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O75093

- SLIT1_HUMAN

UniProt

O75093 - SLIT1_HUMAN

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Protein
Slit homolog 1 protein
Gene
SLIT1, KIAA0813, MEGF4, SLIL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

GO - Molecular functioni

  1. Roundabout binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB

GO - Biological processi

  1. axon extension involved in axon guidance Source: UniProtKB
  2. axon guidance Source: UniProtKB
  3. dorsal/ventral axon guidance Source: Ensembl
  4. establishment of nucleus localization Source: Ensembl
  5. forebrain morphogenesis Source: UniProtKB
  6. motor neuron axon guidance Source: UniProtKB
  7. negative chemotaxis Source: UniProtKB
  8. negative regulation of axon extension involved in axon guidance Source: Ensembl
  9. negative regulation of synapse assembly Source: UniProtKB
  10. retinal ganglion cell axon guidance Source: Ensembl
  11. spinal cord development Source: Ensembl
  12. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_22237. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name:
Multiple EGF-like domains protein 4
Gene namesi
Name:SLIT1
Synonyms:KIAA0813, MEGF4, SLIL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11085. SLIT1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 15341501Slit homolog 1 protein
PRO_0000007722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi286 ↔ 295 By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi443 ↔ 466 By similarity
Disulfide bondi445 ↔ 487 By similarity
Disulfide bondi513 ↔ 519 By similarity
Disulfide bondi517 ↔ 526 By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi675 ↔ 698 By similarity
Disulfide bondi677 ↔ 719 By similarity
Glycosylationi762 – 7621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi801 – 8011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi806 – 8061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi929 ↔ 940 By similarity
Disulfide bondi934 ↔ 950 By similarity
Disulfide bondi952 ↔ 961 By similarity
Disulfide bondi968 ↔ 979 By similarity
Disulfide bondi973 ↔ 991 By similarity
Disulfide bondi993 ↔ 1002 By similarity
Disulfide bondi1009 ↔ 1020 By similarity
Disulfide bondi1014 ↔ 1029 By similarity
Glycosylationi1026 – 10261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1031 ↔ 1040 By similarity
Disulfide bondi1047 ↔ 1060 By similarity
Disulfide bondi1054 ↔ 1069 By similarity
Disulfide bondi1071 ↔ 1080 By similarity
Glycosylationi1079 – 10791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1087 ↔ 1098 By similarity
Disulfide bondi1092 ↔ 1107 By similarity
Disulfide bondi1109 ↔ 1118 By similarity
Disulfide bondi1131 ↔ 1142 By similarity
Disulfide bondi1136 ↔ 1151 By similarity
Disulfide bondi1153 ↔ 1162 By similarity
Glycosylationi1189 – 11891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1259 – 12591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1306 – 13061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1313 ↔ 1339 By similarity
Disulfide bondi1342 ↔ 1352 By similarity
Disulfide bondi1347 ↔ 1362 By similarity
Disulfide bondi1364 ↔ 1373 By similarity
Disulfide bondi1381 ↔ 1391 By similarity
Disulfide bondi1386 ↔ 1401 By similarity
Disulfide bondi1403 ↔ 1412 By similarity
Disulfide bondi1422 ↔ 1432 By similarity
Disulfide bondi1427 ↔ 1442 By similarity
Disulfide bondi1444 ↔ 1453 By similarity
Disulfide bondi1459 ↔ 1498 By similarity
Disulfide bondi1477 ↔ 1512 By similarity
Disulfide bondi1488 ↔ 1528 By similarity
Disulfide bondi1492 ↔ 1530 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75093.
PaxDbiO75093.
PRIDEiO75093.

PTM databases

PhosphoSiteiO75093.

Expressioni

Tissue specificityi

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.1 Publication

Gene expression databases

BgeeiO75093.
CleanExiHS_SLIT1.
GenevestigatoriO75093.

Organism-specific databases

HPAiHPA006879.

Interactioni

Subunit structurei

Interacts with ROBO1 and GREM1 By similarity.

Protein-protein interaction databases

BioGridi112472. 1 interaction.
IntActiO75093. 2 interactions.
MINTiMINT-2797238.
STRINGi9606.ENSP00000266058.

Structurei

3D structure databases

ProteinModelPortaliO75093.
SMRiO75093. Positions 30-1454.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNT
Add
BLAST
Repeati62 – 8322LRR 1
Add
BLAST
Repeati86 – 10722LRR 2
Add
BLAST
Repeati110 – 13122LRR 3
Add
BLAST
Repeati134 – 15522LRR 4
Add
BLAST
Repeati158 – 17922LRR 5
Add
BLAST
Repeati182 – 20322LRR 6
Add
BLAST
Domaini215 – 26551LRRCT 1
Add
BLAST
Domaini273 – 30937LRRNT 2
Add
BLAST
Repeati310 – 33122LRR 7
Add
BLAST
Repeati334 – 35522LRR 8
Add
BLAST
Repeati358 – 37922LRR 9
Add
BLAST
Repeati382 – 40322LRR 10
Add
BLAST
Repeati406 – 42722LRR 11
Add
BLAST
Domaini439 – 48951LRRCT 2
Add
BLAST
Domaini504 – 54037LRRNT 3
Add
BLAST
Repeati541 – 56222LRR 12
Add
BLAST
Repeati566 – 58722LRR 13
Add
BLAST
Repeati590 – 61122LRR 14
Add
BLAST
Repeati614 – 63522LRR 15
Add
BLAST
Repeati638 – 65922LRR 16
Add
BLAST
Domaini671 – 72151LRRCT 3
Add
BLAST
Domaini725 – 76137LRRNT 4
Add
BLAST
Repeati762 – 78322LRR 17
Add
BLAST
Repeati785 – 80622LRR 18
Add
BLAST
Repeati809 – 83022LRR 19
Add
BLAST
Repeati833 – 85422LRR 20
Add
BLAST
Domaini866 – 91651LRRCT 4
Add
BLAST
Domaini927 – 96236EGF-like 1
Add
BLAST
Domaini964 – 100340EGF-like 2
Add
BLAST
Domaini1005 – 104137EGF-like 3
Add
BLAST
Domaini1043 – 108139EGF-like 4
Add
BLAST
Domaini1083 – 111937EGF-like 5
Add
BLAST
Domaini1127 – 116337EGF-like 6
Add
BLAST
Domaini1166 – 1339174Laminin G-like
Add
BLAST
Domaini1340 – 137435EGF-like 7
Add
BLAST
Domaini1377 – 141337EGF-like 8
Add
BLAST
Domaini1418 – 145437EGF-like 9
Add
BLAST
Domaini1459 – 153476CTCK
Add
BLAST

Sequence similaritiesi

Contains 9 EGF-like domains.
Contains 4 LRRCT domains.
Contains 4 LRRNT domains.

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiO75093.
KOiK06838.
OrthoDBiEOG78WKQW.
PhylomeDBiO75093.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75093-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT     50
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV 100
ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR 150
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS 200
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG 250
LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL 300
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP 350
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA 400
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL 450
ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED 500
YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN 550
EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ 600
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT 650
TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN 700
PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK 750
HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS 800
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG 850
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME 900
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC 950
ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP 1000
TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD 1050
LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD 1100
EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV 1150
CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN 1200
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE 1250
LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR 1300
LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG 1350
ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS 1400
CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG 1450
ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG 1500
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA 1534
Length:1,534
Mass (Da):167,926
Last modified:April 17, 2007 - v4
Checksum:i47B11CE6704A3E1D
GO
Isoform 2 (identifier: O75093-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Show »
Length:815
Mass (Da):90,633
Checksum:i4E435E97AD79F37C
GO

Sequence cautioni

The sequence BAA32465.3 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti824 – 8241P → L.
Corresponds to variant rs2817673 [ dbSNP | Ensembl ].
VAR_049003

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 3381I → IRPLSFCSPCR in isoform 2.
VSP_009706
Alternative sequencei790 – 81324Missing in isoform 2.
VSP_009707Add
BLAST
Alternative sequencei830 – 1534705Missing in isoform 2.
VSP_009708Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991A → V in BAA32465. 1 Publication
Sequence conflicti163 – 1631Q → R in BAA35184. 1 Publication
Sequence conflicti829 – 8291Q → P in AAK31796. 1 Publication
Sequence conflicti966 – 9661D → N in BAA35184. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017167 mRNA. Translation: BAA35184.1.
AB011537 mRNA. Translation: BAA32465.3. Different initiation.
AL442123, AL512424 Genomic DNA. Translation: CAH70918.1.
AL512424, AL442123 Genomic DNA. Translation: CAI14258.1.
CH471066 Genomic DNA. Translation: EAW49958.1.
BC146851 mRNA. Translation: AAI46852.1.
AY029183 mRNA. Translation: AAK31796.1.
CCDSiCCDS7453.1. [O75093-1]
RefSeqiNP_003052.2. NM_003061.2. [O75093-1]
UniGeneiHs.632082.

Genome annotation databases

EnsembliENST00000266058; ENSP00000266058; ENSG00000187122. [O75093-1]
GeneIDi6585.
KEGGihsa:6585.
UCSCiuc001kmw.2. human. [O75093-1]
uc009xvh.1. human. [O75093-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017167 mRNA. Translation: BAA35184.1 .
AB011537 mRNA. Translation: BAA32465.3 . Different initiation.
AL442123 , AL512424 Genomic DNA. Translation: CAH70918.1 .
AL512424 , AL442123 Genomic DNA. Translation: CAI14258.1 .
CH471066 Genomic DNA. Translation: EAW49958.1 .
BC146851 mRNA. Translation: AAI46852.1 .
AY029183 mRNA. Translation: AAK31796.1 .
CCDSi CCDS7453.1. [O75093-1 ]
RefSeqi NP_003052.2. NM_003061.2. [O75093-1 ]
UniGenei Hs.632082.

3D structure databases

ProteinModelPortali O75093.
SMRi O75093. Positions 30-1454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112472. 1 interaction.
IntActi O75093. 2 interactions.
MINTi MINT-2797238.
STRINGi 9606.ENSP00000266058.

PTM databases

PhosphoSitei O75093.

Proteomic databases

MaxQBi O75093.
PaxDbi O75093.
PRIDEi O75093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266058 ; ENSP00000266058 ; ENSG00000187122 . [O75093-1 ]
GeneIDi 6585.
KEGGi hsa:6585.
UCSCi uc001kmw.2. human. [O75093-1 ]
uc009xvh.1. human. [O75093-2 ]

Organism-specific databases

CTDi 6585.
GeneCardsi GC10M098747.
H-InvDB HIX0079168.
HIX0170440.
HGNCi HGNC:11085. SLIT1.
HPAi HPA006879.
MIMi 603742. gene.
neXtProti NX_O75093.
PharmGKBi PA35938.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000116120.
HOVERGENi HBG057959.
InParanoidi O75093.
KOi K06838.
OrthoDBi EOG78WKQW.
PhylomeDBi O75093.
TreeFami TF332887.

Enzyme and pathway databases

Reactomei REACT_22237. Netrin-1 signaling.

Miscellaneous databases

ChiTaRSi SLIT1. human.
GeneWikii SLIT1.
GenomeRNAii 6585.
NextBioi 25625.
PROi O75093.
SOURCEi Search...

Gene expression databases

Bgeei O75093.
CleanExi HS_SLIT1.
Genevestigatori O75093.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view ]
SMARTi SM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 4 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
    Itoh A., Miyabayashi T., Ohno M., Sakano S.
    Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Nakayama M., Nakajima D., Ohara O.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Conserved modularity and potential for alternate splicing in mouse and human Slit genes."
    Little M., Rumballe B., Georgas K., Yamada T., Teasdale R.D.
    Int. J. Dev. Biol. 46:385-391(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-1534 (ISOFORM 2).
  9. "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes."
    Wong K., Park H.T., Wu J.Y., Rao Y.
    Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiSLIT1_HUMAN
AccessioniPrimary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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