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O75093 (SLIT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Slit homolog 1 protein

Short name=Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name=Multiple EGF-like domains protein 4
Gene names
Name:SLIT1
Synonyms:KIAA0813, MEGF4, SLIL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1534 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Subunit structure

Interacts with ROBO1 and GREM1 By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. Ref.1

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 9 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 20 LRR (leucine-rich) repeats.

Contains 4 LRRCT domains.

Contains 4 LRRNT domains.

Sequence caution

The sequence BAA32465.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Leucine-rich repeat
Repeat
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon extension involved in axon guidance

Inferred from direct assay PubMed 16840550. Source: UniProtKB

axon guidance

Inferred from direct assay PubMed 11748139. Source: UniProtKB

dorsal/ventral axon guidance

Inferred from electronic annotation. Source: Ensembl

establishment of nucleus localization

Inferred from electronic annotation. Source: Ensembl

forebrain morphogenesis

Non-traceable author statement Ref.1. Source: UniProtKB

motor neuron axon guidance

Inferred from mutant phenotype PubMed 16162649. Source: UniProtKB

negative chemotaxis

Inferred from direct assay PubMed 11748139. Source: UniProtKB

negative regulation of axon extension involved in axon guidance

Inferred from electronic annotation. Source: Ensembl

negative regulation of synapse assembly

Inferred from sequence or structural similarity. Source: UniProtKB

retinal ganglion cell axon guidance

Inferred from electronic annotation. Source: Ensembl

spinal cord development

Inferred from electronic annotation. Source: Ensembl

tangential migration from the subventricular zone to the olfactory bulb

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionRoundabout binding

Inferred from physical interaction PubMed 15207848. Source: UniProtKB

calcium ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75093-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75093-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 15341501Slit homolog 1 protein
PRO_0000007722

Regions

Domain34 – 6128LRRNT
Repeat62 – 8322LRR 1
Repeat86 – 10722LRR 2
Repeat110 – 13122LRR 3
Repeat134 – 15522LRR 4
Repeat158 – 17922LRR 5
Repeat182 – 20322LRR 6
Domain215 – 26551LRRCT 1
Domain273 – 30937LRRNT 2
Repeat310 – 33122LRR 7
Repeat334 – 35522LRR 8
Repeat358 – 37922LRR 9
Repeat382 – 40322LRR 10
Repeat406 – 42722LRR 11
Domain439 – 48951LRRCT 2
Domain504 – 54037LRRNT 3
Repeat541 – 56222LRR 12
Repeat566 – 58722LRR 13
Repeat590 – 61122LRR 14
Repeat614 – 63522LRR 15
Repeat638 – 65922LRR 16
Domain671 – 72151LRRCT 3
Domain725 – 76137LRRNT 4
Repeat762 – 78322LRR 17
Repeat785 – 80622LRR 18
Repeat809 – 83022LRR 19
Repeat833 – 85422LRR 20
Domain866 – 91651LRRCT 4
Domain927 – 96236EGF-like 1
Domain964 – 100340EGF-like 2
Domain1005 – 104137EGF-like 3
Domain1043 – 108139EGF-like 4
Domain1083 – 111937EGF-like 5
Domain1127 – 116337EGF-like 6
Domain1166 – 1339174Laminin G-like
Domain1340 – 137435EGF-like 7
Domain1377 – 141337EGF-like 8
Domain1418 – 145437EGF-like 9
Domain1459 – 153476CTCK

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation5711N-linked (GlcNAc...) Potential
Glycosylation6301N-linked (GlcNAc...) Potential
Glycosylation7621N-linked (GlcNAc...) Potential
Glycosylation8011N-linked (GlcNAc...) Potential
Glycosylation8061N-linked (GlcNAc...) Potential
Glycosylation10261N-linked (GlcNAc...) Potential
Glycosylation10791N-linked (GlcNAc...) Potential
Glycosylation11891N-linked (GlcNAc...) Potential
Glycosylation12591N-linked (GlcNAc...) Potential
Glycosylation13061N-linked (GlcNAc...) Potential
Disulfide bond286 ↔ 295 By similarity
Disulfide bond443 ↔ 466 By similarity
Disulfide bond445 ↔ 487 By similarity
Disulfide bond513 ↔ 519 By similarity
Disulfide bond517 ↔ 526 By similarity
Disulfide bond675 ↔ 698 By similarity
Disulfide bond677 ↔ 719 By similarity
Disulfide bond929 ↔ 940 By similarity
Disulfide bond934 ↔ 950 By similarity
Disulfide bond952 ↔ 961 By similarity
Disulfide bond968 ↔ 979 By similarity
Disulfide bond973 ↔ 991 By similarity
Disulfide bond993 ↔ 1002 By similarity
Disulfide bond1009 ↔ 1020 By similarity
Disulfide bond1014 ↔ 1029 By similarity
Disulfide bond1031 ↔ 1040 By similarity
Disulfide bond1047 ↔ 1060 By similarity
Disulfide bond1054 ↔ 1069 By similarity
Disulfide bond1071 ↔ 1080 By similarity
Disulfide bond1087 ↔ 1098 By similarity
Disulfide bond1092 ↔ 1107 By similarity
Disulfide bond1109 ↔ 1118 By similarity
Disulfide bond1131 ↔ 1142 By similarity
Disulfide bond1136 ↔ 1151 By similarity
Disulfide bond1153 ↔ 1162 By similarity
Disulfide bond1313 ↔ 1339 By similarity
Disulfide bond1342 ↔ 1352 By similarity
Disulfide bond1347 ↔ 1362 By similarity
Disulfide bond1364 ↔ 1373 By similarity
Disulfide bond1381 ↔ 1391 By similarity
Disulfide bond1386 ↔ 1401 By similarity
Disulfide bond1403 ↔ 1412 By similarity
Disulfide bond1422 ↔ 1432 By similarity
Disulfide bond1427 ↔ 1442 By similarity
Disulfide bond1444 ↔ 1453 By similarity
Disulfide bond1459 ↔ 1498 By similarity
Disulfide bond1477 ↔ 1512 By similarity
Disulfide bond1488 ↔ 1528 By similarity
Disulfide bond1492 ↔ 1530 By similarity

Natural variations

Alternative sequence3381I → IRPLSFCSPCR in isoform 2.
VSP_009706
Alternative sequence790 – 81324Missing in isoform 2.
VSP_009707
Alternative sequence830 – 1534705Missing in isoform 2.
VSP_009708
Natural variant8241P → L.
Corresponds to variant rs2817673 [ dbSNP | Ensembl ].
VAR_049003

Experimental info

Sequence conflict991A → V in BAA32465. Ref.2
Sequence conflict1631Q → R in BAA35184. Ref.1
Sequence conflict8291Q → P in AAK31796. Ref.8
Sequence conflict9661D → N in BAA35184. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 4.
Checksum: 47B11CE6704A3E1D

FASTA1,534167,926
        10         20         30         40         50         60 
MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT GLQAIPKNIP 

        70         80         90        100        110        120 
RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV ERGAFDDMKE LERLRLNRNQ 

       130        140        150        160        170        180 
LHMLPELLFQ NNQALSRLDL SENAIQAIPR KAFRGATDLK NLQLDKNQIS CIEEGAFRAL 

       190        200        210        220        230        240 
RGLEVLTLNN NNITTIPVSS FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT 

       250        260        270        280        290        300 
QCSGPASLRG LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL 

       310        320        330        340        350        360 
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP DAFQGLRSLN 

       370        380        390        400        410        420 
SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA FQDLQNLSLL SLYDNKIQSL 

       430        440        450        460        470        480 
AKGTFTSLRA IQTLHLAQNP FICDCNLKWL ADFLRTNPIE TSGARCASPR RLANKRIGQI 

       490        500        510        520        530        540 
KSKKFRCSAK EQYFIPGTED YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ 

       550        560        570        580        590        600 
STAELRLNNN EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ 

       610        620        630        640        650        660 
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT TVSPGAFDTL 

       670        680        690        700        710        720 
QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN PDFLRQIPLQ DVAFPDFRCE 

       730        740        750        760        770        780 
EGQEEGGCLP RPQCPQECAC LDTVVRCSNK HLRALPKGIP KNVTELYLDG NQFTLVPGQL 

       790        800        810        820        830        840 
STFKYLQLVD LSNNKISSLS NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH 

       850        860        870        880        890        900 
GNDISTLQEG IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME 

       910        920        930        940        950        960 
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC ACPSGYKGRD 

       970        980        990       1000       1010       1020 
CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP TCGVNTDDCV DHACANGGVC 

      1030       1040       1050       1060       1070       1080 
VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC 

      1090       1100       1110       1120       1130       1140 
SENQDDCRDH RCQNGAQCMD EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA 

      1150       1160       1170       1180       1190       1200 
NCVDQGNRPV CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN 

      1210       1220       1230       1240       1250       1260 
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE LVAFDQMVNL 

      1270       1280       1290       1300       1310       1320 
SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR LWQILNGTGF HGCIRNLYIN 

      1330       1340       1350       1360       1370       1380 
NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG ICQPNATPGP MCHCEAGWVG LHCDQPADGP 

      1390       1400       1410       1420       1430       1440 
CHGHKCVHGQ CVPLDALSYS CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA 

      1450       1460       1470       1480       1490       1500 
HCVCDPGFSG ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG 

      1510       1520       1530 
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 4E435E97AD79F37C
Show »

FASTA81590,633

References

« Hide 'large scale' references
[1]"Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
Itoh A., Miyabayashi T., Ohno M., Sakano S.
Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]Nakayama M., Nakajima D., Ohara O.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"Conserved modularity and potential for alternate splicing in mouse and human Slit genes."
Little M., Rumballe B., Georgas K., Yamada T., Teasdale R.D.
Int. J. Dev. Biol. 46:385-391(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1534 (ISOFORM 2).
[9]"Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes."
Wong K., Park H.T., Wu J.Y., Rao Y.
Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB017167 mRNA. Translation: BAA35184.1.
AB011537 mRNA. Translation: BAA32465.3. Different initiation.
AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
CH471066 Genomic DNA. Translation: EAW49958.1.
BC146851 mRNA. Translation: AAI46852.1.
AY029183 mRNA. Translation: AAK31796.1.
CCDSCCDS7453.1. [O75093-1]
RefSeqNP_003052.2. NM_003061.2. [O75093-1]
UniGeneHs.632082.

3D structure databases

ProteinModelPortalO75093.
SMRO75093. Positions 30-1454.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112472. 1 interaction.
IntActO75093. 2 interactions.
MINTMINT-2797238.
STRING9606.ENSP00000266058.

PTM databases

PhosphoSiteO75093.

Proteomic databases

MaxQBO75093.
PaxDbO75093.
PRIDEO75093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
GeneID6585.
KEGGhsa:6585.
UCSCuc001kmw.2. human. [O75093-1]
uc009xvh.1. human. [O75093-2]

Organism-specific databases

CTD6585.
GeneCardsGC10M098747.
H-InvDBHIX0079168.
HIX0170440.
HGNCHGNC:11085. SLIT1.
HPAHPA006879.
MIM603742. gene.
neXtProtNX_O75093.
PharmGKBPA35938.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116120.
HOVERGENHBG057959.
InParanoidO75093.
KOK06838.
OrthoDBEOG78WKQW.
PhylomeDBO75093.
TreeFamTF332887.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

BgeeO75093.
CleanExHS_SLIT1.
GenevestigatorO75093.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLIT1. human.
GeneWikiSLIT1.
GenomeRNAi6585.
NextBio25625.
PROO75093.
SOURCESearch...

Entry information

Entry nameSLIT1_HUMAN
AccessionPrimary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM