O75093 (SLIT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Slit homolog 1 protein
Short name=Slit-1

Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name=Multiple EGF-like domains protein 4

Gene names

Name:	SLIT1
Synonyms:	KIAA0813, MEGF4, SLIL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Subunit structure	Interacts with ROBO1 and GREM1 By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. Ref.1
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 9 EGF-like domains. Contains 1 laminin G-like domain. Contains 20 LRR (leucine-rich) repeats. Contains 4 LRRCT domains. Contains 4 LRRNT domains.
Sequence caution	The sequence BAA32465.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Leucine-rich repeat Repeat Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension involved in axon guidance Inferred from direct assay PubMed 16840550. Source: UniProtKB dorsal/ventral axon guidance Inferred from electronic annotation. Source: Compara establishment of nucleus localization Inferred from electronic annotation. Source: Compara forebrain morphogenesis Non-traceable author statement Ref.1. Source: UniProtKB motor neuron axon guidance Inferred from mutant phenotype PubMed 16162649. Source: UniProtKB negative chemotaxis Inferred from direct assay PubMed 11748139. Source: UniProtKB negative regulation of axon extension involved in axon guidance Inferred from electronic annotation. Source: Compara negative regulation of synapse assembly Inferred from sequence or structural similarity. Source: UniProtKB retinal ganglion cell axon guidance Inferred from electronic annotation. Source: Compara spinal cord development Inferred from electronic annotation. Source: Compara tangential migration from the subventricular zone to the olfactory bulb Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA extracellular space Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	calcium ion binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75093-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75093-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1534	1501	Slit homolog 1 protein		PRO_0000007722
Regions
	Domain	34 – 61	28	LRRNT
	Repeat	62 – 83	22	LRR 1
	Repeat	86 – 107	22	LRR 2
	Repeat	110 – 131	22	LRR 3
	Repeat	134 – 155	22	LRR 4
	Repeat	158 – 179	22	LRR 5
	Repeat	182 – 203	22	LRR 6
	Domain	215 – 265	51	LRRCT 1
	Domain	273 – 309	37	LRRNT 2
	Repeat	310 – 331	22	LRR 7
	Repeat	334 – 355	22	LRR 8
	Repeat	358 – 379	22	LRR 9
	Repeat	382 – 403	22	LRR 10
	Repeat	406 – 427	22	LRR 11
	Domain	439 – 489	51	LRRCT 2
	Domain	504 – 540	37	LRRNT 3
	Repeat	541 – 562	22	LRR 12
	Repeat	566 – 587	22	LRR 13
	Repeat	590 – 611	22	LRR 14
	Repeat	614 – 635	22	LRR 15
	Repeat	638 – 659	22	LRR 16
	Domain	671 – 721	51	LRRCT 3
	Domain	725 – 761	37	LRRNT 4
	Repeat	762 – 783	22	LRR 17
	Repeat	785 – 806	22	LRR 18
	Repeat	809 – 830	22	LRR 19
	Repeat	833 – 854	22	LRR 20
	Domain	866 – 916	51	LRRCT 4
	Domain	927 – 962	36	EGF-like 1
	Domain	964 – 1003	40	EGF-like 2
	Domain	1005 – 1041	37	EGF-like 3
	Domain	1043 – 1081	39	EGF-like 4
	Domain	1083 – 1119	37	EGF-like 5
	Domain	1127 – 1163	37	EGF-like 6
	Domain	1166 – 1339	174	Laminin G-like
	Domain	1340 – 1374	35	EGF-like 7
	Domain	1377 – 1413	37	EGF-like 8
	Domain	1418 – 1454	37	EGF-like 9
	Domain	1459 – 1534	76	CTCK
Amino acid modifications
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	406	1	N-linked (GlcNAc...) Potential
	Glycosylation	571	1	N-linked (GlcNAc...) Potential
	Glycosylation	630	1	N-linked (GlcNAc...) Potential
	Glycosylation	762	1	N-linked (GlcNAc...) Potential
	Glycosylation	801	1	N-linked (GlcNAc...) Potential
	Glycosylation	806	1	N-linked (GlcNAc...) Potential
	Glycosylation	1026	1	N-linked (GlcNAc...) Potential
	Glycosylation	1079	1	N-linked (GlcNAc...) Potential
	Glycosylation	1189	1	N-linked (GlcNAc...) Potential
	Glycosylation	1259	1	N-linked (GlcNAc...) Potential
	Glycosylation	1306	1	N-linked (GlcNAc...) Potential
	Disulfide bond	286 ↔ 295		By similarity
	Disulfide bond	443 ↔ 466		By similarity
	Disulfide bond	445 ↔ 487		By similarity
	Disulfide bond	513 ↔ 519		By similarity
	Disulfide bond	517 ↔ 526		By similarity
	Disulfide bond	675 ↔ 698		By similarity
	Disulfide bond	677 ↔ 719		By similarity
	Disulfide bond	929 ↔ 940		By similarity
	Disulfide bond	934 ↔ 950		By similarity
	Disulfide bond	952 ↔ 961		By similarity
	Disulfide bond	968 ↔ 979		By similarity
	Disulfide bond	973 ↔ 991		By similarity
	Disulfide bond	993 ↔ 1002		By similarity
	Disulfide bond	1009 ↔ 1020		By similarity
	Disulfide bond	1014 ↔ 1029		By similarity
	Disulfide bond	1031 ↔ 1040		By similarity
	Disulfide bond	1047 ↔ 1060		By similarity
	Disulfide bond	1054 ↔ 1069		By similarity
	Disulfide bond	1071 ↔ 1080		By similarity
	Disulfide bond	1087 ↔ 1098		By similarity
	Disulfide bond	1092 ↔ 1107		By similarity
	Disulfide bond	1109 ↔ 1118		By similarity
	Disulfide bond	1131 ↔ 1142		By similarity
	Disulfide bond	1136 ↔ 1151		By similarity
	Disulfide bond	1153 ↔ 1162		By similarity
	Disulfide bond	1313 ↔ 1339		By similarity
	Disulfide bond	1342 ↔ 1352		By similarity
	Disulfide bond	1347 ↔ 1362		By similarity
	Disulfide bond	1364 ↔ 1373		By similarity
	Disulfide bond	1381 ↔ 1391		By similarity
	Disulfide bond	1386 ↔ 1401		By similarity
	Disulfide bond	1403 ↔ 1412		By similarity
	Disulfide bond	1422 ↔ 1432		By similarity
	Disulfide bond	1427 ↔ 1442		By similarity
	Disulfide bond	1444 ↔ 1453		By similarity
	Disulfide bond	1459 ↔ 1498		By similarity
	Disulfide bond	1477 ↔ 1512		By similarity
	Disulfide bond	1488 ↔ 1528		By similarity
	Disulfide bond	1492 ↔ 1530		By similarity
Natural variations
	Alternative sequence	338	1	I → IRPLSFCSPCR in isoform 2.		VSP_009706
	Alternative sequence	790 – 813	24	Missing in isoform 2.		VSP_009707
	Alternative sequence	830 – 1534	705	Missing in isoform 2.		VSP_009708
	Natural variant	824	1	P → L. Corresponds to variant rs2817673 [ dbSNP | Ensembl ].		VAR_049003
Experimental info
	Sequence conflict	99	1	A → V in BAA32465. Ref.2
	Sequence conflict	163	1	Q → R in BAA35184. Ref.1
	Sequence conflict	829	1	Q → P in AAK31796. Ref.8
	Sequence conflict	966	1	D → N in BAA35184. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 4. Checksum: 47B11CE6704A3E1D	FASTA	1,534	167,926
	10 20 30 40 50 60 MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT GLQAIPKNIP 70 80 90 100 110 120 RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV ERGAFDDMKE LERLRLNRNQ 130 140 150 160 170 180 LHMLPELLFQ NNQALSRLDL SENAIQAIPR KAFRGATDLK NLQLDKNQIS CIEEGAFRAL 190 200 210 220 230 240 RGLEVLTLNN NNITTIPVSS FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT 250 260 270 280 290 300 QCSGPASLRG LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL 310 320 330 340 350 360 TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP DAFQGLRSLN 370 380 390 400 410 420 SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA FQDLQNLSLL SLYDNKIQSL 430 440 450 460 470 480 AKGTFTSLRA IQTLHLAQNP FICDCNLKWL ADFLRTNPIE TSGARCASPR RLANKRIGQI 490 500 510 520 530 540 KSKKFRCSAK EQYFIPGTED YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ 550 560 570 580 590 600 STAELRLNNN EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ 610 620 630 640 650 660 LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT TVSPGAFDTL 670 680 690 700 710 720 QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN PDFLRQIPLQ DVAFPDFRCE 730 740 750 760 770 780 EGQEEGGCLP RPQCPQECAC LDTVVRCSNK HLRALPKGIP KNVTELYLDG NQFTLVPGQL 790 800 810 820 830 840 STFKYLQLVD LSNNKISSLS NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH 850 860 870 880 890 900 GNDISTLQEG IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME 910 920 930 940 950 960 GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC ACPSGYKGRD 970 980 990 1000 1010 1020 CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP TCGVNTDDCV DHACANGGVC 1030 1040 1050 1060 1070 1080 VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC 1090 1100 1110 1120 1130 1140 SENQDDCRDH RCQNGAQCMD EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA 1150 1160 1170 1180 1190 1200 NCVDQGNRPV CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN 1210 1220 1230 1240 1250 1260 GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE LVAFDQMVNL 1270 1280 1290 1300 1310 1320 SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR LWQILNGTGF HGCIRNLYIN 1330 1340 1350 1360 1370 1380 NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG ICQPNATPGP MCHCEAGWVG LHCDQPADGP 1390 1400 1410 1420 1430 1440 CHGHKCVHGQ CVPLDALSYS CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA 1450 1460 1470 1480 1490 1500 HCVCDPGFSG ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG 1510 1520 1530 LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA
	Isoform 2 (B) [UniParc]. Checksum: 4E435E97AD79F37C	FASTA	815	90,633
	10 20 30 40 50 60 MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT GLQAIPKNIP 70 80 90 100 110 120 RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV ERGAFDDMKE LERLRLNRNQ 130 140 150 160 170 180 LHMLPELLFQ NNQALSRLDL SENAIQAIPR KAFRGATDLK NLQLDKNQIS CIEEGAFRAL 190 200 210 220 230 240 RGLEVLTLNN NNITTIPVSS FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT 250 260 270 280 290 300 QCSGPASLRG LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL 310 320 330 340 350 360 TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIRP LSFCSPCRDL SNNQIAEIAP 370 380 390 400 410 420 DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA FQDLQNLSLL 430 440 450 460 470 480 SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL ADFLRTNPIE TSGARCASPR 490 500 510 520 530 540 RLANKRIGQI KSKKFRCSAK EQYFIPGTED YQLNSECNSD VVCPHKCRCE ANVVECSSLK 550 560 570 580 590 600 LTKIPERIPQ STAELRLNNN EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS 610 620 630 640 650 660 VSELHLTANQ LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT 670 680 690 700 710 720 TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN PDFLRQIPLQ 730 740 750 760 770 780 DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK HLRALPKGIP KNVTELYLDG 790 800 810 NQFTLVPGQL STFKYLQLVI LSYNALQCIP PLAFQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system." Itoh A., Miyabayashi T., Ohno M., Sakano S. Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening." Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O. Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	Nakayama M., Nakajima D., Ohara O. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Conserved modularity and potential for alternate splicing in mouse and human Slit genes." Little M., Rumballe B., Georgas K., Yamada T., Teasdale R.D. Int. J. Dev. Biol. 46:385-391(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1534 (ISOFORM 2).
[9]	"Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes." Wong K., Park H.T., Wu J.Y., Rao Y. Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB017167 mRNA. Translation: BAA35184.1. AB011537 mRNA. Translation: BAA32465.3. Different initiation. AL442123, AL512424 Genomic DNA. Translation: CAH70918.1. AL512424, AL442123 Genomic DNA. Translation: CAI14258.1. CH471066 Genomic DNA. Translation: EAW49958.1. BC146851 mRNA. Translation: AAI46852.1. AY029183 mRNA. Translation: AAK31796.1.
IPI	IPI00296434. IPI00871419.
RefSeq	NP_003052.2. NM_003061.2.
UniGene	Hs.632082.
3D structure databases
ProteinModelPortal	O75093.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75093. 1 interaction.
MINT	MINT-2797238.
STRING	9606.ENSP00000266058.
PTM databases
PhosphoSite	O75093.
Proteomic databases
PaxDb	O75093.
PRIDE	O75093.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266058; ENSP00000266058; ENSG00000187122.
GeneID	6585.
KEGG	hsa:6585.
UCSC	uc001kmw.2. human.
Organism-specific databases
CTD	6585.
GeneCards	GC10M098747.
H-InvDB	HIX0079168. HIX0170440.
HGNC	HGNC:11085. SLIT1.
HPA	HPA006879.
MIM	603742. gene.
neXtProt	NX_O75093.
PharmGKB	PA35938.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000116120.
HOVERGEN	HBG057959.
InParanoid	O75093.
KO	K06838.
OrthoDB	EOG4VDPXM.
PhylomeDB	O75093.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	O75093.
Bgee	O75093.
CleanEx	HS_SLIT1.
Genevestigator	O75093.
GermOnline	ENSG00000187122. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000483. Cys-rich_flank_reg_C. IPR006207. Cys_knot_C. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR003645. Fol_N. IPR001791. Laminin_G. IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00008. EGF. 3 hits. PF12661. hEGF. 2 hits. PF02210. Laminin_G_2. 1 hit. PF00560. LRR_1. 1 hit. PF12799. LRR_4. 1 hit. PF01463. LRRCT. 4 hits. PF01462. LRRNT. 4 hits. [Graphical view]
SMART	SM00041. CT. 1 hit. SM00181. EGF. 7 hits. SM00179. EGF_CA. 2 hits. SM00274. FOLN. 4 hits. SM00282. LamG. 1 hit. SM00369. LRR_TYP. 10 hits. SM00082. LRRCT. 4 hits. SM00013. LRRNT. 4 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00022. EGF_1. 9 hits. PS01186. EGF_2. 8 hits. PS50026. EGF_3. 9 hits. PS01187. EGF_CA. 2 hits. PS50025. LAM_G_DOMAIN. 1 hit. PS51450. LRR. 21 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLIT1. human.
GenomeRNAi	6585.
NextBio	25625.
SOURCE	Search...

Entry information

Entry name

SLIT1_HUMAN

Accession

Primary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 126 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.