Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Slit homolog 1 protein

Gene

SLIT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • heparin binding Source: GO_Central
  • Roundabout binding Source: UniProtKB

GO - Biological processi

  • axon extension involved in axon guidance Source: UniProtKB
  • axon guidance Source: UniProtKB
  • dorsal/ventral axon guidance Source: Ensembl
  • establishment of nucleus localization Source: Ensembl
  • forebrain morphogenesis Source: UniProtKB
  • motor neuron axon guidance Source: UniProtKB
  • negative chemotaxis Source: UniProtKB
  • negative regulation of synapse assembly Source: UniProtKB
  • regulation of axonogenesis Source: GO_Central
  • retinal ganglion cell axon guidance Source: Ensembl
  • Roundabout signaling pathway Source: GO_Central
  • tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:G66-32469-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
SIGNORiO75093.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name:
Multiple EGF-like domains protein 4
Gene namesi
Name:SLIT1
Synonyms:KIAA0813, MEGF4, SLIL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11085. SLIT1.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: UniProtKB
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6585.
OpenTargetsiENSG00000187122.
PharmGKBiPA35938.

Polymorphism and mutation databases

BioMutaiSLIT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000772234 – 1534Slit homolog 1 proteinAdd BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi286 ↔ 295By similarity
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi443 ↔ 466By similarity
Disulfide bondi445 ↔ 487By similarity
Disulfide bondi513 ↔ 519By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi571N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi675 ↔ 698By similarity
Disulfide bondi677 ↔ 719By similarity
Glycosylationi762N-linked (GlcNAc...)Sequence analysis1
Glycosylationi801N-linked (GlcNAc...)Sequence analysis1
Glycosylationi806N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi929 ↔ 940By similarity
Disulfide bondi934 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 991By similarity
Disulfide bondi993 ↔ 1002By similarity
Disulfide bondi1009 ↔ 1020By similarity
Disulfide bondi1014 ↔ 1029By similarity
Glycosylationi1026N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1047 ↔ 1060By similarity
Disulfide bondi1054 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1107By similarity
Disulfide bondi1109 ↔ 1118By similarity
Disulfide bondi1131 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1151By similarity
Disulfide bondi1153 ↔ 1162By similarity
Glycosylationi1189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1306N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1313 ↔ 1339By similarity
Disulfide bondi1342 ↔ 1352By similarity
Disulfide bondi1347 ↔ 1362By similarity
Disulfide bondi1364 ↔ 1373By similarity
Disulfide bondi1381 ↔ 1391By similarity
Disulfide bondi1386 ↔ 1401By similarity
Disulfide bondi1403 ↔ 1412By similarity
Disulfide bondi1422 ↔ 1432By similarity
Disulfide bondi1427 ↔ 1442By similarity
Disulfide bondi1444 ↔ 1453By similarity
Disulfide bondi1459 ↔ 1498By similarity
Disulfide bondi1477 ↔ 1512By similarity
Disulfide bondi1488 ↔ 1528By similarity
Disulfide bondi1492 ↔ 1530By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO75093.
PaxDbiO75093.
PeptideAtlasiO75093.
PRIDEiO75093.

PTM databases

iPTMnetiO75093.
PhosphoSitePlusiO75093.

Expressioni

Tissue specificityi

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000187122.
CleanExiHS_SLIT1.
ExpressionAtlasiO75093. baseline and differential.
GenevisibleiO75093. HS.

Organism-specific databases

HPAiHPA006879.

Interactioni

Subunit structurei

Interacts with ROBO1 and GREM1.By similarity

GO - Molecular functioni

  • Roundabout binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112472. 1 interactor.
IntActiO75093. 8 interactors.
MINTiMINT-2797238.
STRINGi9606.ENSP00000266058.

Structurei

3D structure databases

ProteinModelPortaliO75093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 61LRRNTAdd BLAST28
Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Domaini215 – 265LRRCT 1Add BLAST51
Domaini273 – 309LRRNT 2Add BLAST37
Repeati310 – 331LRR 7Add BLAST22
Repeati334 – 355LRR 8Add BLAST22
Repeati358 – 379LRR 9Add BLAST22
Repeati382 – 403LRR 10Add BLAST22
Repeati406 – 427LRR 11Add BLAST22
Domaini439 – 489LRRCT 2Add BLAST51
Domaini504 – 540LRRNT 3Add BLAST37
Repeati541 – 562LRR 12Add BLAST22
Repeati566 – 587LRR 13Add BLAST22
Repeati590 – 611LRR 14Add BLAST22
Repeati614 – 635LRR 15Add BLAST22
Repeati638 – 659LRR 16Add BLAST22
Domaini671 – 721LRRCT 3Add BLAST51
Domaini725 – 761LRRNT 4Add BLAST37
Repeati762 – 783LRR 17Add BLAST22
Repeati785 – 806LRR 18Add BLAST22
Repeati809 – 830LRR 19Add BLAST22
Repeati833 – 854LRR 20Add BLAST22
Domaini866 – 916LRRCT 4Add BLAST51
Domaini927 – 962EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini964 – 1003EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini1005 – 1041EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini1043 – 1081EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1083 – 1119EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini1127 – 1163EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1166 – 1339Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1340 – 1374EGF-like 7PROSITE-ProRule annotationAdd BLAST35
Domaini1377 – 1413EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini1418 – 1454EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini1459 – 1534CTCKPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129708.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75093.
KOiK06838.
OrthoDBiEOG091G0MHP.
PhylomeDBiO75093.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 5 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 18 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75093-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR
160 170 180 190 200
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN
560 570 580 590 600
EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ
610 620 630 640 650
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT
660 670 680 690 700
TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME
910 920 930 940 950
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP
1010 1020 1030 1040 1050
TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD
1060 1070 1080 1090 1100
LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD
1110 1120 1130 1140 1150
EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV
1160 1170 1180 1190 1200
CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN
1210 1220 1230 1240 1250
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE
1260 1270 1280 1290 1300
LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR
1310 1320 1330 1340 1350
LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG
1360 1370 1380 1390 1400
ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS
1410 1420 1430 1440 1450
CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG
1460 1470 1480 1490 1500
ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG
1510 1520 1530
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA
Length:1,534
Mass (Da):167,926
Last modified:April 17, 2007 - v4
Checksum:i47B11CE6704A3E1D
GO
Isoform 2 (identifier: O75093-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Show »
Length:815
Mass (Da):90,633
Checksum:i4E435E97AD79F37C
GO

Sequence cautioni

The sequence BAA32465 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99A → V in BAA32465 (PubMed:9693030).Curated1
Sequence conflicti163Q → R in BAA35184 (PubMed:9813312).Curated1
Sequence conflicti829Q → P in AAK31796 (PubMed:12141424).Curated1
Sequence conflicti966D → N in BAA35184 (PubMed:9813312).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049003824P → L.Corresponds to variant rs2817673dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009706338I → IRPLSFCSPCR in isoform 2. 1 Publication1
Alternative sequenceiVSP_009707790 – 813Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_009708830 – 1534Missing in isoform 2. 1 PublicationAdd BLAST705

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017167 mRNA. Translation: BAA35184.1.
AB011537 mRNA. Translation: BAA32465.3. Different initiation.
AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
CH471066 Genomic DNA. Translation: EAW49958.1.
BC146851 mRNA. Translation: AAI46852.1.
AY029183 mRNA. Translation: AAK31796.1.
CCDSiCCDS7453.1. [O75093-1]
RefSeqiNP_003052.2. NM_003061.2. [O75093-1]
UniGeneiHs.632082.

Genome annotation databases

EnsembliENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
GeneIDi6585.
KEGGihsa:6585.
UCSCiuc001kmw.3. human. [O75093-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017167 mRNA. Translation: BAA35184.1.
AB011537 mRNA. Translation: BAA32465.3. Different initiation.
AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
CH471066 Genomic DNA. Translation: EAW49958.1.
BC146851 mRNA. Translation: AAI46852.1.
AY029183 mRNA. Translation: AAK31796.1.
CCDSiCCDS7453.1. [O75093-1]
RefSeqiNP_003052.2. NM_003061.2. [O75093-1]
UniGeneiHs.632082.

3D structure databases

ProteinModelPortaliO75093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112472. 1 interactor.
IntActiO75093. 8 interactors.
MINTiMINT-2797238.
STRINGi9606.ENSP00000266058.

PTM databases

iPTMnetiO75093.
PhosphoSitePlusiO75093.

Polymorphism and mutation databases

BioMutaiSLIT1.

Proteomic databases

EPDiO75093.
PaxDbiO75093.
PeptideAtlasiO75093.
PRIDEiO75093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
GeneIDi6585.
KEGGihsa:6585.
UCSCiuc001kmw.3. human. [O75093-1]

Organism-specific databases

CTDi6585.
DisGeNETi6585.
GeneCardsiSLIT1.
H-InvDBHIX0079168.
HIX0170440.
HGNCiHGNC:11085. SLIT1.
HPAiHPA006879.
MIMi603742. gene.
neXtProtiNX_O75093.
OpenTargetsiENSG00000187122.
PharmGKBiPA35938.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129708.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75093.
KOiK06838.
OrthoDBiEOG091G0MHP.
PhylomeDBiO75093.
TreeFamiTF332887.

Enzyme and pathway databases

BioCyciZFISH:G66-32469-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
SIGNORiO75093.

Miscellaneous databases

ChiTaRSiSLIT1. human.
GeneWikiiSLIT1.
GenomeRNAii6585.
PROiO75093.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187122.
CleanExiHS_SLIT1.
ExpressionAtlasiO75093. baseline and differential.
GenevisibleiO75093. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 5 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 18 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIT1_HUMAN
AccessioniPrimary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 161 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.