOiK06838.
OrthoDBiEOG78WKQW.
PhylomeDBiO75093.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75093-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR
160 170 180 190 200
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN
560 570 580 590 600
EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ
610 620 630 640 650
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT
660 670 680 690 700
TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME
910 920 930 940 950
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP
1010 1020 1030 1040 1050
TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD
1060 1070 1080 1090 1100
LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD
1110 1120 1130 1140 1150
EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV
1160 1170 1180 1190 1200
CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN
1210 1220 1230 1240 1250
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE
1260 1270 1280 1290 1300
LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR
1310 1320 1330 1340 1350
LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG
1360 1370 1380 1390 1400
ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS
1410 1420 1430 1440 1450
CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG
1460 1470 1480 1490 1500
ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG
1510 1520 1530
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA
Length:1,534
Mass (Da):167,926
Last modified:April 17, 2007 - v4
Checksum:i47B11CE6704A3E1D
GO
Isoform 2 (identifier: O75093-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Show »
Length:815
Mass (Da):90,633
Checksum:i4E435E97AD79F37C
GO

Sequence cautioni

The sequence BAA32465.3 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991A → V in BAA32465. (PubMed:9693030)Curated
Sequence conflicti163 – 1631Q → R in BAA35184. (PubMed:9813312)Curated
Sequence conflicti829 – 8291Q → P in AAK31796. (PubMed:12141424)Curated
Sequence conflicti966 – 9661D → N in BAA35184. (PubMed:9813312)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti824 – 8241P → L.
Corresponds to variant rs2817673 [ dbSNP | Ensembl ].
VAR_049003

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 3381I → IRPLSFCSPCR in isoform 2. 1 PublicationVSP_009706
Alternative sequencei790 – 81324Missing in isoform 2. 1 PublicationVSP_009707Add
BLAST
Alternative sequencei830 – 1534705Missing in isoform 2. 1 PublicationVSP_009708Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017167 mRNA. Translation: BAA35184.1.
AB011537 mRNA. Translation: BAA32465.3. Different initiation.
AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
CH471066 Genomic DNA. Translation: EAW49958.1.
BC146851 mRNA. Translation: AAI46852.1.
AY029183 mRNA. Translation: AAK31796.1.
CCDSiCCDS7453.1. [O75093-1]
RefSeqiNP_003052.2. NM_003061.2. [O75093-1]
UniGeneiHs.632082.

Genome annotation databases

EnsembliENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
GeneIDi6585.
KEGGihsa:6585.
UCSCiuc001kmw.2. human. [O75093-1]
uc009xvh.1. human. [O75093-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017167 mRNA. Translation: BAA35184.1 .
AB011537 mRNA. Translation: BAA32465.3 . Different initiation.
AL442123 , AL512424 Genomic DNA. Translation: CAH70918.1 .
AL512424 , AL442123 Genomic DNA. Translation: CAI14258.1 .
CH471066 Genomic DNA. Translation: EAW49958.1 .
BC146851 mRNA. Translation: AAI46852.1 .
AY029183 mRNA. Translation: AAK31796.1 .
CCDSi CCDS7453.1. [O75093-1 ]
RefSeqi NP_003052.2. NM_003061.2. [O75093-1 ]
UniGenei Hs.632082.

3D structure databases

ProteinModelPortali O75093.
SMRi O75093. Positions 30-1454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112472. 1 interaction.
IntActi O75093. 2 interactions.
MINTi MINT-2797238.
STRINGi 9606.ENSP00000266058.

PTM databases

PhosphoSitei O75093.

Proteomic databases

MaxQBi O75093.
PaxDbi O75093.
PRIDEi O75093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266058 ; ENSP00000266058 ; ENSG00000187122 . [O75093-1 ]
GeneIDi 6585.
KEGGi hsa:6585.
UCSCi uc001kmw.2. human. [O75093-1 ]
uc009xvh.1. human. [O75093-2 ]

Organism-specific databases

CTDi 6585.
GeneCardsi GC10M098747.
H-InvDB HIX0079168.
HIX0170440.
HGNCi HGNC:11085. SLIT1.
HPAi HPA006879.
MIMi 603742. gene.
neXtProti NX_O75093.
PharmGKBi PA35938.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000116120.
HOVERGENi HBG057959.
InParanoidi O75093.
KOi K06838.
OrthoDBi EOG78WKQW.
PhylomeDBi O75093.
TreeFami TF332887.

Enzyme and pathway databases

Reactomei REACT_22237. Netrin-1 signaling.

Miscellaneous databases

ChiTaRSi SLIT1. human.
GeneWikii SLIT1.
GenomeRNAii 6585.
NextBioi 25625.
PROi O75093.
SOURCEi Search...

Gene expression databases

Bgeei O75093.
CleanExi HS_SLIT1.
ExpressionAtlasi O75093. baseline.
Genevestigatori O75093.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view ]
SMARTi SM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
    Itoh A., Miyabayashi T., Ohno M., Sakano S.
    Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Nakayama M., Nakajima D., Ohara O.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Conserved modularity and potential for alternate splicing in mouse and human Slit genes."
    Little M., Rumballe B., Georgas K., Yamada T., Teasdale R.D.
    Int. J. Dev. Biol. 46:385-391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1534 (ISOFORM 2).
  9. "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes."
    Wong K., Park H.T., Wu J.Y., Rao Y.
    Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiSLIT1_HUMAN
AccessioniPrimary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3