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O75093

- SLIT1_HUMAN

UniProt

O75093 - SLIT1_HUMAN

Protein

Slit homolog 1 protein

Gene

SLIT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 4 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. Roundabout binding Source: UniProtKB

    GO - Biological processi

    1. axon extension involved in axon guidance Source: UniProtKB
    2. axon guidance Source: UniProtKB
    3. dorsal/ventral axon guidance Source: Ensembl
    4. establishment of nucleus localization Source: Ensembl
    5. forebrain morphogenesis Source: UniProtKB
    6. motor neuron axon guidance Source: UniProtKB
    7. negative chemotaxis Source: UniProtKB
    8. negative regulation of axon extension involved in axon guidance Source: Ensembl
    9. negative regulation of synapse assembly Source: UniProtKB
    10. retinal ganglion cell axon guidance Source: Ensembl
    11. spinal cord development Source: Ensembl
    12. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_22237. Netrin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Slit homolog 1 protein
    Short name:
    Slit-1
    Alternative name(s):
    Multiple epidermal growth factor-like domains protein 4
    Short name:
    Multiple EGF-like domains protein 4
    Gene namesi
    Name:SLIT1
    Synonyms:KIAA0813, MEGF4, SLIL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:11085. SLIT1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 15341501Slit homolog 1 proteinPRO_0000007722Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi286 ↔ 295By similarity
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi443 ↔ 466By similarity
    Disulfide bondi445 ↔ 487By similarity
    Disulfide bondi513 ↔ 519By similarity
    Disulfide bondi517 ↔ 526By similarity
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi675 ↔ 698By similarity
    Disulfide bondi677 ↔ 719By similarity
    Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi929 ↔ 940By similarity
    Disulfide bondi934 ↔ 950By similarity
    Disulfide bondi952 ↔ 961By similarity
    Disulfide bondi968 ↔ 979By similarity
    Disulfide bondi973 ↔ 991By similarity
    Disulfide bondi993 ↔ 1002By similarity
    Disulfide bondi1009 ↔ 1020By similarity
    Disulfide bondi1014 ↔ 1029By similarity
    Glycosylationi1026 – 10261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1031 ↔ 1040By similarity
    Disulfide bondi1047 ↔ 1060By similarity
    Disulfide bondi1054 ↔ 1069By similarity
    Disulfide bondi1071 ↔ 1080By similarity
    Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1087 ↔ 1098By similarity
    Disulfide bondi1092 ↔ 1107By similarity
    Disulfide bondi1109 ↔ 1118By similarity
    Disulfide bondi1131 ↔ 1142By similarity
    Disulfide bondi1136 ↔ 1151By similarity
    Disulfide bondi1153 ↔ 1162By similarity
    Glycosylationi1189 – 11891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1259 – 12591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1306 – 13061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1313 ↔ 1339By similarity
    Disulfide bondi1342 ↔ 1352By similarity
    Disulfide bondi1347 ↔ 1362By similarity
    Disulfide bondi1364 ↔ 1373By similarity
    Disulfide bondi1381 ↔ 1391By similarity
    Disulfide bondi1386 ↔ 1401By similarity
    Disulfide bondi1403 ↔ 1412By similarity
    Disulfide bondi1422 ↔ 1432By similarity
    Disulfide bondi1427 ↔ 1442By similarity
    Disulfide bondi1444 ↔ 1453By similarity
    Disulfide bondi1459 ↔ 1498By similarity
    Disulfide bondi1477 ↔ 1512By similarity
    Disulfide bondi1488 ↔ 1528By similarity
    Disulfide bondi1492 ↔ 1530By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO75093.
    PaxDbiO75093.
    PRIDEiO75093.

    PTM databases

    PhosphoSiteiO75093.

    Expressioni

    Tissue specificityi

    Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.1 Publication

    Gene expression databases

    BgeeiO75093.
    CleanExiHS_SLIT1.
    GenevestigatoriO75093.

    Organism-specific databases

    HPAiHPA006879.

    Interactioni

    Subunit structurei

    Interacts with ROBO1 and GREM1.By similarity

    Protein-protein interaction databases

    BioGridi112472. 1 interaction.
    IntActiO75093. 2 interactions.
    MINTiMINT-2797238.
    STRINGi9606.ENSP00000266058.

    Structurei

    3D structure databases

    ProteinModelPortaliO75093.
    SMRiO75093. Positions 30-1454.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 6128LRRNTAdd
    BLAST
    Repeati62 – 8322LRR 1Add
    BLAST
    Repeati86 – 10722LRR 2Add
    BLAST
    Repeati110 – 13122LRR 3Add
    BLAST
    Repeati134 – 15522LRR 4Add
    BLAST
    Repeati158 – 17922LRR 5Add
    BLAST
    Repeati182 – 20322LRR 6Add
    BLAST
    Domaini215 – 26551LRRCT 1Add
    BLAST
    Domaini273 – 30937LRRNT 2Add
    BLAST
    Repeati310 – 33122LRR 7Add
    BLAST
    Repeati334 – 35522LRR 8Add
    BLAST
    Repeati358 – 37922LRR 9Add
    BLAST
    Repeati382 – 40322LRR 10Add
    BLAST
    Repeati406 – 42722LRR 11Add
    BLAST
    Domaini439 – 48951LRRCT 2Add
    BLAST
    Domaini504 – 54037LRRNT 3Add
    BLAST
    Repeati541 – 56222LRR 12Add
    BLAST
    Repeati566 – 58722LRR 13Add
    BLAST
    Repeati590 – 61122LRR 14Add
    BLAST
    Repeati614 – 63522LRR 15Add
    BLAST
    Repeati638 – 65922LRR 16Add
    BLAST
    Domaini671 – 72151LRRCT 3Add
    BLAST
    Domaini725 – 76137LRRNT 4Add
    BLAST
    Repeati762 – 78322LRR 17Add
    BLAST
    Repeati785 – 80622LRR 18Add
    BLAST
    Repeati809 – 83022LRR 19Add
    BLAST
    Repeati833 – 85422LRR 20Add
    BLAST
    Domaini866 – 91651LRRCT 4Add
    BLAST
    Domaini927 – 96236EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini964 – 100340EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1005 – 104137EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1043 – 108139EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1083 – 111937EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1127 – 116337EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1166 – 1339174Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini1340 – 137435EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1377 – 141337EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1418 – 145437EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1459 – 153476CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 9 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 20 LRR (leucine-rich) repeats.Curated
    Contains 4 LRRCT domains.Curated
    Contains 4 LRRNT domains.Curated

    Keywords - Domaini

    EGF-like domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116120.
    HOVERGENiHBG057959.
    InParanoidiO75093.
    KOiK06838.
    OrthoDBiEOG78WKQW.
    PhylomeDBiO75093.
    TreeFamiTF332887.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00008. EGF. 3 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view]
    SMARTiSM00041. CT. 1 hit.
    SM00181. EGF. 7 hits.
    SM00179. EGF_CA. 2 hits.
    SM00274. FOLN. 4 hits.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 21 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75093-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT     50
    GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV 100
    ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR 150
    KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS 200
    FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG 250
    LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL 300
    TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP 350
    DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA 400
    FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL 450
    ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED 500
    YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN 550
    EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ 600
    LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT 650
    TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN 700
    PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK 750
    HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS 800
    NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG 850
    IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME 900
    GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC 950
    ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP 1000
    TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD 1050
    LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD 1100
    EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV 1150
    CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN 1200
    GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE 1250
    LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR 1300
    LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG 1350
    ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS 1400
    CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG 1450
    ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG 1500
    LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA 1534
    Length:1,534
    Mass (Da):167,926
    Last modified:April 17, 2007 - v4
    Checksum:i47B11CE6704A3E1D
    GO
    Isoform 2 (identifier: O75093-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         338-338: I → IRPLSFCSPCR
         790-813: Missing.
         830-1534: Missing.

    Show »
    Length:815
    Mass (Da):90,633
    Checksum:i4E435E97AD79F37C
    GO

    Sequence cautioni

    The sequence BAA32465.3 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991A → V in BAA32465. (PubMed:9693030)Curated
    Sequence conflicti163 – 1631Q → R in BAA35184. (PubMed:9813312)Curated
    Sequence conflicti829 – 8291Q → P in AAK31796. (PubMed:12141424)Curated
    Sequence conflicti966 – 9661D → N in BAA35184. (PubMed:9813312)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti824 – 8241P → L.
    Corresponds to variant rs2817673 [ dbSNP | Ensembl ].
    VAR_049003

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei338 – 3381I → IRPLSFCSPCR in isoform 2. 1 PublicationVSP_009706
    Alternative sequencei790 – 81324Missing in isoform 2. 1 PublicationVSP_009707Add
    BLAST
    Alternative sequencei830 – 1534705Missing in isoform 2. 1 PublicationVSP_009708Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017167 mRNA. Translation: BAA35184.1.
    AB011537 mRNA. Translation: BAA32465.3. Different initiation.
    AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
    AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
    CH471066 Genomic DNA. Translation: EAW49958.1.
    BC146851 mRNA. Translation: AAI46852.1.
    AY029183 mRNA. Translation: AAK31796.1.
    CCDSiCCDS7453.1. [O75093-1]
    RefSeqiNP_003052.2. NM_003061.2. [O75093-1]
    UniGeneiHs.632082.

    Genome annotation databases

    EnsembliENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
    GeneIDi6585.
    KEGGihsa:6585.
    UCSCiuc001kmw.2. human. [O75093-1]
    uc009xvh.1. human. [O75093-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017167 mRNA. Translation: BAA35184.1 .
    AB011537 mRNA. Translation: BAA32465.3 . Different initiation.
    AL442123 , AL512424 Genomic DNA. Translation: CAH70918.1 .
    AL512424 , AL442123 Genomic DNA. Translation: CAI14258.1 .
    CH471066 Genomic DNA. Translation: EAW49958.1 .
    BC146851 mRNA. Translation: AAI46852.1 .
    AY029183 mRNA. Translation: AAK31796.1 .
    CCDSi CCDS7453.1. [O75093-1 ]
    RefSeqi NP_003052.2. NM_003061.2. [O75093-1 ]
    UniGenei Hs.632082.

    3D structure databases

    ProteinModelPortali O75093.
    SMRi O75093. Positions 30-1454.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112472. 1 interaction.
    IntActi O75093. 2 interactions.
    MINTi MINT-2797238.
    STRINGi 9606.ENSP00000266058.

    PTM databases

    PhosphoSitei O75093.

    Proteomic databases

    MaxQBi O75093.
    PaxDbi O75093.
    PRIDEi O75093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266058 ; ENSP00000266058 ; ENSG00000187122 . [O75093-1 ]
    GeneIDi 6585.
    KEGGi hsa:6585.
    UCSCi uc001kmw.2. human. [O75093-1 ]
    uc009xvh.1. human. [O75093-2 ]

    Organism-specific databases

    CTDi 6585.
    GeneCardsi GC10M098747.
    H-InvDB HIX0079168.
    HIX0170440.
    HGNCi HGNC:11085. SLIT1.
    HPAi HPA006879.
    MIMi 603742. gene.
    neXtProti NX_O75093.
    PharmGKBi PA35938.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116120.
    HOVERGENi HBG057959.
    InParanoidi O75093.
    KOi K06838.
    OrthoDBi EOG78WKQW.
    PhylomeDBi O75093.
    TreeFami TF332887.

    Enzyme and pathway databases

    Reactomei REACT_22237. Netrin-1 signaling.

    Miscellaneous databases

    ChiTaRSi SLIT1. human.
    GeneWikii SLIT1.
    GenomeRNAii 6585.
    NextBioi 25625.
    PROi O75093.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75093.
    CleanExi HS_SLIT1.
    Genevestigatori O75093.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00008. EGF. 3 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view ]
    SMARTi SM00041. CT. 1 hit.
    SM00181. EGF. 7 hits.
    SM00179. EGF_CA. 2 hits.
    SM00274. FOLN. 4 hits.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 21 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
      Itoh A., Miyabayashi T., Ohno M., Sakano S.
      Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Nakayama M., Nakajima D., Ohara O.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Conserved modularity and potential for alternate splicing in mouse and human Slit genes."
      Little M., Rumballe B., Georgas K., Yamada T., Teasdale R.D.
      Int. J. Dev. Biol. 46:385-391(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1534 (ISOFORM 2).
    9. "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes."
      Wong K., Park H.T., Wu J.Y., Rao Y.
      Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiSLIT1_HUMAN
    AccessioniPrimary (citable) accession number: O75093
    Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 139 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3